Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like...Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of transprecursor of porphyrinogen.Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere(SCS)bulks,maintaining a unique dome deformation,and making atomic out-of-plane deviation.In this way,this metallic complex integrates at least three key features of the pocket structure,the differentiated axial ligations,and the ring distortion,making it an ideal heme analog.展开更多
基金supported by the Institute of Elemento-organic Chemistry,Nankai University and the Scientific Research Fund of Hunan Provincial Education Department(No.20A195)Hunan Provincial Natural Science Foundation of China(No.2020JJ4292)the Science and Technology innovation Program of Hunan Province(No.2021RC5028).
文摘Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of transprecursor of porphyrinogen.Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere(SCS)bulks,maintaining a unique dome deformation,and making atomic out-of-plane deviation.In this way,this metallic complex integrates at least three key features of the pocket structure,the differentiated axial ligations,and the ring distortion,making it an ideal heme analog.
