期刊文献+
共找到400篇文章
< 1 2 20 >
每页显示 20 50 100
POSSIBLY用法译评
1
作者 吴国良 冯春灿 《上海翻译》 CSSCI 北大核心 2012年第2期59-63,共5页
英语情态副词及其相关的形容词,用法上常常既有相通之处,也有不同之处。本文拟对possibly及其相关的形容词、副词在语义、修饰、句法、位置等方面加以辨析。
关键词 possibly 用法特征 句法特征
在线阅读 下载PDF
An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall 被引量:6
2
作者 WANG Ya Lin QIN Jin Hong +3 位作者 ZHANG Cui Cai GUO Xiao Kui JIANG Xiu Gao HE Ping 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第1期56-59,共4页
A total of 26 leptospirosis cases occurred in the outbreak, of whom six died after hospitalization. All 26 patients were clinically diagnosed as leptospirosis Microscopic agglutination test (MAT) revealed that 13 of... A total of 26 leptospirosis cases occurred in the outbreak, of whom six died after hospitalization. All 26 patients were clinically diagnosed as leptospirosis Microscopic agglutination test (MAT) revealed that 13 of 26 patients were affected with laboratory confirmed leptospirosis. Furthermore, MAT data suggested that serogroup Icterohaemorrhagiae were the main pathogens responsible for this outbreak. And the rainfall data suggested that the increased rainfall might be responsible for the leptospirosis outbreak in Lezhi County. This outbreak has reminded us that leptospirosis should not be neglected, especially during flood season, although its incidence rate is low. 展开更多
关键词 2010 China in 2010 May possibly Be Linked to Rainfall An Outbreak of Leptospirosis in Lezhi County
暂未订购
JIMTOF2024展会报告(上)
3
作者 符祚钢 《世界制造技术与装备市场》 2025年第1期54-60,共7页
2024年日本机床展览会(JIMTOF2024)于2024年11月5~10日在东京Tokyo Big Sight举办,展出面积118540平方米。展会以“技术传承提供无限可能(Technologies passed down to the future offer unlimited possibilities)”为主题。
关键词 technologies passed down JIMTOF machine tool exhibition tokyo big sight unlimited possibilities
在线阅读 下载PDF
Possibly non-unital operator system structures on a possibly non-unital function system
4
作者 Jianze LI 《Frontiers of Mathematics in China》 SCIE CSCD 2012年第5期847-855,共9页
In this paper, we first give the definition of possibly non-unital function system, which is a characterization of the self-adjoint subspace of the space of continuous functions on a compact Hausdorff space with the i... In this paper, we first give the definition of possibly non-unital function system, which is a characterization of the self-adjoint subspace of the space of continuous functions on a compact Hausdorff space with the induced order and norm structure. Similar to operator system case, we define the unitalization of a possibly non-unital function system. Then we construct two possibly non-unital operator system structures on a given possibly non-unital function system, which are the analogues of minimal and maximal operator spaces on a normed space. These two structures have many interesting relations with the minimal and maximal operator system structures on a given function system. 展开更多
关键词 possibly non-unital function system operator system possibly non-unital operator system
原文传递
Recurrent generalized pustular psoriasis possibly triggered by apremilast 被引量:2
5
作者 Wen-Ming Wang Dan Shu +1 位作者 Yan-Yun Jiang Hong-Zhong Jin 《Chinese Medical Journal》 SCIE CAS CSCD 2020年第10期1259-1260,共2页
To the Editor:Generalized pustular psoriasis(GPP)is a rare,life-threatening skin disease characterized by recurrent episodes of pustulation.Apremilast,a phosphodiesterase 4(PDE4)inhibitor,is a relatively new drug for ... To the Editor:Generalized pustular psoriasis(GPP)is a rare,life-threatening skin disease characterized by recurrent episodes of pustulation.Apremilast,a phosphodiesterase 4(PDE4)inhibitor,is a relatively new drug for the treatment of moderate to severe plaque psoriasis.Herein,we reported a patient of recurrent GPP possibly triggered by apremilast. 展开更多
关键词 PSORIASIS PDE4 possibly
原文传递
Solid Waste Management:A MADM Approach Using Fuzzy Parameterized Possibility Single-Valued Neutrosophic Hypersoft Expert Settings
6
作者 Tmader Alballa Muhammad Ihsan +2 位作者 Atiqe Ur Rahman Noorah Ayed Alsorayea Hamiden Abd El-Wahed Khalifa 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期531-553,共23页
The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Ma... The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties. 展开更多
关键词 Hypersoft expert set Sanchez’s method decision making optimization solid waste management possibility grade fuzzy parameterization
在线阅读 下载PDF
How to spot Deepfakes
7
作者 吴爱香 《疯狂英语(初中天地)》 2025年第4期40-41,共2页
Pre-reading What is a Deepfake,and how is it created?What are Deepfakes?A Deepfake is a video,image or audio clip that has been created using artificial intelligence.The idea is to make it as realistic as possible.
