[Objective] Insecticidal activities of alkaloids extracted from 12 poisonous plants in Changbai Mountain were studied in the paper,to provide the basis for development and utilization of poisonous plants in Changbai M...[Objective] Insecticidal activities of alkaloids extracted from 12 poisonous plants in Changbai Mountain were studied in the paper,to provide the basis for development and utilization of poisonous plants in Changbai Mountain.[Method] Leaf disc method was used to study the effects of alkaloids extracted from 12 poisonous plants on the growth and development of 3-5 instars of cabbage worm （Pieris rapae） and their antifeedant activities.[Result] The effects of alkaloids extracted from different poisonous plants on the growth and development of cabbage worm were also different.Five treatments of alkaloids extracted from Sophora flavescens,Datura stramonium L.,Arisaema amurense Maxim.,Veratum dahuricum Loes.and Tripterygium regelii Spragne et Takeda made the weight of test insects gradually decrease and finally die;the alkaloid treatments of Pueraria lobata （Willd.） Ohwi,Aconitum kusnezoffii Reichb.,Cimicifuga dahurica （Turcz.） Maxim.and Corydalis ambigua Schleeht.could make cabbage worm pupate ahead of time,but the pupa state was deformed;the antifeedant rates of cabbage worm after the treatments of P.lobata,A.kusnezoffii,C.dahurica,A.amurense,V.dahuricum and C.ambigua for 48 h were all over 90%,and the antifeedant rates of C.dahurica and C.ambigua were the highest as 100%.[Conclusion]The reports on the insecticidal activities of five poisonous plants including P.lobata,A.kusnezoffii,C.dahurica,C.ambigua and A.amurense are rare,and they have important values on the development of botanical pesticides.展开更多
The aim is to select a universal DNA barcode for identifying all poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants. We chose 4 commonly used regions as candidate DN...The aim is to select a universal DNA barcode for identifying all poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants. We chose 4 commonly used regions as candidate DNA barcodes(ITS2, psb A-trn H,matK and rbc L) and compared their identification efficiency in 106 species from 27 families and 65 genera totally. Data analysis was performed including the information of sequence alignment, inter/intra-specific genetic distance and data distribution, identification efficiency and the situation of Neighbor-Joining(NJ) phylogenetic trees. We found ITS2 sequence region had high variation, stable genetic distance and identification efficiency relatively. The topological structure of NJ phylogenetic tree showed monophyletic. Our findings show that ITS2 can be applied as a universal barcode for identifying poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants.展开更多
Objective Poisonous plants are a deadly threat to public health in China. The traditional clinical diagnosis of the toxic plants is inefficient, fallible, and dependent upon experts. In this study, we tested the perfo...Objective Poisonous plants are a deadly threat to public health in China. The traditional clinical diagnosis of the toxic plants is inefficient, fallible, and dependent upon experts. In this study, we tested the performance of DNA barcodes for identification of the most threatening poisonous plants in China. Methods Seventy-four accessions of 27 toxic plant species in 22 genera and 17 families were sampled and three DNA barcodes （motK, rbcL, and ITS） were amplified, sequenced and tested. Three methods, Blast, pairwise global alignment （PWG） distance, and Tree-Building were tested for discrimination power. Results The primer universality of all the three markers was high. Except in the case of ITS for Hemerocollis minor, the three barcodes were successfully generated from all the selected species. Among the three methods applied, Blast showed the lowest discrimination rate, whereas PWG Distance and Tree-Building methods were equally effective. The ITS barcode showed highest discrimination rates using the PWG Distance and Tree-Building methods. When the barcodes were combined, discrimination rates were increased for the Blast method.展开更多
Western grassland is the main source of living and means of production of western inhabitants. For many years, desertification and poisonous-weeds growth in grassland were resulted from over-grazing, over-reclaiming, ...Western grassland is the main source of living and means of production of western inhabitants. For many years, desertification and poisonous-weeds growth in grassland were resulted from over-grazing, over-reclaiming, over-spading and population growth. Western natural ecological environment is destroyed severly. Meanwhile, it has restricted the sustainable development of animal husbandry. The fast spreading poisonous-weeds, which caused grassland ecology unbalance, is one of the considerable bioecology problems and an important index of grassland degeneration. Based on analysis and induction of previous data, this article introduced the situation of poisonous-weeds disaster of western grassland in recent decades, category and distribution of poisonous-weeds, integrated control and reasonable utilization.展开更多
The field control effects of different concentrations of indoxacarb baits,fipronil baits and chlorfenapyr baits on Solenopsis invicta was evaluated. The results showed that at 21 post administration,the control effect...The field control effects of different concentrations of indoxacarb baits,fipronil baits and chlorfenapyr baits on Solenopsis invicta was evaluated. The results showed that at 21 post administration,the control effects of 0. 04% indoxacarb on nests and worker ants reached 100%; the control effect of 0. 02% and0. 06% indoxacarb on active nests and worker ants were 87. 50% and 100%,respectively; 0. 000 25% and 0. 000 5% fipronil and 0. 05% chlorfenapyr also had significant control effects on active nests and worker ants. At 30 d post administration,the decline rates of ant colony grade treated by 0. 04% and 0. 06% indoxacarb,0. 000 25% fipronil and 0. 05% chlorfenapyr were 100%,100%,91. 44% and 98. 11%,respectively,and the comprehensive control effect reached 97. 18%.展开更多
