OBJECTIVE:To evaluate the effect of electroacupuncture on rapid gastric emptying by comparing the effectiveness of electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)(He-Mu acupoints)versus electroacupuncture a...OBJECTIVE:To evaluate the effect of electroacupuncture on rapid gastric emptying by comparing the effectiveness of electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)(He-Mu acupoints)versus electroacupuncture at Zhongwan(CV12)alone.METHODS:Sixty-five patients were randomly divided into two groups;33 patients in the He-Mu acupoints group received electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12),while 32 patients in the single acupoint group received electroacupuncture only at Zhongwan(CV12).Both groups were treated once daily for 30 min,five times per week for 3 weeks.Before and after the 3-week treatment course,patients underwent gastric emptying scintigraphy and were assessed using the Traditional Chinese Medicine(TCM)symptom scale of gastrointestinal diseases.The two groups were compared regarding the percentages of gastric retention at 30 and 60 min and the TCM symptom scores.RESULTS:After the treatment course,the percentages of gastric retention at 30 and 60 min were significantly improved in both groups compared with the pre-treatment values(P<0.01).The improvement in the gastric retention was significantly better in the He-Mu acupoints group than the single acupoint group at 30 min(P<0.01)and 60 min(P<0.05).The TCM symptom score was significantly decreased after the treatment course in both groups(P<0.01).The improvement in the TCM symptom score was significantly better in the He-Mu acupoints group than the single acupoint group(P<0.01).The total effective rate was 93.55%(29/31)in the He-Mu acupoints group and 77.42%(24/31)in the single acupoint group.The treatment effect was better in the He-Mu acupoints group than the single acupoint group(P<0.05).CONCLUSIONS:Electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)or at Zhongwan(CV12)alone is effective in treating rapid gastric emptying.Furthermore,electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)is more effective than electroacupuncture at Zhongwan(CV12)alone.展开更多
BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electr...BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.展开更多
Objective： We aimed to determine the effect of neostigmine injections given at the Zusanli （ST 36） acupoint whentreating postpartum urinary retention. Methods： We conducted a systematic review to identify randomiz...Objective： We aimed to determine the effect of neostigmine injections given at the Zusanli （ST 36） acupoint whentreating postpartum urinary retention. Methods： We conducted a systematic review to identify randomized controlledtrials （RCTs） involving neostigmine injections given at the Zusanli （ST 36） acupoint for treating postpartum urinaryretention. We searched the Cochrane Library, Pubmed, Web of Science, Chinese National Knowledge Infrastructure, VipDatabase, and Chinese Biomedical Literature Database from the creation of the database to December 30, 2016. Bias riskassessment was performed using Revman 5.3 software from Cochrane based on the criteria set out in the CochraneHandbook for Systematic Reviews of Interventions, version 5.1.0. Results： Thirteen studies were included with 627participants in the treatment group and 584 participants in the control group. （1） Overall response rate： neostigmineinjections given at the Zusanli （ST 36） acupoint have a better curative effect than injections given in muscle, odds ratio（OR） = 8.74, 95% confidence interval （CI） [5.83, 13.10], Z = 10.49 （P 〈 0.001）; （2） Comparison of effects at differentdosages： （i） 0.5 mg of neostigmine Zusanli （ST 36） acupoint injection group has better effect than 1 mg of neostigmineintramuscular injection group, OR = 15.84, 95% CI [5.74, 43.72],Z = 5.34 （P 〈 0.001）, （ii） 0.5 mg of neostigmineinjection given at the Zusanli acupoint has a better curative effect than 0.5 mg of neostigmine injection given in muscle ,OR = 7.30, 95% CI [3.47, 15.34], Z = 5.24 （P 〈 0.001）; （iii） 1 mg of neostigmine injection at the Zusanli （ST 36）acupoint has better efficacy than 1 mg of neostigmine injection in muscle, OR = 7.76, 95% CI [4.46, 13.52], Z = 7.25 （P〈 0.001）. Conclusion： Neostigmine injections at the Zusanli （ST 36） acupoint have beneficial effects in treatingpostpartum urinary retention. However, the low quality of the studies included in the meta-analysis raises questions overthe reliability of the results. Further studies are still needed.展开更多
This paper reports that 65 cases with functional constipation were treated by putting one Wang Bu Liu Xing (semen vaccariae) seed on each acupoint, Intestinum crassum, Intestinum tenue,Sympathicum, Lung, Spleen, Subco...This paper reports that 65 cases with functional constipation were treated by putting one Wang Bu Liu Xing (semen vaccariae) seed on each acupoint, Intestinum crassum, Intestinum tenue,Sympathicum, Lung, Spleen, Subcortex, of auricula and pressing, associated with acupuncture at Zusanli point on both sides. The patients were instructed to press the stuck seed twice a day for 3 to 5 minutes each time. Auricular acupoints of both sides were used alternately every 2 days. The electric acupuncture was applied at Zusanli points about 30 minutes each time every other day. Ten times (i. e. 20 days) make one course of treatment and the routine treatment consists of 1 to 2 courses. The results showed that all the patients were cured, patients with Shi Mi (the constipation of excess type) were cured after one course of treatrnent while Xu Mi (the constipation of deficiency type) were cured after two courses. The study suggests that this kind of treatment is an ideal therapy for functional constipation. The pathogenesis and mechanism of treatment of auricular acupuncture pressing associated with acupuncture at Zusanli point for constipation are discussed.展开更多
OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with no...OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with non-small-cell lung cancer(NSCLC).METHODS: Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) every day for 6 weeks, while group B received no intervention(control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.RESULTS: Five participants dropped out, leaving afinal total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B(P <0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life(P < 0.001) and function(P < 0.05), and significantly lower in terms of symptoms(P < 0.05).CONCLUSION: The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli(ST 36) and Feishu(BL13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.展开更多
OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(A.Dex)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)acupoint.METHODS:Thirty 6-week-old female BALB/c mice were sens...OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(A.Dex)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)acupoint.METHODS:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control group.One hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(O.Dex group),while three groups received A.Dex at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,respectively.AR symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th day.We isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing score.Spleen weight was measured using an electronic microbalance.The levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent assays.The serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde spectrofluorometry.Western blot analysis was performed on nasal mucosal tissue extracts.RESULTS:A.Dex significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized mice.A.Dex significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized mice.A.Dex significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-land macrophage-inflammatory protein-2)in AR mice.A.Dex effectively attenuated the expression of caspase-1 and receptorinteractingprotein-2 in nasal mucosal tissue.CONCLUSION:A.Dex may be a new and useful therapy for AR.展开更多
We had treated 102 cases of obstinate peptic ulcer and chronic gastritis with ametal ring embedded in Zusanli acupoint since October 1989 to October 1992,and got satisfactorytherapeutic effects.The total effective rat...We had treated 102 cases of obstinate peptic ulcer and chronic gastritis with ametal ring embedded in Zusanli acupoint since October 1989 to October 1992,and got satisfactorytherapeutic effects.The total effective rate is 96.08%,the cure rate of peptic ulcer is 87.32%,therecurrence rate is significantly lower than that of control group(P【0.001),and it has no side-effect.展开更多
BACKGROUND： Ceramide galactosyltransferase （CGT） protein and mRNA expression defect can cause the abnormal morphology and slowing conduction velocity of peripheral nerve. Morphologic change and functional disorder ...BACKGROUND： Ceramide galactosyltransferase （CGT） protein and mRNA expression defect can cause the abnormal morphology and slowing conduction velocity of peripheral nerve. Morphologic change and functional disorder of myelin sheath and axon appear when diabetic peripheral neuropathy （DPN） occurs. Whether electroacupuncture at Zusanfi（ST 36） and Shenshu（BL 32） points can enhance the expression of CGT protein and mRNA in the DPN tissue？ OBJECTIVE： To observe the effect of electroacupuncture at Zusanfi and Shenshu points on motor, sensory conduction velocity and CGT mRNA and its protein expression of sciatic nerve in rats with DPN. DESIGN： A randomized and controlled animal experiment SETTING ： Department of Neurology and Central Laboratory, Yueyang Hospital of Traditional Chinese ＆ Western Medicine, Shanghai University of Traditional Chinese Medicine. MATERIALS ： Totally 60 healthy male Wistar rats of clean grade, aged 4 month, with body mass of 200 to 220 g, were enrolled in this study. Streptozotocin （STZ, Sigma Company of USA, Batch No. S-0130）. METHODS： This study was carried out in the Animal Experimental Center and Central Laboratory, Yueyang Hospital of Traditional Chinese ＆ Western Medicine during February 2005 to March 2006. （1） Fifteen rats were randomly chosen,serving as normal group.AU the other rats were intraperitoneally injected once with STZ to develop experimental diabetic rat models. If fasting blood glucose was ≥ 15 mmol/L,sensory nerve and motor nerve conduction velocity of sciatic nerve was obviously slowed, tail-swaying temperature threshold was increased and myelinated nerve fiber of sciatic nerve changed, DPN models were successful. The successful model rats were randomly assigned into 3 groups： model group, control group（electroacupuncture at non-meridian-non-acupoint）and electroacupuncture group [electroacupuncture at Zusan/i and Shenshu points], with 15 rats each. The rats in the normal group and model group were untouched. In the electroacupuncture group （electroacupuncture at Zusanfi and Shenshu points）, Shenshu point （double） and Zusanfi point （double） were chosen referencing to The Atlas of the Rat＇s Acupoints. G6805- Ⅱ electric acupuncture apparatus was used, and current intensity was controlled at 20 min/time, once every other day, 12 times within 24 days. In the control group, the tip of rat-tail was stimulated, and the concrete procedures were the same as in the electroacupuncture at Zusanfi and Shenshu points. （2） Motor nerve conduction velocity and sensory nerve conduction velocity of rats were detected with neuroelectrophysiology detector in the end of the treatment, and the expressions of CGT protein and mRNA of sciatic nerve were detected with immunohistochemical method and fluorescent quantitative PCR technique. MAIN OUTCOME MEASURES： （1） Motor and sensory nerve conduction velocity. （2） The expression of CGT protein and its mRNA. RESULTS： All the 60 rats entered the stage of result analysis. （1） Comparison of motor and sensory nerve conduction velocity of rats after