Guizhi Fuling capsule(GFC), a traditional Chinese medicine(TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various c...Guizhi Fuling capsule(GFC), a traditional Chinese medicine(TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various chemical structure types, quality control of GFC remains great challenge. In the present study, an ultra performance liquid chromatography hybrid triple-quadrupole mass spectrometry(UPLC-QQQ MS) method with ultrafast positive/negative ionization switching was developed for simultaneous determination of 18 bioactive components in GFC, including methyl gallate, ethyl gallate, oxypaeoniflorin, benzoic acid, albiflorin, paeonolide, paeoniflorin, 1, 2, 3, 4, 6-pentagalloylglucose, mudanpioside C, benzoyloxypaeoniflorin, benzoylpaeoniflorin, pachymic acid, amygdalin, cinnamaldehyde, paeonol, cinnamic acid, 4-hydroxybenzoic acid, and gallic acid. Separation was performed on an Agilent Zorbax Extend–C18 column(2.1 mm × 50 mm, 1.8 μm), using a gradient elution with acetonitrile and water containing 0.1% formic acid. Cholic acid was selected as the internal standard. This newly developed method was fully validated for linearity, precision, accuracy, and stability, and then applied to quality assessment of GFC. Finally, the batch-to-batch reproducibility of GFC samples was evaluated by the cosine ration and Euclidean distance method, which showed high quality consistency. The results demonstrated that the developed method provided a reasonable and powerful manner for quality control of GFC.展开更多
Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has f...Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has focused predominantly on the adverse aspects of risk-taking(i.e.,negative risk-taking),overlooked the positive counterpart(i.e.,positive risk-taking),and lacked a detailed examination of both.This study aims to elucidate the distinct characteristics and interrelationships of positive and negative risk-taking behaviors among adoles-cents and to identify the key factors that influence these behaviors.Through a comprehensive synthesis of theoretical and empirical literature,we explore the multifaceted nature of risk-taking,highlighting its complex influencing factors,including individual traits,family dynamics,peer influence,school environment,and broader community contexts.By identifying the shared and unique factors contributing to positive and negative risk-taking behaviors,we can enable adolescents to navigate this complex stage of life and design targeted interventions.Future research directions include the application of person-centered approaches,the implementation of longitudinal tracking and the interactive effects of influencing factors,among other aspects.展开更多
We employ the Multi-Scale Log-Periodic Power Law Singularity Confidence Indicator(MS-LPPLS-CI)approach to identify positive and negative bubbles in the short-,medium,and long-term for the Indian stock market,using wee...We employ the Multi-Scale Log-Periodic Power Law Singularity Confidence Indicator(MS-LPPLS-CI)approach to identify positive and negative bubbles in the short-,medium,and long-term for the Indian stock market,using weekly data from November 2003 to December 2020.We use a nonparametric causality-in-quantiles approach to analyze the predictive impact of monetary policy shocks on bubble indicators.We find,in general,strong evidence of predictability across the entire conditional distribution for the two monetary policy shock factors,with stronger impacts for negative bubbles.Our findings have critical implications for the Reserve Bank of India,academics,and investors.展开更多
Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water...Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water storage channel on the north side and a 230 m wide muddy water floodway channel on the south side will be formed.Two rubber dams are constructed in the water storage channels to form a 'Xianyang Lake' with an area of 1.24×106 m2,meanwhile,along both sides of Weihe River in this section,slope protection and flood prevention as well as a series of greening and cultural landscape projects are to be constructed.This project,with flood prevention as the core,aims to improve the living environment and protect ecological environment,and realize the comprehensive treatment of river way flood-proofing,desilting,sewage purification,greening and beautification.The construction of Xianyang Lake greatly improves the image of Xianyang City and generates considerable economic,social and ecological benefits,however,it also has negative effects,such as insufficient lake water supply,original ecology being intervened by human activities,aggravating local fiscal burden,and potential threats to the flood-proofing in the lower reaches of Weihe River.The author puts forwards that 'creating a lake by damming the river' in the process of urbanization and solving the conflicts between sectional interests and integrated interests should follow natural laws and go along the track of sustainable development,which is also the orientation of future work,and the concrete reform scheme is to be further studied.展开更多
