Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu...Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.展开更多
High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by t...High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by the alloy interface structures.Despite substantial efforts,a comprehensive overview of interface engineering of high-performance alloys has not been presented so far.In this study,the interfaces in high-performance alloys,particularly grain and phase boundaries,were systematically examined,with emphasis on their crystallographic characteristics and chemical element segregations.The effects of the interfaces on the electrical conductivity,mechanical strength,toughness,hydrogen embrittlement resistance,and thermal stability of the alloys were elucidated.Moreover,correlations among various types of interfaces and advanced experimental and computational techniques were examined using big data analytics,enabling robust design strategies.Challenges currently faced in the field of interface engineering and emerging opportunities in the field are also discussed.The study results would guide the development of next-generation high-performance alloys.展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmolo...Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmology,Capital Medical University Director,National Engineering Research Center for Ophthalmic Diagnosis and Treatment National Distinguished Physician Member,Academic Advisory Committee.展开更多
The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative...The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative engineering talents with both scientific and technological literacy and humanistic feelings for the great rejuvenation of the Chinese nation through a historical narrative and a deep understanding of engineering talent cultivation in China.By tracing back to the formation of educator Mei Yiqi’s engineering intentions,the integration of engineering knowledge,and the history of engineering education governance,this paper proposes the key to the collaborative development of future learning centers in engineering university in the era of artificial intelligence.Firstly,it is necessary to update educational concepts and view learners as dynamically self-empowered individuals with plural existences.Secondly,attention should be paid to dynamic knowledge of possibilities,and cross-subject and interdisciplinary cognition and reflection should be carried out based on the types of engineering knowledge.Thirdly,it is essential to establish an engineering talent cultivation model with problem-guided knowledge learning as the core.With the support of digital network platforms and artificial intelligence technology,an infinite link of ideas and knowledge can be established through comprehensive textual methods,constructing learners’own“infinite library”and a spiritual world that is proactive,creative,and cultural.展开更多
Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantiall...Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.展开更多
Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,wri...Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,writing test cases,conducting functional and performance tests,and optimizing the product based on feedback.In government procurement projects,quality evaluation focuses on process compliance,security,and functional compatibility.KPI evaluation trees are commonly used for quantitative assessment,and a dynamic adjustment mechanism for indicators needs to be established to cope with complex demands.In addition,risk-driven testing and agile development should be combined to set up quality access control to ensure that each iteration version meets expectations.The multi-dimensional quality assurance and verification scoring mechanism can effectively enhance product reliability and reduce project risks.展开更多
With the rapid development of China’s economy,the demand for high-end talents in the field of engineering technology is becoming increasingly prominent.Engineering doctors,as an important force in this field,have a d...With the rapid development of China’s economy,the demand for high-end talents in the field of engineering technology is becoming increasingly prominent.Engineering doctors,as an important force in this field,have a direct impact on the progress of national technological innovation and the upgrading of industrial structure.Currently,there are still some issues in the university-enterprise collaboration for engineering doctor training in China,such as unclear cooperation mechanisms and responsibility divisions,insufficient corporate participation and enthusiasm,and imperfect evaluation and feedback mechanisms.This paper aims to explore the university-enterprise collaborative training path of engineering doctors from the perspective of deep integration,analyzing multiple dimensions including training objectives,curriculum design,practical sessions,mentor teams,and evaluation systems,in order to provide reference for the reform and practice of engineering doctor training in China.展开更多
