Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy(PCT)for lymphedema(LE).Insurers,such as the Centers for Medicare/Medicaid(CMS),however,desire visual proof th...Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy(PCT)for lymphedema(LE).Insurers,such as the Centers for Medicare/Medicaid(CMS),however,desire visual proof that PCT moves lymph.Near infrared fuorescence lymphatic imaging(NIRFLI)was used to visualize lymphatic anatomy and function in four subjects with primary and cancer treatment-related LE of the lower extremities before,during,and after PCT.Optically transparent and windowed PCT garments allowed visualization of lymph movement during single,1h PCT treatment sessions.Visualization revealed significant extravascular and lymphatic vascular movement of intradermally injected dye in all subjects.In one subject with sufficient patent lymphatic vessels to allow quantification of lymph pumping velocities and frequencies,these values were significantly increased during and after PCT as compared to pre-treatment values.Lymphatic contractile activity in patent lymphatic vessels occurred in concert with the sequential cycling of PCT.Direct visualization revealed increased lymphatic function,during and after PCT therapy,in all LE-affected extremities.Further studies are warranted to assess the effects of PCT pressure and sequences on lymph uptake and movement.展开更多
Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the ...Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.展开更多
Intermittent pneumatic compression(IPC)is a noninvasive therapy choice for patients with peripheral arterial diseases,which typically inflates cuffs with a fixed compression period to facilitate peripheral perfusion.T...Intermittent pneumatic compression(IPC)is a noninvasive therapy choice for patients with peripheral arterial diseases,which typically inflates cuffs with a fixed compression period to facilitate peripheral perfusion.The fixed compression period ignores the synergistic effect between human cardiac pulsation and external inter-mittent compression,limiting the potential of IPC therapy.Meanwhile,existing IPC devices cannot directly assess peripheral perfusion in the target lower limb to provide feedback for adjusting treatment parameters and improving therapeutic efficacy.This work develops a cardiac cycle-synchronous IPC prototype,featuring an innovative flexible perfusion sensor module that enables real-time synchronization of compression with local blood perfusion distribution.By continuously monitoring peripheral perfusion distribution,the system adjusts compression timing based on real-time data,offering enhanced therapeutic efficacy compared to traditional fixed-period IPC treatments.We compare the therapeutic efficacy between an asynchronous mode and three cardiac cycle-synchronous modes.The results of on-body experiments show that the systole synchronous mode outperforms other modes,significantly improving the peripheral perfusion index(PPI)and augmentation index compared to the resting state.On the control side,the PPI had no significant difference between rest and treatment phase,which suggests that IPC treatment would not damage the peripheral blood perfusion on other body parts.The developed cardiac cycle-synchronous IPC prototype demonstrates that a good synchronization between the compression and the cardiac cycle might bring better therapeutic efficacy.The proposed prototype and the exploration of cardiac cycle-synchronous IPC therapy strategies are conducive to the development of non-invasive and intelligent therapies.展开更多
基金NIH/NCI grant U54 CA 136404 and NIH/NCI grant R01 CA201487.
文摘Previous studies have shown cost effectiveness and quality-of-life benefit of pneumatic compression therapy(PCT)for lymphedema(LE).Insurers,such as the Centers for Medicare/Medicaid(CMS),however,desire visual proof that PCT moves lymph.Near infrared fuorescence lymphatic imaging(NIRFLI)was used to visualize lymphatic anatomy and function in four subjects with primary and cancer treatment-related LE of the lower extremities before,during,and after PCT.Optically transparent and windowed PCT garments allowed visualization of lymph movement during single,1h PCT treatment sessions.Visualization revealed significant extravascular and lymphatic vascular movement of intradermally injected dye in all subjects.In one subject with sufficient patent lymphatic vessels to allow quantification of lymph pumping velocities and frequencies,these values were significantly increased during and after PCT as compared to pre-treatment values.Lymphatic contractile activity in patent lymphatic vessels occurred in concert with the sequential cycling of PCT.Direct visualization revealed increased lymphatic function,during and after PCT therapy,in all LE-affected extremities.Further studies are warranted to assess the effects of PCT pressure and sequences on lymph uptake and movement.
文摘Objective:To investigate and analyze the long-term clinical effects of acupoint application combined with pneumatic compression therapy in the prevention of deep venous thrombosis after hip fracture surgery among the elderly.Methods:Sixty elderly patients who had undergone hip fracture surgery from February 2021 to February 2022 were selected as the research subjects.The patients were divided into two groups via drawing lots.Both the groups received nursing care,but the patients in the observation group were treated with TCM acupoint application combined with pneumatic compression therapy,whereas the control group received pneumatic compression therapy.The evaluation indicators included the patients’quality of life and complications.Results:The incidence of lower extremity deep vein thrombosis in the observation group was more than twice(0.3%),whereas the incidence of lower extremity complications in the control group was more than 6 times(20%).There was a significant difference between the two groups(p<0.05).Conclusion:Traditional Chinese medicine acupoint application combined with pneumatic compression therapy is beneficial for the prevention of postoperative lower extremity deep vein thrombosis among elderly patients.In addition,the patients’overall quality-of-life scores in both physiological and psychological aspects improved significantly,which carries significant clinical reference value.
基金supported by the National Key Research and Development Program of China(Grant number 2023YFC3603500)the National Natural Science Foundation of China(Grant Number 12332019 and U20A20390)the Fundamental Research Funds for the Central Universities.
文摘Intermittent pneumatic compression(IPC)is a noninvasive therapy choice for patients with peripheral arterial diseases,which typically inflates cuffs with a fixed compression period to facilitate peripheral perfusion.The fixed compression period ignores the synergistic effect between human cardiac pulsation and external inter-mittent compression,limiting the potential of IPC therapy.Meanwhile,existing IPC devices cannot directly assess peripheral perfusion in the target lower limb to provide feedback for adjusting treatment parameters and improving therapeutic efficacy.This work develops a cardiac cycle-synchronous IPC prototype,featuring an innovative flexible perfusion sensor module that enables real-time synchronization of compression with local blood perfusion distribution.By continuously monitoring peripheral perfusion distribution,the system adjusts compression timing based on real-time data,offering enhanced therapeutic efficacy compared to traditional fixed-period IPC treatments.We compare the therapeutic efficacy between an asynchronous mode and three cardiac cycle-synchronous modes.The results of on-body experiments show that the systole synchronous mode outperforms other modes,significantly improving the peripheral perfusion index(PPI)and augmentation index compared to the resting state.On the control side,the PPI had no significant difference between rest and treatment phase,which suggests that IPC treatment would not damage the peripheral blood perfusion on other body parts.The developed cardiac cycle-synchronous IPC prototype demonstrates that a good synchronization between the compression and the cardiac cycle might bring better therapeutic efficacy.The proposed prototype and the exploration of cardiac cycle-synchronous IPC therapy strategies are conducive to the development of non-invasive and intelligent therapies.