Assuming a two-component, positive and negative mass, superfluid/supersolid for space (the Winterberg model), we model the Higgs field as a condensate made up of a positive and a negative mass, planckion pair. The con...Assuming a two-component, positive and negative mass, superfluid/supersolid for space (the Winterberg model), we model the Higgs field as a condensate made up of a positive and a negative mass, planckion pair. The connection is shown to be consistent (compatible) with the underlying field equations for each field, and the continuity equation is satisfied for both species of planckions, as well as for the Higgs field. An inherent length scale for space (the vacuum) emerges, which we estimate from previous work to be of the order of, l<sub>+</sub> (0) = l<sub>-</sub> (0) = 5.032E-19 meters, for an undisturbed (unperturbed) vacuum. Thus we assume a lattice structure for space, made up of overlapping positive and negative mass wave functions, ψ<sub>+</sub>, and, ψ<sub>-</sub>, which together bind to form the Higgs field, giving it its rest mass of 125.35 Gev/c<sup>2</sup> with a coherence length equal to its Compton wavelength. If the vacuum experiences an extreme disturbance, such as in a LHC pp collision, it is conjectured that severe dark energy results, on a localized level, with a partial disintegration of the Higgs force field in the surrounding space. The Higgs boson as a quantum excitation in this field results when the vacuum reestablishes itself, within 10<sup>-22</sup> seconds, with positive and negative planckion mass number densities equalizing in the disturbed region. Using our fundamental equation relating the Higgs field, φ, to the planckion ψ<sub>+</sub> and ψ<sub>-</sub> wave functions, we calculate the overall vacuum pressure (equal to vacuum energy density), as well as typical ψ<sub>+</sub> and ψ<sub>-</sub> displacements from equilibrium within the vacuum.展开更多
BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM ...BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.展开更多
The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscilla...The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscillation of neutral differential equation with positive and negative coefficients are obtained.展开更多
As the native language transfer inevitably exerts definite influences on English study,the paper is to give a more detailed analysis to the positive and negative effects in one's L2 learning.In English teaching,th...As the native language transfer inevitably exerts definite influences on English study,the paper is to give a more detailed analysis to the positive and negative effects in one's L2 learning.In English teaching,the full use of the positive effect of the native language transfer and the utmost elimination of the negative effect of the native language transfer would bring about a great advance in English quality improvement of the learners.The learners should be taught not to avoid negative influence.展开更多
BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear rol...BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear role in N1c stage remains to be defined.AIM To evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.METHODS We retrospectively identified 107 consecutive patients who had N1c CRC radically resected at China-Japan Friendship Hospital.The combination of TDs and NLNs was calculated by the formula NLNTD=NLN/(TD+1).Cutoff values of NLNs and NLNTD were determined using the R package“survminer”.Disease-free survival(DFS),overall survival(OS)and cancer-specific survival(CSS)were determined using the Kaplan-Meier method to assess the impact of NLNTD on prognosis.Results were compared using the log-rank test.RESULTS The median follow-up time was 63.17(45.33-81.37)months for DFS,with 33.64%(36/107)of patients experiencing recurrence during follow-up.Five-year DFS was 66.0%(57.3%-76.0%).There was no significant difference in prognosis between patients with>12 and≤12 NLNs(P=0.058)for DFS.Similar results were seen according to the number of TDs.The definition of NLNTD=NLN/(TD+1)with a cutoff value of 6 divided patients into two groups with different DFS(P=0.005).Five-year DFS for patients with NLNTD>6 was 73.5%(63.6%-85.0%),compared with 50.0%(35.7%-70.0%)for those with NLNTD≤6.These two groups had different prognosis without perineural invasion(P=0.012)or lymphovascular invasion(P=0.002)even neither(P=0.053).Similar results were seen for OS and CSS.CONCLUSION NLNTD could serve as important prognostic factor for outcomes in N1c CRC patients.These patients could be stratified for prognosis through NLNTD and the high-risk should be given more attention during treatment.展开更多
