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Temporary plugging agent transport behavior within visualized multi-fracture created during TPDF in a horizontal well: An experimental study
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作者 Yu-Shi Zou Dian-Yu Li +4 位作者 Can Yang Yan-Chao Li Shi-Cheng Zhang Long-Qing Zou Xin-Fang Ma 《Petroleum Science》 2025年第9期3671-3687,共17页
Temporary plugging and diversion fracturing(TPDF)is widely used to promote the uniform and complex distribution of multi-clustered hydraulic fractures(HFs)in a horizontal well of the unconventional formations.However,... Temporary plugging and diversion fracturing(TPDF)is widely used to promote the uniform and complex distribution of multi-clustered hydraulic fractures(HFs)in a horizontal well of the unconventional formations.However,the migration behavior of temporary plugging agent(TPA),as a function of the concentration and particle size of TPA and cluster-perforation numbers,etc.,determining the effectiveness of this technique,remains unclear.Therefore,this study conducted innovatively a series of TPDF simulation experiments on transparent polymethyl methacrylate(PMMA)specimens(cubic block of 30 cm×30 cm×30 cm)to explore visually the migration behavior of TPA in multi-clustered HFs in a horizontal well.A laboratory hydraulic sandblasting perforation completion technique was implemented to simulate the multi-cluster perforations.All the distributions of wellbore,perforations,HFs,and TPA can be seen clearly inside the PMMA specimen post the experiment.The results show that there are four characteristic plugging positions for the TPA:mouth of HF,middle of HF,tip of HF,and the intersection of HFs.Small particle size TPA tends to migrate to the fracture tip for plugging,while large particle size TPA tends to plug at the fracture mouth.The migration of the TPA is influenced obviously by the morphology of the fracture wall.A smooth fracture wall is conducive to the migration of the TPA to the far end of HFs,but not conducive to generating the plugging zone and HF diversion.In contrast,a"leaf vein"fracture of rough wall is conducive to generating the plugging layer and the diversion of HFs,but not conducive to the migration of the TPA to the far end of HFs.The migration ability of TPA in a"shell"pattern is intermediate between the two above cases.Increasing TPA concentration can encourage TPA to migrate more quickly to the characteristic plugging position,and thereby to promote the creation of effective plugging and subsequently the multi-stage diversion of the HFs.Nevertheless,excessive concentration may cause the TPA to settle prematurely,affecting the propagation of the HFs to the far end.Increasing the number of clusters to a certain extent can encourage TPA to migrate into the HFs and form plugging,and promote the diversion.An evaluation system for the migration ability of granular TPA has been established,and it was calculated that when there is no plugging expectation target,the comprehensive migration ability of small particle size TPA is stronger than that of large particle size TPA.This research provides theoretical foundation for the optimization of temporary plugging parameters. 展开更多
关键词 Temporary plugging and diversion fracturing(TPDF) Polymethyl methacrylate(PMMA) Multi-cluster perforation Temporary plugging agent migration Visualization plugging position
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Structural formation and evolution mechanisms of fracture plugging zone 被引量:1
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作者 XU Chengyuan ZHANG Jingyi +5 位作者 KANG Yili XU Feng LIN Chong YAN Xiaopeng JING Haoran SHANG Xiangyu 《Petroleum Exploration and Development》 CSCD 2021年第1期232-242,共11页
A coupled CFD-DEM method is used to simulate the formation process of fracture plugging zone.A photo-elastic system characterizing mesoscale force chain network developed by our own is used to model the pressure evolu... A coupled CFD-DEM method is used to simulate the formation process of fracture plugging zone.A photo-elastic system characterizing mesoscale force chain network developed by our own is used to model the pressure evolution in fracture plugging zone to reveal the evolution mechanism of the structure of fracture plugging zone.A theoretical basis is provided for improving the lost circulation control effect in fractured reservoirs and novel methods are proposed for selecting loss control materials and designing loss control formula.CFD-DEM simulation results show that bridging probability is the key factor determining the formation of fracture plugging zone and fracture plugging efficiency.Critical and absolute bridging concentrations are proposed as the key indexes for loss control formula