We study iterative processes of stochastic approximation for finding fixed points of weakly contractive and nonexpansive operators in Hilbert spaces under the condition that operators are given with random errors. We ...We study iterative processes of stochastic approximation for finding fixed points of weakly contractive and nonexpansive operators in Hilbert spaces under the condition that operators are given with random errors. We prove mean square convergence and convergence almost sure (a.s.) of iterative approximations and establish both asymptotic and nonasymptotic estimates of the convergence rate in degenerate and non-degenerate cases. Previously the stochastic approximation algorithms were studied mainly for optimization problems.展开更多
Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detecti...Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10^(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).展开更多
Light Detection And Ranging (LiDAR) is a well-established active remote sensing technology that can provide accurate digital elevation measurements for the terrain and non-ground objects such as vegetations and buildi...Light Detection And Ranging (LiDAR) is a well-established active remote sensing technology that can provide accurate digital elevation measurements for the terrain and non-ground objects such as vegetations and buildings, etc. Non-ground objects need to be removed for creation of a Digital Terrain Model (DTM) which is a continuous surface representing only ground surface points. This study aimed at comparative analysis of three main filtering approaches for stripping off non-ground objects namely;Gaussian low pass filter, focal analysis mean filter and DTM slope-based filter of varying window sizes in creation of a reliable DTM from airborne LiDAR point clouds. A sample of LiDAR data provided by the ISPRS WG III/4 captured at Vaihingen in Germany over a pure residential area has been used in the analysis. Visual analysis has indicated that Gaussian low pass filter has given blurred DTMs of attenuated high-frequency objects and emphasized low-frequency objects while it has achieved improved removal of non-ground object at larger window sizes. Focal analysis mean filter has shown better removal of nonground objects compared to Gaussian low pass filter especially at large window sizes where details of non-ground objects almost have diminished in the DTMs from window sizes of 25 × 25 and greater. DTM slope-based filter has created bare earth models that have been full of gabs at the positions of the non-ground objects where the sizes and numbers of that gabs have increased with increasing the window sizes of filter. Those gaps have been closed through exploitation of the spline interpolation method in order to get continuous surface representing bare earth landscape. Comparative analysis has shown that the minimum elevations of the DTMs increase with increasing the filter widow sizes till 21 × 21 and 31 × 31 for the Gaussian low pass filter and the focal analysis mean filter respectively. On the other hand, the DTM slope-based filter has kept the minimum elevation of the original data, that could be due to noise in the LiDAR data unchanged. Alternatively, the three approaches have produced DTMs of decreasing maximum elevation values and consequently decreasing ranges of elevations due to increases in the filter window sizes. Moreover, the standard deviations of the created DTMs from the three filters have decreased with increasing the filter window sizes however, the decreases have been continuous and steady in the cases of the Gaussian low pass filter and the focal analysis mean filters while in the case of the DTM slope-based filter the standard deviations of the created DTMs have decreased with high rates till window size of 31 × 31 then they have kept unchanged due to more increases in the filter window sizes.展开更多
OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with no...OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with non-small-cell lung cancer(NSCLC).METHODS: Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) every day for 6 weeks, while group B received no intervention(control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.RESULTS: Five participants dropped out, leaving afinal total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B(P <0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life(P < 0.001) and function(P < 0.05), and significantly lower in terms of symptoms(P < 0.05).CONCLUSION: The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli(ST 36) and Feishu(BL13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.展开更多
In this paper, a new class of over-relaxed proximal point algorithms for solving nonlinear operator equations with (A,η,m)-monotonicity framework in Hilbert spaces is introduced and studied. Further, by using the gen...In this paper, a new class of over-relaxed proximal point algorithms for solving nonlinear operator equations with (A,η,m)-monotonicity framework in Hilbert spaces is introduced and studied. Further, by using the generalized resolvent operator technique associated with the (A,η,m)-monotone operators, the approximation solvability of the operator equation problems and the convergence of iterative sequences generated by the algorithm are discussed. Our results improve and generalize the corresponding results in the literature.展开更多
