Ionic liquids(ILs),recognized for their negligible vapor pressure,thermal stability,and structural tailorability,offer targeted inhibition of clay expansion.Compared to ILs,polyionic liquids(PILs)possess stronger mech...Ionic liquids(ILs),recognized for their negligible vapor pressure,thermal stability,and structural tailorability,offer targeted inhibition of clay expansion.Compared to ILs,polyionic liquids(PILs)possess stronger mechanical properties and adsorption capabilities,showing even greater potential in inhibiting clay swelling.In this work,we synthesized and characterized an imidazole-based ionic liquid(IL-NH_(2)),a polyionic liquid(PIL-ABHIm),and a PIL/IL combination.Their inhibitory performance was rigorously evaluated under simulated drilling conditions through immersion tests,linear swelling tests,among others.Additionally,the mechanisms underlying their interaction with clay minerals were elucidated through contact angle measurements,Fourier-transform infrared spectroscopy,X-ray diffraction(XRD),Zeta potential analysis,and molecular electrostatic potential(MEP)analysis.This work demonstrates that IL-NH_2inhibits osmotic hydration by altering the interlayer structure of the clay,while PIL-ABHIm reduces surface hydration by forming a hydrophobic barrier on the clay surface.PIL/IL combines both mechanisms,significantly enhancing the stability of clay through the dual mechanisms of cation exchange and hydrophobic barriers.These findings reveal an innovative mechanism by which PIL/IL combination inhibits clay hydration and swelling,providing a scientific foundation for their application in drilling fluids.展开更多
An efficient extraction-free oxidative desulfurization(ODS)process using a series of cross-linked polyionic liquid phosphotungstate(CLPIL-PW)catalysts is reported.The cross-linked PILs were prepared with DVB and 1-n-a...An efficient extraction-free oxidative desulfurization(ODS)process using a series of cross-linked polyionic liquid phosphotungstate(CLPIL-PW)catalysts is reported.The cross-linked PILs were prepared with DVB and 1-n-alkyl-3-vinyl imidazole hydrobromide(alkyl=ethyl,butyl,octyl,dodecyl),and were then assembled with phosphotungstic acid(H_(3)PW_(12)O_(40))to form the catalysts.The CLPIL-PWs have been applied to the oxidative removal of dibenzothiophene(DBT)from model oil with H_(2)O_(2) as an oxidant.The effects of ionic liquid(IL)cationic species,varying the DVB/IL molar ratio in the polymerization process,and varying operating conditions were investigated.The CLPIL-PWs were characterized by inductively coupled plasma(ICP)mass spectrometry,elemental analysis,scanning electron microscopy(SEM),Fourier transform infra-red(FTIR)spectroscopy,X-ray diffraction(XRD),^(13)C and^(31)P nuclear magnetic resonance(NMR)spectroscopy.The polydivinylbenzene-co-1-n-octyl-3-vinyl imidazole phosphotungstate(P(DVB-OVIm)PW)exhibited the highest DBT removal efficiency(99.9%)and remarkable recyclability,and could be reused eight times without reducing its activity.Finally,an extraction-free ODS mechanism is proposed.展开更多
Bioinspired energy‐autonomous interactive electronics are prevalent.However,self‐powered artificial skins are often challenging to be combined with excellent mechanical properties,optical transparency,autonomous att...Bioinspired energy‐autonomous interactive electronics are prevalent.However,self‐powered artificial skins are often challenging to be combined with excellent mechanical properties,optical transparency,autonomous attachability,and biocompatibility.Herein,a robust ecological polyionic skin(polyionic eco‐skin)based on triboelectric mechanism consisting of ethyl cellulose/waterborne polyurethane/Cu nanoparticles(EWC)green electroactive sensitive material and polyethylene oxide/waterborne polyurethane/phytic acid(PWP)polyionic current collector is proposed.The polyionic eco‐skin features sufficient stretchability(90%)and low Young's modulus(0.8MPa)close to that of human soft tissue,high transparency(>84%of transmission)in the visible light range,and broad static/dynamic adhesiveness,which endows it with strong adaptive implementation capacity in flexible curved electronics.More importantly,the self‐powered polyionic eco‐skin exhibits enhanced force‐electric conversion performance by coordinating the effect of nanoparticlepolymer interfacial polarization and porous structure of sensitive material.Integrating multiple characteristics enables the polyionic ecoskin to effectively convert biomechanical energy into electrical energy,supporting self‐powered functionality for itself and related circuits.Moreover,the eco‐skin can be utilized to construct an interactive system and realize the remote noncontact manipulation of targets.The polyionic eco‐skin holds tremendous application potential in self‐powered security systems,human-machine interaction interfaces,and bionic robots,which is expected to inject new vitality into a human-cyber-physical intelligence integration.展开更多
