Geomorphic dynamics of alluvial rivers in response to upstream damming have substantial impacts on navigation, habitat protection, and channel stability. The purpose of this study was to determine how flow and sedimen...Geomorphic dynamics of alluvial rivers in response to upstream damming have substantial impacts on navigation, habitat protection, and channel stability. The purpose of this study was to determine how flow and sediment regimes, and meander characteristics affect the morphological adjustment of bends in the Lower Jingjiang Reach(LJR) before and after the Three Gorges Project(TGP). Based on detailed field measurements and hydrological and topographic datasets from 1991 to 2016, banks and point bars morphodynamics of 12continuous bends in the LJR were comprehensively analyzed. Point bars in the LJR mainly experienced a net deposition before the TGP operation, but substantially deteriorated with a net erosion rate of 4.6 million m^(3) yr^(-1) in the post-TGP periods(2003–2016), and erosion on heads and upstream margins of point bars was a general adjustment pattern in the 12 bends.The most significant morphological changes of point bars and banks occurred in 2006–2011,indicating a delayed response of the channel evolution of the LJR to damming. Detailed observations suggested that the medium discharges(16,000–18,000 m^(3) s^(-1)) were the most contributive discharges in shaping the morphology of point bars and banks in the LJR after damming. In addition, we revealed the importance of sediment supply on meander deformation of the LJR, driven by sediment exchange over point bars, and more upstream planform deformation tended to occur in bends with high sinuosity(>2.0) in the LJR after damming.The relationship between meander deformation and sinuosity was manifested through the geometric adjustment range of point bars. The morphological adjustments of point bars in the highly curved or compound bends of the LJR were more conducive to cause flow deflections,leading to form concave-bank bars after the TGP operation.展开更多
Point bars are well developed on the Yellow River delta, an~ which theShengli I point bar is the most typical. The point bar, being about 4 km in length and several tensto more than 100 meters in width, is located on ...Point bars are well developed on the Yellow River delta, an~ which theShengli I point bar is the most typical. The point bar, being about 4 km in length and several tensto more than 100 meters in width, is located on the south side of the Shengli Bridge in KenliCounty, Dongying, Shandong. It is a typical fine-grained point bar with silt, which is predominant,some clay and minor plant debris and clay boulders. The Shengli I Point bar has complicated 3-Dstructures. Firstly, in a plane view, it comprises mainly eight sedimentary units, bar edge, baredge, bar platform, bar plain, bar channel, bar gully, bar pond and bar bay, developing side by sideand superimposed one by one m a complex way. Secondly, its vertical structures are very complex dueto the partial superimposition of the 8 sedimentary units. Besides hydatogenesis, very intensivewind erosion, eolian, ice and meltwater actions are also visible on the Shengli I point bar. Thecomplex form is made even more complicated because of the above co-actions.展开更多
In order to solve dynamic Problems caused by the internal structure of fluvial reservoir,it is necessa-ry to study the fine anatomy of Point bar. Taking Minghuazhen Formation in the northern block of Q oilfield, Bohai...In order to solve dynamic Problems caused by the internal structure of fluvial reservoir,it is necessa-ry to study the fine anatomy of Point bar. Taking Minghuazhen Formation in the northern block of Q oilfield, Bohai Sea as an examPle,the authors studied identification marks,distribution Pattern and scale of Point bar based on coring,logging and dynamic data. The results show that the length of Point bar and the width of lateral accretion body are 713-911 m and 71-111m,resPectively;the diP angle and the thickness of lateral accretion bedding are 3. 5o-5. 9o and 0. 1-0. 5 m. The lateral accretion beddings are the key factor affecting the seePage velocity of the tracer.展开更多
Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such...Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.展开更多
In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted...In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted under his guidance,alongside customer practices and reflections on various scientific literature both domestically and internationally,it is posited that,as articulated in the monograph,misconceptions regarding his theory and technology in Western scientific literature prior to 1985 continue to persist.This ongoing dissemination of misunderstandings has resulted in a near stagnation of research and has adversely impacted the Chinese academic community as well.Consequently,it is essential to delineate the characteristics and main points of its theory and technology,with the aim of offering guidance to individuals seeking to comprehend its foundational purpose.LP technology is a dynamic physical technology that continuously and uninterruptedly extracts air from a closed container and simultaneously introduces fresh,low-pressure moist air from the external environment,while maintaining specific levels of humidity and/or temperature within the container and upholding a predetermined pressure value.Preservation technology is the collective term for the set of various technical parameters associated with preservation,including pressure,relative humidity,and other relevant factors,to which LP equipment is specifically designed.The theory of LP is characterized by the enhanced diffusion of gases and vapors that enter and exit the commodity in a dynamic manner under low pressure conditions.The theoretical points involve equipment performance,low pressure,the impact of trace concentrations of gases such as O_(2),CO_(2) and C_(2)H_(4) that naturally occur at low pressure,diffusive mass transfer,heat transfer,and impacts on the activity of enzymes associated with maturation and