This paper presents an analysis of the effect of parasitic resistances on the performance of DC-DC Single Ended Pri- mary Inductor Converter (SEPIC) in photovoltaic maximum power point tracking (MPPT) applications. Th...This paper presents an analysis of the effect of parasitic resistances on the performance of DC-DC Single Ended Pri- mary Inductor Converter (SEPIC) in photovoltaic maximum power point tracking (MPPT) applications. The energy storage elements incorporated in the SEPIC converter possess parasitic resistances. Although ideal components significantly simplifies model development, but neglecting the parasitic effects in models may sometimes lead to failure in predicting first scale stability and actual performance. Therefore, the effects of parasitics have been taken into consideration for improving the model accuracy, stability, robustness and dynamic performance analysis of the converter. Detail mathematical model of SEPIC converter including inductive parasitic has been developed. The performance of the converter in tracking MPP at different irradiance levels has been analyzed for variation in parasitic resistance. The converter efficiency has been found above 83% for insolation level of 600 W/m2 when the parasitic resistance in the energy storage element has been ignored. However, as the parasitic resistance of both of the inductor has increased to 1 ohm, a fraction of the power managed by the converter has dissipated;as a result the efficiency of the converter has reduced to 78% for the same insolation profile. Although the increasing value of the parasitic has assisted the converter to converge quickly to reach the maximum power point. Furthermore it has also been observed that the peak to peak load current ripple is reduced. The obtained simulation results have validated the competent of the MPPT converter model.展开更多
A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(F...A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(FGMEE)structures.By introducing the modified Newmark method,the displacement,electrical potential and magnetic potential of the structures under transient mechanical loading were obtained.Based on G space theory and the weakened weak(W2)formulation,the equations of the multi-physics coupling problems were derived.Using triangular background elements,the free vibration and transient responses of three numerical examples were studied.Results proved that CM-NS-RPIM performed better than the standard FEM by reducing the overly-stiff of structures.Moreover,CM-NS-RPIM could reduce the number of nodes while guaranteeing the accuracy.Besides,triangular elements could be generated automatically even for complex geometries.Therefore,the effectiveness and validity of CM-NS-RPIM were demonstrated,which were valuable for the design of intelligence devices,such as energy harvesters and sensors.展开更多
BACKGROUND Numerous studies investigated cell-based therapies for myocardial infarction(MI).The conflicting results of these studies have established the need for developing innovative approaches for applying cell-bas...BACKGROUND Numerous studies investigated cell-based therapies for myocardial infarction(MI).The conflicting results of these studies have established the need for developing innovative approaches for applying cell-based therapy for MI.Experimental studies on animal models demonstrated the potential of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UAADRCs)for treating acute MI.In contrast,studies on the treatment of chronic MI(CMI;>4 wk post-MI)with UA-ADRCs have not been published so far.Among several methods for delivering cells to the myocardium,retrograde delivery into a temporarily blocked coronary vein has recently been demonstrated as an effective option.AIM To test the hypothesis that in experimentally-induced chronic myocardial infarction(CMI;>4 wk post-MI)in pigs,retrograde delivery of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UA-ADRCs)into a temporarily blocked coronary vein improves cardiac function and structure.METHODS The left anterior descending(LAD)coronary artery of pigs was blocked for 180 min at time point T0.Then,either 18×106 UA-ADRCs prepared at“point of care”or saline as control were retrogradely delivered via an over-the-wire balloon catheter placed in the temporarily blocked LAD vein 4 wk after T0(T1).Effects of cells or saline were assessed by cardiac magnetic resonance(CMR)imaging,late gadolinium enhancement CMR imaging,and post mortem histologic analysis 10 wk after T0(T2).RESULTS Unlike the delivery of saline,delivery of UA-ADRCs demonstrated statistically significant improvements in cardiac function and structure at T2 compared to T1(all values given as mean±SE):Increased mean LVEF(UA-ADRCs group:34.3%±2.9%at T1 vs 40.4±2.6%at T2,P=0.037;saline group:37.8%±2.6%at T1 vs 36.2%±2.4%at T2,P>0.999),increased mean cardiac output(UA-ADRCs group:2.7±0.2 L/min at T1 vs 3.8±0.2 L/min at T2,P=0.002;saline group:3.4±0.3 L/min at T1 vs 3.6±0.3 L/min at T2,P=0.798),increased mean mass of the left ventricle(UA-ADRCs group:55.3±5.0 g at T1 vs 71.3±4.5 g at T2,P<0.001;saline group:63.2±3.4 g at T1 vs 68.4±4.0 g at T2,P=0.321)and reduced mean relative amount of scar volume of the left ventricular wall(UA-ADRCs group:20.9%±2.3%at T1 vs 16.6%±1.2%at T2,P=0.042;saline group:17.6%±1.4%at T1 vs 22.7%±1.8%at T2,P=0.022).CONCLUSION Retrograde cell delivery of UA-ADRCs in a porcine model for the study of CMI significantly improved myocardial function,increased myocardial mass and reduced the formation of scar tissue.展开更多