The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has bee...The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.展开更多
In order to improve the electrical conductivity of nylon 6(PA6)and avoid misfires and explosions caused by static charge accumulation,a quaternary ammonium salt polyionic liquid(PIL)antistatic agent was synthesized in...In order to improve the electrical conductivity of nylon 6(PA6)and avoid misfires and explosions caused by static charge accumulation,a quaternary ammonium salt polyionic liquid(PIL)antistatic agent was synthesized in this paper.The surface resistance of PA6 was reduced to 10~8Ωwith the addition of 2 wt%antistatic agent,and the mechanical properties and aging resistance of the substrate were improved.Meanwhile,the morphology and crystallinity of PIL/PA6 composites were further characterized by scanning electron microscope(SEM),energy dispersion spectrometer(EDS)and X-ray diffraction(XRD).It is worth noting that the quaternary ammonium salt polyionic liquid antistatic agent synthesized in this paper has the advantages of excellent antistatic effect,durability,low cost,and simple reaction condition,so it has a broad application prospect in the antistatic aspect of PA6.展开更多
The stability of perovskite solar cells(PSCs)is adversely affected by nonradiative recombination resulting from buried interface defects.Herein,we synthesize a polyionic liquid,poly(p-vinylbenzyl trimethylam-monium he...The stability of perovskite solar cells(PSCs)is adversely affected by nonradiative recombination resulting from buried interface defects.Herein,we synthesize a polyionic liquid,poly(p-vinylbenzyl trimethylam-monium hexafluorophosphate)(PTA),and introduce it into the buried interface of PSCs.The quaternary ammonium cation(N(-CH_(3))^(3+))in PTA can fill the vacancies of organic cations within the perovskite structure and reduce shallow energy level defects.Additionally,the hexafluorophosphate(PF6−)in PTA forms a Lewis acid-base interaction with Pb^(2+)in the perovskite layer,effectively passivating deep en-ergy level defects.Furthermore,hydrogen bonding can be established between organic cations and the PF6−anion,preventing the formation of shallow energy level defects.Through this synergistic mecha-nism,the deep and shallow energy level defects are effectively mitigated,resulting in improved device performance.As a result,the resulting treated inverted PSC exhibits an impressive power conversion ef-ficiency(PCE)of 24.72%.Notably,the PTA-treated PSCs exhibit remarkable stability,with 88.5%of the original PCE retained after undergoing heat aging at 85℃ for 1078 h,and 89.1%of the initial PCE main-tained following continuous exposure to light for 1100 h at the maximum power point.Synergistically suppressing multiple defects at the buried interface through the use of polyionic liquids is a promising way to improve the commercial viability of PSCs.展开更多
Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles...Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles are easily removed from tumor tissues due to the high tumor interstitial fluid pressure.To address these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly sizeswitchable feature was engineered in this study.The micelles are consisting of methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an optimal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),encapsulated.The net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of micelles.DE-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral pH.Results indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse model.Collectively,the sizeswitchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.展开更多
A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular su...A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular surface.The granules have an average diameter of 1.38-1.53 mm and the drug content reaches 62.89％.The external release tests showed T_(50) to be 45 rain and the total release time 4 h in an artificial gastric juice,while no more than 60％ of the drug was released in the same period of time in an ar- tificial intestinal fluid.The various factors affecting the external release were examined.展开更多