The article presents the composition and current state of poisonous plants distributed on the Ustyurt plateau. Ustyurt is one of the largest deserts in Central Asia, differing from other deserts of the world in geogra...The article presents the composition and current state of poisonous plants distributed on the Ustyurt plateau. Ustyurt is one of the largest deserts in Central Asia, differing from other deserts of the world in geographical location, relief, flora and fauna and other features. The territory of Ustyurt occupies 21.3 million hectares, of which the Karakalpak part accounts for 7.2 million hectares. Poisonous alkaloid-bearing plants of the Karakalpak part of the Ustyurt plateau Anabasis aphylla, Atriplex flabellum, Kalidium capsicum, Salsola arbusculaeformis, Salsola foliosa, Aellenia subaphylla, Anabasis brachiata, Rheum tataricum, Capparis spinosa, Glycyrrhiza aspera. Alkaloid-bearing plants that are not eaten or poorly eaten by cattle Ephedra distachya, Delphinium songaricum, Anabasis salsa, alkaloid-bearing plants eaten by animals without harm Carex physodes, Eremopyrum orientale, Agrophyllum repens, Astragalus amodendron, Astragalus villosissimus, species of the genera Calligonum, Salsola. Poisonous plants of the Karakalpak part of the Ustyurt plateau. An analysis of the pasture flora of the Karakalpak part of the Ustyurt plateau shows that 62 species of wild poisonous plants belonging to 49 genera and 19 families grow here. Although these plants are considered poisonous, but in modern pharmaceutics and medicine, they are used as medicinal.展开更多
AIM To report our experience of acute kidney injury(AKI) developed after exposure to poisonous substance.METHODS Retrospective study where data was collected from case records of patients coming to this institute duri...AIM To report our experience of acute kidney injury(AKI) developed after exposure to poisonous substance.METHODS Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016.This institution is a tertiary care center for renal care in the metropolitan city of Karachi,Pakistan.History of ingested substance,symptoms on presentation,basic laboratory tests on arrival,mode of treatment and outcome were recorded from all patients and are presented here.Patients developing AKI after snake envenomation or scorpion stings are not included in this study.RESULTS During studied period 184 cases of AKI developing after poisoning were seen at our institution.The largest group was from paraphenyline diamine poisoning comprising 135 patients,followed by methanol in 8,organophosphorus compounds in 5,paraquat in 5,copper sulphate in 5,tartaric acid in 4,phenobarbitone in 3 and benzodiazipines,datura,rat killer,fish gall bladder,arsenic,boiler water,ammonium dichromate,acetic acid and herbs with lesser frequency.In 8 patients multiple substances were ingested in combination.Renal replacement therapy was required in 96% of patients.Complete recovery was seen in 72.28% patients,20% died during acute phase of illness.CONCLUSION It is important to report poisonous substances causing vital organ failure to increase awareness among general population as well as health care providers.展开更多
This work utilizes a statistical approach of Principal Component Ana-lysis(PCA)towards the detection of Methane(CH_(4))-Carbon Monoxide(CO)Poi-soning occurring in coal mines,forestfires,drainage systems etc.where the ...This work utilizes a statistical approach of Principal Component Ana-lysis(PCA)towards the detection of Methane(CH_(4))-Carbon Monoxide(CO)Poi-soning occurring in coal mines,forestfires,drainage systems etc.where the CH_(4) and CO emissions are very high in closed buildings or confined spaces during oxi-dation processes.Both methane and carbon monoxide are highly toxic,colorless and odorless gases.Both of the gases have their own toxic levels to be detected.But during their combined presence,the toxicity of the either one goes unidentified may be due to their low levels which may lead to an explosion.By using PCA,the correlation of CO and CH_(4) data is carried out and by identifying the areas of high correlation(along the principal component axis)the explosion suppression action can be triggered earlier thus avoiding adverse effects of massive explosions.Wire-less Sensor Network is deployed and simulations are carried with heterogeneous sensors(Carbon Monoxide and Methane sensors)in NS-2 Mannasim framework.The rise in the value of CO even when CH_(4) is below the toxic level may become hazardous to the people around.Thus our proposed methodology will detect the combined presence of both the gases(CH_(4) and CO)and provide an early warning in order to avoid any human losses or toxic effects.展开更多
Maqianzi(马钱子Strychnos)is also called“Fanmubie(番木鳖),"“Kushi(苦实)”and“QianJi drug(牵机药).”The alias“Fanmubie”shows its origin and its characteristics.The name of“Kushi”implies its taste and flavor....Maqianzi(马钱子Strychnos)is also called“Fanmubie(番木鳖),"“Kushi(苦实)”and“QianJi drug(牵机药).”The alias“Fanmubie”shows its origin and its characteristics.The name of“Kushi”implies its taste and flavor.“Qianji Drug vividly shows the clinical manifestations of the poisoning of Maqianzi.The name of“Maqianzi”is the comprehensive display of its characteristic,toxicity,etc.,Maqianzi is famous for its poison,which is often used in the treatment of various intractable diseases.It shows the poison Culture in the Western Regions,meanwhile it also displays the unique charm of Traditional herbs in transforming poison into treasure.展开更多