senescence.The technology is characterized by dynamic low pressure,and the range of commodities preserved is comparable to that of refrigeration.However,certain commodities exiting the hypobaric environment possess subsequent preservation advantages that are not available through refrigeration.The main points of the technology encompass an extended sotrage life,a postponement of quality degradation,minimized water loss,the suppression of pathogen growth,and the killing of both internal and external insects of the commodity under dynamic low pressure conditions.The core advantage of LP technology lies in its ability to significantly reduce water loss,inhibit respiration and C_(2)H_(4) action,and pathogen growth,killing insects and modulate the activity of enzymes associated with maturation and senescence in post-harvest fresh horticultural products.Consequently,this technology plays a crucial role in prolonging the post-harvest lifespan of these commodities and mitigating quality degradation.Over the past decade,researchers in China have developed a hypobaric short period treatment technology,grounded in LP theory and technical practice,which is commonly referred to as hypobaric treatment.This method has garnered significant attention,leading to an increase in both domestic and international research.A growing body of literature categorizes LP as hypobaric treatment,while some studies also consider vacuum packaging and modified atmosphere packaging(MAP)as LP or hypobaric treatment.Misunderstandings are exacerbated by confusion surrounding nomenclature,which,in conjunction with pre-existing misconceptions,represents a significant barrier to both the research and practical application of the technology.The successful commercial implementation of a vacuum cold fresh chain,centered on LP or hypobaric treatment technology,may be the sole solution to the prevailing misunderstandings associated with LP.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
Precipitation samples collected at Point Barrow, Alaska in the August and September of 1994 was analyzed for pH, conductivity and all major ions. A mean pH value of 5.53 was gained, and the samples' conductiv...Precipitation samples collected at Point Barrow, Alaska in the August and September of 1994 was analyzed for pH, conductivity and all major ions. A mean pH value of 5.53 was gained, and the samples' conductivity showed no linear correlation with its acidity, which did not agree to the similar work results on the Qinghai Tibet Plateau. Cl - and Na + were found to originate mainly with seasalt. The concentrations of SO 2- 4 varied from event to event. But the exSO 2- 4 concentrations remained small, which indicated less anthropogenic effect on the environment at the site.展开更多
OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intens...OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intensity as indices.METHODS:We randomly divided 64 patients into a treatment group(32 cases) and a control group(32 cases).Two drop-outs occurred in each group.Patients in the treatment group received tender point deep tissue massage plus lumbar traction and patients in the control group received lumbar traction,alone.We used a tissue hardness meter/algometer and visual analog scale(VAS) to assess the pressure pain threshold,muscle hardness and pain intensity.RESULTS:Following treatment,we obtained the following results in the treatment and control groups,respectively:the pressure pain threshold difference was 1.5±0.8 and 1.1±0.7;the muscle hardness difference was 4.2±1.6 and 3.5±1.3;and the VAS score difference was 1.9±0.9 and 1.4±0.8.Compared to the control group,the treatment group had higher pressure pain threshold(t=2.09,P<0.05),and lower muscle hardness(t=2.05,P<0.05) and pain intensity(t=2.46,P<0.05).CONCLUSION:Lumbar tender point deep tissue massage combined with lumbar traction produced better improvement in pressure pain threshold,muscle hardness and pain intensity in patients with chronic non-specific low back pain than with lumbar traction alone.展开更多
BACKGROUND：It has been shown that interleukin-1 （IL-1） may cause inflammatory reactions, which stimulate the nerve root of patients with lumbar intervertebral disc protrusion and leads to pain. Whether the clinical...BACKGROUND：It has been shown that interleukin-1 （IL-1） may cause inflammatory reactions, which stimulate the nerve root of patients with lumbar intervertebral disc protrusion and leads to pain. Whether the clinical curative effects of acupuncture in the treatment of lumbar and leg pain are linked to an inhibition of local IL-1 secretion is unknown. OBJECTIVE： To assess the influence of acupuncture on IL-1, this study was designed to verify the effects of acupuncture at the ＂Huatuojiaji （Extra）＂ point on the nerve root in a rat model of lumbar nerve root compression, compared with administration of meloxicam, a non-steroidal anti-inflammatory drug. DESIGN, TIME AND SETTING： Randomized, controlled, molecular biology experiment, performed at the Experimental Center, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University between September 2005 and April 2006. MATERIALS： Forty healthy adult Sprague Dawley rats of either gender were included in this study. The rats were randomly and evenly divided into the following four groups： normal control, model, acupuncture and meloxicam groups. Lumbar nerve root compression was induced in rats in the model, acupuncture, and meloxicam groups by inserting a specially made silicon rubber slice at the juncture of the L5 nerve root and the dural sac. The acupuncture needle （pattern number N3030, 30#, 1.5 inch） was purchased from Suzhou Medical Appliance Factory, China. IL-1 enzyme linked immunosorbent assay （ELISA） kit was purchased from Santa Cruz Biotechnology, Inc., USA. METHODS： The acupuncture group was acupunctured at the ＂Huatuojiaji＂ point, which is lateral to the compressed L5-6 nerve root, with an acupuncture depth of 0.5 cm. There were two treatment courses, each of involved seven 20-minute acupuncture sessions, one session a day. The meloxicam group was administered intragastrically 3.75 