The abundant microbe-associated molecular patterns(MAMPs)and nanoscale structures of bacterial extracellular vesicles(bEVs)collectively facilitate their versatile biological activities.Building on these inherent prope...The abundant microbe-associated molecular patterns(MAMPs)and nanoscale structures of bacterial extracellular vesicles(bEVs)collectively facilitate their versatile biological activities.Building on these inherent properties,engineering methods encompassing physical,chemical,and genetic modifications have been strategically employed to enhance the functional diversity of bEVs.Therefore,bEVs are being explored as innovative and promising platforms for developing immunotherapeutic strategies targeting diverse pathological states.To establish a foundational understanding of bEVs,we first summarized their biogenesis,classification,structures and biomolecular constituents of bEVs.This review discusses techniques for bEV production and modification and explores the immunological characteristics and effects of engineered bEVs,along with their biomedical applications.Special attention is devoted to advanced engineering approaches and outlining the challenges and emerging avenues in the development of engineered bEVs.This review aims to systematically construct an evidence-based and comprehensive framework that promotes translational optimization and clinical implementation of engineered bEVs,thereby maximizing their application potential in the biomedical field.展开更多
This study focuses on the teaching reform of the communication application development course based on the core requirements of engineering education accreditation.To address key challenges such as the disconnection b...This study focuses on the teaching reform of the communication application development course based on the core requirements of engineering education accreditation.To address key challenges such as the disconnection between software and hardware teaching and insufficient practical skills among students,a project-driven“learning-practiceapplication”teaching model is proposed.By optimizing course content,innovating teaching methods,and introducing university-industry collaboration mechanisms,the reform aligns the curriculum more closely with engineering education standards and industry demands.The approach significantly enhances students’comprehensive skills,practical abilities,and employability.This study provides theoretical foundations and practical strategies for the teaching reform of courses in communication engineering.展开更多
The advanced oxidation process presents a perfect solution for eliminating organic pollutants in water resources,and the local microenvironment and surface state of metal reactive sites are crucial for the selective a...The advanced oxidation process presents a perfect solution for eliminating organic pollutants in water resources,and the local microenvironment and surface state of metal reactive sites are crucial for the selective activation of peroxomonosulfate(PMS),which possibly determines the degradation pathways of organic contaminants.In this study,by virtue of the precursor alternation,we constructed the state-switched dual metal species with the porous carbon fibers through the electrospinning strategy.Impressively,the optimal catalyst,featuring the electron-deficient cobalt surface oxidative state and most abundant oxygen vacancies(Ov)with MnO_(2)within porous carbon fibers,provides abundant mesoporosity,facilitating the diffusion and accommodation of big carbamazepine molecules during the reaction process.Benefiting from the tandem configuration of carbon fiber-encapsulated nanocrystalline species,a p-n heterojunction configuration evidenced by Mott-Schottky analysis induced local built-in electric field(BIEF)between electron-deficient cobalt and Ov-rich MnO_(2)within carbon matrix-mediated interfacial interactions,which optimizes the adsorption and activation of PMS and intermediates,increases the concentration of reactive radicals around the active site,and significantly enhances the degradation performance.As a result,the optimal catalyst could achieve 100%degradation of 20 ppm carbamazepine(CBZ)within only 4 min with a rate constant of 1.099 min^(-1),showcasing a low activation energy(50 kJ mol^(-1)),obviously outperforming the other counterparts.We further demonstrated the generation pathways of active species by activation of PMS mainly including sulfate radical(·SO_(4)^(-)),hydroxyl radical(·OH),superoxide radicals(·O_(2)^(-)),and singlet oxygen(^(1)O_(2)),unveiling their contribution to CBZ degradation.The degradation route of CBZ and toxicity analysis of various intermediates were further evaluated.By anchoring the optimal catalyst onto polyester fiber sponge,the photothermal conversion synergistic monolith floatable catalyst and its easy recovery can be achieved,showing good reproducibility and generalizability in the practical application.展开更多
Existing creep constitutive models rarely incorporate studies on the coupling mechanism between creep damage and rock strain softening/hardening.This study analyzed the strain softening and hardening behaviors of argi...Existing creep constitutive models rarely incorporate studies on the coupling mechanism between creep damage and rock strain softening/hardening.This study analyzed the strain softening and hardening behaviors of argillaceous sandstone and sandy mudstone during load-induced failure based on the plastic increment theory.These behaviors were then coupled with an improved Burgers creep model to establish a coupled creep-damage and plastic softening/hardening model.Finally,the validity and engineering applicability of the proposed model were verified through FLAC~(3D)numerical simulations.The numerical simulation results of standard cylindrical specimens show that the established coupling model can effectively reflect the unloading creep deformation law and failure characteristics of argillaceous sandstone and sandy mudstone.Taking the diversion tunnel of a hydropower station in Northwest China as an example for engineering application,the coupled creep-damage and plastic softening/hardening model is introduced into FLAC~(3D)to carry out numerical simulation calculation of the tunnel under excavation and unsupported creep conditions.The results show that the uncoordinated deformation of the upper and lower walls of the surrounding rock of the tunnel is more prominent.When the buried depth of the tunnel increases to 80 m,the monitoring point C in the sandy mudstone area of the upper wall shows nonlinear accelerated deformation under unsupported creep conditions,and the maximum displacement in the horizontal direction reaches 44.5 mm,and the maximum displacement in the vertical direction reaches 53.5 mm.The coupled creep-damage and plastic softening/hardening model established in the research results can well describe the whole process of uncoordinated deformation and failure in the unloading creep process of soft-hard interbedded rock mass.展开更多