The current status of marine poisonous fish species ranging in the Aegean Sea coastline in Turkey were introduced.Turkey is a peninsula surrounded by seas with different ecological features on three sides.The total le...The current status of marine poisonous fish species ranging in the Aegean Sea coastline in Turkey were introduced.Turkey is a peninsula surrounded by seas with different ecological features on three sides.The total length of shoreline is 8333 km including the islands.The total number of fish species in Turkish seas is 512,of which 449 live in the Aegean Sea followed by the Mediterranean Sea(441 species),the Marmara Sea(257 species)and the Black Sea(154species).On the Aegean Sea coasts,the richest sea regarding fish diversity,the number of poisonous fish species is also high.This mini-review revealed 51 poisonous fish species belonging to 14 families in the Turkish Aegean Sea.On the Aegean Sea coasts poisonous fish species can be categorized into three groups:(i)Fish that contain venomous spines on the tail or on the operculum(ii)Fish that carry poisonous bite and(iii)Fish having poisonous flesh or liver.Poisoning fish that contain venomous spines on the tail or on the operculum mostly are dangerous because of their poisonous thorns whereas the passive poisonous fish species poison when they are eaten.These toxins can cause morbidity and rarely,mortality in humans.Apart from these,swallowing the blood of species such as European eel Anguilla anguilla and European conger Conger conger might also cause poisoning.Besides,as there has been an invasion of puffer fish especially on the Turkish Mediterranean and Aegean coasts in recent years,there is a danger in question.Thus,it is very important to particularly draw attention to these fish on the Turkish coasts.展开更多
In some cases, poisonous contaminants may be released from bottom sludge inopen channels. The equation of advection and diffusion for the related problem was analyzed in thispaper. The conditions for the definite solu...In some cases, poisonous contaminants may be released from bottom sludge inopen channels. The equation of advection and diffusion for the related problem was analyzed in thispaper. The conditions for the definite solution to the equation were given. The analytic solution ofpoisonous gas concentration distribution was worked out. The reasonableness of this solution wasdiscussed. The result is also of significance for other similar problems.展开更多
Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,l...Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,leading to more poisoning incidents.It has a fatality rate as high as 76%after poisoning.[1]Here,we report a successful treatment of a patient with mixed pesticide poisoning caused by lethaldose emamectin benzoate(EB)and chlorfenapyr in the Department of Critical Care Medicine,Yangzhou Hongquan Hospital.展开更多
BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute pois...BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute poisoning.METHODS:This retrospective study included 18 patients with acute oral chlorfenapyr poisoning treated at our department between January 2022 and January 2024.All patients received conventional therapies combined with blood purification,including HP,CRRT,and PE.HP was performed three sessions within the fi rst 24 h,followed by CRRT and PE.Serial blood samples were collected to measure plasma concentrations of chlorfenapyr and tralopyril using gas chromatography/liquid chromatography-mass spectrometry(GC/LC-MS).The toxin-clearance eff ects were assessed using a linear mixed-eff ects(LME)model.RESULTS:The hourly decline rate of the plasma chlorfenapyr concentration(median[IQR])was 8.83%(1.79%)for HP,4.12%(1.26%)for CRRT,and 6.85%(1.44%)for PE.LME analysis showed higher decline rate in the plasma concentration with HP(β=5.00;P<0.001)and PE(β=2.15;P=0.003)compared to CRRT.For tralopyril,the hourly decline rates were 3.04%(0.62%)for HP,1.82%(0.48%)for CRRT,and 3.01%(0.37%)for PE.LME analysis showed that the clearance effects of HP(β=0.027;P<0.001)and PE(β=0.022;P=0.001)were superior to CRRT.Pre-treatment toxin levels and the interval from hospital admission to blood purifi cation showed no signifi cant interaction with clearance outcomes.CONCLUSION:In our study,HP was associated with a higher decline rate in plasma chlorfenapyr concentration compared to CRRT and PE,supporting HP as a preferred early intervention.However,all three methods showed limited effi cacy in reducing tralopyril levels.Further research into the toxicokinetics and mechanisms of chlorfenapyr is warranted to optimize purifi cation strategies.展开更多