From January 1993 to December 1996, we treated 482 cases of cervical spondylopathy with a combined method of point-injection and needle-warming via moxibustion. Except for the cases of sympathetic nerve type and spina...From January 1993 to December 1996, we treated 482 cases of cervical spondylopathy with a combined method of point-injection and needle-warming via moxibustion. Except for the cases of sympathetic nerve type and spinal cord type, the combined method was superior to traction therapy in the control group and reported as follows.Clinical DataThe Criteria of Diagnosis and Curative Effect in TCM issued by the State Administrative Bureau of TCM and Pharmacy in 1994 was adopted for the enrollment of patients of cervical spondylopathy and the pathological typing. Only the patients who had completed the treatment and with complete records were collected for analysis.展开更多
A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of th...A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.展开更多
This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After bou...This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After boundary layer approximation,the governing equations are achieved(namely Maxwell,upper convected material derivative,thermal and concentration diffusions).By using the self-similarity transformations the governing PDEs are converted into nonlinear ODEs and solved by RK-4 method in combination with Newton Raphson(shooting technique).The effects of developed parameters on velocity,temperature,concentration,fraction factor,heat and mass diffusions are exemplified through graphs and tabular form and are deliberated in detail.Numerical values of fraction factor,heat and mass transfer rates with several parameters are computed and examined.It is noticed that the temperature is more impactable for higher values of radiative heat transport,thermal conductivity and viscous dissipation.The comparison data for some limiting case are acquired and are originated to be in good agreement with previously published articles.展开更多
By using Leray-Schauder nonlinear alternative, Banach contraction theorem and Guo-Krasnosel’skii theorem, we discuss the existence, uniqueness and positivity of solution to the third-order multi-point nonhomogeneous ...By using Leray-Schauder nonlinear alternative, Banach contraction theorem and Guo-Krasnosel’skii theorem, we discuss the existence, uniqueness and positivity of solution to the third-order multi-point nonhomogeneous boundary value problem (BVP1): where for The interesting point lies in the fact that the nonlinear term is allowed to depend on the first order derivative .展开更多
Several problems arising in science and engineering are modeled by differential equations that involve conditions that are specified at more than one point. The non-linear two-point boundary value problem (TPBVP) (Br...Several problems arising in science and engineering are modeled by differential equations that involve conditions that are specified at more than one point. The non-linear two-point boundary value problem (TPBVP) (Bratu’s equation, Troesch’s problems) occurs engineering and science, including the modeling of chemical reactions diffusion processes and heat transfer. An analytical expression pertaining to the concentration of substrate is obtained using Homotopy perturbation method for all values of parameters. These approximate analytical results were found to be in good agreement with the simulation results.展开更多
Neuritis of lateral cutaneous nerve of thigh, also called meralgia paresthetica, is a commonly encountered disease in clinical practice. The author has treated 28 cases of meralgia paresthetica since 1996 by acupunctu...Neuritis of lateral cutaneous nerve of thigh, also called meralgia paresthetica, is a commonly encountered disease in clinical practice. The author has treated 28 cases of meralgia paresthetica since 1996 by acupuncture plus point-injection with satisfactory results. A report follows.Clinical Data Among the 28 cases, 13 were male and 15 female. Their age ranged from 24 to 72 years, most of the patients being 35 to 50 years; the duration of illness varied from one month to ten years and 6 cases were affected on left side, 8 cases on right side and 14 cases on both sides.展开更多