The electroredox behavior of novel modified electrodes coated with complexes of different polyviologens was investigated using cyclic voltammetry. The influences of compositions of electrolyte complex on the reversibi...The electroredox behavior of novel modified electrodes coated with complexes of different polyviologens was investigated using cyclic voltammetry. The influences of compositions of electrolyte complex on the reversibility of the modified electrode and the electrochromic properties were studied also. It was found that all the ratios of integrated charges of cathodic to anodic scan (Qc/QA) are close to 1, which indicates that these modified electrodes have good reversible behavior. Repeated stepping over the first wave for 500 scans, the PSS-PX(p)V modified electrode showed excellent stability. The first reduction potential (E1), decrease of current height (Dec%), response time (tre tox) of various polyviologen modified electrodes were reported. In addition, the effect of the coverage of polyviologen on the electrode surface was also examined. The rate of electron transfer in this heterogeneous system is diffusion-controlled, consistent with the Conttrell equation.展开更多
A novel potentiometric detection strategy based on functionalized magnetic nanoparticles has been developed for rapid and sensitive sensing of polyions.Highly dispersed magnetic nanoparticles coated with ion exchanger...A novel potentiometric detection strategy based on functionalized magnetic nanoparticles has been developed for rapid and sensitive sensing of polyions.Highly dispersed magnetic nanoparticles coated with ion exchanger and plasticizer could promote an in situ cooperative ion-pairing interaction between the ion exchanger and the polyion analyte in sample solution by dramatically reducing the mass-transfer distance.With applying a magnetic field,the nanoparticles can be attached to the surface of ion exchanger free polymeric membrane.The observed potential signals are related to the polyion concentrations.The proposed polymeric membrane electrode exhibits a linear relationship between the greatest potential response slope（dE/dt） and the logarithm of protamine concentration in the range of 0.05-5μg/mL with a lower detection limit of 0.033μg/mL.展开更多
Polyion complex （PIC） micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly（N-isopropylacrylamide）-b-poly（L-glutamic acid...Polyion complex （PIC） micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly（N-isopropylacrylamide）-b-poly（L-glutamic acid） and poly（N-isopropylacrylamide）-b-poly（L-lysine）. Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides （NCA）, ε-benzyloxycarbonyl-L-lysine （Lys（Z）-NCA） or γ-benzyl-L-glutamate （BLG-NCA） with amino-terminated poly（N-isopropylacrylamide） macroinitiator and the subsequent deprotection reaction. The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy. Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.展开更多
A polymeric membrane ion-selective electrode for determination of heparin is described in this paper.Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition...A polymeric membrane ion-selective electrode for determination of heparin is described in this paper.Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin.The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate.The potentiometric response to the concentration of heparin is Unear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.展开更多
Poly(2,2'-disulfonyl-4,4'-benzidine terephthalamide) (PBDT), a kind of liquid-crystalline (LC) molecule, has high molecular weight, negative charge and a semi-rigid structure. The aqueous solution of PBDT show...Poly(2,2'-disulfonyl-4,4'-benzidine terephthalamide) (PBDT), a kind of liquid-crystalline (LC) molecule, has high molecular weight, negative charge and a semi-rigid structure. The aqueous solution of PBDT shows nematic liquid crystalline state above a critical PBDT concentration, CLC*, of 2 wt%-3wt%. Different from the flexible polyelectrolyte, PBDT shows a variety of self-assembling structures in aqueous solution with and without salt due to the semi-rigid nature and highly charged property. In addition, the hydrogels with ordered structure are developed by polymerizing a cationic monomer N-[3-(N,N-dimethylamino) propyl] acrylamide methyl chloride quarternary (DMAPAA-Q) in the presence of a small amount of PBDT below the CLC*. During the polymerization of cationic monomer, the polycations form a complex with semi-rigid PBDT through electrostatic interaction; these complexes self-assemble into ordered structures that are frozen in the hydrogel. Several different structures, including the anisotropic, dual network-like structure, and cylindrically symmetric structure, with various length scales from micrometer to millimeter, are observed. The hydrogels with ordered liquid crystalline assemblies and particular optical properties should promise applications in many fields, such as in bionics, tissue engineering, and mechano-optical sensors.展开更多