mg/kg meloxicam （5 mg meloxicam /10 mL physiological saline）. Rats in the normal control group and model group received an intragastric administration of 10 mL/kg physiological saline. All administrations were performed once a day. MAIN OUTCOME MEASURES： At day 14 post-surgery, the IL-1 level in the compressed nerve root was determined by a streptavidin-peroxidase （S-P） immunohistochemical method, and IL-1β mRNA expression in the compressed nerve root was simultaneously detected by real-time reverse transcription-polymerase chain reaction. RESULTS： The expression levels of IL-1 and IL-1β mRNA in the L5 nerve root were significantly higher in the model group than in the control group （P 〈 0.01）. However, the expression levels of IL-1 and IL-1β mRNA were significantly lower in the acupuncture and meloxicam groups than in the model group （P 〈 0.05–0.01）. Expression levels of IL-1 and IL-1β mRNA were significantly higher in the acupuncture group than in the meloxicam group （P 〈 0.01）. CONCLUSION： Acupuncture at the ＂Huatuojiaji＂ point decreases the IL-1 level by inhibiting IL-1β mRNA expression to a greater extent than meloxicam administration.展开更多
Grain kernel discoloration(KD)in cereal crops leads to down-grading grain quality and substantial economic losses worldwide.Breeding KD tolerant varieties requires a clear understanding of the genetic basis underlying...Grain kernel discoloration(KD)in cereal crops leads to down-grading grain quality and substantial economic losses worldwide.Breeding KD tolerant varieties requires a clear understanding of the genetic basis underlying this trait.Here,we generated a high-density single nucleotide polymorphisms(SNPs)map for a diverse barley germplasm and collected trait data from two independent field trials for five KD related traits:grain brightness(TL),redness(Ta),yellowness(Tb),black point impact(Tbpi),and total black point in percentage(Tbpt).Although grain brightness and black point is genetically correlated,the grain brightness traits(TL,Ta,and Tb)have significantly higher heritability than that of the black point traits(Tbpt and Tbpi),suggesting black point traits may be more susceptible to environmental influence.Using genome-wide association studies(GWAS),we identified a total of 37 quantitative trait loci(QTL),including two major QTL hotspots on chromosomes 4H and 7H,respectively.The two QTL hotspots are associated with all five KD traits.Further genetic linkage and gene transcription analyses identified candidate genes for the grain KD,including several genes in the flavonoid pathway and plant peroxidase.Our study provides valuable insights into the genetic basis for the grain KD in barley and would greatly facilitate future breeding programs for improving grain KD resistance.展开更多
Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and west...Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and western medication.Methods:A total of 210 patients with intractable lumbodynia after lumbar disc herniation were randomly divided into pestle needle group,electroacupuncture group and western medication group,with 70 cases in each group.The pestle needle group was treated with pestle needle poking Yāoyángguān-Bāzhèn(GV3-Bāzhèn)points.The electroacupuncture group was treated with conventional electroacupuncture,and the western medication group was treated with oral diclofenac sodium dual release enteric-coated capsules(Difene).The pestle needle group and the electroacupuncture group were treated once a day,and there was 1 day of rest after 6 days of treatment,and a course of treatment included 7 days,and a total of 3 courses of treatment were performed.The western medication group took 1 Difene capsule(75 mg)at a time,with once a day continuing for 21 days.Visual Analog Scale(VAS),Pain Rating Index(PRI)and Present Pain Intensity(PPI)were used to observe the improvement of pain before and after treatment,and the waist muscle tone was examined and the clinical efficacy was observed.Results:The post-treatment VAS,PRI,and PPI scores of the three groups were all lower than pretreatment,and the differences were statistically significant(all P<0.05).There were no statistically significant differences in VAS,PRI and PPI scores between pestle needle group and western medication group(all P>0.05).Meanwhile,they were all lower than the electroacupuncture group,and the differences were statistically significant(both P<0.05).After treatment,the waist muscle tone of the three groups was higher than that pre-treatment,and the differences were statistically significant(all P<0.05).After treatment,the waist muscle tone of the pestle needle group was higher than the electroacupuncture group,and the electroacupuncture group was higher than the western medication group,and the differences were statistically significant(both P<0.05).The total effective rate was 88.57%in the pestle needle group,80%in the electroacupuncture group,and 77.14%in the western medication group,and there were no statistically significant differences among the groups(P>0.05).Conclusions:Pestle needle poking GV3-Bāzhèn points can effectively relieve intractable lumbodynia after lumbar disc herniation surgery,decrease VAS,PRI,PPI scores and relieve waist muscle tone,and the effect was remarkable.展开更多
In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the f...In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the following.展开更多
Single cell trapping in vitro by microfluidic device is an emerging approach for the study of the relationship between single cells and their dynamic biochemical microenvironments. In this paper, a hydrodynamic-based ...Single cell trapping in vitro by microfluidic device is an emerging approach for the study of the relationship between single cells and their dynamic biochemical microenvironments. In this paper, a hydrodynamic-based microfluidic device for single cell trapping is designed using a combination of stagnation point flow and physical barrier.The microfluidic device overcomes the weakness of the traditional ones, which have been only based upon either stagnation point flows or physical barriers, and can conveniently load dynamic biochemical signals to the trapped cell. In addition, it can connect with a programmable syringe pump and a microscope to constitute an integrated experimental system.It is experimentally verified that the microfluidic system can trap single cells in vitro even under flow disturbance and conveniently load biochemical signals to the trapped cell. The designed micro-device would provide a simple yet effective experimental platform for further study of the interactions between single cells and their microenvironments.展开更多
