Mueller matrix imaging is emerging for the quantitative characterization of pathological microstructures and is especially sensitive to fibrous structures.Liver fibrosis is a characteristic of many types of chronic li...Mueller matrix imaging is emerging for the quantitative characterization of pathological microstructures and is especially sensitive to fibrous structures.Liver fibrosis is a characteristic of many types of chronic liver diseases.The clinical diagnosis of liver fibrosis requires time-consuming multiple staining processes that specifically target on fibrous structures.The staining proficiency of technicians and the subjective visualization of pathologists may bring inconsistency to clinical diagnosis.Mueller matrix imaging can reduce the multiple staining processes and provide quantitative diagnostic indicators to characterize liver fibrosis tissues.In this study,a fibersensitive polarization feature parameter(PFP)was derived through the forward sequential feature selection(SFS)and linear discriminant analysis(LDA)to target on the identification of fibrous structures.Then,the Pearson correlation coeffcients and the statistical T-tests between the fiber-sensitive PFP image textures and the liver fibrosis tissues were calculated.The results show the gray level run length matrix(GLRLM)-based run entropy that measures the heterogeneity of the PFP image was most correlated to the changes of liver fibrosis tissues at four stages with a Pearson correlation of 0.6919.The results also indicate the highest Pearson correlation of 0.9996 was achieved through the linear regression predictions of the combination of the PFP image textures.This study demonstrates the potential of deriving a fiber-sensitive PFP to reduce the multiple staining process and provide textures-based quantitative diagnostic indicators for the staging of liver fibrosis.展开更多
Despite progress in HfO_(2)thin-film ferroelectrics,issues like high coercive fields persist,and the dynamics of twisted ferroelectricity remain largely unexplored.Here,we explore how sliding and twisting in bilayer H...Despite progress in HfO_(2)thin-film ferroelectrics,issues like high coercive fields persist,and the dynamics of twisted ferroelectricity remain largely unexplored.Here,we explore how sliding and twisting in bilayer HfO_(2)enables low barrier switching.Among 144 sliding configurations,two exhibit strong in-plane polarization(2360 pC/m)with a low switching barrier of 9.57 meV/f.u.Twisting generates polar textures associated with moirépatterns,which drive ferroelectricity via a soft zonecenter mode,as revealed by machine-learning-assisted first-principles calculations.The in-plane(out-of-plane)polarization values for HfO_(2)at twist angles of 21.79°,27.80°,and 46.83°are 430(5.82),367(2.20),and 1057(0.03)pC/m,respectively.For 21.79°and 27.80°twisting,switching barriers drop to 1.74 and 0.18 meV/f.u.,indicating superlubric-like transitions.Notably,the 46.83°twisted bilayer shows an almost barrier-free polar evolution(0.03 meV/f.u.),attributed to sharply enhanced zonecenter phonon linewidths.Our findings establish a moiré-engineered switching route for 2D ferroelectrics.展开更多
基金supported by the National Natural Science Foundation of China(NSFC)(Nos.11974206 and 61527826).
文摘Mueller matrix imaging is emerging for the quantitative characterization of pathological microstructures and is especially sensitive to fibrous structures.Liver fibrosis is a characteristic of many types of chronic liver diseases.The clinical diagnosis of liver fibrosis requires time-consuming multiple staining processes that specifically target on fibrous structures.The staining proficiency of technicians and the subjective visualization of pathologists may bring inconsistency to clinical diagnosis.Mueller matrix imaging can reduce the multiple staining processes and provide quantitative diagnostic indicators to characterize liver fibrosis tissues.In this study,a fibersensitive polarization feature parameter(PFP)was derived through the forward sequential feature selection(SFS)and linear discriminant analysis(LDA)to target on the identification of fibrous structures.Then,the Pearson correlation coeffcients and the statistical T-tests between the fiber-sensitive PFP image textures and the liver fibrosis tissues were calculated.The results show the gray level run length matrix(GLRLM)-based run entropy that measures the heterogeneity of the PFP image was most correlated to the changes of liver fibrosis tissues at four stages with a Pearson correlation of 0.6919.The results also indicate the highest Pearson correlation of 0.9996 was achieved through the linear regression predictions of the combination of the PFP image textures.This study demonstrates the potential of deriving a fiber-sensitive PFP to reduce the multiple staining process and provide textures-based quantitative diagnostic indicators for the staging of liver fibrosis.
基金funded by the Science and Technology Commission of Shanghai Municipality(No.24CL2901702)We acknowledge the Supercomputer Center,Institute for Solid State Physics,the University of Tokyo(Project number 2024-Cb-0042).
文摘Despite progress in HfO_(2)thin-film ferroelectrics,issues like high coercive fields persist,and the dynamics of twisted ferroelectricity remain largely unexplored.Here,we explore how sliding and twisting in bilayer HfO_(2)enables low barrier switching.Among 144 sliding configurations,two exhibit strong in-plane polarization(2360 pC/m)with a low switching barrier of 9.57 meV/f.u.Twisting generates polar textures associated with moirépatterns,which drive ferroelectricity via a soft zonecenter mode,as revealed by machine-learning-assisted first-principles calculations.The in-plane(out-of-plane)polarization values for HfO_(2)at twist angles of 21.79°,27.80°,and 46.83°are 430(5.82),367(2.20),and 1057(0.03)pC/m,respectively.For 21.79°and 27.80°twisting,switching barriers drop to 1.74 and 0.18 meV/f.u.,indicating superlubric-like transitions.Notably,the 46.83°twisted bilayer shows an almost barrier-free polar evolution(0.03 meV/f.u.),attributed to sharply enhanced zonecenter phonon linewidths.Our findings establish a moiré-engineered switching route for 2D ferroelectrics.