PLL-PEG-PLL was synthesized by deprotection of the amino group of PLL(Z)-PEG-PLL(Z). The properties of the polyion complex (PIC) micelles comprising of PLL-PEG-PLL and DNA were investigated. The results showed that th...PLL-PEG-PLL was synthesized by deprotection of the amino group of PLL(Z)-PEG-PLL(Z). The properties of the polyion complex (PIC) micelles comprising of PLL-PEG-PLL and DNA were investigated. The results showed that the core of PIC was formed by PLL and DNA through electrostatic interactions, and PEG was shell of PIC, so PIC micelles in aque- ous medium were homogenous with no precipitation even under the neutral condition, and PIC had the characteristic of stability, which were very important in gene therapy. At the same time, the results showed PLL-PEG-PLL could condense DNA, longer PLL blocks were generally more effective at condensation, and the nuclease resistance of DNA was increased remarkably. PIC was spherical with diameter of 10―35 nm, which could be easily taken up by cells. Transfection experiments in vitro showed that the DNA encapsulated could be expressed in the cell line SF9.展开更多
基金funding from the National Natural Science Foundation of China(Nos.51991361 and 52288101)the Young Scientists Fund of the National Natural Science Foundation(No.52204023)。
文摘Ionic liquids(ILs),recognized for their negligible vapor pressure,thermal stability,and structural tailorability,offer targeted inhibition of clay expansion.Compared to ILs,polyionic liquids(PILs)possess stronger mechanical properties and adsorption capabilities,showing even greater potential in inhibiting clay swelling.In this work,we synthesized and characterized an imidazole-based ionic liquid(IL-NH_(2)),a polyionic liquid(PIL-ABHIm),and a PIL/IL combination.Their inhibitory performance was rigorously evaluated under simulated drilling conditions through immersion tests,linear swelling tests,among others.Additionally,the mechanisms underlying their interaction with clay minerals were elucidated through contact angle measurements,Fourier-transform infrared spectroscopy,X-ray diffraction(XRD),Zeta potential analysis,and molecular electrostatic potential(MEP)analysis.This work demonstrates that IL-NH_2inhibits osmotic hydration by altering the interlayer structure of the clay,while PIL-ABHIm reduces surface hydration by forming a hydrophobic barrier on the clay surface.PIL/IL combines both mechanisms,significantly enhancing the stability of clay through the dual mechanisms of cation exchange and hydrophobic barriers.These findings reveal an innovative mechanism by which PIL/IL combination inhibits clay hydration and swelling,providing a scientific foundation for their application in drilling fluids.
基金supported by the Natural Science Foundation of Heilongjiang Province of China (Grant No. LH2019B025)
文摘An efficient extraction-free oxidative desulfurization(ODS)process using a series of cross-linked polyionic liquid phosphotungstate(CLPIL-PW)catalysts is reported.The cross-linked PILs were prepared with DVB and 1-n-alkyl-3-vinyl imidazole hydrobromide(alkyl=ethyl,butyl,octyl,dodecyl),and were then assembled with phosphotungstic acid(H_(3)PW_(12)O_(40))to form the catalysts.The CLPIL-PWs have been applied to the oxidative removal of dibenzothiophene(DBT)from model oil with H_(2)O_(2) as an oxidant.The effects of ionic liquid(IL)cationic species,varying the DVB/IL molar ratio in the polymerization process,and varying operating conditions were investigated.The CLPIL-PWs were characterized by inductively coupled plasma(ICP)mass spectrometry,elemental analysis,scanning electron microscopy(SEM),Fourier transform infra-red(FTIR)spectroscopy,X-ray diffraction(XRD),^(13)C and^(31)P nuclear magnetic resonance(NMR)spectroscopy.The polydivinylbenzene-co-1-n-octyl-3-vinyl imidazole phosphotungstate(P(DVB-OVIm)PW)exhibited the highest DBT removal efficiency(99.9%)and remarkable recyclability,and could be reused eight times without reducing its activity.Finally,an extraction-free ODS mechanism is proposed.
基金supported by the National Natural Science Foundation of China(52403284,52473270 and T2422028)the Natural Science Foundation of Jiangsu Province(BK20240481)+3 种基金the fellowship of China National Postdoctoral Program for Innovative Talents(BX20240408)the National Key R&D Program of China(2022YFA1203304)the Suzhou Institute of Nano‐Tech and Nano‐Bionics,Chinese Academy of Sciences(start‐up grant E1552102)Jiangsu Funding Program for Excellent Postdoctoral Talent.