A new algorithm called homotopy iteration method based on the homotopy function is studied and improved. By the improved homotopy iteration method, Polynomial systems with high Order and deficient can be solved fast a...A new algorithm called homotopy iteration method based on the homotopy function is studied and improved. By the improved homotopy iteration method, Polynomial systems with high Order and deficient can be solved fast and efficiently comparing to the original homotopy iteration method. Numerical examples for the ninepoint path synthesis of four-bar linkages show the advantages and efficiency of the improved homotopy iteration method.展开更多
Following votes by the Barremian Working Group,the International Subcommission on Cretaceous Stratigraphy and the International Commission on Stratigraphy,the Executive Committee of the International Union of Geologic...Following votes by the Barremian Working Group,the International Subcommission on Cretaceous Stratigraphy and the International Commission on Stratigraphy,the Executive Committee of the International Union of Geological Sciences unanimously approved in March 2023 the Global Stratotype Section and Point(GSSP)for the Barremian Stage(Lower Cretaceous).The base of the Barremian Stage is defined at the base of bed 171 of the Río Argos section,near Caravaca(SE Spain)and correlated by the first appearance of the ammonite species Taveraidiscus hugii.This event falls within the NC5C calcareous nannofossil Subzone,the Lilliputianella semielongata planktonic foraminiferal Zone,and the Dorothia ouachensis benthic foraminiferal Zone.It roughly coincides with the beginning of a slightly negative trend interval in theδ^(13)C curve.Indirect calibration to the magnetostratigraphic scale suggests that the boundary falls in the lowermost part of polarity chron M3r.According to the astrochronological analysis,a time interval of 0.74 myr separates the beginning of the late Hauterivian Faraoni Episode from the base of the Barremian,which is dated at 125.77 MA.展开更多
In order to advance the understanding of the impact dynamics of granular flow in complex geological settings,this paper studied the impact dynamics of granular flow on rigid barriers with a number of Material Point Me...In order to advance the understanding of the impact dynamics of granular flow in complex geological settings,this paper studied the impact dynamics of granular flow on rigid barriers with a number of Material Point Method(MPM)numerical tests.The impact behavior of granular flow on a rigid barrier was characterized by the initial dynamic impact stage,dynamic surge impact stage,compression impact stage and static stage of granular flow,where the impact force of granular flow was comprised of the dynamic and static forces of granular flow.The impact behavior of granular flow on a rigid barrier was characterized by the states of the fast or slow impact behavior of granular flow.The angle of slope and aspect ratio of granular soil greatly affected the impact behavior of granular flow on a column rigid barrier,where a power model was proposed to quantify the residual(Fnr)-over-maximum(Fnmax)normal impact force ratio of granular flow Fnr⁄Fnmax incorporating the effects of the angle of slope and aspect ratio of granular soil.With the increase of the column rigid barrier up to the semi-infinite column rigid barrier,the impact dynamics of granular flow gradually increased up to a maximum by progressively transforming the overflow into the dynamic surge impact of the incoming flow on the rigid barrier to capture more granular soil of granular flow against the rigid barrier.Presence of water in granular flow,i.e.,a mixture of solid and liquid in granular flow,yielded a dynamic coupling contribution of the solid and liquid,being accompanied by the whole dynamic process of granular flow,on the impact behavior of granular flow on a rigid barrier,where the liquid-phase material of granular flow,i.e.,the water,was predominant to contribute on the normal impact force of granular flow in comparison with the solid-phase material of granular flow.In addition,other factors,e.g.,the shape of rigid barrier(i.e.,the column barrier,arch barrier and circle barrier),and the gravity(i.e.,in the gravitational environment of the Moon,Earth and Mars),greatly affected the impact behavior of granular flow on a rigid barrier as well.展开更多
32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acu...32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acupuncture as the controls. The resultsshowed that treatment by electroacupuncture at Huatuojiaji points was superior inanalgesic effect and clinical total effective rate to that by conventional acupuncture. It isconsidered that the mechanism of treatment by electroacupuncture at Huatuojiaji pointsis related to the trunk of posterior ramus of the spinal nerve where the points are located.展开更多
By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we...By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.展开更多
基金Key Program of National Natural Science Foundation of China,No.U2040219National Natural Science Foundation of China,No.51579015Program of National Key Research and Development Plan of China,No.2016YFC0402108, No.2016YFC0402103。