electroacupuncture： Motor nerve conduction velocity of rats in the model group[（31.37±3.69） m/s], control group [（32.74±5.42） m/s] and electroacupuncture group [（41.30 ±1.15） m/s] was significantly lower than that in the normal group [（41.30±1.15） m/s, P 〈 0.01]; The sensory nerve conduction velocity of rats in the model group[（18.17±9.54） m/s], control group [（21.39±5.61） m/s]and electroacupuncture group [（35.81 ±4.59） m/s] was significantly lower than that in the normal group [（46.38± 6.32） m/s,P 〈 0.01]; The motor and sensory nerve conduction velocity of electroacupuncture group was significantly higher than that in the model group [（38.04±2.01） m/s vs. （32.74±5.42） m/s,（35.81±4.59） m/s vs. （21.39±5.61） m/s,P 〈 0.01]. （2） Comparison of the expression of CGT protein of sciatic nerve of rats： The number of CGT positive cells of sciatic nerve in model group, control group or electroacupuncture group was significantly smaller than that in normal group [（9 770.33±1 461.73）, （10 588.13±1119.52）, （27 518.27± 9 078.29）, （37 769.67±4 021.81）/μm^2,P 〈 0.01]; The number of CGT positive cells of the sciatic nerve in the electroacupuncture group was significantly larger than that in the model group and control group （P 〈 0.01）. The number of CGT positive cells of sciatic nerve was close between control group and electroacupuncture group （P 〉 0.05）. （3） Comparison of CGT mRNA expression of sciatic nerve of rats： Ct value of CGT mRNA of sciatic nerve of rats in the model group,control group and electroacupuncture group was significantly higher than that in the normal group （13.75±2.60,14.81±2.80,11.67±1.75,9.30±0.98, P 〈 0.01 ）; Ct value of CGT mRNA of sciatic nerve of rats in the electroacupuncture group was significantly lower than that in the model group and control group （P 〈 0.01）, and that was close between electroacupuncture group and control group （P 〉 0.05）. CONCLUSION ： Electroacupuncture at Zusanfi and Shenshu points can increase motor and sensory nerve conduction velocity of rats with DPN. It might be associated with up-regulating the expression of CGT mRNA and its protein.展开更多
The Effects of electroacupuncture (EA) at Weiwanxiashu (EX-B3) and Zusanli (ST 36) points on blood glucose (BG) and plasma pancreatic glucagon (PG) contents were dynamically observed in diabetic rabbits induced by All...The Effects of electroacupuncture (EA) at Weiwanxiashu (EX-B3) and Zusanli (ST 36) points on blood glucose (BG) and plasma pancreatic glucagon (PG) contents were dynamically observed in diabetic rabbits induced by Alloxan. It is found that acupuncture at Weiwanxiashu point can significantly lower the BG content and inhibit release of PG; no significant changes in BG and PG are found when acupuncture is given at Zusanli (ST 36) point alone, however BG and PG contents decrease more obviously when acupuncture employed at both Zusanli and Weiwanxiashu, suggesting that Zusanli has a marked synergetic action with Weiwanxiashu.展开更多
In 1970s,sedatives or spasmolytics needed to beadministered 30 minutes prior to performingenteroscopy to relieve abdominal colic during theexamination.Owing to the improvement in operatingskills,such drugs are no more...In 1970s,sedatives or spasmolytics needed to beadministered 30 minutes prior to performingenteroscopy to relieve abdominal colic during theexamination.Owing to the improvement in operatingskills,such drugs are no more used today.However,anumber of patients still suffer from abdominal coliccaused by irritated colon in the process ofenteroscopy.For severe cases,the operator has nochoice but to suspend the examination.To find a展开更多
3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with m...3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with multi-scale targets,remains challenging.This paper proposes an enhanced segmentation method integrating improved PointNet++with a coverage-voted strategy.The coverage-voted strategy reduces data while preserving multi-scale target topology.The segmentation is achieved using an enhanced PointNet++algorithm with a normalization preprocessing head,resulting in a 94%accuracy for common supporting components.Ablation experiments show that the preprocessing head and coverage strategies increase segmentation accuracy by 20%and 2%,respectively,and improve Intersection over Union(IoU)for bearing plate segmentation by 58%and 20%.The accuracy of the current pretraining segmentation model may be affected by variations in surface support components,but it can be readily enhanced through re-optimization with additional labeled point cloud data.This proposed method,combined with a previously developed machine learning model that links rock bolt load and the deformation field of its bearing plate,provides a robust technique for simultaneously measuring the load of multiple rock bolts in a single laser scan.展开更多
The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie poin...The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie point(STP).However,due to pronounced spatial heterogeneity in seawater and sea ice properties across the Arctic,the use of an STP often leads to regionally biased.To address this limitation,this study proposes a multi-tie point(MTP)sea ice thickness retrieval method based on SMOS brightness temperature and sea ice concentration time series.Multiple seawater and sea ice tie-point values are identified through point-by-point time series analysis,quality control,and statistical hypothesis testing,allowing spatial variability in radiometric properties to be explicitly considered.The MTP-based retrieval is applied to Arctic freeze-up conditions.Validation against independent SMOS thin sea ice thickness products shows that the MTP approach yields significantly reduced bias and root mean square error compared with the conventional STP method,with statistically significant improvements confirmed by paired t-tests.While retrieval accuracy stabilizes beyond a certain number of tie points,the preprocessing cost associated with tie-point selection increases substantially.Considering both accuracy and efficiency,the MTP framework provides a practical and robust approach for large-scale Arctic thin sea ice thickness retrieval and enables improved characterization of regional freezing processes and maximum ice thickness.展开更多
