The cold sintering process(CSP)is a green and innovative method of material densification at low temperatures(<350°C).The traditional CSP entails the addition of liquid phases as a solvent to achieve material ...The cold sintering process(CSP)is a green and innovative method of material densification at low temperatures(<350°C).The traditional CSP entails the addition of liquid phases as a solvent to achieve material densification through the dissolution-precipitation mechanism.However,it is difficult to realize for materials with low solubility.To address this challenge,a universal cold sintering method without the addition of liquid phases has been proposed in this work.The addition of a special polyester-polymer assisted the densification of insoluble ceramics,and hydroxyapatite(HA)and Al_(2)O_(3)were successfully sintered below 100°C,achieving 95-100%densities in a short time(5-20 min).This achievement can be attributed to the low glass transition temperature and the abundance of active sites(C=O)of the polyester-polymer.The denser ceramics exhibited enhanced mechanical properties,with the compression strength of polymer-assisted CSP HA increasing by 147.3%compared to the nanoparticles.Additionally,serving as an advanced bone substitute material,HA underwent quantitative analysis using the CCK-8 method and assessed the impact of polymer presence on cell proliferation and cytotoxicity.Meanwhile,a tight bonding between the polymer and ceramic materials was achieved during CSP,providing a generalized method for designing multifunctional ceramic-polymer.展开更多
基金supported by the Jilin Provincial Natural Science Foundation(No.20240101118JC)the funds of Medical+X cross innovation team granted by medical department of Jilin University(No.2022JBGS07)+1 种基金the Jilin Province Science and Technology development project(No.20210101437JC)the WU JIEPING Medical Foundation(No.320.6750.2023-3-20 to TGM)。
文摘The cold sintering process(CSP)is a green and innovative method of material densification at low temperatures(<350°C).The traditional CSP entails the addition of liquid phases as a solvent to achieve material densification through the dissolution-precipitation mechanism.However,it is difficult to realize for materials with low solubility.To address this challenge,a universal cold sintering method without the addition of liquid phases has been proposed in this work.The addition of a special polyester-polymer assisted the densification of insoluble ceramics,and hydroxyapatite(HA)and Al_(2)O_(3)were successfully sintered below 100°C,achieving 95-100%densities in a short time(5-20 min).This achievement can be attributed to the low glass transition temperature and the abundance of active sites(C=O)of the polyester-polymer.The denser ceramics exhibited enhanced mechanical properties,with the compression strength of polymer-assisted CSP HA increasing by 147.3%compared to the nanoparticles.Additionally,serving as an advanced bone substitute material,HA underwent quantitative analysis using the CCK-8 method and assessed the impact of polymer presence on cell proliferation and cytotoxicity.Meanwhile,a tight bonding between the polymer and ceramic materials was achieved during CSP,providing a generalized method for designing multifunctional ceramic-polymer.