文摘Geomorphic dynamics of alluvial rivers in response to upstream damming have substantial impacts on navigation, habitat protection, and channel stability. The purpose of this study was to determine how flow and sediment regimes, and meander characteristics affect the morphological adjustment of bends in the Lower Jingjiang Reach(LJR) before and after the Three Gorges Project(TGP). Based on detailed field measurements and hydrological and topographic datasets from 1991 to 2016, banks and point bars morphodynamics of 12continuous bends in the LJR were comprehensively analyzed. Point bars in the LJR mainly experienced a net deposition before the TGP operation, but substantially deteriorated with a net erosion rate of 4.6 million m^(3) yr^(-1) in the post-TGP periods(2003–2016), and erosion on heads and upstream margins of point bars was a general adjustment pattern in the 12 bends.The most significant morphological changes of point bars and banks occurred in 2006–2011,indicating a delayed response of the channel evolution of the LJR to damming. Detailed observations suggested that the medium discharges(16,000–18,000 m^(3) s^(-1)) were the most contributive discharges in shaping the morphology of point bars and banks in the LJR after damming. In addition, we revealed the importance of sediment supply on meander deformation of the LJR, driven by sediment exchange over point bars, and more upstream planform deformation tended to occur in bends with high sinuosity(>2.0) in the LJR after damming.The relationship between meander deformation and sinuosity was manifested through the geometric adjustment range of point bars. The morphological adjustments of point bars in the highly curved or compound bends of the LJR were more conducive to cause flow deflections,leading to form concave-bank bars after the TGP operation.
文摘Point bars are well developed on the Yellow River delta, an~ which theShengli I point bar is the most typical. The point bar, being about 4 km in length and several tensto more than 100 meters in width, is located on the south side of the Shengli Bridge in KenliCounty, Dongying, Shandong. It is a typical fine-grained point bar with silt, which is predominant,some clay and minor plant debris and clay boulders. The Shengli I Point bar has complicated 3-Dstructures. Firstly, in a plane view, it comprises mainly eight sedimentary units, bar edge, baredge, bar platform, bar plain, bar channel, bar gully, bar pond and bar bay, developing side by sideand superimposed one by one m a complex way. Secondly, its vertical structures are very complex dueto the partial superimposition of the 8 sedimentary units. Besides hydatogenesis, very intensivewind erosion, eolian, ice and meltwater actions are also visible on the Shengli I point bar. Thecomplex form is made even more complicated because of the above co-actions.
基金Supported by Project of Fine Reservoir Description Technology of Heavy Oil Reservoir(No.1507)
文摘In order to solve dynamic Problems caused by the internal structure of fluvial reservoir,it is necessa-ry to study the fine anatomy of Point bar. Taking Minghuazhen Formation in the northern block of Q oilfield, Bohai Sea as an examPle,the authors studied identification marks,distribution Pattern and scale of Point bar based on coring,logging and dynamic data. The results show that the length of Point bar and the width of lateral accretion body are 713-911 m and 71-111m,resPectively;the diP angle and the thickness of lateral accretion bedding are 3. 5o-5. 9o and 0. 1-0. 5 m. The lateral accretion beddings are the key factor affecting the seePage velocity of the tracer.
文摘Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.
文摘In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted under his guidance,alongside customer practices and reflections on various scientific literature both domestically and internationally,it is posited that,as articulated in the monograph,misconceptions regarding his theory and technology in Western scientific literature prior to 1985 continue to persist.This ongoing dissemination of misunderstandings has resulted in a near stagnation of research and has adversely impacted the Chinese academic community as well.Consequently,it is essential to delineate the characteristics and main points of its theory and technology,with the aim of offering guidance to individuals seeking to comprehend its foundational purpose.LP technology is a dynamic physical technology that continuously and uninterruptedly extracts air from a closed container and simultaneously introduces fresh,low-pressure moist air from the external environment,while maintaining specific levels of humidity and/or temperature within the container and upholding a predetermined pressure value.Preservation technology is the collective term for the set of various technical parameters associated with preservation,including pressure,relative humidity,and other relevant factors,to which LP equipment is specifically designed.The theory of LP is characterized by the enhanced diffusion of gases and vapors that enter and exit the commodity in a dynamic manner under low pressure conditions.The theoretical points involve equipment performance,low pressure,the impact of trace concentrations of gases such as O_(2),CO_(2) and C_(2)H_(4) that naturally occur at low pressure,diffusive mass transfer,heat transfer,and impacts on the activity of enzymes associated with maturation and senescence.The technology is characterized by dynamic low pressure,and the range of commodities preserved is comparable to that of refrigeration.However,certain commodities exiting the hypobaric environment possess subsequent preservation advantages that are not available through refrigeration.The main points of the technology encompass an extended sotrage life,a postponement of quality degradation,minimized water loss,the suppression of pathogen growth,and the killing of both internal and external insects of the commodity under dynamic low pressure conditions.The core advantage of LP technology lies in its ability to significantly reduce water loss,inhibit respiration and C_(2)H_(4) action,and pathogen growth,killing insects and modulate the activity of enzymes associated with maturation and senescence in post-harvest fresh horticultural products.Consequently,this technology plays a crucial role in prolonging the post-harvest lifespan of these commodities and mitigating quality degradation.Over the past decade,researchers in China have developed a hypobaric short period treatment technology,grounded in LP theory and technical practice,which is commonly referred to as hypobaric treatment.This method has garnered significant attention,leading to an increase in both domestic and international research.A growing body of literature categorizes LP as hypobaric treatment,while some studies also consider vacuum packaging and modified atmosphere packaging(MAP)as LP or hypobaric treatment.Misunderstandings are exacerbated by confusion surrounding nomenclature,which,in conjunction with pre-existing misconceptions,represents a significant barrier to both the research and practical application of the technology.The successful commercial implementation of a vacuum cold fresh chain,centered on LP or hypobaric treatment technology,may be the sole solution to the prevailing misunderstandings associated with LP.