针对自动驾驶场景下,近处干扰点云误检率高、远处稀疏点云漏检率高的问题,提出了一种基于改进PointPillars的自动驾驶障碍物点云检测算法.首先,通过聚合模块和共享多层感知机(shared multi-layer perceptron,MLP)对柱体内点云进行特征编...针对自动驾驶场景下,近处干扰点云误检率高、远处稀疏点云漏检率高的问题,提出了一种基于改进PointPillars的自动驾驶障碍物点云检测算法.首先,通过聚合模块和共享多层感知机(shared multi-layer perceptron,MLP)对柱体内点云进行特征编码,采用最大池化与平均池化叠加的方法将点云的显著特征与细节特征映射为柱体特征;其次,针对算法对伪图特征关注与利用不充分的问题,引入坐标注意力(coordinate attention,CA)机制和残差连接的伪图特征提取模块(attention and residual second block,ARSB),将深层与浅层特征图进行融合,优化算法梯度,增强算法对有效目标的关注度.试验结果表明:改进算法对全局点云检测精度较高,平均精度优于PointPillars、稀疏到稠密3D目标检测器(STD)等点云目标检测算法,在汽车类别上的检测精度优势明显,检测速度较快,符合实时性要求.展开更多
The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band ...The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band braiding has received widespread attention.However,a systematic exploration and visualization of non-Abelian braiding and the associated knot transformations in four-band systems remains unexplored.Here,we propose a theoretical model of NH four-band braiding,provide its phase diagram,and establish its trivial,Abelian,and non-Abelian braiding rules.Additionally,we report on special knots,such as the Hopf and Solomon links in braided knots,and reveal that their transformations are accompanied by and mediated through exceptional points.Our work provides a detailed case for studying NH multiband braiding and knot structures in four-band systems,which could offer insights for topological photonics and analog information processing applications.展开更多
Evaluating rock mass quality using three-dimensional(3D)point clouds is crucial for discontinuity extraction and is widely applied in various industrial sectors.However,the utilization of this method in geological sur...Evaluating rock mass quality using three-dimensional(3D)point clouds is crucial for discontinuity extraction and is widely applied in various industrial sectors.However,the utilization of this method in geological surveys remains limited.Notable limitations of current research include the scarcity of validation using simple geometric shapes for discontinuity extraction methods,and the lack of studies that target both planar and linear discontinuity.To address these gaps,this study proposes a workflow for identifying discontinuity planes and traces in rock outcrops from photogrammetric 3D modeling,employing the Compass and Facets plugins in the open-source CloudCompare software.Prior to field application,the efficacy of the extraction methods was first evaluated using experimental datasets of a cube and an isosceles triangular prism generated under laboratory-controlled conditions.This validation demonstrated exceptional accuracy,with the dip and dip direction(DDD)of extracted structures consistently within±2°of the actual values.Following this rigorous laboratory validation,this methodology was applied to a more complex natural rock outcrop(Miocene–Pliocene deposits in Japan),demonstrating its applicability in realistic geological settings for identifying structures.The results showed that the dip and dip direction trends of the extracted bedding planes and faults were consistent with field measurements,achieving a time reduction of approximately 40%compared to traditional methods.In conclusion,through strictly controlled initial verification and subsequent successful application to a complex natural setting,this study confirmed that the proposed workflow can effectively and efficiently extract discontinuous geological structures from point clouds.展开更多
Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(Me...Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
基金Supported by the National Key Basic Research and Development Program(973 Program)Funded Project(No.2014CB543100)Key Research and Development Projects in Shandong Province(No.2015GSF18143)。
文摘OBJECTIVE:To evaluate the effect of electroacupuncture on rapid gastric emptying by comparing the effectiveness of electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)(He-Mu acupoints)versus electroacupuncture at Zhongwan(CV12)alone.METHODS:Sixty-five patients were randomly divided into two groups;33 patients in the He-Mu acupoints group received electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12),while 32 patients in the single acupoint group received electroacupuncture only at Zhongwan(CV12).Both groups were treated once daily for 30 min,five times per week for 3 weeks.Before and after the 3-week treatment course,patients underwent gastric emptying scintigraphy and were assessed using the Traditional Chinese Medicine(TCM)symptom scale of gastrointestinal diseases.The two groups were compared regarding the percentages of gastric retention at 30 and 60 min and the TCM symptom scores.RESULTS:After the treatment course,the percentages of gastric retention at 30 and 60 min were significantly improved in both groups compared with the pre-treatment values(P<0.01).The improvement in the gastric retention was significantly better in the He-Mu acupoints group than the single acupoint group at 30 min(P<0.01)and 60 min(P<0.05).The TCM symptom score was significantly decreased after the treatment course in both groups(P<0.01).The improvement in the TCM symptom score was significantly better in the He-Mu acupoints group than the single acupoint group(P<0.01).The total effective rate was 93.55%(29/31)in the He-Mu acupoints group and 77.42%(24/31)in the single acupoint group.The treatment effect was better in the He-Mu acupoints group than the single acupoint group(P<0.05).CONCLUSIONS:Electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)or at Zhongwan(CV12)alone is effective in treating rapid gastric emptying.Furthermore,electroacupuncture at both Zusanli(ST36)and Zhongwan(CV12)is more effective than electroacupuncture at Zhongwan(CV12)alone.