关键词 VIDEO artificial intelligencethe audio clip deepfakes make realistic possible audioclip ARTIFICIALINTELLIGENCE image
在线阅读 下载PDF
Black Hole Possibly Caught in Creation
8
作者 Robert Roy Britt 肖萧 《当代外语研究》 2004年第8期7-8,共2页
神秘的黑洞是如何形成的?这个问题一直困扰着科学家。最近科学家正在关注着一颗星球爆炸的整个过程,希望能从中找出黑洞产生的原因。
关键词 Black Hole possibly Caught in Creation
原文传递
Enhanced DDoS Detection Using Advanced Machine Learning and Ensemble Techniques in Software Defined Networking
9
作者 Hira Akhtar Butt Khoula Said Al Harthy +3 位作者 Mumtaz Ali Shah Mudassar Hussain Rashid Amin Mujeeb Ur Rehman 《Computers, Materials & Continua》 SCIE EI 2024年第11期3003-3031,共29页
Detecting sophisticated cyberattacks,mainly Distributed Denial of Service(DDoS)attacks,with unexpected patterns remains challenging in modern networks.Traditional detection systems often struggle to mitigate such atta... Detecting sophisticated cyberattacks,mainly Distributed Denial of Service(DDoS)attacks,with unexpected patterns remains challenging in modern networks.Traditional detection systems often struggle to mitigate such attacks in conventional and software-defined networking(SDN)environments.While Machine Learning(ML)models can distinguish between benign and malicious traffic,their limited feature scope hinders the detection of new zero-day or low-rate DDoS attacks requiring frequent retraining.In this paper,we propose a novel DDoS detection framework that combines Machine Learning(ML)and Ensemble Learning(EL)techniques to improve DDoS attack detection and mitigation in SDN environments.Our model leverages the“DDoS SDN”dataset for training and evaluation and employs a dynamic feature selection mechanism that enhances detection accuracy by focusing on the most relevant features.This adaptive approach addresses the limitations of conventional ML models and provides more accurate detection of various DDoS attack scenarios.Our proposed ensemble model introduces an additional layer of detection,increasing reliability through the innovative application of ensemble techniques.The proposed solution significantly enhances the model’s ability to identify and respond to dynamic threats in SDNs.It provides a strong foundation for proactive DDoS detection and mitigation,enhancing network defenses against evolving threats.Our comprehensive runtime analysis of Simultaneous Multi-Threading(SMT)on identical configurations shows superior accuracy and efficiency,with significantly reduced computational time,making it ideal for real-time DDoS detection in dynamic,rapidly changing SDNs.Experimental results demonstrate that our model achieves outstanding performance,outperforming traditional algorithms with 99%accuracy using Random Forest(RF)and K-Nearest Neighbors(KNN)and 98%accuracy using XGBoost. 展开更多
关键词 Table 1(continued)OSI layer Possible DDoS attack Data link MAC Address Flooding Physical Cable disconnection JaMMING physical impersonation
在线阅读 下载PDF
Report for Type 2 Bayes-Fuzzy Estimation in No-Data Problem
10
作者 Houju Hori Jr. Kazuhisa Takemura Yukio Matsumoto 《Applied Mathematics》 2024年第1期46-50,共5页
It is well known that the system (1 + 1) can be unequal to 2, because this system has both observation error and system error. Furthermore, we must provide our mustered service within our cool head and warm heart, whe... It is well known that the system (1 + 1) can be unequal to 2, because this system has both observation error and system error. Furthermore, we must provide our mustered service within our cool head and warm heart, where two states of nature are existing upon us. Any system is regarded as the two-dimensional variable error model. On the other hand, we consider that the fuzziness is existing in this system. Though we can usually obtain the fuzzy number from the possibility theory, it is not fuzzy but possibility, because the possibility function is as same as the likelihood function, and we can obtain the possibility