In order to reduce the cost of high performance polyvinyl alcohol（PVA） fiber reinforced cementitious material（called engineered cementitious composites,ECC）,a ductile ECC material is developed using domestic PVA f...In order to reduce the cost of high performance polyvinyl alcohol（PVA） fiber reinforced cementitious material（called engineered cementitious composites,ECC）,a ductile ECC material is developed using domestic PVA fibers along with other local ingredients,such as fly ash,cement and sand.In addition to the economic analysis of ECC,the four-point bending test and the optical microscope are employed to investigate the deflection capacity of ECC,its crack width and the occurrence of the self-healing phenomenon.The experimental results suggest that ECC made with domestic ingredients exhibits larger deformability and the average crack width is controlled around 60 μm.Furthermore,the self-healing behavior is observed in cracks of the specimens after cycles of wet and dry curing.The economic analysis shows that the cost of ECC can be greatly reduced via employing domestic PVA fibers.It is,therefore,feasible to produce low cost ECC material employing domestic PVA fibers,while simultaneously retaining high material ductility.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into ...The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the procedure.However, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.展开更多
Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications....Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic.展开更多
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien...Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
Recently,defect architectured photocatalysis is proved to be the most versatile choice for high solar to chemical energy conversion processes.Defect engineering strategies are of great demand to effectively tune the e...Recently,defect architectured photocatalysis is proved to be the most versatile choice for high solar to chemical energy conversion processes.Defect engineering strategies are of great demand to effectively tune the electronic microstructure and surface morphologies of semiconductors to boost charge carrier concentration and extend light harvesting capability.This review provides a comprehensive insight to various kinds of defects along with their synthesis procedures and controlling mechanism to uplift photocatalytic activity.In addition,the contribution made by defects and material optimization techniques toward electronic band structure of the photocatalyst,the optimal concentration of defects,the key adsorption processes,charge distribution,and transfer dynamics have been explained in detail.Further,to clarify the relationship between photocatalytic activity and defect states in real,a comprehensive outlook to the versatile photocatalytic applications has been presented to highlight current challenges and future applications.Defect engineering therefore stands as the next step toward advancement in the design and configuration of modern photocatalysts for high efficiency photocatalysis.展开更多
In terms of rock engineering and technology in hydropower construction,the slope stability and monitoring techniques for high slopes of Three Gorges Project,the stability and support technology for high slopes of hydr...In terms of rock engineering and technology in hydropower construction,the slope stability and monitoring techniques for high slopes of Three Gorges Project,the stability and support technology for high slopes of hydropower projects in deep river valley,the stabilization techniques for underground cavern group with large span and high side walls are introduced in this paper.As for rock engineering and technology in highway and railway construction,the Qinghai-Tibet Railway — new construction techniques in permafrost,the support techniques for large squeezing deformation in Wuqiaoling Tunnel,the construction techniques for tunnels in alpine and high-altitude region,the geological prediction techniques for tunnels in karst region,the microseismic monitoring and early warning techniques for rockbursts in deep and long tunnels are presented.For rock engineering and technology inmining engineering,the innovative techniques for roadway support inmines,the simultaneous extraction technique of pillarless coal and gas in coal seams with low permeability,the safe and efficient deep openmining technology,advances in monitoring,early warning and treatment ofmine dynamic disasters are discussed.In addition,the new anchorage techniques and precision blasting technique in rock engineering are introduced.展开更多
基金supported by grants from the Jiangxi Provincial Natural Science Foundation,No.20242BAB26134(to XF)the National Natural Science Foundation of China,Nos.82060638(to TC),82060222(to XF),82460237(to XF)+1 种基金the Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,Nos.20194BCJ22032(to TC),20213BCJL22049(to XF)Science and Technology Plan of Jiangxi Health Planning Committee,No.202210390(to XF).
