The detection of identity-by-descent(IBD)segments is widely used to infer relatedness in many fields,including forensics and ancient DNA analysis.However,existing methods are often ineffective for poor-quality DNA sam...The detection of identity-by-descent(IBD)segments is widely used to infer relatedness in many fields,including forensics and ancient DNA analysis.However,existing methods are often ineffective for poor-quality DNA samples.Here,we propose a method,clusIBD,which can robustly detect IBD segments using unphased genetic data with a high rate of genotyping error.We evaluated and compared the performance of clusIBD with that of IBIS,TRUFFLE,and IBDseq using simulated data,artificial poor-quality materials,and ancient DNA samples.The results show that clusIBD outperforms these existing tools and could be used for kinship inference in fields such as ancient DNA analysis and criminal investigation.clusIBD is publicly available at GitHub(https://github.com/Ryan620/clusIBD/)and BioCode(https://ngdc.cncb.ac.cn/biocode/tool/BT007882).展开更多
This research study fabrics to ensure that they are free from carcinogenic dyes. It has been observed that there are poor-quality fabrics and consumers go to buy them without paying attention to the risks of using pro...This research study fabrics to ensure that they are free from carcinogenic dyes. It has been observed that there are poor-quality fabrics and consumers go to buy them without paying attention to the risks of using prohibited materials in the manufacture of these fabrics, and the use of unknown dyes has proven that some of them cause diseases to humans, especially children, that cause cancerous diseases. With the study sample consisting of (7), the study results indicate the presence of toxic formaldehyde in all sample dyes obtained from discount markets and online shopping.展开更多
基金funded by the National Natural Science Foundation of China(Grant No.82302125)the National Key R&D Program of China(Grant No.2024YFC3306702).
文摘The detection of identity-by-descent(IBD)segments is widely used to infer relatedness in many fields,including forensics and ancient DNA analysis.However,existing methods are often ineffective for poor-quality DNA samples.Here,we propose a method,clusIBD,which can robustly detect IBD segments using unphased genetic data with a high rate of genotyping error.We evaluated and compared the performance of clusIBD with that of IBIS,TRUFFLE,and IBDseq using simulated data,artificial poor-quality materials,and ancient DNA samples.The results show that clusIBD outperforms these existing tools and could be used for kinship inference in fields such as ancient DNA analysis and criminal investigation.clusIBD is publicly available at GitHub(https://github.com/Ryan620/clusIBD/)and BioCode(https://ngdc.cncb.ac.cn/biocode/tool/BT007882).
文摘This research study fabrics to ensure that they are free from carcinogenic dyes. It has been observed that there are poor-quality fabrics and consumers go to buy them without paying attention to the risks of using prohibited materials in the manufacture of these fabrics, and the use of unknown dyes has proven that some of them cause diseases to humans, especially children, that cause cancerous diseases. With the study sample consisting of (7), the study results indicate the presence of toxic formaldehyde in all sample dyes obtained from discount markets and online shopping.