design.With the increase of absolute bridging concentration,the governing factor of bridging is changed from material grain size to the combination of material grain size and friction force.Results of photo-elastic experiments show that mesoscale force chain network is the intrinsic factor affecting the evolution of pressure exerting on the fracture plugging zone and determines the macroscopic strength of fracture plugging zone.Performance parameters of loss control material affect the force chain network structure and the ratio of stronger force chain,and further impact the stability and strength of fracture plugging zone.Based on the study results,the loss control formula is optimized and new-type loss control material is designed.Laboratory experiments results show that the fracture plugging efficiency and strength is effectively improved. 展开更多
关键词 lost circulation formation damage control fracture plugging zone plugging zone structure plugging strength plugging efficiency CFD-DEM simulation photo-elastic experiment loss control material
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Enhanced Load-Settlement Curve Forecasts for Open-Ended Pipe Piles Incorporating Soil Plug Constraints Using Shallow and Deep Neural Networks
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作者 Luttfi A.AL-HADDAD Mohammed Y.FATTAH +2 位作者 Wissam H.S.AL-SOUDANI Sinan A.AL-HADDAD Alaa Abdulhady JABER 《China Ocean Engineering》 2025年第3期562-572,共11页
This study investigates the load-bearing capacity of open-ended pipe piles in sandy soil, with a specific focus on the impact of soil plug constraints at four levels(no plug, 25% plug, 50% plug, and full plug). Levera... This study investigates the load-bearing capacity of open-ended pipe piles in sandy soil, with a specific focus on the impact of soil plug constraints at four levels(no plug, 25% plug, 50% plug, and full plug). Leveraging a dataset comprising open-ended pipe piles with varying geometrical and geotechnical properties, this research employs shallow neural network(SNN) and deep neural network(DNN) models to predict plugging conditions for both driven and pressed installation types. This paper underscores the importance of key parameters such as the settlement value,applied load, installation type, and soil configuration(loose, medium, and dense) in accurately predicting pile settlement. These findings offer valuable insights for optimizing pile design and construction in geotechnical engineering,addressing a longstanding challenge in the field. The study demonstrates the potential of the SNN and DNN models in precisely identifying plugging conditions before pile driving, with the SNN achieving R2 values ranging from0.444 to 0.711 and RMSPE values ranging from 24.621% to 48.663%, whereas the DNN exhibits superior performance, with R2 values ranging from 0.815 to 0.942 and RMSPE values ranging from 4.419% to 10.325%. These results have significant implications for enhancing construction practices and reducing uncertainties associated with pile foundation projects in addition to leveraging artificial intelligence tools to avoid long experimental procedures. 展开更多
关键词 pipe piles soil plug artificial neural network bearing capacity forecasts
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Technology of milling bridge plugs and field applications in shale gas horizontal wells with severe casing deformation
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作者 Gang Xiang Jialin Liu Xiaolong Ma 《Natural Gas Industry B》 2025年第1期64-70,共7页
Milling bridge plugs in shale gas wells with severe casing deformation often leads to the accumulation of cuttings,increasing the risk of stuck drill bits.Friction in the wellbore further complicates tool deployment i... Milling bridge plugs in shale gas wells with severe casing deformation often leads to the accumulation of cuttings,increasing the risk of stuck drill bits.Friction in the wellbore further complicates tool deployment into the horizontal section,posing challenges to efficient plug drilling and achieving wellbore access to the target layer.This paper integrates the theory of positive displacement motors and models their actual working characteristics to study the milling of bridge plugs in severely deformed horizontal wells.It examines the effects of coiled tubing diameter and wall thickness on the bending load of horizontal sections and discusses key technical requirements,including the timing of plug drilling,extending the run in the horizontal section,parameter control,and real-time field analysis.Field practices have shown that after casing deformation occurs,priority should be given to drilling out the bridge plugs below the point of deformation.The primary factors contributing to stuck