Purpose: This study was performed to assess the utility and safety of an In-Office INR Monitoring Device and present a safe and efficient protocol for the management of patients on oral anticoagulants and/or antithrom...Purpose: This study was performed to assess the utility and safety of an In-Office INR Monitoring Device and present a safe and efficient protocol for the management of patients on oral anticoagulants and/or antithrombolytics requiring routine office oral and maxillofacial surgery. Patients and Methods: Sixty-one patients requiring “minor” oral and maxillofacial surgery being treated chronically with oral anticoagulation (warfarin) were entered into the study and compared in 2 groups. The control group (n = 29) was managed by discontinuing warfarin and any anti-platelet medication(s) prior to surgery. In the study group (n = 30), the decision to continue or withhold warfarin was determined by a protocol in which patients are 1) stratified based on risk for thromboembolism, and 2) classified as requiring “major” or “minor” surgery. Procedures categorized as “minor” surgery included dental extraction(s), dental implants, soft tissue and bone biopsies, and preprosthetic bone surgery, and incision and drainage. Warfarin and antiplatelet medication were not withheld in these patients, and a Point-of-Care In-Office INR Monitoring Device was used to obtain INR levels on the day of consultation and surgery. Local measures including removal of granulation tissue, packing, suturing, etc. were utilized for hemostasis. Results: The 30 patients in the study group maintained on warfarin readily achieved hemostasis using intraoperative local measures. The mean INR measured by the In-Office INR Monitoring Device was 2.36 with a range from 1.3 to 3.2. Study group patients underwent a total of 131 separate procedures including 108 dental extractions (impactions), placement of dental implants, preprosthetic bony surgery, bone cyst removal, soft tissue biopsies, facial skin cancer repair, and incision and drainage. One patient (3%) required “minor” intervention with removal of a “liver clot” on postop day 2 with repacking and suturing. The 29 patients in the control group discontinued off of war farin underwent a total of 99 procedures. One patient (3%) also required a “minor” intervention (repacking of extraction site). There were no “major” complications in either group. Conclusions: This study supports previous studies that minor oral surgery procedures can be safely performed while maintaining patients on warfarin minimizing the risk of a potentially devastating thromboembolic event. When deciding whether or not to withhold warfarin, this study supports the use of the proposed protocol based on 1) risk stratification for thromboembolism, 2) the need for “minor” versus “major” surgery, 3) and utilization of an In-Office INR Monitoring Device. An In-Office Point-of-Care INR measuring device can be a very effective tool to safely simplify and make the perioperative management of the anticoagulated patient more efficient for the patient and oral and maxillo facial surgeon.展开更多
A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy spee...A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy speech is established. Then the likelihood ratio test based on binary hypothesis test is carried out. The decision criterion of conventional maximum a posterior incorporating the inter-frame correlation leads to two separate thresholds. Speech endpoint detection decision is finally made depend on the previous frame and the observed spectrum, and the speech endpoint is searched based on the decision. Compared with the typical algorithms, the proposed method operates robust in the airplane cockpit voice background.展开更多
There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earth...There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earthquakes from January 2009 through August 2013. Frequency distributions with increments of M = 0.1 verified the trough of the diminished incidence to be between M = 3.6 and 3.7 with an abrupt increase between M = 3.9 and 4.0. The calculated equivalent photon wavelength for the energies associated with M = 3.6 approaches Planck’s Length while the related time increment is the cutoff frequency for the Zero Point Fluctuation force coupled to gravity. The conspicuous congruence between Planck’s time and length and the lower than expected frequency based upon Gaussian assumptions of distribution for the discrete band of energy associated with this magnitude range of earthquakes suggests a conduit may exist between intrinsic features of Planck space-time and geophysical processes. The existence of such a connection would encourage alternative explanations for sun-seismic activities as due to solar instabilities. Instead, it may reflect influence upon both from alterations in the structure of space being traversed by the solar system as it moves through the galaxy.展开更多
With injection of Injectio Radici Astragli into the point Zusanli (ST 36), we have obtained quite satisfactory therapeutic results for treating leukopenia and the impairment in immune functions occurred in cancer chem...With injection of Injectio Radici Astragli into the point Zusanli (ST 36), we have obtained quite satisfactory therapeutic results for treating leukopenia and the impairment in immune functions occurred in cancer chemotherapy. A report follows.展开更多
文摘We study iterative processes of stochastic approximation for finding fixed points of weakly contractive and nonexpansive operators in Hilbert spaces under the condition that operators are given with random errors. We prove mean square convergence and convergence almost sure (a.s.) of iterative approximations and establish both asymptotic and nonasymptotic estimates of the convergence rate in degenerate and non-degenerate cases. Previously the stochastic approximation algorithms were studied mainly for optimization problems.