文摘BACKGROUND Postoperative intestinal paralysis is common in gastrointestinal surgery,and the study of electroacupuncture mechanisms is of great significance.AIM To explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint(ST36)in postoperative intestinal paralysis following gastrointestinal surgery.METHODS A total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups:A control group and an electroacupuncture group,with 75 patients in each.The control group received conventional Western medical treatment,while the electroacupuncture group received electroacupuncture in addition to this,at the bilateral Zusanli acupoints.Both groups received treatment for 7 days.Clinical efficacy,gastrointestinal function recovery,and gastrointestinal hormone[motilin(MTL),gastrin(GAS)],neurotransmitter[vasoactive intestinal peptide(VIP),nitric oxide(NO)],and inflammatory cytokine[tumor necrosis factor-α(TNF-α),serum interleukin-6(IL-6),interleukin-1β(IL-1β)]levels were compared between the two groups before and seven days after treatment.Adverse reactions were also recorded.RESULTS The electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds,as well as faster first defecation and first flatus than the control group(P<0.05).After seven days of treatment,MTL and GAS levels were significantly higher and VIP,NO,TNF-α,IL-6 and IL-1βlevels were significantly lower in the electroacupuncture group than in the control group(P<0.05).No adverse reactions were observed in either group during treatment.CONCLUSION Electroacupuncture at the Zusanli acupoint can enhance clinical efficacy,promote the recovery of gastrointestinal function,and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery.This mechanism may involve excitation of the vagus nerve and activation of the cholinergic antiinflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.
文摘Objective： We aimed to determine the effect of neostigmine injections given at the Zusanli （ST 36） acupoint whentreating postpartum urinary retention. Methods： We conducted a systematic review to identify randomized controlledtrials （RCTs） involving neostigmine injections given at the Zusanli （ST 36） acupoint for treating postpartum urinaryretention. We searched the Cochrane Library, Pubmed, Web of Science, Chinese National Knowledge Infrastructure, VipDatabase, and Chinese Biomedical Literature Database from the creation of the database to December 30, 2016. Bias riskassessment was performed using Revman 5.3 software from Cochrane based on the criteria set out in the CochraneHandbook for Systematic Reviews of Interventions, version 5.1.0. Results： Thirteen studies were included with 627participants in the treatment group and 584 participants in the control group. （1） Overall response rate： neostigmineinjections given at the Zusanli （ST 36） acupoint have a better curative effect than injections given in muscle, odds ratio（OR） = 8.74, 95% confidence interval （CI） [5.83, 13.10], Z = 10.49 （P 〈 0.001）; （2） Comparison of effects at differentdosages： （i） 0.5 mg of neostigmine Zusanli （ST 36） acupoint injection group has better effect than 1 mg of neostigmineintramuscular injection group, OR = 15.84, 95% CI [5.74, 43.72],Z = 5.34 （P 〈 0.001）, （ii） 0.5 mg of neostigmineinjection given at the Zusanli acupoint has a better curative effect than 0.5 mg of neostigmine injection given in muscle ,OR = 7.30, 95% CI [3.47, 15.34], Z = 5.24 （P 〈 0.001）; （iii） 1 mg of neostigmine injection at the Zusanli （ST 36）acupoint has better efficacy than 1 mg of neostigmine injection in muscle, OR = 7.76, 95% CI [4.46, 13.52], Z = 7.25 （P〈 0.001）. Conclusion： Neostigmine injections at the Zusanli （ST 36） acupoint have beneficial effects in treatingpostpartum urinary retention. However, the low quality of the studies included in the meta-analysis raises questions overthe reliability of the results. Further studies are still needed.
文摘This paper reports that 65 cases with functional constipation were treated by putting one Wang Bu Liu Xing (semen vaccariae) seed on each acupoint, Intestinum crassum, Intestinum tenue,Sympathicum, Lung, Spleen, Subcortex, of auricula and pressing, associated with acupuncture at Zusanli point on both sides. The patients were instructed to press the stuck seed twice a day for 3 to 5 minutes each time. Auricular acupoints of both sides were used alternately every 2 days. The electric acupuncture was applied at Zusanli points about 30 minutes each time every other day. Ten times (i. e. 20 days) make one course of treatment and the routine treatment consists of 1 to 2 courses. The results showed that all the patients were cured, patients with Shi Mi (the constipation of excess type) were cured after one course of treatrnent while Xu Mi (the constipation of deficiency type) were cured after two courses. The study suggests that this kind of treatment is an ideal therapy for functional constipation. The pathogenesis and mechanism of treatment of auricular acupuncture pressing associated with acupuncture at Zusanli point for constipation are discussed.
基金Supported by the National Nature Science Foundation of China(No.81273848)
文摘OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with non-small-cell lung cancer(NSCLC).METHODS: Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) every day for 6 weeks, while group B received no intervention(control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.RESULTS: Five participants dropped out, leaving afinal total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B(P <0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life(P < 0.001) and function(P < 0.05), and significantly lower in terms of symptoms(P < 0.05).CONCLUSION: The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli(ST 36) and Feishu(BL13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.