measure by the maximal likelihood method (i.e. max product method proposed by Dr. Hideo Tanaka). Therefore, Fuzzy is regarded as the only one case according to Vague, which has both some state of nature in this world and another state of nature in the other world. Here, we can consider that Type 1 Vague Event in other world can be obtained by mapping and translating from Type 1 fuzzy Event in this world. We named this estimation as Type 1 Bayes-Fuzzy Estimation. When the Vague Events were abnormal (ex. under War), we need to consider that another world could exist around other world. In this case, we call it Type 2 Bayes-Fuzzy Estimation. Where Hori et al. constructed the stochastic different equation upon Type 1 Vague Events, along with the general following probabilistic introduction method from the single regression model, multi-regression model, AR model, Markov (decision) process, to the stochastic different equation. Furthermore, we showed that the system theory approach is Possibility Markov Process, and that the making decision approach is Sequential Bayes Estimation, too. After all, Type 1 Bays-Fuzzy estimation is the special case in Bayes estimation, because the pareto solutions can exist in two stochastic different equations upon Type 2 Vague Events, after we ignore one equation each other (note that this is Type 1 case), we can obtain both its system solution and its decision solution. Here, it is noted that Type 2 Vague estimation can be applied to the shallow abnormal decision problem with possibility reserved judgement. However, it is very important problem that we can have no idea for possibility reserved judgement under the deepest abnormal envelopment (ex. under War). Expect for this deepest abnormal decision problem, Bayes estimation can completely cover fuzzy estimation. In this paper, we explain our flowing study and further research object forward to this deepest abnormal decision problem. 展开更多
关键词 Bayes-Fuzzy Estimation Possibility Markov Process Possibility Reserved Judgement
在线阅读 下载PDF
Mathematical Modeling of Possibility Markov Chains by Possibility Theory
11
作者 Yoshiki Uemura Takemura Kazuhisa Kenji Kita 《Applied Mathematics》 2024年第8期499-507,共9页
Statistical regression models are input-oriented estimation models that account for observation errors. On the other hand, an output-oriented possibility regression model that accounts for system fluctuations is propo... Statistical regression models are input-oriented estimation models that account for observation errors. On the other hand, an output-oriented possibility regression model that accounts for system fluctuations is proposed. Furthermore, the possibility Markov chain is proposed, which has a disidentifiable state (posterior) and a nondiscriminable state (prior). In this paper, we first take up the entity efficiency evaluation problem as a case study of the posterior non-discriminable production possibility region and mention Fuzzy DEA with fuzzy constraints. Next, the case study of the ex-ante non-discriminable event setting is discussed. Finally, we introduce the measure of the fuzzy number and the equality relation and attempt to model the possibility Markov chain mathematically. Furthermore, we show that under ergodic conditions, the direct sum state can be decomposed and reintegrated using fuzzy OR logic. We had already constructed the Possibility Markov process based on the indifferent state of this world. In this paper, we try to extend it to the indifferent event in another world. It should be noted that we can obtain the possibility transfer matrix by full use of possibility theory. 展开更多
关键词 Possibility Markov Chain Ergodic Condition Direct Sum State Prior Indiscriminate State Posterior Discriminatory State
在线阅读 下载PDF
A Blind Spot in the Reframing of a Universe of Possibles: Towards a Suitable Model for Decision-Making Theory and A.I.