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
文摘Precipitation samples collected at Point Barrow, Alaska in the August and September of 1994 was analyzed for pH, conductivity and all major ions. A mean pH value of 5.53 was gained, and the samples' conductivity showed no linear correlation with its acidity, which did not agree to the similar work results on the Qinghai Tibet Plateau. Cl - and Na + were found to originate mainly with seasalt. The concentrations of SO 2- 4 varied from event to event. But the exSO 2- 4 concentrations remained small, which indicated less anthropogenic effect on the environment at the site.
基金Supported by the Olympic Games scientific research project of the General Administration of Sport of China No.2011A020the National Natural Science Foundation of China(No.61172007/F010810)
文摘OBJECTIVE:To observe the therapeutic effect of lumbar tender point deep tissue massage plus lumbar traction on chronic non-specific low back pain using change in pressure pain threshold,muscle hardness and pain intensity as indices.METHODS:We randomly divided 64 patients into a treatment group(32 cases) and a control group(32 cases).Two drop-outs occurred in each group.Patients in the treatment group received tender point deep tissue massage plus lumbar traction and patients in the control group received lumbar traction,alone.We used a tissue hardness meter/algometer and visual analog scale(VAS) to assess the pressure pain threshold,muscle hardness and pain intensity.RESULTS:Following treatment,we obtained the following results in the treatment and control groups,respectively:the pressure pain threshold difference was 1.5±0.8 and 1.1±0.7;the muscle hardness difference was 4.2±1.6 and 3.5±1.3;and the VAS score difference was 1.9±0.9 and 1.4±0.8.Compared to the control group,the treatment group had higher pressure pain threshold(t=2.09,P<0.05),and lower muscle hardness(t=2.05,P<0.05) and pain intensity(t=2.46,P<0.05).CONCLUSION:Lumbar tender point deep tissue massage combined with lumbar traction produced better improvement in pressure pain threshold,muscle hardness and pain intensity in patients with chronic non-specific low back pain than with lumbar traction alone.
文摘BACKGROUND：It has been shown that interleukin-1 （IL-1） may cause inflammatory reactions, which stimulate the nerve root of patients with lumbar intervertebral disc protrusion and leads to pain. Whether the clinical curative effects of acupuncture in the treatment of lumbar and leg pain are linked to an inhibition of local IL-1 secretion is unknown. OBJECTIVE： To assess the influence of acupuncture on IL-1, this study was designed to verify the effects of acupuncture at the ＂Huatuojiaji （Extra）＂ point on the nerve root in a rat model of lumbar nerve root compression, compared with administration of meloxicam, a non-steroidal anti-inflammatory drug. DESIGN, TIME AND SETTING： Randomized, controlled, molecular biology experiment, performed at the Experimental Center, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University between September 2005 and April 2006. MATERIALS： Forty healthy adult Sprague Dawley rats of either gender were included in this study. The rats were randomly and evenly divided into the following four groups： normal control, model, acupuncture and meloxicam groups. Lumbar nerve root compression was induced in rats in the model, acupuncture, and meloxicam groups by inserting a specially made silicon rubber slice at the juncture of the L5 nerve root and the dural sac. The acupuncture needle （pattern number N3030, 30#, 1.5 inch） was purchased from Suzhou Medical Appliance Factory, China. IL-1 enzyme linked immunosorbent assay （ELISA） kit was purchased from Santa Cruz Biotechnology, Inc., USA. METHODS： The acupuncture group was acupunctured at the ＂Huatuojiaji＂ point, which is lateral to the compressed L5-6 nerve root, with an acupuncture depth of 0.5 cm. There were two treatment courses, each of involved seven 20-minute acupuncture sessions, one session a day. The meloxicam group was administered intragastrically 3.75 mg/kg meloxicam （5 mg meloxicam /10 mL physiological saline）. Rats in the normal control group and model group received an intragastric administration of 10 mL/kg physiological saline. All administrations were performed once a day. MAIN OUTCOME MEASURES： At day 14 post-surgery, the IL-1 level in the compressed nerve root was determined by a streptavidin-peroxidase （S-P） immunohistochemical method, and IL-1β mRNA expression in the compressed nerve root was simultaneously detected by real-time reverse transcription-polymerase chain reaction. RESULTS： The expression levels of IL-1 and IL-1β mRNA in the L5 nerve root were significantly higher in the model group than in the control group （P 〈 0.01）. However, the expression levels of IL-1 and IL-1β mRNA were significantly lower in the acupuncture and meloxicam groups than in the model group （P 〈 0.05–0.01）. Expression levels of IL-1 and IL-1β mRNA were significantly higher in the acupuncture group than in the meloxicam group （P 〈 0.01）. CONCLUSION： Acupuncture at the ＂Huatuojiaji＂ point decreases the IL-1 level by inhibiting IL-1β mRNA expression to a greater extent than meloxicam administration.