基金Supported by Basic Science Research Program through the National Research Foundation of Korea Funded by the Ministry of Education(2016R1D1A1B03931625)
文摘OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(A.Dex)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)acupoint.METHODS:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control group.One hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(O.Dex group),while three groups received A.Dex at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,respectively.AR symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th day.We isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing score.Spleen weight was measured using an electronic microbalance.The levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent assays.The serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde spectrofluorometry.Western blot analysis was performed on nasal mucosal tissue extracts.RESULTS:A.Dex significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized mice.A.Dex significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized mice.A.Dex significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-land macrophage-inflammatory protein-2)in AR mice.A.Dex effectively attenuated the expression of caspase-1 and receptorinteractingprotein-2 in nasal mucosal tissue.CONCLUSION:A.Dex may be a new and useful therapy for AR.
文摘We had treated 102 cases of obstinate peptic ulcer and chronic gastritis with ametal ring embedded in Zusanli acupoint since October 1989 to October 1992,and got satisfactorytherapeutic effects.The total effective rate is 96.08%,the cure rate of peptic ulcer is 87.32%,therecurrence rate is significantly lower than that of control group(P【0.001),and it has no side-effect.
基金the National Nat-ural Science Foundation of Chi-na, No. 30472238 the Grantfrom Bureau of Public Health ofShanghai City, No. 05JC14053Shanghai Key Subjects Con-struction Program, No. T0302
文摘BACKGROUND： Ceramide galactosyltransferase （CGT） protein and mRNA expression defect can cause the abnormal morphology and slowing conduction velocity of peripheral nerve. Morphologic change and functional disorder of myelin sheath and axon appear when diabetic peripheral neuropathy （DPN） occurs. Whether electroacupuncture at Zusanfi（ST 36） and Shenshu（BL 32） points can enhance the expression of CGT protein and mRNA in the DPN tissue？ OBJECTIVE： To observe the effect of electroacupuncture at Zusanfi and Shenshu points on motor, sensory conduction velocity and CGT mRNA and its protein expression of sciatic nerve in rats with DPN. DESIGN： A randomized and controlled animal experiment SETTING ： Department of Neurology and Central Laboratory, Yueyang Hospital of Traditional Chinese ＆ Western Medicine, Shanghai University of Traditional Chinese Medicine. MATERIALS ： Totally 60 healthy male Wistar rats of clean grade, aged 4 month, with body mass of 200 to 220 g, were enrolled in this study. Streptozotocin （STZ, Sigma Company of USA, Batch No. S-0130）. METHODS： This study was carried out in the Animal Experimental Center and Central Laboratory, Yueyang Hospital of Traditional Chinese ＆ Western Medicine during February 2005 to March 2006. （1） Fifteen rats were randomly chosen,serving as normal group.AU the other rats were intraperitoneally injected once with STZ to develop experimental diabetic rat models. If fasting blood glucose was ≥ 15 mmol/L,sensory nerve and motor nerve conduction velocity of sciatic nerve was obviously slowed, tail-swaying temperature threshold was increased and myelinated nerve fiber of sciatic nerve changed, DPN models were successful. The successful model rats were randomly assigned into 3 groups： model group, control group（electroacupuncture at non-meridian-non-acupoint）and electroacupuncture group [electroacupuncture at Zusan/i and Shenshu points], with 15 rats each. The rats in the normal group and model group were untouched. In the electroacupuncture group （electroacupuncture at Zusanfi and Shenshu points）, Shenshu point （double） and Zusanfi point （double） were chosen referencing to The Atlas of the Rat＇s Acupoints. G6805- Ⅱ electric acupuncture apparatus was used, and current intensity was controlled at 20 min/time, once every other day, 12 times within 24 days. In the control group, the tip of rat-tail was stimulated, and the concrete procedures were the same as in the electroacupuncture at Zusanfi and Shenshu points. （2） Motor nerve conduction velocity and sensory nerve conduction velocity of rats were detected with neuroelectrophysiology detector in the end of the treatment, and the expressions of CGT protein and mRNA of sciatic nerve were detected with immunohistochemical method and fluorescent quantitative PCR technique. MAIN OUTCOME MEASURES： （1） Motor and sensory nerve conduction velocity. （2） The expression of CGT protein and its mRNA. RESULTS： All the 60 rats entered the stage of result analysis. （1） Comparison of motor and sensory nerve conduction velocity of rats after electroacupuncture： Motor nerve conduction velocity of rats in the model group[（31.37±3.69） m/s], control group [（32.74±5.42） m/s] and electroacupuncture group [（41.30 ±1.15） m/s] was significantly lower than that in the normal group [（41.30±1.15） m/s, P 〈 0.01]; The sensory nerve conduction velocity of rats in the model group[（18.17±9.54） m/s], control group [（21.39±5.61） m/s]and electroacupuncture group [（35.81 ±4.59） m/s] was significantly lower than that in the normal group [（46.38± 6.32） m/s,P 〈 0.01]; The motor and sensory nerve conduction velocity of electroacupuncture group was significantly higher than that in the model group [（38.04±2.01） m/s vs. （32.74±5.42） m/s,（35.81±4.59） m/s vs. （21.39±5.61） m/s,P 〈 0.01]. （2） Comparison of the expression of CGT protein of sciatic nerve of rats： The number of CGT positive cells of sciatic nerve in model group, control group or electroacupuncture group was significantly smaller than that in normal group [（9 770.33±1 461.73）, （10 588.13±1119.52）, （27 518.27± 9 078.29）, （37 769.67±4 021.81）/μm^2,P 〈 0.01]; The number of CGT positive cells of the sciatic nerve in the electroacupuncture group was significantly larger than that in the model group and control group （P 〈 0.01）. The number of CGT positive cells of sciatic nerve was close between control group and electroacupuncture group （P 〉 0.05）. （3） Comparison of CGT mRNA expression of sciatic nerve of rats： Ct value of CGT mRNA of sciatic nerve of rats in the model group,control group and electroacupuncture group was significantly higher than that in the normal group （13.75±2.60,14.81±2.80,11.67±1.75,9.30±0.98, P 〈 0.01 ）; Ct value of CGT mRNA of sciatic nerve of rats in the electroacupuncture group was significantly lower than that in the model group and control group （P 〈 0.01）, and that was close between electroacupuncture group and control group （P 〉 0.05）. CONCLUSION ： Electroacupuncture at Zusanfi and Shenshu points can increase motor and sensory nerve conduction velocity of rats with DPN. It might be associated with up-regulating the expression of CGT mRNA and its protein.