文摘Bioinspired energy‐autonomous interactive electronics are prevalent.However,self‐powered artificial skins are often challenging to be combined with excellent mechanical properties,optical transparency,autonomous attachability,and biocompatibility.Herein,a robust ecological polyionic skin(polyionic eco‐skin)based on triboelectric mechanism consisting of ethyl cellulose/waterborne polyurethane/Cu nanoparticles(EWC)green electroactive sensitive material and polyethylene oxide/waterborne polyurethane/phytic acid(PWP)polyionic current collector is proposed.The polyionic eco‐skin features sufficient stretchability(90%)and low Young's modulus(0.8MPa)close to that of human soft tissue,high transparency(>84%of transmission)in the visible light range,and broad static/dynamic adhesiveness,which endows it with strong adaptive implementation capacity in flexible curved electronics.More importantly,the self‐powered polyionic eco‐skin exhibits enhanced force‐electric conversion performance by coordinating the effect of nanoparticlepolymer interfacial polarization and porous structure of sensitive material.Integrating multiple characteristics enables the polyionic ecoskin to effectively convert biomechanical energy into electrical energy,supporting self‐powered functionality for itself and related circuits.Moreover,the eco‐skin can be utilized to construct an interactive system and realize the remote noncontact manipulation of targets.The polyionic eco‐skin holds tremendous application potential in self‐powered security systems,human-machine interaction interfaces,and bionic robots,which is expected to inject new vitality into a human-cyber-physical intelligence integration.
基金support from the National Key R&D Program of China(2021YFA0716304)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB 0470301),the National Natural Science Foundation of China(U23A20623,21972153,and 52075524)+2 种基金Gansu Province Science and Technology Plan(20JR10RA060,22ZD6GA002,and 22ZD6GA025)Openning Project of State Key Laboratory of Solid Lubrication,LICP(LSL-2004)the Taishan Scholars Program.
文摘The polyionic liquid poly-PEGMA-r-METAC(PPM)with quaternary ammonium has been synthesized and evaluated as additive in aqueous lubricating fluids.The rheological behavior of aqueous lubricating fluids with PPM has been characterized to confirm PPM’s function as a viscosity modifier.The tribological behavior of aqueous lubricating fluids with PPM has been investigated on SRV-V and MTM testing machines.It was found that PPM has excellent viscosity-increasing,lubricating,and anti-wear properties as an additive for aqueous,which can be attributed to the ability of PPM to form the protective film and boundary tribofilm generated from complex tribochemical reaction on rubbing surface.The obtained PPM with dual functions of anti-corrosion additives and viscosity index improver can play an important role in diverse lubrication regimes.
基金supported by the Natural Science Foundation of Guangdong Province(Project No.2021A1515010140)the Natural Science Foundation of Shandong Province(Project No.ZR2020ME065)
文摘In order to improve the electrical conductivity of nylon 6(PA6)and avoid misfires and explosions caused by static charge accumulation,a quaternary ammonium salt polyionic liquid(PIL)antistatic agent was synthesized in this paper.The surface resistance of PA6 was reduced to 10~8Ωwith the addition of 2 wt%antistatic agent,and the mechanical properties and aging resistance of the substrate were improved.Meanwhile,the morphology and crystallinity of PIL/PA6 composites were further characterized by scanning electron microscope(SEM),energy dispersion spectrometer(EDS)and X-ray diffraction(XRD).It is worth noting that the quaternary ammonium salt polyionic liquid antistatic agent synthesized in this paper has the advantages of excellent antistatic effect,durability,low cost,and simple reaction condition,so it has a broad application prospect in the antistatic aspect of PA6.
基金supported by the Science,Technology,and Innovation Commission of Shenzhen Municipality(No.GJHZ20220913143204008)the Shccig-Qinling Program(No.SMYJY202300294C)+3 种基金National Natural Science Foundation of China(Nos.22261142666,52372225,52172237,22305191)the Shaanxi Science Fund for Distinguished Young Scholars(No.2022JC-21)the Research Fund of the State Key Laboratory of Solidification Processing(NPU)China(No.2021-QZ-02).