基金supported by the Australian Grain Research and Development Corporation(UMU00047)。
文摘Grain kernel discoloration(KD)in cereal crops leads to down-grading grain quality and substantial economic losses worldwide.Breeding KD tolerant varieties requires a clear understanding of the genetic basis underlying this trait.Here,we generated a high-density single nucleotide polymorphisms(SNPs)map for a diverse barley germplasm and collected trait data from two independent field trials for five KD related traits:grain brightness(TL),redness(Ta),yellowness(Tb),black point impact(Tbpi),and total black point in percentage(Tbpt).Although grain brightness and black point is genetically correlated,the grain brightness traits(TL,Ta,and Tb)have significantly higher heritability than that of the black point traits(Tbpt and Tbpi),suggesting black point traits may be more susceptible to environmental influence.Using genome-wide association studies(GWAS),we identified a total of 37 quantitative trait loci(QTL),including two major QTL hotspots on chromosomes 4H and 7H,respectively.The two QTL hotspots are associated with all five KD traits.Further genetic linkage and gene transcription analyses identified candidate genes for the grain KD,including several genes in the flavonoid pathway and plant peroxidase.Our study provides valuable insights into the genetic basis for the grain KD in barley and would greatly facilitate future breeding programs for improving grain KD resistance.
基金Supported by Plan of Shanghai Commission of Science and Technology: No. 18401902400)Special Disease Construction Project of Shanghai Traditional Chinese Medicine: No. ZY(20182020)- FWTX-4020Characteristic Diagnosis and Treatment Technology Upgrade Project of TCM:No. ZY(2018-2020)-ZYJS-01
文摘Objective:To observe the differences of clinical efficacy of intractable lumbodynia after lumbar disc herniation surgery treated by pestle needling at Yāoyángguān Bāzhèn points,electroacupuncture and western medication.Methods:A total of 210 patients with intractable lumbodynia after lumbar disc herniation were randomly divided into pestle needle group,electroacupuncture group and western medication group,with 70 cases in each group.The pestle needle group was treated with pestle needle poking Yāoyángguān-Bāzhèn(GV3-Bāzhèn)points.The electroacupuncture group was treated with conventional electroacupuncture,and the western medication group was treated with oral diclofenac sodium dual release enteric-coated capsules(Difene).The pestle needle group and the electroacupuncture group were treated once a day,and there was 1 day of rest after 6 days of treatment,and a course of treatment included 7 days,and a total of 3 courses of treatment were performed.The western medication group took 1 Difene capsule(75 mg)at a time,with once a day continuing for 21 days.Visual Analog Scale(VAS),Pain Rating Index(PRI)and Present Pain Intensity(PPI)were used to observe the improvement of pain before and after treatment,and the waist muscle tone was examined and the clinical efficacy was observed.Results:The post-treatment VAS,PRI,and PPI scores of the three groups were all lower than pretreatment,and the differences were statistically significant(all P<0.05).There were no statistically significant differences in VAS,PRI and PPI scores between pestle needle group and western medication group(all P>0.05).Meanwhile,they were all lower than the electroacupuncture group,and the differences were statistically significant(both P<0.05).After treatment,the waist muscle tone of the three groups was higher than that pre-treatment,and the differences were statistically significant(all P<0.05).After treatment,the waist muscle tone of the pestle needle group was higher than the electroacupuncture group,and the electroacupuncture group was higher than the western medication group,and the differences were statistically significant(both P<0.05).The total effective rate was 88.57%in the pestle needle group,80%in the electroacupuncture group,and 77.14%in the western medication group,and there were no statistically significant differences among the groups(P>0.05).Conclusions:Pestle needle poking GV3-Bāzhèn points can effectively relieve intractable lumbodynia after lumbar disc herniation surgery,decrease VAS,PRI,PPI scores and relieve waist muscle tone,and the effect was remarkable.