文摘Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.
基金supported by the National Natural Science Foundation of China(Nos.52122408 and 52474397)the High-level Talent Research Start-up Project Funding of Henan Academy of Sciences(No.242017127)+1 种基金the financial support from the Fundamental Research Funds for the Central Universities(University of Science and Technology Beijing(USTB),Nos.FRF-TP-2021-04C1 and 06500135)supported by USTB MatCom of Beijing Advanced Innovation Center for Materials Genome Engineering。
文摘High-performance alloys are indispensable in modern engineering because of their exceptional strength,ductility,corrosion resistance,fatigue resistance,and thermal stability,which are all significantly influenced by the alloy interface structures.Despite substantial efforts,a comprehensive overview of interface engineering of high-performance alloys has not been presented so far.In this study,the interfaces in high-performance alloys,particularly grain and phase boundaries,were systematically examined,with emphasis on their crystallographic characteristics and chemical element segregations.The effects of the interfaces on the electrical conductivity,mechanical strength,toughness,hydrogen embrittlement resistance,and thermal stability of the alloys were elucidated.Moreover,correlations among various types of interfaces and advanced experimental and computational techniques were examined using big data analytics,enabling robust design strategies.Challenges currently faced in the field of interface engineering and emerging opportunities in the field are also discussed.The study results would guide the development of next-generation high-performance alloys.
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
文摘Profile of Prof.Ning-Li Wang Academician of the Chinese Academy of Engineering(CAE)Member of the International Academy of Ophthalmology Director,Ophthalmology Center,Beijing Tongren Hospital Dean,School of Ophthalmology,Capital Medical University Director,National Engineering Research Center for Ophthalmic Diagnosis and Treatment National Distinguished Physician Member,Academic Advisory Committee.
基金2024 General Research Topic of the Chinese Society of Educational Development Strategy,“Research on the Collaborative Development of‘Future Learning Centers’in Engineering University under New Strategic Needs”(Project No.:ZLB20240820)。
文摘The collaborative development of future learning centers in engineering university is a crucial component of integrating education,technology,and talent development.Its essence lies in cultivating top-notch innovative engineering talents with both scientific and technological literacy and humanistic feelings for the great rejuvenation of the Chinese nation through a historical narrative and a deep understanding of engineering talent cultivation in China.By tracing back to the formation of educator Mei Yiqi’s engineering intentions,the integration of engineering knowledge,and the history of engineering education governance,this paper proposes the key to the collaborative development of future learning centers in engineering university in the era of artificial intelligence.Firstly,it is necessary to update educational concepts and view learners as dynamically self-empowered individuals with plural existences.Secondly,attention should be paid to dynamic knowledge of possibilities,and cross-subject and interdisciplinary cognition and reflection should be carried out based on the types of engineering knowledge.Thirdly,it is essential to establish an engineering talent cultivation model with problem-guided knowledge learning as the core.With the support of digital network platforms and artificial intelligence technology,an infinite link of ideas and knowledge can be established through comprehensive textual methods,constructing learners’own“infinite library”and a spiritual world that is proactive,creative,and cultural.
基金funded by Science and Technology Project of Hebei Education Department[QN2023085].
文摘Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.
文摘Quality engineers play a key role in software product development,covering various stages such as requirements analysis,design,coding,testing,and delivery.Its responsibilities include formulating quality standards,writing test cases,conducting functional and performance tests,and optimizing the product based on feedback.In government procurement projects,quality evaluation focuses on process compliance,security,and functional compatibility.KPI evaluation trees are commonly used for quantitative assessment,and a dynamic adjustment mechanism for indicators needs to be established to cope with complex demands.In addition,risk-driven testing and agile development should be combined to set up quality access control to ensure that each iteration version meets expectations.The multi-dimensional quality assurance and verification scoring mechanism can effectively enhance product reliability and reduce project risks.
