Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These f...Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.展开更多
Dear Editor, Herbal medicines have been used for prevention and treatment of human diseases and promotion of healthy living. These medicines, often self medicated and consumed as concentrated extracts, are not strict...Dear Editor, Herbal medicines have been used for prevention and treatment of human diseases and promotion of healthy living. These medicines, often self medicated and consumed as concentrated extracts, are not strictly regulated. Considering their popular use and increasing safety concerns, thorough evaluations of their efficacy and safety are warranted to protect consumers from potential adverse effects. Toxicity tests （acute, sub- acute and chronic） using animals are widely applied to evaulate adverse effects of a drug and thereby determine its ＂No Observed Adverse Effect Level＂ （NOAEL）.展开更多
Background:Mixed Anxiety Depressive Disorder(MADD)is a prevalent mental health condition affecting overall well-being.Unani medicine offers therapeutic interventions,including Majoon Najah,a polyherbal Unani phar-maco...Background:Mixed Anxiety Depressive Disorder(MADD)is a prevalent mental health condition affecting overall well-being.Unani medicine offers therapeutic interventions,including Majoon Najah,a polyherbal Unani phar-macopoeial formulation with potential anxiolytic and antidepressant properties.Majoon Najah contains several medicinal plants known for their neuroprotective and mood-stabilizing effects,including Terminalia chebula Retz.(Post-e-Halela Kabli),Terminalia bellerica Roxb.(Post-e-Balela),Emblica officinalis Gaertn.(Aamla),and Cuscuta reflexa Roxb.(Aftimoon)etc.Objective:This study aimed to evaluate the safety and efficacy of Majoon Najah in patients diagnosed with MADD.Methods:A prospective,open-label,single-arm,before-after study was conducted at Regional Research Institute of Unani Medicine,Chennai,India.A total of 76 patients aged 18-60 years with MADD were enrolled.The study was approved by the Institutional Ethics Committee on 18 July 2019 and registered with Clinical Trial Registry-India(CTRI)on 2 February 2020.Participants received polyherbal Unani formulation 5gm orally twice daily with water for 6 weeks.Efficacy was assessed using the Hamilton Anxiety Rating Scale(HAM-A)and Hamilton Depres-sion Rating Scale(HAM-D)at baseline and follow-ups.Safety was evaluated through laboratory investigations.Statistical analysis used repeated-measures ANOVA(P<0.05).Results:The results revealed that significant reductions were observed in HAM-A(27.43±8.16 to 6.92±4.26)and HAM-D scores(20.53±5.40 to 5.52±3.38)(P<0.05).No significant biochemical or haematological changes were noted(P>0.05).Treatment response analysis showed 19.73%of participants achieved complete relief,55.26%showed significant relief,and 25%showed partial relief.Conclusion:This finding inferred that polyherbal Unani formulation,Majoon Najah is a safe and effective interven-tion for reducing anxiety and depression symptoms without adverse effects,supporting its safe therapeutic use in Unani medicine for managing MADD.The study was subsequently registered with the Clinical trial Registry-India(CTRI)with CTRI number CTRI/2020/02/023429.展开更多
文摘Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.
文摘Dear Editor, Herbal medicines have been used for prevention and treatment of human diseases and promotion of healthy living. These medicines, often self medicated and consumed as concentrated extracts, are not strictly regulated. Considering their popular use and increasing safety concerns, thorough evaluations of their efficacy and safety are warranted to protect consumers from potential adverse effects. Toxicity tests （acute, sub- acute and chronic） using animals are widely applied to evaulate adverse effects of a drug and thereby determine its ＂No Observed Adverse Effect Level＂ （NOAEL）.
基金funded by Central Council for Research in Unani Medicine(CCRUM),New Delhi,Ministry of Ayush,Government of India。
文摘Background:Mixed Anxiety Depressive Disorder(MADD)is a prevalent mental health condition affecting overall well-being.Unani medicine offers therapeutic interventions,including Majoon Najah,a polyherbal Unani phar-macopoeial formulation with potential anxiolytic and antidepressant properties.Majoon Najah contains several medicinal plants known for their neuroprotective and mood-stabilizing effects,including Terminalia chebula Retz.(Post-e-Halela Kabli),Terminalia bellerica Roxb.(Post-e-Balela),Emblica officinalis Gaertn.(Aamla),and Cuscuta reflexa Roxb.(Aftimoon)etc.Objective:This study aimed to evaluate the safety and efficacy of Majoon Najah in patients diagnosed with MADD.Methods:A prospective,open-label,single-arm,before-after study was conducted at Regional Research Institute of Unani Medicine,Chennai,India.A total of 76 patients aged 18-60 years with MADD were enrolled.The study was approved by the Institutional Ethics Committee on 18 July 2019 and registered with Clinical Trial Registry-India(CTRI)on 2 February 2020.Participants received polyherbal Unani formulation 5gm orally twice daily with water for 6 weeks.Efficacy was assessed using the Hamilton Anxiety Rating Scale(HAM-A)and Hamilton Depres-sion Rating Scale(HAM-D)at baseline and follow-ups.Safety was evaluated through laboratory investigations.Statistical analysis used repeated-measures ANOVA(P<0.05).Results:The results revealed that significant reductions were observed in HAM-A(27.43±8.16 to 6.92±4.26)and HAM-D scores(20.53±5.40 to 5.52±3.38)(P<0.05).No significant biochemical or haematological changes were noted(P>0.05).Treatment response analysis showed 19.73%of participants achieved complete relief,55.26%showed significant relief,and 25%showed partial relief.Conclusion:This finding inferred that polyherbal Unani formulation,Majoon Najah is a safe and effective interven-tion for reducing anxiety and depression symptoms without adverse effects,supporting its safe therapeutic use in Unani medicine for managing MADD.The study was subsequently registered with the Clinical trial Registry-India(CTRI)with CTRI number CTRI/2020/02/023429.