文摘In recent years, the authors have treated 30 cases of acute lumbar sprain by acupuncture combined with point medicinal injection at Tianzhu (BL 10), and obtained quite good therapeutic results, as is reported in the following.
基金supported by the National Natural Science Foundation of China (Grants 11172060 and 31370948)
文摘Single cell trapping in vitro by microfluidic device is an emerging approach for the study of the relationship between single cells and their dynamic biochemical microenvironments. In this paper, a hydrodynamic-based microfluidic device for single cell trapping is designed using a combination of stagnation point flow and physical barrier.The microfluidic device overcomes the weakness of the traditional ones, which have been only based upon either stagnation point flows or physical barriers, and can conveniently load dynamic biochemical signals to the trapped cell. In addition, it can connect with a programmable syringe pump and a microscope to constitute an integrated experimental system.It is experimentally verified that the microfluidic system can trap single cells in vitro even under flow disturbance and conveniently load biochemical signals to the trapped cell. The designed micro-device would provide a simple yet effective experimental platform for further study of the interactions between single cells and their microenvironments.
文摘A new algorithm called homotopy iteration method based on the homotopy function is studied and improved. By the improved homotopy iteration method, Polynomial systems with high Order and deficient can be solved fast and efficiently comparing to the original homotopy iteration method. Numerical examples for the ninepoint path synthesis of four-bar linkages show the advantages and efficiency of the improved homotopy iteration method.
文摘Following votes by the Barremian Working Group,the International Subcommission on Cretaceous Stratigraphy and the International Commission on Stratigraphy,the Executive Committee of the International Union of Geological Sciences unanimously approved in March 2023 the Global Stratotype Section and Point(GSSP)for the Barremian Stage(Lower Cretaceous).The base of the Barremian Stage is defined at the base of bed 171 of the Río Argos section,near Caravaca(SE Spain)and correlated by the first appearance of the ammonite species Taveraidiscus hugii.This event falls within the NC5C calcareous nannofossil Subzone,the Lilliputianella semielongata planktonic foraminiferal Zone,and the Dorothia ouachensis benthic foraminiferal Zone.It roughly coincides with the beginning of a slightly negative trend interval in theδ^(13)C curve.Indirect calibration to the magnetostratigraphic scale suggests that the boundary falls in the lowermost part of polarity chron M3r.According to the astrochronological analysis,a time interval of 0.74 myr separates the beginning of the late Hauterivian Faraoni Episode from the base of the Barremian,which is dated at 125.77 MA.
基金supported by the Sichuan Science and Technology Program - China (Grant no. 2023ZYD0149)National Natural Science Foundation of China (Grant no. U22A20603)CAS "Light of West China" Program - China (Grant No. Fangwei Yu)
文摘In order to advance the understanding of the impact dynamics of granular flow in complex geological settings,this paper studied the impact dynamics of granular flow on rigid barriers with a number of Material Point Method(MPM)numerical tests.The impact behavior of granular flow on a rigid barrier was characterized by the initial dynamic impact stage,dynamic surge impact stage,compression impact stage and static stage of granular flow,where the impact force of granular flow was comprised of the dynamic and static forces of granular flow.The impact behavior of granular flow on a rigid barrier was characterized by the states of the fast or slow impact behavior of granular flow.The angle of slope and aspect ratio of granular soil greatly affected the impact behavior of granular flow on a column rigid barrier,where a power model was proposed to quantify the residual(Fnr)-over-maximum(Fnmax)normal impact force ratio of granular flow Fnr⁄Fnmax incorporating the effects of the angle of slope and aspect ratio of granular soil.With the increase of the column rigid barrier up to the semi-infinite column rigid barrier,the impact dynamics of granular flow gradually increased up to a maximum by progressively transforming the overflow into the dynamic surge impact of the incoming flow on the rigid barrier to capture more granular soil of granular flow against the rigid barrier.Presence of water in granular flow,i.e.,a mixture of solid and liquid in granular flow,yielded a dynamic coupling contribution of the solid and liquid,being accompanied by the whole dynamic process of granular flow,on the impact behavior of granular flow on a rigid barrier,where the liquid-phase material of granular flow,i.e.,the water,was predominant to contribute on the normal impact force of granular flow in comparison with the solid-phase material of granular flow.In addition,other factors,e.g.,the shape of rigid barrier(i.e.,the column barrier,arch barrier and circle barrier),and the gravity(i.e.,in the gravitational environment of the Moon,Earth and Mars),greatly affected the impact behavior of granular flow on a rigid barrier as well.
文摘32 cases of the third lumbar transverse process syndrome were treated mainly byelectroacupuncture at Huatuojiaji points of the first and second lumbar vertebrae, andanother 30 cases of the syndrome by conventional acupuncture as the controls. The resultsshowed that treatment by electroacupuncture at Huatuojiaji points was superior inanalgesic effect and clinical total effective rate to that by conventional acupuncture. It isconsidered that the mechanism of treatment by electroacupuncture at Huatuojiaji pointsis related to the trunk of posterior ramus of the spinal nerve where the points are located.
文摘By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.