基金financially supported by the National Key Research and Development Program of China(2021YFF0703600)。
文摘Highlights By conjugating the same anti-N monoclonal antibody(mAb4-mAb1)with colloidal gold or fluorescent microspheres,this study developed two rapid point-of-care antigen immunochromatographic strips for the detection of porcine deltacoronavirus.The fluorescent microsphere-based lateral flow test strip demonstrated a sensitivity of 10^(1.7)TCID_(50)/0.1 mL,which is fourfold higher than that of the colloidal gold-based assay.Porcine deltacoronavirus(PDCoV)is a recently identified enteric coronavirus that causes an acute infectious disease in piglets,leading to diarrhea,vomiting,dehydration,and mortality(Hu et al.2015).
文摘Light Detection And Ranging (LiDAR) is a well-established active remote sensing technology that can provide accurate digital elevation measurements for the terrain and non-ground objects such as vegetations and buildings, etc. Non-ground objects need to be removed for creation of a Digital Terrain Model (DTM) which is a continuous surface representing only ground surface points. This study aimed at comparative analysis of three main filtering approaches for stripping off non-ground objects namely;Gaussian low pass filter, focal analysis mean filter and DTM slope-based filter of varying window sizes in creation of a reliable DTM from airborne LiDAR point clouds. A sample of LiDAR data provided by the ISPRS WG III/4 captured at Vaihingen in Germany over a pure residential area has been used in the analysis. Visual analysis has indicated that Gaussian low pass filter has given blurred DTMs of attenuated high-frequency objects and emphasized low-frequency objects while it has achieved improved removal of non-ground object at larger window sizes. Focal analysis mean filter has shown better removal of nonground objects compared to Gaussian low pass filter especially at large window sizes where details of non-ground objects almost have diminished in the DTMs from window sizes of 25 × 25 and greater. DTM slope-based filter has created bare earth models that have been full of gabs at the positions of the non-ground objects where the sizes and numbers of that gabs have increased with increasing the window sizes of filter. Those gaps have been closed through exploitation of the spline interpolation method in order to get continuous surface representing bare earth landscape. Comparative analysis has shown that the minimum elevations of the DTMs increase with increasing the filter widow sizes till 21 × 21 and 31 × 31 for the Gaussian low pass filter and the focal analysis mean filter respectively. On the other hand, the DTM slope-based filter has kept the minimum elevation of the original data, that could be due to noise in the LiDAR data unchanged. Alternatively, the three approaches have produced DTMs of decreasing maximum elevation values and consequently decreasing ranges of elevations due to increases in the filter window sizes. Moreover, the standard deviations of the created DTMs from the three filters have decreased with increasing the filter window sizes however, the decreases have been continuous and steady in the cases of the Gaussian low pass filter and the focal analysis mean filters while in the case of the DTM slope-based filter the standard deviations of the created DTMs have decreased with high rates till window size of 31 × 31 then they have kept unchanged due to more increases in the filter window sizes.
基金Supported by the National Nature Science Foundation of China(No.81273848)
文摘OBJECTIVE: To evaluate the effect of heat stimulation via scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) on the neutrophil-to-lymphocyte ratio(NLR) and quality of life in patients with non-small-cell lung cancer(NSCLC).METHODS: Seventy patients with NSCLC were randomly assigned into two groups: group A received scar-producing moxibustion at the acupoints Zusanli(ST 36) and Feishu(BL 13) every day for 6 weeks, while group B received no intervention(control group). Outcome measures were the NLR and the scores from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30). The NLR and the EORTC QLQ-C30 were assessed at baseline and at the end of 6 weeks.RESULTS: Five participants dropped out, leaving afinal total of 65 participants who completed the trial. Groups A and B had a similar mean NLR at baseline. After the treatment course, the NLR in group A was significantly lower than that in group B(P <0.001). Compared with group B, the EORTC QLQ-C30 scores in group A were significantly greater in terms of global health status or quality of life(P < 0.001) and function(P < 0.05), and significantly lower in terms of symptoms(P < 0.05).CONCLUSION: The present study suggests that performing scar-producing moxibustion by heat-stimulating the acupoints Zusanli(ST 36) and Feishu(BL13) effectively decreases the NLR and improves the quality of life in patients with NSCLC.
文摘In this paper, a new class of over-relaxed proximal point algorithms for solving nonlinear operator equations with (A,η,m)-monotonicity framework in Hilbert spaces is introduced and studied. Further, by using the generalized resolvent operator technique associated with the (A,η,m)-monotone operators, the approximation solvability of the operator equation problems and the convergence of iterative sequences generated by the algorithm are discussed. Our results improve and generalize the corresponding results in the literature.