The Loess positive and negative terrains （P-N terrains）, which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction metho...The Loess positive and negative terrains （P-N terrains）, which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction method from high-resolution Digital Elevation Models. Using 5 m-resolution DEMs as original test data, P-N terrains of 48 geomorphological units in different parts of Shaanxi Loess Plateau are extracted accurately. Then six indicators for depicting the geomorphologic landscape and spatial configuration characteristic of P-N terrains are proposed. The spatial distribution rules of these indicators and the relationship between the P-N terrains and Loess relief are discussed for further understanding of Loess landforms. Finally, with the integration of P-N terrains and traditional terrain indices, a series of un-supervised classification methods are applied to make a proper landform classification in northern Shaanxi. Results show that P-N terrains are an effect clue to reveal energy and substance distribution rules on the Loess Plateau. A continuous change of P-N terrains from south to north in Shaanxi Loess Plateau shows an obvious spatial difference of Loess land-forms and the positive terrain area only accounted for 60.5% in this region. The P-N terrains participant landform classification method increases validity of the result, especially in the Loess tableland, Loess tableland-ridge and the Loess low-hill area. This research is significant on the study of Loess landforms with the Digital Terrains Analysis methods.展开更多
The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed sca...The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed scale can serve to elucidate the structural characteristics and spatial patterns of P-N terrains, which benefits a better understanding of watershed evolution and suitable scales for loess landform research. The Two-Term Local Quadrat Variance Analysis(TTLQV) is calculated as the average of the square of the difference between the block totals of all possible adjacent pairs of block size, which can be used to detect both the scale and the intensity of landscape patches(e.g., plant/animal communities and gully networks). In this study, we determined the latitudinal and longitudinal spatial scale of P-N terrain patterns within 104 uniformly distributed watersheds in our target soil and water conservation region. The results showed that TTLQV is very effective for examining the scale of P-N terrain patterns. There were apparently three types of P-N terrain pattern in latitudinal direction(i.e., Loess Tableland type, Loess Hill type, and Transitional Form between Sand and Loess type), whereas there were both lower and higher values for P-N terrain pattern scales in all loess landforms in the longitudinal direction. The P-N terrain pattern alsoclearly presented anisotropy, suggesting that gully networks in the main direction were well-developed while others were relatively undeveloped. In addition, the relationships between the first scales and controlling factors(i.e., gully density, nibble degree, watershed area, mean watershed slope, NDVI, precipitation, loess thickness, and loess landforms) revealed that the first scales are primarily controlled by watershed area and loess landforms. This may indicate that the current spatial pattern of P-N terrains is characterized by internal force. In selecting suitable study areas in China' Loess Plateau, it is crucial to understand four control variables: the spatial scale of the P-N terrain pattern, the watershed area, the main direction of the watershed, and the loess landforms.展开更多
Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagn...Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagnetic field in rocket-triggered lightning and tower-initiated lightning discharges; available channel base current data recorded in rocket-triggered lightning are also used. The negative leaders propagate in a stepped fashion accompanied by many branches. The stems ahead of the negative leader tip determine the manner and direction of the leader propagation, and even the branching and winding of the lightning channel. The impulsive current, electromagnetic field, and related optical images suggest that the positive leader may develop in a step-like fashion at its initial stage of triggered lightning. However, the stepping processes of the positive leader are obviously different from those of the negative leader. Tower-initiated lightning revealed that the most conspicuous characteristics of the stepwise positive leader involve the intermittent brush-like corona zone in front of the leader tip and the luminosity enhancement of the channel behind the tip. In rockettriggered lightning flashes, the charge transferred during an individual step for the negative leader was nearly an order greater than for the positive counterpart. The successive streamers ahead of the leader tip are essential for both negative and positive leader propagation, and the stems could be formed from one or more streamers in the previous negative streamer zone with the main leader channel dim. High-resolution observation of tower lightning also revealed a new type of bidirectional recoil leader, with polarity contrary to the traditional one, traversing in negative channels associated with tower-initiated and rocket-triggered lightning.展开更多
A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the ze...A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the zero solution of this equation is obtained, which improves and extends the all known results in the literature.展开更多
In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions i...In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions in the literature.展开更多