基金supported in part by the 2023 College Student Innovation and Entrepreneurship Training 430 Program Project of China(Grant No.202310699159)2024 Graduate Education Comprehensive Reform,Development and Innovation Project of Northwestern Polytechnical University(Grant No.KCJG202432)2023 Northwestern Polytechnical University Degree and Postgraduate Education Research Funding(Grant No.2023YMs014)。
文摘With the rapid development of China’s economy,the demand for high-end talents in the field of engineering technology is becoming increasingly prominent.Engineering doctors,as an important force in this field,have a direct impact on the progress of national technological innovation and the upgrading of industrial structure.Currently,there are still some issues in the university-enterprise collaboration for engineering doctor training in China,such as unclear cooperation mechanisms and responsibility divisions,insufficient corporate participation and enthusiasm,and imperfect evaluation and feedback mechanisms.This paper aims to explore the university-enterprise collaborative training path of engineering doctors from the perspective of deep integration,analyzing multiple dimensions including training objectives,curriculum design,practical sessions,mentor teams,and evaluation systems,in order to provide reference for the reform and practice of engineering doctor training in China.
基金supported by the Postdoctoral Fellowship Program of CPSF(GZB20230284)the Jiangxi Province Science Foundation for Youths(20242BAB21030 and 20242BAB21031)the Central Government Guide Local Special Fund Project for Scientific and Technological Development of Jiangxi Province(20221ZDD02001).
文摘The abundant microbe-associated molecular patterns(MAMPs)and nanoscale structures of bacterial extracellular vesicles(bEVs)collectively facilitate their versatile biological activities.Building on these inherent properties,engineering methods encompassing physical,chemical,and genetic modifications have been strategically employed to enhance the functional diversity of bEVs.Therefore,bEVs are being explored as innovative and promising platforms for developing immunotherapeutic strategies targeting diverse pathological states.To establish a foundational understanding of bEVs,we first summarized their biogenesis,classification,structures and biomolecular constituents of bEVs.This review discusses techniques for bEV production and modification and explores the immunological characteristics and effects of engineered bEVs,along with their biomedical applications.Special attention is devoted to advanced engineering approaches and outlining the challenges and emerging avenues in the development of engineered bEVs.This review aims to systematically construct an evidence-based and comprehensive framework that promotes translational optimization and clinical implementation of engineered bEVs,thereby maximizing their application potential in the biomedical field.
基金Quality Engineering Project of Higher Education Institutions in Anhui Province(2023aqnujyxm26,2023sx060,2023zyxwjxalk124)Natural Science Key Research Project for Higher Education Institutions of Anhui Province(2024AH051117,2024AH051126)+1 种基金Excellent Young Backbone Teachers’Domestic and Foreign Visiting and Training Program in Universities(gxgnfx20220262022)Research and Industrialization Project of High Precision Positioning System for Intelligent Connected Vehicles。
文摘This study focuses on the teaching reform of the communication application development course based on the core requirements of engineering education accreditation.To address key challenges such as the disconnection between software and hardware teaching and insufficient practical skills among students,a project-driven“learning-practiceapplication”teaching model is proposed.By optimizing course content,innovating teaching methods,and introducing university-industry collaboration mechanisms,the reform aligns the curriculum more closely with engineering education standards and industry demands.The approach significantly enhances students’comprehensive skills,practical abilities,and employability.This study provides theoretical foundations and practical strategies for the teaching reform of courses in communication engineering.