The performance of deep recommendation models degrades significantly under data poisoning attacks.While adversarial training methods such as Vulnerability-Aware Training(VAT)enhance robustness by injecting perturbatio...The performance of deep recommendation models degrades significantly under data poisoning attacks.While adversarial training methods such as Vulnerability-Aware Training(VAT)enhance robustness by injecting perturbations into embeddings,they remain limited by coarse-grained noise and a static defense strategy,leaving models susceptible to adaptive attacks.This study proposes a novel framework,Self-Purification Data Sanitization(SPD),which integrates vulnerability-aware adversarial training with dynamic label correction.Specifically,SPD first identifies high-risk users through a fragility scoring mechanism,then applies self-purification by replacing suspicious interactions with model-predicted high-confidence labels during training.This closed-loop process continuously sanitizes the training data and breaks the protection ceiling of conventional adversarial training.Experiments demonstrate that SPD significantly improves the robustness of both Matrix Factorization(MF)and LightGCN models against various poisoning attacks.We show that SPD effectively suppresses malicious gradient propagation and maintains recommendation accuracy.Evaluations on Gowalla and Yelp2018 confirmthat SPD-trainedmodels withstandmultiple attack strategies—including Random,Bandwagon,DP,and Rev attacks—while preserving performance.展开更多
Aconitines are a group of highly bioactive and toxic compounds found in aconitum species.[1]It is clinically used to treat rheumatism,rheumatoid arthritis,osteoarthritis,and cancer.[2]In folk medicine,aconitine is oft...Aconitines are a group of highly bioactive and toxic compounds found in aconitum species.[1]It is clinically used to treat rheumatism,rheumatoid arthritis,osteoarthritis,and cancer.[2]In folk medicine,aconitine is often soaked in white wine to make medicinal wine,which is used to treat rheumatism,joint pain,and other diseases.[3]Improper use of aconitine can cause adverse effects in the nervous system and digestive system,as well as cardiovascular dysfunction,especially arrhythmia.[4]Because of its high toxicity when it is improperly handled,aconitine has attracted widespread attention.展开更多
The objective of this study was to understand the effect of long-term aconitine(AC)oral administration on the digestive tract and serum metabolism.Subjects consumed either 0.9%Na Cl(n=8)or AC(n=17)gavage designed to r...The objective of this study was to understand the effect of long-term aconitine(AC)oral administration on the digestive tract and serum metabolism.Subjects consumed either 0.9%Na Cl(n=8)or AC(n=17)gavage designed to represent human chronic AC administrations for 13 days.Organ pathology was determined using hematoxylin-eosin staining and immunohistochemistry.Fecal and proximal intestinal content samples were collected to perform shotgun metagenomic sequencing.Serum samples were collected,and untargeted metabolomics was performed.In this study,AC administration induced proximal intestine,liver,and kidney injury.Microbiome composition remained stable after AC exposure,while several microbes presented dynamic alteration.Moreover,AC affected the abundance of the fatty acid biosynthesis rate-limiting gene acc A at day 7.AC induces 30 serum metabolites to significantly change at day 14,including several short-chain acylcarnitines.WGCNA revealed 2 sub-modules associated with the level of several short-chain acylcarnitines.In summary,AC affects the digestive tract and serum metabolism after chronic administration.AC may affect the enrichment of microbial-derived acc A gene.The abundance of serum acylcarnitines detected in the AC group may associate with its anti-heart failure effects.展开更多
Organophosphate pesticide poisoning is an acute form of poisoning primarily found in underdeveloped regions.Its main clinical manifestations include muscarinic symptoms,nicotinic symptoms,and central nervous system di...Organophosphate pesticide poisoning is an acute form of poisoning primarily found in underdeveloped regions.Its main clinical manifestations include muscarinic symptoms,nicotinic symptoms,and central nervous system disturbances.This report presents a case of a middleaged female who developed extremely rare symptoms of optic nerve damage after ingesting a large amount of an organophosphate pesticide.展开更多
AB_(2)-type Ti-based hydrogen storage alloys(HSAs)are promising for industrial hydrogen feeding systems due to their moderate operating conditions and high hydrogen storage capacity.However,their practical application...AB_(2)-type Ti-based hydrogen storage alloys(HSAs)are promising for industrial hydrogen feeding systems due to their moderate operating conditions and high hydrogen storage capacity.However,their practical application is hindered by unavoidable impurity gases in hydrogen feedstocks,which significantly impair the performance of HSAs.Furthermore,the absence of clear evaluation criteria for poisoning behaviors and mechanisms hinders efforts to develop effective mitigation strategies.To address this gap,we used calculated surface interaction energy changes(ΔE)and experimental investigations to classify and rank the poisoning potential of impurity gases on a C14 Laves-phase Ti_(0.86)Zr_(0.15)Mn_(1.5)Cr_(0.07)(VFe)0.43 alloy.Impurity gases were classified into two types of weak-adsorption and strong-adsorption impurity gases by comparing theirΔE with that of H_(2)(ΔE_(H_(2))=-1.6001 eV).AsΔE>ΔE_(H_(2)) ,weak-adsorption impurity gases(Ar,He,CH4,and N2)induce poisoning by forming enriched blocking layers that impede H_(2) diffusion.This blocking effect can be alleviated under gas flow conditions.AsΔE<ΔE_(H_(2)),strong adsorption gases are further divided into two types based on their reactivity with the alloy.Non-reactive strong-adsorption impurity gases(CO and CO_(2) )preferentially occupy surface active sites,blocking H_(2) adsorption and dissociation.In contrast,reactive strong-adsorption impurity gases(such as O_(2))form dense passivation layers that completely prevent hydrogen ingress.Accordingly,surface modification offers an effective approach to mitigate gas-induced poisoning by altering the interaction mechanism.This study establishes the parameter-based criteria for classifying impurity gas poisoning mechanisms in AB_(2)-type Ti-based HSAs.It provides fundamental insights for guiding the design of poisoning-resistant materials and the development of mitigation strategies.展开更多