In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are o...In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are obtained for the oscillation of the dynamic equations.The main result is illustrated by an example.展开更多
Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/C...Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/CaCu_(3)Ti_(4)O_(12)(Cu/CCTO) percolative metacomposites,successfully achieved both epsilon-negative and ε'-near-zero(ENZ)responses in the radio-frequency band.Before percolation,a large number of electric dipoles in the metacomposites achieved resonance characteristics near the ENZ point under the excitation of radio frequency electromagnetic fields,and as the Cu content increased,the ENZ frequency varied from 942,858,862 to 632 MHz.展开更多
Objective:To investigate the unusual presentation of brucellosis.Methods:This prospective study was carried out on 46 patients suspected to brucellosis.The diagnosis was made with isolation of brucella species by Bone...Objective:To investigate the unusual presentation of brucellosis.Methods:This prospective study was carried out on 46 patients suspected to brucellosis.The diagnosis was made with isolation of brucella species by Bone Marrow culture.Results:Among 40 culture positive patients,there were two unusual presentations of brucellosis: Afebrile culture positive and culture positive seronegative brucellosis.Conclusion:Some brucellosis patients would not match with criteria for diagnosis of brucellosis.Although it is needed to have positive serology or culture for diagnosis of brucellosis but sometimes,it is the clinical experiences,which help to diagnose and treat these kinds of patients.展开更多
Objective： A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide（TC） regimen was inferior to docetaxel, anthracycline and cyclophosphamide（TAC） in neoadjuvant treatment o...Objective： A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide（TC） regimen was inferior to docetaxel, anthracycline and cyclophosphamide（TAC） in neoadjuvant treatment of triple-negative breast cancer（TNBC） and human epidermal growth factor receptor-2-（HER2）-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcomes have been investigated.Methods： TNBC or HER2-positive patients were randomized to receive 6 cycles of TC or TAC neoadjuvant treatment. The primary endpoint was pathological complete remission（p CR）. Secondary endpoints included clinical response rate, event-free survival（EFS）, and overall survival（OS）.Results： A cohort of 96 patients consisted of 45 in TC and 51 in TAC arm. With a median follow-up period of53（range, 8-76） months, the patients achieving p CR post neoadjuvant chemotherapy exhibited superior EFS and OS than patients without p CR（P〈0.05）. TAC treatment resulted in consistently better EFS than TC treatment：the estimated 5-year EFS was 66.1% vs. 29.8%（P=0.002）. Moreover, the estimated 5-year OS was also in favor of TAC： 88.4% vs. 51.6%（P〈0.001）. Multivariable analysis demonstrated that the treatment regimen was an independent prognostic factor, and patients treated with TAC had a superior EFS [hazard ratio（HR）, 0.48; 95%confidence interval（95% CI）, 0.26-0.90; P=0.021] and OS（HR, 0.20; 95% CI, 0.08-0.60; P=0.003）.Conclusions： The updated long-term follow-up data demonstrated a sustained benefit in EFS and OS from anthracycline-containing TAC treatment, indicating that anthracycline is an essential and effective drug in this clinical trial.展开更多
基金supported by the Specialized Research Fund for the Doctoral Program of Higher Education(No.20130096140001)the 111 Project(No.B16046)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘Guizhi Fuling capsule(GFC), a traditional Chinese medicine(TCM) with effects of promoting blood circulation and dissipating blood stasis, has been widely used in the clinic. Because of the complex matrix and various chemical structure types, quality control of GFC remains great challenge. In the present study, an ultra performance liquid chromatography hybrid triple-quadrupole mass spectrometry(UPLC-QQQ MS) method with ultrafast positive/negative ionization switching was developed for simultaneous determination of 18 bioactive components in GFC, including methyl gallate, ethyl gallate, oxypaeoniflorin, benzoic acid, albiflorin, paeonolide, paeoniflorin, 1, 2, 3, 4, 6-pentagalloylglucose, mudanpioside C, benzoyloxypaeoniflorin, benzoylpaeoniflorin, pachymic acid, amygdalin, cinnamaldehyde, paeonol, cinnamic acid, 4-hydroxybenzoic acid, and gallic acid. Separation was performed on an Agilent Zorbax Extend–C18 column(2.1 mm × 50 mm, 1.8 μm), using a gradient elution with acetonitrile and water containing 0.1% formic acid. Cholic acid was selected as the internal standard. This newly developed method was fully validated for linearity, precision, accuracy, and stability, and then applied to quality assessment of GFC. Finally, the batch-to-batch reproducibility of GFC samples was evaluated by the cosine ration and Euclidean distance method, which showed high quality consistency. The results demonstrated that the developed method provided a reasonable and powerful manner for quality control of GFC.