文摘This paper presents an analysis of the effect of parasitic resistances on the performance of DC-DC Single Ended Pri- mary Inductor Converter (SEPIC) in photovoltaic maximum power point tracking (MPPT) applications. The energy storage elements incorporated in the SEPIC converter possess parasitic resistances. Although ideal components significantly simplifies model development, but neglecting the parasitic effects in models may sometimes lead to failure in predicting first scale stability and actual performance. Therefore, the effects of parasitics have been taken into consideration for improving the model accuracy, stability, robustness and dynamic performance analysis of the converter. Detail mathematical model of SEPIC converter including inductive parasitic has been developed. The performance of the converter in tracking MPP at different irradiance levels has been analyzed for variation in parasitic resistance. The converter efficiency has been found above 83% for insolation level of 600 W/m2 when the parasitic resistance in the energy storage element has been ignored. However, as the parasitic resistance of both of the inductor has increased to 1 ohm, a fraction of the power managed by the converter has dissipated;as a result the efficiency of the converter has reduced to 78% for the same insolation profile. Although the increasing value of the parasitic has assisted the converter to converge quickly to reach the maximum power point. Furthermore it has also been observed that the peak to peak load current ripple is reduced. The obtained simulation results have validated the competent of the MPPT converter model.
基金co-supported by the National Key R&D Program of China(Nos.2018YFF01012401-05)the National Natural Science Foundation of China(No.51975243)+2 种基金Jilin Provincial Department of Education(No.JJKH20180084KJ),Chinathe Fundamental Research Funds for the Central Universities and Jilin Provincial Department of Science&Technology Fund Project,China(Nos.20170101043JC and 20180520072JH)Graduate Innovation Fund of Jilin University,China(No.101832018C184).
文摘A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(FGMEE)structures.By introducing the modified Newmark method,the displacement,electrical potential and magnetic potential of the structures under transient mechanical loading were obtained.Based on G space theory and the weakened weak(W2)formulation,the equations of the multi-physics coupling problems were derived.Using triangular background elements,the free vibration and transient responses of three numerical examples were studied.Results proved that CM-NS-RPIM performed better than the standard FEM by reducing the overly-stiff of structures.Moreover,CM-NS-RPIM could reduce the number of nodes while guaranteeing the accuracy.Besides,triangular elements could be generated automatically even for complex geometries.Therefore,the effectiveness and validity of CM-NS-RPIM were demonstrated,which were valuable for the design of intelligence devices,such as energy harvesters and sensors.
基金Supported by Alliance of Cardiovascular Researchers(New Orleans,LA 70102,United States),No.2013-AH-01(to Haenel A)
文摘BACKGROUND Numerous studies investigated cell-based therapies for myocardial infarction(MI).The conflicting results of these studies have established the need for developing innovative approaches for applying cell-based therapy for MI.Experimental studies on animal models demonstrated the potential of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UAADRCs)for treating acute MI.In contrast,studies on the treatment of chronic MI(CMI;>4 wk post-MI)with UA-ADRCs have not been published so far.Among several methods for delivering cells to the myocardium,retrograde delivery into a temporarily blocked coronary vein has recently been demonstrated as an effective option.AIM To test the hypothesis that in experimentally-induced chronic myocardial infarction(CMI;>4 wk post-MI)in pigs,retrograde delivery of fresh,uncultured,unmodified,autologous adipose-derived regenerative cells(UA-ADRCs)into a temporarily blocked coronary vein improves cardiac function and structure.METHODS The left anterior descending(LAD)coronary artery of pigs was blocked for 180 min at time point T0.Then,either 18×106 UA-ADRCs prepared at“point of care”or saline as control were retrogradely delivered via an over-the-wire balloon catheter placed in the temporarily blocked LAD vein 4 wk after T0(T1).Effects of cells or saline were assessed by cardiac magnetic resonance(CMR)imaging,late gadolinium enhancement CMR imaging,and post mortem histologic analysis 10 wk after T0(T2).RESULTS Unlike the delivery of saline,delivery of UA-ADRCs demonstrated statistically significant improvements in cardiac function and structure at T2 compared to T1(all values given as mean±SE):Increased mean LVEF(UA-ADRCs group:34.3%±2.9%at T1 vs 40.4±2.6%at T2,P=0.037;saline group:37.8%±2.6%at T1 vs 36.2%±2.4%at T2,P>0.999),increased mean cardiac output(UA-ADRCs group:2.7±0.2 L/min at T1 vs 3.8±0.2 L/min at T2,P=0.002;saline group:3.4±0.3 L/min at T1 vs 3.6±0.3 L/min at T2,P=0.798),increased mean mass of the left ventricle(UA-ADRCs group:55.3±5.0 g at T1 vs 71.3±4.5 g at T2,P<0.001;saline group:63.2±3.4 g at T1 vs 68.4±4.0 g at T2,P=0.321)and reduced mean relative amount of scar volume of the left ventricular wall(UA-ADRCs group:20.9%±2.3%at T1 vs 16.6%±1.2%at T2,P=0.042;saline group:17.6%±1.4%at T1 vs 22.7%±1.8%at T2,P=0.022).CONCLUSION Retrograde cell delivery of UA-ADRCs in a porcine model for the study of CMI significantly improved myocardial function,increased myocardial mass and reduced the formation of scar tissue.