基金Supported by School Fund in Yanbian University (201015)~~
文摘[Objective] Insecticidal activities of alkaloids extracted from 12 poisonous plants in Changbai Mountain were studied in the paper,to provide the basis for development and utilization of poisonous plants in Changbai Mountain.[Method] Leaf disc method was used to study the effects of alkaloids extracted from 12 poisonous plants on the growth and development of 3-5 instars of cabbage worm （Pieris rapae） and their antifeedant activities.[Result] The effects of alkaloids extracted from different poisonous plants on the growth and development of cabbage worm were also different.Five treatments of alkaloids extracted from Sophora flavescens,Datura stramonium L.,Arisaema amurense Maxim.,Veratum dahuricum Loes.and Tripterygium regelii Spragne et Takeda made the weight of test insects gradually decrease and finally die;the alkaloid treatments of Pueraria lobata （Willd.） Ohwi,Aconitum kusnezoffii Reichb.,Cimicifuga dahurica （Turcz.） Maxim.and Corydalis ambigua Schleeht.could make cabbage worm pupate ahead of time,but the pupa state was deformed;the antifeedant rates of cabbage worm after the treatments of P.lobata,A.kusnezoffii,C.dahurica,A.amurense,V.dahuricum and C.ambigua for 48 h were all over 90%,and the antifeedant rates of C.dahurica and C.ambigua were the highest as 100%.[Conclusion]The reports on the insecticidal activities of five poisonous plants including P.lobata,A.kusnezoffii,C.dahurica,C.ambigua and A.amurense are rare,and they have important values on the development of botanical pesticides.
基金supported by National Standardization Research Project(Nos.ZYBZH-Y-TJ-43,ZYBZH-C-JS-37,ZYBZH-C-JS-29,and ZYBZH-Y-JIN-34)Independent project of Institute of Chinese Materia Medica,Academy of Chinese Medical Sciences(No.ZXKT17021)+1 种基金Key Research Project of China Academy of Chinese Medical Sciences of the 13th Five-Year Plan(No.ZZ10-007)National key research and development plan(No.2017YFB1002303)
文摘The aim is to select a universal DNA barcode for identifying all poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants. We chose 4 commonly used regions as candidate DNA barcodes(ITS2, psb A-trn H,matK and rbc L) and compared their identification efficiency in 106 species from 27 families and 65 genera totally. Data analysis was performed including the information of sequence alignment, inter/intra-specific genetic distance and data distribution, identification efficiency and the situation of Neighbor-Joining(NJ) phylogenetic trees. We found ITS2 sequence region had high variation, stable genetic distance and identification efficiency relatively. The topological structure of NJ phylogenetic tree showed monophyletic. Our findings show that ITS2 can be applied as a universal barcode for identifying poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants.
基金supported by the Fundamental Research Funds for the Central Universities(grant no.TD2012-04)the Scientific Research Foundation of the State Human Resource Ministry and the Education Ministry for Returned Chinese Scholars(to L.Xie)+2 种基金the State Key Laboratory Program from the State Key Laboratory of Systematic and Evolutionary Botany(grant no.LSEB2011-07)the Main Direction Program of Knowledge Innovation of the Chinese Academy of Sciences(grant no.KSCX2-EW-Z-1)the National Natural Science Foundation of China(grant nos.31170201,81072317,31110103911)
文摘Objective Poisonous plants are a deadly threat to public health in China. The traditional clinical diagnosis of the toxic plants is inefficient, fallible, and dependent upon experts. In this study, we tested the performance of DNA barcodes for identification of the most threatening poisonous plants in China. Methods Seventy-four accessions of 27 toxic plant species in 22 genera and 17 families were sampled and three DNA barcodes （motK, rbcL, and ITS） were amplified, sequenced and tested. Three methods, Blast, pairwise global alignment （PWG） distance, and Tree-Building were tested for discrimination power. Results The primer universality of all the three markers was high. Except in the case of ITS for Hemerocollis minor, the three barcodes were successfully generated from all the selected species. Among the three methods applied, Blast showed the lowest discrimination rate, whereas PWG Distance and Tree-Building methods were equally effective. The ITS barcode showed highest discrimination rates using the PWG Distance and Tree-Building methods. When the barcodes were combined, discrimination rates were increased for the Blast method.
基金funded by National Nature Science Foundation of China(31072175)Tibet Project Supported by Ministry of Agriculture of the People's Republic of China(20071010)
文摘Western grassland is the main source of living and means of production of western inhabitants. For many years, desertification and poisonous-weeds growth in grassland were resulted from over-grazing, over-reclaiming, over-spading and population growth. Western natural ecological environment is destroyed severly. Meanwhile, it has restricted the sustainable development of animal husbandry. The fast spreading poisonous-weeds, which caused grassland ecology unbalance, is one of the considerable bioecology problems and an important index of grassland degeneration. Based on analysis and induction of previous data, this article introduced the situation of poisonous-weeds disaster of western grassland in recent decades, category and distribution of poisonous-weeds, integrated control and reasonable utilization.