基金financially supported by the National Natural Science Foundation of China(No.21908085)the Natural Science Foundation of Jiangsu province(No.BK20241950)+3 种基金China Postdoctoral Science Foundation(No.2023M731422)the Open Project of State Key Laboratory of Materials Chemical Engineering(No.SKL-MCE-23B)Hubei Key Laboratory of Processing and Application of Catalytic materials(No.202441204)the Science and Technology Plan School-Enterprise Cooperation Industry-University-Research Forward-looking Project of Zhangjiagang(No.ZKYY2341)
文摘The advanced oxidation process presents a perfect solution for eliminating organic pollutants in water resources,and the local microenvironment and surface state of metal reactive sites are crucial for the selective activation of peroxomonosulfate(PMS),which possibly determines the degradation pathways of organic contaminants.In this study,by virtue of the precursor alternation,we constructed the state-switched dual metal species with the porous carbon fibers through the electrospinning strategy.Impressively,the optimal catalyst,featuring the electron-deficient cobalt surface oxidative state and most abundant oxygen vacancies(Ov)with MnO_(2)within porous carbon fibers,provides abundant mesoporosity,facilitating the diffusion and accommodation of big carbamazepine molecules during the reaction process.Benefiting from the tandem configuration of carbon fiber-encapsulated nanocrystalline species,a p-n heterojunction configuration evidenced by Mott-Schottky analysis induced local built-in electric field(BIEF)between electron-deficient cobalt and Ov-rich MnO_(2)within carbon matrix-mediated interfacial interactions,which optimizes the adsorption and activation of PMS and intermediates,increases the concentration of reactive radicals around the active site,and significantly enhances the degradation performance.As a result,the optimal catalyst could achieve 100%degradation of 20 ppm carbamazepine(CBZ)within only 4 min with a rate constant of 1.099 min^(-1),showcasing a low activation energy(50 kJ mol^(-1)),obviously outperforming the other counterparts.We further demonstrated the generation pathways of active species by activation of PMS mainly including sulfate radical(·SO_(4)^(-)),hydroxyl radical(·OH),superoxide radicals(·O_(2)^(-)),and singlet oxygen(^(1)O_(2)),unveiling their contribution to CBZ degradation.The degradation route of CBZ and toxicity analysis of various intermediates were further evaluated.By anchoring the optimal catalyst onto polyester fiber sponge,the photothermal conversion synergistic monolith floatable catalyst and its easy recovery can be achieved,showing good reproducibility and generalizability in the practical application.
基金funded by the Natural Science Foundation of China(Grant No.U22A20600)。
文摘Existing creep constitutive models rarely incorporate studies on the coupling mechanism between creep damage and rock strain softening/hardening.This study analyzed the strain softening and hardening behaviors of argillaceous sandstone and sandy mudstone during load-induced failure based on the plastic increment theory.These behaviors were then coupled with an improved Burgers creep model to establish a coupled creep-damage and plastic softening/hardening model.Finally,the validity and engineering applicability of the proposed model were verified through FLAC~(3D)numerical simulations.The numerical simulation results of standard cylindrical specimens show that the established coupling model can effectively reflect the unloading creep deformation law and failure characteristics of argillaceous sandstone and sandy mudstone.Taking the diversion tunnel of a hydropower station in Northwest China as an example for engineering application,the coupled creep-damage and plastic softening/hardening model is introduced into FLAC~(3D)to carry out numerical simulation calculation of the tunnel under excavation and unsupported creep conditions.The results show that the uncoordinated deformation of the upper and lower walls of the surrounding rock of the tunnel is more prominent.When the buried depth of the tunnel increases to 80 m,the monitoring point C in the sandy mudstone area of the upper wall shows nonlinear accelerated deformation under unsupported creep conditions,and the maximum displacement in the horizontal direction reaches 44.5 mm,and the maximum displacement in the vertical direction reaches 53.5 mm.The coupled creep-damage and plastic softening/hardening model established in the research results can well describe the whole process of uncoordinated deformation and failure in the unloading creep process of soft-hard interbedded rock mass.
基金The National Natural Science Foundation of China (No.51008071,51278097)the Natural Science Foundation of Jiangsu Province(No.BK2010413)+2 种基金Teaching & Research Excellence Grant for Young Faculty Member at Southeast Universitythe Program for Special Talents in Six Major Fields of Jiangsu Province(No.2011-JZ-011)the Scientific Research Innovation Project for College Graduates in Jiangsu Province(No.CXLX_0136)
文摘In order to reduce the cost of high performance polyvinyl alcohol（PVA） fiber reinforced cementitious material（called engineered cementitious composites,ECC）,a ductile ECC material is developed using domestic PVA fibers along with other local ingredients,such as fly ash,cement and sand.In addition to the economic analysis of ECC,the four-point bending test and the optical microscope are employed to investigate the deflection capacity of ECC,its crack width and the occurrence of the self-healing phenomenon.The experimental results suggest that ECC made with domestic ingredients exhibits larger deformability and the average crack width is controlled around 60 μm.Furthermore,the self-healing behavior is observed in cracks of the specimens after cycles of wet and dry curing.The economic analysis shows that the cost of ECC can be greatly reduced via employing domestic PVA fibers.It is,therefore,feasible to produce low cost ECC material employing domestic PVA fibers,while simultaneously retaining high material ductility.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
基金National Research Foundation of Korea(NRF-2017R1A2B3004972)IPET(No.109023–05-5-CG000)The BK21 PLUS Program for Creative Veterinary Science Research
文摘The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the procedure.However, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle.