基金Soft Science Special Project of Gansu Basic Research Plan,No.25JRZA072Youth Project of Philosophy and Social Science Foundation of Gansu Province,No.2024QN015+1 种基金General Project of Philosophy and Social Science Foundation of Gansu Province,No.2024YB049Lanzhou Philosophy and Social Science Planning Project,No.24-B13.
文摘Adolescence is a crucial period marked by significant developmental changes,during which risk-taking behaviors can be both a normative part of development and a potential source of concern.However,prior research has focused predominantly on the adverse aspects of risk-taking(i.e.,negative risk-taking),overlooked the positive counterpart(i.e.,positive risk-taking),and lacked a detailed examination of both.This study aims to elucidate the distinct characteristics and interrelationships of positive and negative risk-taking behaviors among adoles-cents and to identify the key factors that influence these behaviors.Through a comprehensive synthesis of theoretical and empirical literature,we explore the multifaceted nature of risk-taking,highlighting its complex influencing factors,including individual traits,family dynamics,peer influence,school environment,and broader community contexts.By identifying the shared and unique factors contributing to positive and negative risk-taking behaviors,we can enable adolescents to navigate this complex stage of life and design targeted interventions.Future research directions include the application of person-centered approaches,the implementation of longitudinal tracking and the interactive effects of influencing factors,among other aspects.
文摘We employ the Multi-Scale Log-Periodic Power Law Singularity Confidence Indicator(MS-LPPLS-CI)approach to identify positive and negative bubbles in the short-,medium,and long-term for the Indian stock market,using weekly data from November 2003 to December 2020.We use a nonparametric causality-in-quantiles approach to analyze the predictive impact of monetary policy shocks on bubble indicators.We find,in general,strong evidence of predictability across the entire conditional distribution for the two monetary policy shock factors,with stronger impacts for negative bubbles.Our findings have critical implications for the Reserve Bank of India,academics,and investors.
文摘Xianyang Lake is the abbreviation of Weihe River(Xianyang Urban Area Section) Comprehensive Treatment Project,which is to build a partition wall in the middle of the 500 wide Weihe River Valley,then a 270 m wide water storage channel on the north side and a 230 m wide muddy water floodway channel on the south side will be formed.Two rubber dams are constructed in the water storage channels to form a 'Xianyang Lake' with an area of 1.24×106 m2,meanwhile,along both sides of Weihe River in this section,slope protection and flood prevention as well as a series of greening and cultural landscape projects are to be constructed.This project,with flood prevention as the core,aims to improve the living environment and protect ecological environment,and realize the comprehensive treatment of river way flood-proofing,desilting,sewage purification,greening and beautification.The construction of Xianyang Lake greatly improves the image of Xianyang City and generates considerable economic,social and ecological benefits,however,it also has negative effects,such as insufficient lake water supply,original ecology being intervened by human activities,aggravating local fiscal burden,and potential threats to the flood-proofing in the lower reaches of Weihe River.The author puts forwards that 'creating a lake by damming the river' in the process of urbanization and solving the conflicts between sectional interests and integrated interests should follow natural laws and go along the track of sustainable development,which is also the orientation of future work,and the concrete reform scheme is to be further studied.