文摘From January 1993 to December 1996, we treated 482 cases of cervical spondylopathy with a combined method of point-injection and needle-warming via moxibustion. Except for the cases of sympathetic nerve type and spinal cord type, the combined method was superior to traction therapy in the control group and reported as follows.Clinical DataThe Criteria of Diagnosis and Curative Effect in TCM issued by the State Administrative Bureau of TCM and Pharmacy in 1994 was adopted for the enrollment of patients of cervical spondylopathy and the pathological typing. Only the patients who had completed the treatment and with complete records were collected for analysis.
基金sponsored by the Open Research Fund of Zhejiang First-foremost Key Subject-Acupuncture & Moxibustion,No. ZTK2010A07
文摘A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal vein before Evans blue was injected, approximately 1 hour prior to harvesting of brain tissue. Results showed that Evans blue leakage into brain tissue and serum nitric oxide synthase activity were significantly increased in model rats. Treatment with blood-letting punctures at twelve Jing-Well points of the hand and/or injection of mannitol into the caudal vein reduced the amount of Evans blue leakage into the brain tissue and serum nitric oxide synthase activity to varying degrees. There was no significant difference between single treatment and combined treatment. Experimental findings indicate that blood-letting punctures at twelve Jing-Well points of the hand can decrease blood-brain barrier permeability and serum nitric oxide synthase activity in rats following middle cerebral artery occlusion, and its effect is similar to that of mannitol injection alone and Jing-Well points plus mannitol injection.
基金funding this work through research groups program under grant number R.G.P-59/40.
文摘This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After boundary layer approximation,the governing equations are achieved(namely Maxwell,upper convected material derivative,thermal and concentration diffusions).By using the self-similarity transformations the governing PDEs are converted into nonlinear ODEs and solved by RK-4 method in combination with Newton Raphson(shooting technique).The effects of developed parameters on velocity,temperature,concentration,fraction factor,heat and mass diffusions are exemplified through graphs and tabular form and are deliberated in detail.Numerical values of fraction factor,heat and mass transfer rates with several parameters are computed and examined.It is noticed that the temperature is more impactable for higher values of radiative heat transport,thermal conductivity and viscous dissipation.The comparison data for some limiting case are acquired and are originated to be in good agreement with previously published articles.
文摘By using Leray-Schauder nonlinear alternative, Banach contraction theorem and Guo-Krasnosel’skii theorem, we discuss the existence, uniqueness and positivity of solution to the third-order multi-point nonhomogeneous boundary value problem (BVP1): where for The interesting point lies in the fact that the nonlinear term is allowed to depend on the first order derivative .
文摘Several problems arising in science and engineering are modeled by differential equations that involve conditions that are specified at more than one point. The non-linear two-point boundary value problem (TPBVP) (Bratu’s equation, Troesch’s problems) occurs engineering and science, including the modeling of chemical reactions diffusion processes and heat transfer. An analytical expression pertaining to the concentration of substrate is obtained using Homotopy perturbation method for all values of parameters. These approximate analytical results were found to be in good agreement with the simulation results.
文摘Neuritis of lateral cutaneous nerve of thigh, also called meralgia paresthetica, is a commonly encountered disease in clinical practice. The author has treated 28 cases of meralgia paresthetica since 1996 by acupuncture plus point-injection with satisfactory results. A report follows.Clinical Data Among the 28 cases, 13 were male and 15 female. Their age ranged from 24 to 72 years, most of the patients being 35 to 50 years; the duration of illness varied from one month to ten years and 6 cases were affected on left side, 8 cases on right side and 14 cases on both sides.