文摘The stability of perovskite solar cells(PSCs)is adversely affected by nonradiative recombination resulting from buried interface defects.Herein,we synthesize a polyionic liquid,poly(p-vinylbenzyl trimethylam-monium hexafluorophosphate)(PTA),and introduce it into the buried interface of PSCs.The quaternary ammonium cation(N(-CH_(3))^(3+))in PTA can fill the vacancies of organic cations within the perovskite structure and reduce shallow energy level defects.Additionally,the hexafluorophosphate(PF6−)in PTA forms a Lewis acid-base interaction with Pb^(2+)in the perovskite layer,effectively passivating deep en-ergy level defects.Furthermore,hydrogen bonding can be established between organic cations and the PF6−anion,preventing the formation of shallow energy level defects.Through this synergistic mecha-nism,the deep and shallow energy level defects are effectively mitigated,resulting in improved device performance.As a result,the resulting treated inverted PSC exhibits an impressive power conversion ef-ficiency(PCE)of 24.72%.Notably,the PTA-treated PSCs exhibit remarkable stability,with 88.5%of the original PCE retained after undergoing heat aging at 85℃ for 1078 h,and 89.1%of the initial PCE main-tained following continuous exposure to light for 1100 h at the maximum power point.Synergistically suppressing multiple defects at the buried interface through the use of polyionic liquids is a promising way to improve the commercial viability of PSCs.
基金supported by the National Natural Science Foundation of China(Nos.81972894,22278442,82273882)。
文摘Size is one of the most important characteristics of nanoparticles to influence their biodistribution and antitumoral efficacy.Particles with large sizes have difficulty in deep tumor penetration,while small particles are easily removed from tumor tissues due to the high tumor interstitial fluid pressure.To address these issues,an intelligent core-crosslinked polyion complex micelle(cPCM)with a reversibly sizeswitchable feature was engineered in this study.The micelles are consisting of methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PLA),mPEG-PLA-(HE)6CC,and mPEG-PLA-(RG)6CC at an optimal mass ratio of 6:1:1 with an antiangiogenic compound,dabigatran etexilate(DE),encapsulated.The net charge inside the micelles is switchable when exposed to different pH conditions,thereby leading to revisable size-change of micelles.DE-loaded micelles(DE@cPCM)can swell and release drugs at the tumor sites with a mildly acidic pH,while they shrink and protect the cargo from leaking into the blood circulation with a neutral pH.Results indicated that DE@cPCM can inhibit tumor angiogenesis in vitro and in vivo,thereby efficiently restraining tumor growth in a 4T1-bearing mouse model.Collectively,the sizeswitchable cPCM is a promising nanoplatform for targeting delivery of anticarcinogens into the matrix of tumor tissues.
基金This project was supported by National Natural Science Foundation of China
文摘A rotundine-polyion complex(PIC)release system was prepared first by granulation of rotundine containing chitosan acetate solution and then by complexing with carboxymethyl glucomannan(CMGM)solution on the granular surface.The granules have an average diameter of 1.38-1.53 mm and the drug content reaches 62.89％.The external release tests showed T_(50) to be 45 rain and the total release time 4 h in an artificial gastric juice,while no more than 60％ of the drug was released in the same period of time in an ar- tificial intestinal fluid.The various factors affecting the external release were examined.
基金Supported by the National Natural Science Foundation of China
文摘The electroredox behavior of novel modified electrodes coated with complexes of different polyviologens was investigated using cyclic voltammetry. The influences of compositions of electrolyte complex on the reversibility of the modified electrode and the electrochromic properties were studied also. It was found that all the ratios of integrated charges of cathodic to anodic scan (Qc/QA) are close to 1, which indicates that these modified electrodes have good reversible behavior. Repeated stepping over the first wave for 500 scans, the PSS-PX(p)V modified electrode showed excellent stability. The first reduction potential (E1), decrease of current height (Dec%), response time (tre tox) of various polyviologen modified electrodes were reported. In addition, the effect of the coverage of polyviologen on the electrode surface was also examined. The rate of electron transfer in this heterogeneous system is diffusion-controlled, consistent with the Conttrell equation.
基金financially supported by the Chinese Academy of Sciences(No.KZCX2-YW-410)the National Natural Science Foundation of China(Nos.40776058 and 20977073)+2 种基金the National 863 High Technology Project of the Ministry of Science and Technology of China(No.2007AA09Z103)the Outstanding Youth Natural Science Foundation of Shandong Province(No.JQ200814)the Taishan Scholar Program of Shandong Province
文摘A novel potentiometric detection strategy based on functionalized magnetic nanoparticles has been developed for rapid and sensitive sensing of polyions.Highly dispersed magnetic nanoparticles coated with ion exchanger and plasticizer could promote an in situ cooperative ion-pairing interaction between the ion exchanger and the polyion analyte in sample solution by dramatically reducing the mass-transfer distance.With applying a magnetic field,the nanoparticles can be attached to the surface of ion exchanger free polymeric membrane.The observed potential signals are related to the polyion concentrations.The proposed polymeric membrane electrode exhibits a linear relationship between the greatest potential response slope（dE/dt） and the logarithm of protamine concentration in the range of 0.05-5μg/mL with a lower detection limit of 0.033μg/mL.