文摘Assuming a two-component, positive and negative mass, superfluid/supersolid for space (the Winterberg model), we model the Higgs field as a condensate made up of a positive and a negative mass, planckion pair. The connection is shown to be consistent (compatible) with the underlying field equations for each field, and the continuity equation is satisfied for both species of planckions, as well as for the Higgs field. An inherent length scale for space (the vacuum) emerges, which we estimate from previous work to be of the order of, l<sub>+</sub> (0) = l<sub>-</sub> (0) = 5.032E-19 meters, for an undisturbed (unperturbed) vacuum. Thus we assume a lattice structure for space, made up of overlapping positive and negative mass wave functions, ψ<sub>+</sub>, and, ψ<sub>-</sub>, which together bind to form the Higgs field, giving it its rest mass of 125.35 Gev/c<sup>2</sup> with a coherence length equal to its Compton wavelength. If the vacuum experiences an extreme disturbance, such as in a LHC pp collision, it is conjectured that severe dark energy results, on a localized level, with a partial disintegration of the Higgs force field in the surrounding space. The Higgs boson as a quantum excitation in this field results when the vacuum reestablishes itself, within 10<sup>-22</sup> seconds, with positive and negative planckion mass number densities equalizing in the disturbed region. Using our fundamental equation relating the Higgs field, φ, to the planckion ψ<sub>+</sub> and ψ<sub>-</sub> wave functions, we calculate the overall vacuum pressure (equal to vacuum energy density), as well as typical ψ<sub>+</sub> and ψ<sub>-</sub> displacements from equilibrium within the vacuum.
文摘BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.
文摘The oscillatory behavior of neutral differential equation with positive and negative coefficients is investigated by mathematics analysis technique and the fixed point principle. Some sufficient conditions for oscillation of neutral differential equation with positive and negative coefficients are obtained.
文摘As the native language transfer inevitably exerts definite influences on English study,the paper is to give a more detailed analysis to the positive and negative effects in one's L2 learning.In English teaching,the full use of the positive effect of the native language transfer and the utmost elimination of the negative effect of the native language transfer would bring about a great advance in English quality improvement of the learners.The learners should be taught not to avoid negative influence.
基金Supported by the National High Level Hospital Clinical Research Funding,No.2023-NHLHCRF-BQ-32 and No.2023-NHLHCRFYYPPLC-ZR-13National Key Research and Development Program of China,No.2024YFE0198300Beijing Municipal Natural Science Foundation,No.7222316.
文摘BACKGROUND The number of tumor deposits(TDs)does not play a part in the current tumor node metastasis staging.Negative lymph node(NLN)status is associated with the prognosis of colorectal cancer(CRC),but its clear role in N1c stage remains to be defined.AIM To evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.METHODS We retrospectively identified 107 consecutive patients who had N1c CRC radically resected at China-Japan Friendship Hospital.The combination of TDs and NLNs was calculated by the formula NLNTD=NLN/(TD+1).Cutoff values of NLNs and NLNTD were determined using the R package“survminer”.Disease-free survival(DFS),overall survival(OS)and cancer-specific survival(CSS)were determined using the Kaplan-Meier method to assess the impact of NLNTD on prognosis.Results were compared using the log-rank test.RESULTS The median follow-up time was 63.17(45.33-81.37)months for DFS,with 33.64%(36/107)of patients experiencing recurrence during follow-up.Five-year DFS was 66.0%(57.3%-76.0%).There was no significant difference in prognosis between patients with>12 and≤12 NLNs(P=0.058)for DFS.Similar results were seen according to the number of TDs.The definition of NLNTD=NLN/(TD+1)with a cutoff value of 6 divided patients into two groups with different DFS(P=0.005).Five-year DFS for patients with NLNTD>6 was 73.5%(63.6%-85.0%),compared with 50.0%(35.7%-70.0%)for those with NLNTD≤6.These two groups had different prognosis without perineural invasion(P=0.012)or lymphovascular invasion(P=0.002)even neither(P=0.053).Similar results were seen for OS and CSS.CONCLUSION NLNTD could serve as important prognostic factor for outcomes in N1c CRC patients.These patients could be stratified for prognosis through NLNTD and the high-risk should be given more attention during treatment.
基金Key Project of National Natural Science Foundation of China, No.40930531 National Youth Science Foundation of China, No.40801148 Anhui Provincial Natural Science Foundation. No. 090412062
文摘The Loess positive and negative terrains （P-N terrains）, which are widely distributed on the Loess Plateau, are discussed for the first time by introducing its characteristic, demarcation as well as extraction method from high-resolution Digital Elevation Models. Using 5 m-resolution DEMs as original test data, P-N terrains of 48 geomorphological units in different parts of Shaanxi Loess Plateau are extracted accurately. Then six indicators for depicting the geomorphologic landscape and spatial configuration characteristic of P-N terrains are proposed. The spatial distribution rules of these indicators and the relationship between the P-N terrains and Loess relief are discussed for further understanding of Loess landforms. Finally, with the integration of P-N terrains and traditional terrain indices, a series of un-supervised classification methods are applied to make a proper landform classification in northern Shaanxi. Results show that P-N terrains are an effect clue to reveal energy and substance distribution rules on the Loess Plateau. A continuous change of P-N terrains from south to north in Shaanxi Loess Plateau shows an obvious spatial difference of Loess land-forms and the positive terrain area only accounted for 60.5% in this region. The P-N terrains participant landform classification method increases validity of the result, especially in the Loess tableland, Loess tableland-ridge and the Loess low-hill area. This research is significant on the study of Loess landforms with the Digital Terrains Analysis methods.