文摘The Effects of electroacupuncture (EA) at Weiwanxiashu (EX-B3) and Zusanli (ST 36) points on blood glucose (BG) and plasma pancreatic glucagon (PG) contents were dynamically observed in diabetic rabbits induced by Alloxan. It is found that acupuncture at Weiwanxiashu point can significantly lower the BG content and inhibit release of PG; no significant changes in BG and PG are found when acupuncture is given at Zusanli (ST 36) point alone, however BG and PG contents decrease more obviously when acupuncture employed at both Zusanli and Weiwanxiashu, suggesting that Zusanli has a marked synergetic action with Weiwanxiashu.
文摘In 1970s,sedatives or spasmolytics needed to beadministered 30 minutes prior to performingenteroscopy to relieve abdominal colic during theexamination.Owing to the improvement in operatingskills,such drugs are no more used today.However,anumber of patients still suffer from abdominal coliccaused by irritated colon in the process ofenteroscopy.For severe cases,the operator has nochoice but to suspend the examination.To find a
基金supported by the National Natural Science Foundation of China(Grant Nos.52304139,52325403)the CCTEG Coal Mining Research Institute funding(Grant No.KCYJY-2024-MS-10).
文摘3D laser scanning technology is widely used in underground openings for high-precision,rapid,and nondestructive structural evaluations.Segmenting large 3D point cloud datasets,particularly in coal mine roadways with multi-scale targets,remains challenging.This paper proposes an enhanced segmentation method integrating improved PointNet++with a coverage-voted strategy.The coverage-voted strategy reduces data while preserving multi-scale target topology.The segmentation is achieved using an enhanced PointNet++algorithm with a normalization preprocessing head,resulting in a 94%accuracy for common supporting components.Ablation experiments show that the preprocessing head and coverage strategies increase segmentation accuracy by 20%and 2%,respectively,and improve Intersection over Union(IoU)for bearing plate segmentation by 58%and 20%.The accuracy of the current pretraining segmentation model may be affected by variations in surface support components,but it can be readily enhanced through re-optimization with additional labeled point cloud data.This proposed method,combined with a previously developed machine learning model that links rock bolt load and the deformation field of its bearing plate,provides a robust technique for simultaneously measuring the load of multiple rock bolts in a single laser scan.
基金supported by the National Key Research and Development Program of China(Grant nos.2023YFC2809103,2024YFC2813505)the Fundamental Research Funds for the Central Universities(Grant nos.2042025kf0083,2042025gf0014)the Antarctic Zhongshan Ice and Space Environment National Observation and Research Station(Grant no.ZSNORS-20252702).
文摘The correlation between the Soil Moisture and Ocean Salinity(SMOS)L-band brightness temperature and thin sea ice thickness has been widely exploited using semi-empirical retrieval approaches based on a single-tie point(STP).However,due to pronounced spatial heterogeneity in seawater and sea ice properties across the Arctic,the use of an STP often leads to regionally biased.To address this limitation,this study proposes a multi-tie point(MTP)sea ice thickness retrieval method based on SMOS brightness temperature and sea ice concentration time series.Multiple seawater and sea ice tie-point values are identified through point-by-point time series analysis,quality control,and statistical hypothesis testing,allowing spatial variability in radiometric properties to be explicitly considered.The MTP-based retrieval is applied to Arctic freeze-up conditions.Validation against independent SMOS thin sea ice thickness products shows that the MTP approach yields significantly reduced bias and root mean square error compared with the conventional STP method,with statistically significant improvements confirmed by paired t-tests.While retrieval accuracy stabilizes beyond a certain number of tie points,the preprocessing cost associated with tie-point selection increases substantially.Considering both accuracy and efficiency,the MTP framework provides a practical and robust approach for large-scale Arctic thin sea ice thickness retrieval and enables improved characterization of regional freezing processes and maximum ice thickness.