文摘Purpose: This study was performed to assess the utility and safety of an In-Office INR Monitoring Device and present a safe and efficient protocol for the management of patients on oral anticoagulants and/or antithrombolytics requiring routine office oral and maxillofacial surgery. Patients and Methods: Sixty-one patients requiring “minor” oral and maxillofacial surgery being treated chronically with oral anticoagulation (warfarin) were entered into the study and compared in 2 groups. The control group (n = 29) was managed by discontinuing warfarin and any anti-platelet medication(s) prior to surgery. In the study group (n = 30), the decision to continue or withhold warfarin was determined by a protocol in which patients are 1) stratified based on risk for thromboembolism, and 2) classified as requiring “major” or “minor” surgery. Procedures categorized as “minor” surgery included dental extraction(s), dental implants, soft tissue and bone biopsies, and preprosthetic bone surgery, and incision and drainage. Warfarin and antiplatelet medication were not withheld in these patients, and a Point-of-Care In-Office INR Monitoring Device was used to obtain INR levels on the day of consultation and surgery. Local measures including removal of granulation tissue, packing, suturing, etc. were utilized for hemostasis. Results: The 30 patients in the study group maintained on warfarin readily achieved hemostasis using intraoperative local measures. The mean INR measured by the In-Office INR Monitoring Device was 2.36 with a range from 1.3 to 3.2. Study group patients underwent a total of 131 separate procedures including 108 dental extractions (impactions), placement of dental implants, preprosthetic bony surgery, bone cyst removal, soft tissue biopsies, facial skin cancer repair, and incision and drainage. One patient (3%) required “minor” intervention with removal of a “liver clot” on postop day 2 with repacking and suturing. The 29 patients in the control group discontinued off of war farin underwent a total of 99 procedures. One patient (3%) also required a “minor” intervention (repacking of extraction site). There were no “major” complications in either group. Conclusions: This study supports previous studies that minor oral surgery procedures can be safely performed while maintaining patients on warfarin minimizing the risk of a potentially devastating thromboembolic event. When deciding whether or not to withhold warfarin, this study supports the use of the proposed protocol based on 1) risk stratification for thromboembolism, 2) the need for “minor” versus “major” surgery, 3) and utilization of an In-Office INR Monitoring Device. An In-Office Point-of-Care INR measuring device can be a very effective tool to safely simplify and make the perioperative management of the anticoagulated patient more efficient for the patient and oral and maxillo facial surgeon.
文摘A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy speech is established. Then the likelihood ratio test based on binary hypothesis test is carried out. The decision criterion of conventional maximum a posterior incorporating the inter-frame correlation leads to two separate thresholds. Speech endpoint detection decision is finally made depend on the previous frame and the observed spectrum, and the speech endpoint is searched based on the decision. Compared with the typical algorithms, the proposed method operates robust in the airplane cockpit voice background.
文摘There has been protracted historical evidence of a relative paucity in the distribution frequency of global earthquakes within the M = 3.5 to 4.0 range. We observed a similar phenomenon for all recently recorded earthquakes from January 2009 through August 2013. Frequency distributions with increments of M = 0.1 verified the trough of the diminished incidence to be between M = 3.6 and 3.7 with an abrupt increase between M = 3.9 and 4.0. The calculated equivalent photon wavelength for the energies associated with M = 3.6 approaches Planck’s Length while the related time increment is the cutoff frequency for the Zero Point Fluctuation force coupled to gravity. The conspicuous congruence between Planck’s time and length and the lower than expected frequency based upon Gaussian assumptions of distribution for the discrete band of energy associated with this magnitude range of earthquakes suggests a conduit may exist between intrinsic features of Planck space-time and geophysical processes. The existence of such a connection would encourage alternative explanations for sun-seismic activities as due to solar instabilities. Instead, it may reflect influence upon both from alterations in the structure of space being traversed by the solar system as it moves through the galaxy.
文摘With injection of Injectio Radici Astragli into the point Zusanli (ST 36), we have obtained quite satisfactory therapeutic results for treating leukopenia and the impairment in immune functions occurred in cancer chemotherapy. A report follows.