基金Supported by Project of Liuzhou Science and Technology Bureau"Investigation and Prevention Countermeasures of Fire Ants in Liuzhou City"(2013J020101)
文摘The field control effects of different concentrations of indoxacarb baits,fipronil baits and chlorfenapyr baits on Solenopsis invicta was evaluated. The results showed that at 21 post administration,the control effects of 0. 04% indoxacarb on nests and worker ants reached 100%; the control effect of 0. 02% and0. 06% indoxacarb on active nests and worker ants were 87. 50% and 100%,respectively; 0. 000 25% and 0. 000 5% fipronil and 0. 05% chlorfenapyr also had significant control effects on active nests and worker ants. At 30 d post administration,the decline rates of ant colony grade treated by 0. 04% and 0. 06% indoxacarb,0. 000 25% fipronil and 0. 05% chlorfenapyr were 100%,100%,91. 44% and 98. 11%,respectively,and the comprehensive control effect reached 97. 18%.
文摘The article presents the composition and current state of poisonous plants distributed on the Ustyurt plateau. Ustyurt is one of the largest deserts in Central Asia, differing from other deserts of the world in geographical location, relief, flora and fauna and other features. The territory of Ustyurt occupies 21.3 million hectares, of which the Karakalpak part accounts for 7.2 million hectares. Poisonous alkaloid-bearing plants of the Karakalpak part of the Ustyurt plateau Anabasis aphylla, Atriplex flabellum, Kalidium capsicum, Salsola arbusculaeformis, Salsola foliosa, Aellenia subaphylla, Anabasis brachiata, Rheum tataricum, Capparis spinosa, Glycyrrhiza aspera. Alkaloid-bearing plants that are not eaten or poorly eaten by cattle Ephedra distachya, Delphinium songaricum, Anabasis salsa, alkaloid-bearing plants eaten by animals without harm Carex physodes, Eremopyrum orientale, Agrophyllum repens, Astragalus amodendron, Astragalus villosissimus, species of the genera Calligonum, Salsola. Poisonous plants of the Karakalpak part of the Ustyurt plateau. An analysis of the pasture flora of the Karakalpak part of the Ustyurt plateau shows that 62 species of wild poisonous plants belonging to 49 genera and 19 families grow here. Although these plants are considered poisonous, but in modern pharmaceutics and medicine, they are used as medicinal.
文摘AIM To report our experience of acute kidney injury(AKI) developed after exposure to poisonous substance.METHODS Retrospective study where data was collected from case records of patients coming to this institute during January 1990 to May 2016.This institution is a tertiary care center for renal care in the metropolitan city of Karachi,Pakistan.History of ingested substance,symptoms on presentation,basic laboratory tests on arrival,mode of treatment and outcome were recorded from all patients and are presented here.Patients developing AKI after snake envenomation or scorpion stings are not included in this study.RESULTS During studied period 184 cases of AKI developing after poisoning were seen at our institution.The largest group was from paraphenyline diamine poisoning comprising 135 patients,followed by methanol in 8,organophosphorus compounds in 5,paraquat in 5,copper sulphate in 5,tartaric acid in 4,phenobarbitone in 3 and benzodiazipines,datura,rat killer,fish gall bladder,arsenic,boiler water,ammonium dichromate,acetic acid and herbs with lesser frequency.In 8 patients multiple substances were ingested in combination.Renal replacement therapy was required in 96% of patients.Complete recovery was seen in 72.28% patients,20% died during acute phase of illness.CONCLUSION It is important to report poisonous substances causing vital organ failure to increase awareness among general population as well as health care providers.
文摘This work utilizes a statistical approach of Principal Component Ana-lysis(PCA)towards the detection of Methane(CH_(4))-Carbon Monoxide(CO)Poi-soning occurring in coal mines,forestfires,drainage systems etc.where the CH_(4) and CO emissions are very high in closed buildings or confined spaces during oxi-dation processes.Both methane and carbon monoxide are highly toxic,colorless and odorless gases.Both of the gases have their own toxic levels to be detected.But during their combined presence,the toxicity of the either one goes unidentified may be due to their low levels which may lead to an explosion.By using PCA,the correlation of CO and CH_(4) data is carried out and by identifying the areas of high correlation(along the principal component axis)the explosion suppression action can be triggered earlier thus avoiding adverse effects of massive explosions.Wire-less Sensor Network is deployed and simulations are carried with heterogeneous sensors(Carbon Monoxide and Methane sensors)in NS-2 Mannasim framework.The rise in the value of CO even when CH_(4) is below the toxic level may become hazardous to the people around.Thus our proposed methodology will detect the combined presence of both the gases(CH_(4) and CO)and provide an early warning in order to avoid any human losses or toxic effects.