基金supported by the National Natural Science Foundation of China (NO. 41201464, 41371424)the Fundamental Research Funds for the Central Universities of China (GK201703042)
文摘The positive and negative terrains(P-N terrains) widely distributed across China's Loess Plateau constitute the dual structure characteristic of loess landforms. Analysis of loess P-N terrains at the watershed scale can serve to elucidate the structural characteristics and spatial patterns of P-N terrains, which benefits a better understanding of watershed evolution and suitable scales for loess landform research. The Two-Term Local Quadrat Variance Analysis(TTLQV) is calculated as the average of the square of the difference between the block totals of all possible adjacent pairs of block size, which can be used to detect both the scale and the intensity of landscape patches(e.g., plant/animal communities and gully networks). In this study, we determined the latitudinal and longitudinal spatial scale of P-N terrain patterns within 104 uniformly distributed watersheds in our target soil and water conservation region. The results showed that TTLQV is very effective for examining the scale of P-N terrain patterns. There were apparently three types of P-N terrain pattern in latitudinal direction(i.e., Loess Tableland type, Loess Hill type, and Transitional Form between Sand and Loess type), whereas there were both lower and higher values for P-N terrain pattern scales in all loess landforms in the longitudinal direction. The P-N terrain pattern alsoclearly presented anisotropy, suggesting that gully networks in the main direction were well-developed while others were relatively undeveloped. In addition, the relationships between the first scales and controlling factors(i.e., gully density, nibble degree, watershed area, mean watershed slope, NDVI, precipitation, loess thickness, and loess landforms) revealed that the first scales are primarily controlled by watershed area and loess landforms. This may indicate that the current spatial pattern of P-N terrains is characterized by internal force. In selecting suitable study areas in China' Loess Plateau, it is crucial to understand four control variables: the spatial scale of the P-N terrain pattern, the watershed area, the main direction of the watershed, and the loess landforms.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41630425, 41761144074)
文摘Leader propagation is a fundamental issue in lightning physics. The propagation characteristics of positive leaders and negative leaders are summarized and compared based on data from high-speed camera and electromagnetic field in rocket-triggered lightning and tower-initiated lightning discharges; available channel base current data recorded in rocket-triggered lightning are also used. The negative leaders propagate in a stepped fashion accompanied by many branches. The stems ahead of the negative leader tip determine the manner and direction of the leader propagation, and even the branching and winding of the lightning channel. The impulsive current, electromagnetic field, and related optical images suggest that the positive leader may develop in a step-like fashion at its initial stage of triggered lightning. However, the stepping processes of the positive leader are obviously different from those of the negative leader. Tower-initiated lightning revealed that the most conspicuous characteristics of the stepwise positive leader involve the intermittent brush-like corona zone in front of the leader tip and the luminosity enhancement of the channel behind the tip. In rockettriggered lightning flashes, the charge transferred during an individual step for the negative leader was nearly an order greater than for the positive counterpart. The successive streamers ahead of the leader tip are essential for both negative and positive leader propagation, and the stems could be formed from one or more streamers in the previous negative streamer zone with the main leader channel dim. High-resolution observation of tower lightning also revealed a new type of bidirectional recoil leader, with polarity contrary to the traditional one, traversing in negative channels associated with tower-initiated and rocket-triggered lightning.
基金the Science Foundation of Educational Committee of Hunan Provinc
文摘A neutral difference equation with positive and negative coefficientsΔ(x n-c nx n-k )+p nx n-l -q nx n-r =0, n=0,1,2,...,is considered and a sufficient condition for the global attractivity of the zero solution of this equation is obtained, which improves and extends the all known results in the literature.