文摘针对自动驾驶场景下,近处干扰点云误检率高、远处稀疏点云漏检率高的问题,提出了一种基于改进PointPillars的自动驾驶障碍物点云检测算法.首先,通过聚合模块和共享多层感知机(shared multi-layer perceptron,MLP)对柱体内点云进行特征编码,采用最大池化与平均池化叠加的方法将点云的显著特征与细节特征映射为柱体特征;其次,针对算法对伪图特征关注与利用不充分的问题,引入坐标注意力(coordinate attention,CA)机制和残差连接的伪图特征提取模块(attention and residual second block,ARSB),将深层与浅层特征图进行融合,优化算法梯度,增强算法对有效目标的关注度.试验结果表明:改进算法对全局点云检测精度较高,平均精度优于PointPillars、稀疏到稠密3D目标检测器(STD)等点云目标检测算法,在汽车类别上的检测精度优势明显,检测速度较快,符合实时性要求.
基金supported by the National Natural Science Foundation of China(Grant Nos.62575099,62075059,61405058)Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515011353)+2 种基金Open Project of the State Key Laboratory of Advanced Optical Communication Systems and Networks of China(Grant No.2024GZKF20)the Natural Science Foundation of Hunan Province(Grant Nos.2020JJ4161 and 2017JJ2048)Scientific Research Foundation of Hunan Provincial Education Department(Grant No.21A0013)。
文摘The strong connection between braids and knots provides valuable insights into studying the topological state and phase classification of various physical systems.The phenomenon of non-Hermitian(NH)two-and three-band braiding has received widespread attention.However,a systematic exploration and visualization of non-Abelian braiding and the associated knot transformations in four-band systems remains unexplored.Here,we propose a theoretical model of NH four-band braiding,provide its phase diagram,and establish its trivial,Abelian,and non-Abelian braiding rules.Additionally,we report on special knots,such as the Hopf and Solomon links in braided knots,and reveal that their transformations are accompanied by and mediated through exceptional points.Our work provides a detailed case for studying NH multiband braiding and knot structures in four-band systems,which could offer insights for topological photonics and analog information processing applications.
文摘Evaluating rock mass quality using three-dimensional(3D)point clouds is crucial for discontinuity extraction and is widely applied in various industrial sectors.However,the utilization of this method in geological surveys remains limited.Notable limitations of current research include the scarcity of validation using simple geometric shapes for discontinuity extraction methods,and the lack of studies that target both planar and linear discontinuity.To address these gaps,this study proposes a workflow for identifying discontinuity planes and traces in rock outcrops from photogrammetric 3D modeling,employing the Compass and Facets plugins in the open-source CloudCompare software.Prior to field application,the efficacy of the extraction methods was first evaluated using experimental datasets of a cube and an isosceles triangular prism generated under laboratory-controlled conditions.This validation demonstrated exceptional accuracy,with the dip and dip direction(DDD)of extracted structures consistently within±2°of the actual values.Following this rigorous laboratory validation,this methodology was applied to a more complex natural rock outcrop(Miocene–Pliocene deposits in Japan),demonstrating its applicability in realistic geological settings for identifying structures.The results showed that the dip and dip direction trends of the extracted bedding planes and faults were consistent with field measurements,achieving a time reduction of approximately 40%compared to traditional methods.In conclusion,through strictly controlled initial verification and subsequent successful application to a complex natural setting,this study confirmed that the proposed workflow can effectively and efficiently extract discontinuous geological structures from point clouds.
基金supported by the Autonomous Government of Andalusia(Spain)under project UMA20-FEDERJA-108also by the Ministry of Science and Innovation of Spain,grant number PID2022-136764OA-I00+1 种基金It includes funds fromthe European Regional Development Fund(ERDF),It is also partially supported by the Fundación Unicaja(PUNI-003_2023)the Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND(ATECH-25-02).
文摘Automatic and accurate medical image segmentation remains a fundamental task in computer-aided diagnosis and treatment planning.Recent advances in foundation models,such as the medical-focused Segment AnythingModel(MedSAM),have demonstrated strong performance but face challenges inmanymedical applications due to anatomical complexity and a limited domain-specific prompt.Thiswork introduces amethodology that enhances segmentation robustness and precision by automatically generating multiple informative point prompts,rather than relying on single inputs.The proposed approach randomly samples sets of spatially distributed point prompts based on image features,enabling MedSAM to better capture fine-grained anatomical structures and boundaries.During inference,probability maps are aggregated to reduce local misclassifications without additional model training.Extensive experiments on various computed tomography(CT)and magnetic resonance imaging(MRI)datasets demonstrate improvements in Dice Similarity Coefficient(DSC)and Normalized Surface Dice(NSD)metrics compared to baseline SAM and Scribble Prompt models.A semi-automatic point sampling version based on the ground truth segmentations yielded enhanced results,achieving up to 92.1%DSC and 86.6%NSD,with significant gains in delineating complex organs such as the pancreas,colon,kidney,and brain tumours.The main novelty of our method consists of effectively combining the results of multiple point prompts into the medical segmentation pipeline so that single-point prompt methods are outperformed.Overall,the proposed model offers a straightforward yet effective approach to improve medical image segmentation performance while maintaining computational efficiency.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