文摘Maqianzi(马钱子Strychnos)is also called“Fanmubie(番木鳖),"“Kushi(苦实)”and“QianJi drug(牵机药).”The alias“Fanmubie”shows its origin and its characteristics.The name of“Kushi”implies its taste and flavor.“Qianji Drug vividly shows the clinical manifestations of the poisoning of Maqianzi.The name of“Maqianzi”is the comprehensive display of its characteristic,toxicity,etc.,Maqianzi is famous for its poison,which is often used in the treatment of various intractable diseases.It shows the poison Culture in the Western Regions,meanwhile it also displays the unique charm of Traditional herbs in transforming poison into treasure.
文摘The current status of marine poisonous fish species ranging in the Aegean Sea coastline in Turkey were introduced.Turkey is a peninsula surrounded by seas with different ecological features on three sides.The total length of shoreline is 8333 km including the islands.The total number of fish species in Turkish seas is 512,of which 449 live in the Aegean Sea followed by the Mediterranean Sea(441 species),the Marmara Sea(257 species)and the Black Sea(154species).On the Aegean Sea coasts,the richest sea regarding fish diversity,the number of poisonous fish species is also high.This mini-review revealed 51 poisonous fish species belonging to 14 families in the Turkish Aegean Sea.On the Aegean Sea coasts poisonous fish species can be categorized into three groups:(i)Fish that contain venomous spines on the tail or on the operculum(ii)Fish that carry poisonous bite and(iii)Fish having poisonous flesh or liver.Poisoning fish that contain venomous spines on the tail or on the operculum mostly are dangerous because of their poisonous thorns whereas the passive poisonous fish species poison when they are eaten.These toxins can cause morbidity and rarely,mortality in humans.Apart from these,swallowing the blood of species such as European eel Anguilla anguilla and European conger Conger conger might also cause poisoning.Besides,as there has been an invasion of puffer fish especially on the Turkish Mediterranean and Aegean coasts in recent years,there is a danger in question.Thus,it is very important to particularly draw attention to these fish on the Turkish coasts.
文摘In some cases, poisonous contaminants may be released from bottom sludge inopen channels. The equation of advection and diffusion for the related problem was analyzed in thispaper. The conditions for the definite solution to the equation were given. The analytic solution ofpoisonous gas concentration distribution was worked out. The reasonableness of this solution wasdiscussed. The result is also of significance for other similar problems.
文摘Pesticide poisoning remains a critical public health challenge worldwide.At present,chlorfenapyr,classifi ed by the World Health Organization(WHO)as a moderately toxic insecticide,is increasingly used in agriculture,leading to more poisoning incidents.It has a fatality rate as high as 76%after poisoning.[1]Here,we report a successful treatment of a patient with mixed pesticide poisoning caused by lethaldose emamectin benzoate(EB)and chlorfenapyr in the Department of Critical Care Medicine,Yangzhou Hongquan Hospital.
基金funded by the Medical Science Research Project of the Hebei Provincial Health and Health Commission(20230550).
文摘BACKGROUND:This study is to evaluate clearance eff ects of hemoperfusion(HP),continuous renal replacement therapy(CRRT),and plasma exchange(PE)for chlorfenapyr and its metabolite tralopyril in patients with acute poisoning.METHODS:This retrospective study included 18 patients with acute oral chlorfenapyr poisoning treated at our department between January 2022 and January 2024.All patients received conventional therapies combined with blood purification,including HP,CRRT,and PE.HP was performed three sessions within the fi rst 24 h,followed by CRRT and PE.Serial blood samples were collected to measure plasma concentrations of chlorfenapyr and tralopyril using gas chromatography/liquid chromatography-mass spectrometry(GC/LC-MS).The toxin-clearance eff ects were assessed using a linear mixed-eff ects(LME)model.RESULTS:The hourly decline rate of the plasma chlorfenapyr concentration(median[IQR])was 8.83%(1.79%)for HP,4.12%(1.26%)for CRRT,and 6.85%(1.44%)for PE.LME analysis showed higher decline rate in the plasma concentration with HP(β=5.00;P<0.001)and PE(β=2.15;P=0.003)compared to CRRT.For tralopyril,the hourly decline rates were 3.04%(0.62%)for HP,1.82%(0.48%)for CRRT,and 3.01%(0.37%)for PE.LME analysis showed that the clearance effects of HP(β=0.027;P<0.001)and PE(β=0.022;P=0.001)were superior to CRRT.Pre-treatment toxin levels and the interval from hospital admission to blood purifi cation showed no signifi cant interaction with clearance outcomes.CONCLUSION:In our study,HP was associated with a higher decline rate in plasma chlorfenapyr concentration compared to CRRT and PE,supporting HP as a preferred early intervention.However,all three methods showed limited effi cacy in reducing tralopyril levels.Further research into the toxicokinetics and mechanisms of chlorfenapyr is warranted to optimize purifi cation strategies.