基金the National Natural Science Foundation of China(1 0 0 71 0 1 8)
文摘In this paper the sufficient conditions for the existence of positive solutions of the neutral difference equations with positive and negative coefficients are established. The results improve some known conclusions in the literature.
基金Supported by the the NNSF of China（60404022 60604004） Supported by the Special Projects in Mathematics Funded by Natural Science Foundation of Hebei Province（07M005）
文摘In this paper,we consider the forced neutral advanced dynamic equations with positive and negative coeffcients[x(t)-R(t)x(t+r)]+P(t)x(t+τ)△Q(t)x(t+δ)= f(t),t≥t0 on a time scale T.Several suffcient conditions are obtained for the oscillation of the dynamic equations.The main result is illustrated by an example.
基金supported by the National Natural Science Foundation of China(No.52461002)
文摘Finely tuning spectral characteristics of the epsilon-negative(ε'<0,EN) response is full of challenges when its regulatory mechanism in metacomposites is not yet clear.Herein,we have meticulously designed Cu/CaCu_(3)Ti_(4)O_(12)(Cu/CCTO) percolative metacomposites,successfully achieved both epsilon-negative and ε'-near-zero(ENZ)responses in the radio-frequency band.Before percolation,a large number of electric dipoles in the metacomposites achieved resonance characteristics near the ENZ point under the excitation of radio frequency electromagnetic fields,and as the Cu content increased,the ENZ frequency varied from 942,858,862 to 632 MHz.
基金eondueted by help and support of Vise caneeller researeh of Shahr-e-kord University of Medieal Seienees and the Network of veterinary seryice of Shahr-e-kord
文摘Objective:To investigate the unusual presentation of brucellosis.Methods:This prospective study was carried out on 46 patients suspected to brucellosis.The diagnosis was made with isolation of brucella species by Bone Marrow culture.Results:Among 40 culture positive patients,there were two unusual presentations of brucellosis: Afebrile culture positive and culture positive seronegative brucellosis.Conclusion:Some brucellosis patients would not match with criteria for diagnosis of brucellosis.Although it is needed to have positive serology or culture for diagnosis of brucellosis but sometimes,it is the clinical experiences,which help to diagnose and treat these kinds of patients.
基金supported in part by the grants from the National Natural Science Foundation of China (Grant No. 81472462)Medical Guidance Foundation of Shanghai Municipal Science and Technology Commission (Grant No. 15411966400)Technology Innovation Act Plan of Shanghai Municipal Science and Technology Commission (Grant No. 14411950200, 14411950201) and Sanofi
文摘Objective： A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide（TC） regimen was inferior to docetaxel, anthracycline and cyclophosphamide（TAC） in neoadjuvant treatment of triple-negative breast cancer（TNBC） and human epidermal growth factor receptor-2-（HER2）-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcomes have been investigated.Methods： TNBC or HER2-positive patients were randomized to receive 6 cycles of TC or TAC neoadjuvant treatment. The primary endpoint was pathological complete remission（p CR）. Secondary endpoints included clinical response rate, event-free survival（EFS）, and overall survival（OS）.Results： A cohort of 96 patients consisted of 45 in TC and 51 in TAC arm. With a median follow-up period of53（range, 8-76） months, the patients achieving p CR post neoadjuvant chemotherapy exhibited superior EFS and OS than patients without p CR（P〈0.05）. TAC treatment resulted in consistently better EFS than TC treatment：the estimated 5-year EFS was 66.1% vs. 29.8%（P=0.002）. Moreover, the estimated 5-year OS was also in favor of TAC： 88.4% vs. 51.6%（P〈0.001）. Multivariable analysis demonstrated that the treatment regimen was an independent prognostic factor, and patients treated with TAC had a superior EFS [hazard ratio（HR）, 0.48; 95%confidence interval（95% CI）, 0.26-0.90; P=0.021] and OS（HR, 0.20; 95% CI, 0.08-0.60; P=0.003）.Conclusions： The updated long-term follow-up data demonstrated a sustained benefit in EFS and OS from anthracycline-containing TAC treatment, indicating that anthracycline is an essential and effective drug in this clinical trial.