文摘Recent regenerative medicine and tissue engineering strategies(using cells, scaffolds, medical devices and gene therapy) have led to fascinating progress of translation of basic research towards clinical applications. In the past decade, great deal of research has focused on developing various three dimensional(3D) organs, such as bone, skin, liver, kidney and ear,using such strategies in order to replace or regenerate damaged organs for the purpose of maintaining or restoring organs' functions that may have been lost due to aging, accident or disease. The surface properties of a material or a device are key aspects in determining the success of the implant in biomedicine, as the majority of biological reactions in human body occur on surfaces or interfaces. Furthermore, it has been established in the literature that cell adhesion and proliferation are, to a great extent, influenced by the micro- and nanosurface characteristics of biomaterials and devices. In addition, it has been shown that the functions of stem cells, mesenchymal stem cells in particular, could be regulated through physical interaction with specific nanotopographical cues. Therefore, guided stem cell proliferation, differentiation and function are of great importance in the regeneration of 3D tissues and organs using tissue engineering strategies. This review will provide an update on the impact of nanotopography on mesenchymal stem cells for the purpose of developing laboratory-based 3D organs and tissues, as well as the most recent research and case studies on this topic.
基金Under the auspices of National Natural Science Foundation of China(No.42293270)。
文摘Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
基金financialy supported by National Natural Science Foundation of China (22002142)China Postdoctoral Science Foundation (2019M652570, 2019M650172 and 2020T130605)+1 种基金Support Plan for College Science and Technology Innovation Team of Henan Province (No. 16IRTSTHN001)the Science & Technology Innovation Talent Plan of Henan Province (No. 174200510018)
文摘Recently,defect architectured photocatalysis is proved to be the most versatile choice for high solar to chemical energy conversion processes.Defect engineering strategies are of great demand to effectively tune the electronic microstructure and surface morphologies of semiconductors to boost charge carrier concentration and extend light harvesting capability.This review provides a comprehensive insight to various kinds of defects along with their synthesis procedures and controlling mechanism to uplift photocatalytic activity.In addition,the contribution made by defects and material optimization techniques toward electronic band structure of the photocatalyst,the optimal concentration of defects,the key adsorption processes,charge distribution,and transfer dynamics have been explained in detail.Further,to clarify the relationship between photocatalytic activity and defect states in real,a comprehensive outlook to the versatile photocatalytic applications has been presented to highlight current challenges and future applications.Defect engineering therefore stands as the next step toward advancement in the design and configuration of modern photocatalysts for high efficiency photocatalysis.
文摘In terms of rock engineering and technology in hydropower construction,the slope stability and monitoring techniques for high slopes of Three Gorges Project,the stability and support technology for high slopes of hydropower projects in deep river valley,the stabilization techniques for underground cavern group with large span and high side walls are introduced in this paper.As for rock engineering and technology in highway and railway construction,the Qinghai-Tibet Railway — new construction techniques in permafrost,the support techniques for large squeezing deformation in Wuqiaoling Tunnel,the construction techniques for tunnels in alpine and high-altitude region,the geological prediction techniques for tunnels in karst region,the microseismic monitoring and early warning techniques for rockbursts in deep and long tunnels are presented.For rock engineering and technology inmining engineering,the innovative techniques for roadway support inmines,the simultaneous extraction technique of pillarless coal and gas in coal seams with low permeability,the safe and efficient deep openmining technology,advances in monitoring,early warning and treatment ofmine dynamic disasters are discussed.In addition,the new anchorage techniques and precision blasting technique in rock engineering are introduced.