文摘The performance of deep recommendation models degrades significantly under data poisoning attacks.While adversarial training methods such as Vulnerability-Aware Training(VAT)enhance robustness by injecting perturbations into embeddings,they remain limited by coarse-grained noise and a static defense strategy,leaving models susceptible to adaptive attacks.This study proposes a novel framework,Self-Purification Data Sanitization(SPD),which integrates vulnerability-aware adversarial training with dynamic label correction.Specifically,SPD first identifies high-risk users through a fragility scoring mechanism,then applies self-purification by replacing suspicious interactions with model-predicted high-confidence labels during training.This closed-loop process continuously sanitizes the training data and breaks the protection ceiling of conventional adversarial training.Experiments demonstrate that SPD significantly improves the robustness of both Matrix Factorization(MF)and LightGCN models against various poisoning attacks.We show that SPD effectively suppresses malicious gradient propagation and maintains recommendation accuracy.Evaluations on Gowalla and Yelp2018 confirmthat SPD-trainedmodels withstandmultiple attack strategies—including Random,Bandwagon,DP,and Rev attacks—while preserving performance.
基金supported by grants from the National Natural Science Foundation of China(82360387)the Key Laboratory of Emergency Medicine of Yunnan Province(202449CE340015).
文摘Aconitines are a group of highly bioactive and toxic compounds found in aconitum species.[1]It is clinically used to treat rheumatism,rheumatoid arthritis,osteoarthritis,and cancer.[2]In folk medicine,aconitine is often soaked in white wine to make medicinal wine,which is used to treat rheumatism,joint pain,and other diseases.[3]Improper use of aconitine can cause adverse effects in the nervous system and digestive system,as well as cardiovascular dysfunction,especially arrhythmia.[4]Because of its high toxicity when it is improperly handled,aconitine has attracted widespread attention.
基金supported by the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-055)the National Natural Science Foundation of China(82471925)。
文摘The objective of this study was to understand the effect of long-term aconitine(AC)oral administration on the digestive tract and serum metabolism.Subjects consumed either 0.9%Na Cl(n=8)or AC(n=17)gavage designed to represent human chronic AC administrations for 13 days.Organ pathology was determined using hematoxylin-eosin staining and immunohistochemistry.Fecal and proximal intestinal content samples were collected to perform shotgun metagenomic sequencing.Serum samples were collected,and untargeted metabolomics was performed.In this study,AC administration induced proximal intestine,liver,and kidney injury.Microbiome composition remained stable after AC exposure,while several microbes presented dynamic alteration.Moreover,AC affected the abundance of the fatty acid biosynthesis rate-limiting gene acc A at day 7.AC induces 30 serum metabolites to significantly change at day 14,including several short-chain acylcarnitines.WGCNA revealed 2 sub-modules associated with the level of several short-chain acylcarnitines.In summary,AC affects the digestive tract and serum metabolism after chronic administration.AC may affect the enrichment of microbial-derived acc A gene.The abundance of serum acylcarnitines detected in the AC group may associate with its anti-heart failure effects.
文摘Organophosphate pesticide poisoning is an acute form of poisoning primarily found in underdeveloped regions.Its main clinical manifestations include muscarinic symptoms,nicotinic symptoms,and central nervous system disturbances.This report presents a case of a middleaged female who developed extremely rare symptoms of optic nerve damage after ingesting a large amount of an organophosphate pesticide.
基金financially supported by the National Key Research and Development Program of China(2022YFB4004302)the National Natural Science Foundation of China(U24A2044)the Guangxi Science and Technology Major Project(No.AA24206007)。
文摘AB_(2)-type Ti-based hydrogen storage alloys(HSAs)are promising for industrial hydrogen feeding systems due to their moderate operating conditions and high hydrogen storage capacity.However,their practical application is hindered by unavoidable impurity gases in hydrogen feedstocks,which significantly impair the performance of HSAs.Furthermore,the absence of clear evaluation criteria for poisoning behaviors and mechanisms hinders efforts to develop effective mitigation strategies.To address this gap,we used calculated surface interaction energy changes(ΔE)and experimental investigations to classify and rank the poisoning potential of impurity gases on a C14 Laves-phase Ti_(0.86)Zr_(0.15)Mn_(1.5)Cr_(0.07)(VFe)0.43 alloy.Impurity gases were classified into two types of weak-adsorption and strong-adsorption impurity gases by comparing theirΔE with that of H_(2)(ΔE_(H_(2))=-1.6001 eV).AsΔE>ΔE_(H_(2)) ,weak-adsorption impurity gases(Ar,He,CH4,and N2)induce poisoning by forming enriched blocking layers that impede H_(2) diffusion.This blocking effect can be alleviated under gas flow conditions.AsΔE<ΔE_(H_(2)),strong adsorption gases are further divided into two types based on their reactivity with the alloy.Non-reactive strong-adsorption impurity gases(CO and CO_(2) )preferentially occupy surface active sites,blocking H_(2) adsorption and dissociation.In contrast,reactive strong-adsorption impurity gases(such as O_(2))form dense passivation layers that completely prevent hydrogen ingress.Accordingly,surface modification offers an effective approach to mitigate gas-induced poisoning by altering the interaction mechanism.This study establishes the parameter-based criteria for classifying impurity gas poisoning mechanisms in AB_(2)-type Ti-based HSAs.It provides fundamental insights for guiding the design of poisoning-resistant materials and the development of mitigation strategies.