12
作者 Gilbert Giacomoni 《Journal of Applied Mathematics and Physics》 2024年第6期2172-2189,共18页
Bayesian inference model is an optimal processing of incomplete information that, more than other models, better captures the way in which any decision-maker learns and updates his degree of rational beliefs about pos... Bayesian inference model is an optimal processing of incomplete information that, more than other models, better captures the way in which any decision-maker learns and updates his degree of rational beliefs about possible states of nature, in order to make a better judgment while taking new evidence into account. Such a scientific model proposed for the general theory of decision-making, like all others in general, whether in statistics, economics, operations research, A.I., data science or applied mathematics, regardless of whether they are time-dependent, have in common a theoretical basis that is axiomatized by relying on related concepts of a universe of possibles, especially the so-called universe (or the world), the state of nature (or the state of the world), when formulated explicitly. The issue of where to stand as an observer or a decision-maker to reframe such a universe of possibles together with a partition structure of knowledge (i.e. semantic formalisms), including a copy of itself as it was initially while generalizing it, is not addressed. Memory being the substratum, whether human or artificial, wherein everything stands, to date, even the theoretical possibility of such an operation of self-inclusion is prohibited by pure mathematics. We make this blind spot come to light through a counter-example (namely Archimedes’ Eureka experiment) and explore novel theoretical foundations, fitting better with a quantum form than with fuzzy modeling, to deal with more than a reference universe of possibles. This could open up a new path of investigation for the general theory of decision-making, as well as for Artificial Intelligence, often considered as the science of the imitation of human abilities, while being also the science of knowledge representation and the science of concept formation and reasoning. 展开更多
关键词 DECISION-MAKING INNOVATION Universe of Possibles A.I. Quantum Form Fuzzy Modeling
在线阅读 下载PDF
Exposure to different severities of famine and subsequent risk of sarcopenia in old age
13
作者 Miao-Miao Lu Yu-Wei Zhou Xi Jin 《Journal of Nutritional Oncology》 2024年第3期73-80,共8页
Background:Poor nutritional status is closely related to the development of sarcopenia and possible sarcopenia.Limited articles have evaluated the impact of undernutrition at different stages of life on the developmen... Background:Poor nutritional status is closely related to the development of sarcopenia and possible sarcopenia.Limited articles have evaluated the impact of undernutrition at different stages of life on the development of sarcopenia or possible sarcopenia in old age.The 1959–1962 Chinese famine provided the possibility for large-scale population studies on the effects of long-term undernutrition or inad-equate intake on various health problems.In this study,we aimed to investigate the effects of long-term reduction of food intake(expo-sure to the 1959–1962 Chinese famine)in early life on the development of sarcopenia and possible sarcopenia in later life.Methods:We used data from the China Health and Retirement Longitudinal Survey(CHARLS)2015 and obtained information on whether participants had experienced famine from the 2014 Life Course Survey of Chinese Residents.After data integration and cleaning,we divided the included participants into five age-exposure cohorts based on birthdate,including cohorts exposed to famine during preschool,midchildhood,young teenage years,teenage years,and adulthood to analyze the long-term effects of exposure to famine on the development of sarcopenia and possible sarcopenia.Results:Exposure