基金financially supported by the National Natural Science Foundation of China (Nos. 20904053, 51021003,51173184)the Ministry of Science and Technology of China (International cooperation program 2011RI0001)the Program of the Science and Technology of Changchun (No. 2010061)
文摘Polyion complex （PIC） micelles were spontaneously formed in aqueous solutions through electrostatic interaction between two oppositely charged block copolymers, poly（N-isopropylacrylamide）-b-poly（L-glutamic acid） and poly（N-isopropylacrylamide）-b-poly（L-lysine）. Their controlled synthesis was achieved via the ring opening polymerization of N-carboxyanhydrides （NCA）, ε-benzyloxycarbonyl-L-lysine （Lys（Z）-NCA） or γ-benzyl-L-glutamate （BLG-NCA） with amino-terminated poly（N-isopropylacrylamide） macroinitiator and the subsequent deprotection reaction. The formation of PIC micelles was confirmed by dynamic light scattering and transmission electron microscopy. Turbidimetric characterization suggested that the formed PIC micelles had a concentration-dependent thermosensitivity and their phase transition behaviors could be easily adjusted either by the block length of coplymers or the concentration of micelles.
基金supported by the National Natural Science Foundation of China(No41176081)the Outstanding Youth Natural Science Foundation of Shandong Province(NoJQ200814)the Taishan Scholar Program of Shandong Province(NoTS20081159)
文摘A polymeric membrane ion-selective electrode for determination of heparin is described in this paper.Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin.The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate.The potentiometric response to the concentration of heparin is Unear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.
基金supported by a Grant-in-Aid for the Specially Promoted Research (18002002) from the Ministry of Education, Science, Sports and Culture of Japan
文摘Poly(2,2'-disulfonyl-4,4'-benzidine terephthalamide) (PBDT), a kind of liquid-crystalline (LC) molecule, has high molecular weight, negative charge and a semi-rigid structure. The aqueous solution of PBDT shows nematic liquid crystalline state above a critical PBDT concentration, CLC*, of 2 wt%-3wt%. Different from the flexible polyelectrolyte, PBDT shows a variety of self-assembling structures in aqueous solution with and without salt due to the semi-rigid nature and highly charged property. In addition, the hydrogels with ordered structure are developed by polymerizing a cationic monomer N-[3-(N,N-dimethylamino) propyl] acrylamide methyl chloride quarternary (DMAPAA-Q) in the presence of a small amount of PBDT below the CLC*. During the polymerization of cationic monomer, the polycations form a complex with semi-rigid PBDT through electrostatic interaction; these complexes self-assemble into ordered structures that are frozen in the hydrogel. Several different structures, including the anisotropic, dual network-like structure, and cylindrically symmetric structure, with various length scales from micrometer to millimeter, are observed. The hydrogels with ordered liquid crystalline assemblies and particular optical properties should promise applications in many fields, such as in bionics, tissue engineering, and mechano-optical sensors.
文摘PLL-PEG-PLL was synthesized by deprotection of the amino group of PLL(Z)-PEG-PLL(Z). The properties of the polyion complex (PIC) micelles comprising of PLL-PEG-PLL and DNA were investigated. The results showed that the core of PIC was formed by PLL and DNA through electrostatic interactions, and PEG was shell of PIC, so PIC micelles in aque- ous medium were homogenous with no precipitation even under the neutral condition, and PIC had the characteristic of stability, which were very important in gene therapy. At the same time, the results showed PLL-PEG-PLL could condense DNA, longer PLL blocks were generally more effective at condensation, and the nuclease resistance of DNA was increased remarkably. PIC was spherical with diameter of 10―35 nm, which could be easily taken up by cells. Transfection experiments in vitro showed that the DNA encapsulated could be expressed in the cell line SF9.