to moderate or severe famine did not significantly increase the risk of possible sarcopenia(P>0.05).In a further stratified analysis,moderate famine exposure in adulthood significantly increased the risk of possible sarcopenia(1.475 times;95%CI:1.104–1.969,P=0.009).However,there was no significant association between famine exposure and possible sarcopenia in the preschool,midchildhood,young teenage,or teenage exposure cohorts(P>0.05).Conclusions:Exposure to famine in preadulthood did not increase the risk of possible sarcopenia in older adults.However,the risk of possible sarcopenia in later life was increased about 50%among participants who were exposed to moderate famine in adulthood. 展开更多
关键词 SARCOPENIA FAMINE Grip strength Possible sarcopenia
暂未订购
Sea-Control Algorithm in Lake Wave Case
14
作者 Yoshiki Uemura Kenji Kita Kazuyuki Matsumoto 《Applied Mathematics》 2024年第12期829-833,共5页
In previous studies, an isosceles triangular-type possibility distribution was employed to represent the analog waves of a Gaussian Process. The model was then projected onto actual waves using Zadeh’s extension prin... In previous studies, an isosceles triangular-type possibility distribution was employed to represent the analog waves of a Gaussian Process. The model was then projected onto actual waves using Zadeh’s extension principle of mapping (Hori et al., 2019). Furthermore, by applying Vague Set and Systems theory, it was shown that the actual waves followed a Gaussian process, and that the system could be efficiently controlled via Monte Carlo simulation. However, due to the use of fuzzy OR logic in the extension principle of mapping and wave synthesis, the resulting ambiguity increased significantly. To address this issue, a Possibility Markov Chain was proposed, incorporating possibility theory to mitigate the explosion of ambiguity. In this study, we propose a novel modeling approach that utilizes a possibility transition matrix without relying on fuzzy OR logic. Additionally, we introduce the Sea-Control Algorithm, which artificially introduces system error into the system function, thereby enabling modification of the possibility transition matrix through the deliberate manipulation of possibility information within the fuzzy system. 展开更多
关键词 Lake Wave Modeling Lake Wave Control Possibility Markov Chain Analog Gaussian Process Vague Event
在线阅读 下载PDF
关于锗的必需性问题 被引量:2
15
作者 秦俊法 《微量元素与健康研究》 CAS 1993年第4期38-40,共3页
在自然界存在的92种元素中,现已在人体中发现81种。根据其生物学作用,可将这些元素分为三类,即必需元素,可能必需元素和非必需元素。目前已知,必需元素共有26种,其中11种是常量元素,15种是微量元素。高等动物必需的微量元素是:Fe、I、Cu... 在自然界存在的92种元素中,现已在人体中发现81种。根据其生物学作用,可将这些元素分为三类,即必需元素,可能必需元素和非必需元素。目前已知,必需元素共有26种,其中11种是常量元素,15种是微量元素。高等动物必需的微量元素是:Fe、I、Cu、Mn、Zn、Co、Mo、Se、Cr、Sn、V、F、Si、Ni 和 As。随着科学技术的发展,还可能发现一些微量元素对生命活动也是必需的。本文讨论锗的必需性问题。 展开更多
关键词 Esstntiality of ELEMENT GERMANIUM possibly ESSENTIAL TRACE ELEMENT
在线阅读 下载PDF
考虑权重因素的非概率可靠性模型 被引量:4
16
作者 方鹏亚 常新龙 简斌 《机械强度》 CAS CSCD 北大核心 2011年第2期225-228,共4页
利用区间变量描述参量的不确定性,基于加权平均理论和PDF(possibility degree formula)区间比较法则,依据非概率区间分析方法,建立考虑权重因素的非概率可靠性模型。该模型更进一步地利用数据信息,提高数据积累阶段的可靠性评估精度;将... 利用区间变量描述参量的不确定性,基于加权平均理论和PDF(possibility degree formula)区间比较法则,依据非概率区间分析方法,建立考虑权重因素的非概率可靠性模型。该模型更进一步地利用数据信息,提高数据积累阶段的可靠性评估精度;将非概率可靠性指标统一到概率可靠度上,有很好的工程应用价值。最后利用算例验证文中提出模型的可行性。 展开更多
关键词 结构可靠性 非概率模型 权重 熵判定 PDF(possibility DEGREE formula)区间比较
在线阅读 下载PDF
Multiple attribute decision making method based on trapezoid fuzzy linguistic variables 被引量:4
17
作者 梁雪春 陈森发 《Journal of Southeast University(English Edition)》 EI CAS 2008年第4期478-481,共4页
The problem of multiple attribute decision making under fuzzy linguistic environments, in which decision makers can only provide their preferences (attribute values)in the form of trapezoid fuzzy linguistic variable... The problem of multiple attribute decision making under fuzzy linguistic environments, in which decision makers can only provide their preferences (attribute values)in the form of trapezoid fuzzy linguistic variables(TFLV), is studied. The formula of the degree of possibility between two TFLVs is defined, and some of its characteristics are studied. Based on the degree of possibility of fuzzy linguistic variables, an approach to ranking the decision alternatives in multiple attribute decision making with TFLV is developed. The trapezoid fuzzy linguistic weighted averaging (TFLWA) operator method is utilized to aggregate the decision information, and then all the alternatives are ranked by comparing the degree of possibility of TFLV. The method can carry out linguistic computation processes easily without loss of linguistic information, and thus makes the decision results reasonable and effective. Finally, the implementation process of the proposed method is illustrated and analyzed by a practical example. 展开更多
关键词 trapezoid fuzzy linguistic variables degree of possibility multiple attribute decision making
在线阅读 下载PDF
CLINICAL INVESTIGATION OF TRADITIONAL CHINESE MEDICINE AND PHARMACY IN TREATING RESPIRATORY TRACT INFECTIONS IN AIDS 被引量:4
18
作者 李国勤 岳玉和 +1 位作者 吕维柏 周志宽 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1996年第1期3-6,共4页
Based on the difference in severity of the disease and complications, 80 cases of acquired immune-deficiency syndrome (AIDS) accompanied with cough were divided into 2 groups: One treated by traditional Chinese medici... Based on the difference in severity of the disease and complications, 80 cases of acquired immune-deficiency syndrome (AIDS) accompanied with cough were divided into 2 groups: One treated by traditional Chinese medicine (TCM group), including 58 cases and the other treated by Integrated Chinese and Western medicine (integrated group), 22 cases. The therapeutic results show that in the TCM group there were 18 cases (31.03%) with clinical cure of the respiratory tract infection, 7 cases with therapeutic effect (12.07%) and 33 cases without any effect (56.90%), for a total rate of 43.10% therapeutic effectiveness; while in the integrated group there were 6 cases with clinical cure (27.27%), 2 cases with therapeutic effect (9.09%) and 14 cases without any effect (63.64%), the total rate of therapeutic effectiveness being 36.36%, slightly lower than in the TCM group and possibly related to greater severity of the disease or complications. 展开更多
关键词 severity COUGH RADIX possibly ACCOMPANIED TABLETS INTRAMUSCULAR slightly COUGH BRONCHIAL
暂未订购
中国高僧与越南“少林寺” 被引量:3
19
作者 谭志词 《东南亚纵横》 2005年第5期15-18,共4页
The But Thap Temple in Bac Ninh province of Viet Nam has two Chinese names,one is Ninh Phuc Temple and the other,an alternative one,Thieu Lam Temple.In the middle of17th century,the Chinese Chuyet Cong and Minh Hanh l... The But Thap Temple in Bac Ninh province of Viet Nam has two Chinese names,one is Ninh Phuc Temple and the other,an alternative one,Thieu Lam Temple.In the middle of17th century,the Chinese Chuyet Cong and Minh Hanh lived and made great contribution to its development.The temple is deeply affected by Chinese culture and the reason for its alˉternative name,the paper argues,is possible related to China’s“North Shao Lin”. 展开更多
关键词 Chinese 少林寺 possible culture 越南 高僧 中国 REASON other GREAT and NAME The one its BUT has two is for of to
在线阅读 下载PDF
Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression 被引量:2
20
作者 Yong-lin Zhao Jin-ning Song +3 位作者 Xu-dong Ma Bin-fei Zhang Dan-dong Li Hong-gang Pang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第6期944-950,共7页
Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to ... Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau(phosphorylated at Ser^(404)(p-tau(S^(404))), and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau(S^(404)) levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury. 展开更多
关键词 axonal diffuse regulating amyloid cortex saline ameliorate minutes possibly inhibit
暂未订购
上一页 1 2 20 下一页 到第
使用帮助 返回顶部