drills in deformed wells include smaller mill shoe sizes and larger cuttings sizes.Short well-washing cycles and targeted cuttings removal can effectively reduce sticking risks.If sticking occurs,high-tonnage pulling should be avoided.Instead,releasing the stick through up-anddown string motion,combined with high-volume nozzle spraying and annulus pumping,is recommended.The selection of coiled tubing should consider diameter,wall thickness,and steel grade to handle complex situations.Larger diameters,thicker walls,and low-frequency,multi-head hydraulic oscillators are more effective for unlocking horizontal sections.This approach can reduce the risk of drill sticking and solve the problem of horizontal section lock-ups,offering a reliable solution for smooth drilling and efficient production in wells with severe casing deformation. 展开更多
关键词 Shale gas Coiled tubing Casing deformation Milling bridge plug Risk control
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Plugging mode of flaky lost circulation materials within fractures and mechanism to enhance pressure-bearing capacity for the plugging zone
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作者 Kun Guo Yi-Li Kang +3 位作者 Cheng-Yuan Xu Chong Lin Ling-Jie Zhang Li-Jun You 《Petroleum Science》 2025年第8期3315-3332,共18页
During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to dril... During drilling operations in deep fractured tight gas reservoirs,lost circulation of working fluid frequently occurs due to the formationʼs low pressure-bearing capacity.Adding lost circulation materials(LCMs)to drilling fluids is the most common method for controlling lost circulation.Among these,granular LCMs are widely used,but the application frequency of flaky LCMs has been increasing annually due to their unique morphology.However,the migration and plugging behavior of flaky LCMs within fractures,and the mechanisms enhancing the pressure-bearing capacity of the plugging zone are not well understood.Therefore,this study conducted visual plugging experiments and dynamic fracture plugging experiments to evaluate the plugging mode and pressure-bearing capacity of the plugging slurry with various particle sizes and concentrations of flaky LCMs.The experimental results demonstrate that the fracture plugging process can be divided into four stages:uniform flow stage of the plugging slurry,formation and development stage of the bridging area,formation and development stage of the plugging area,and pressure-bearing stage of the plugging zone.The inclusion of flaky LCMs notably reduces the duration of stages 1 and 2,while simultaneously increasing the proportion of the plugging zone and enhancing its surface porosity.Flaky LCMs reduce the effective fracture width through“interception”and“co-bridging”modes,thus improving plugging zone formation efficiency.Appropriate particle size and concentration of flaky LCMs increase the area and length of the plugging zone.This reduces the fracture width increment caused by injection pressure and enhances frictional force between the plugging zone and fracture surface,thereby improving the pressure-bearing capacity of the plugging zone.However,excessively high concentrations of flaky LCMs result in decreased structural stability of the plugging zone,and excessively large particle sizes increase the risk of plugging outside fracture inlet.The recommended concentration of flaky LCMs in the plugging slurry is 2%–3%,with a particle size 1.2 to 1.5 times that of the bridging granular LCMs and not exceeding twice the fracture width.This study provides a theoretical foundation for selecting LCMs and designing plugging formulations for field applications. 展开更多
关键词 Lost circulation Flaky lost circulation materials Fracture plugging zone Visualization Pressure-bearing capacity
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Preparation and Application of an Epoxy Soybean Oil-Based Plugging Agent
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作者 Yongming Li Dingyuan Zhang +1 位作者 Yadong Chen Jiandu Ye 《Fluid Dynamics & Materials Processing》 2025年第2期261-277,共17页
Resin plugging agents play a pivotal role in addressing casing damage in oil and gas fields.However,the widespread use of epoxy resin is constrained by its high cost and non-renewable origin,while plant-based resins o... Resin plugging agents play a pivotal role in addressing casing damage in oil and gas fields.However,the widespread use of epoxy resin is constrained by its high cost and non-renewable origin,while plant-based resins often suffer from inadequate mechanical properties,which limit their effectiveness in such applications.This study introduces BEOPA,an innovative,renewable,high-strength resin plugging agent derived from epoxidized soybean oil(ESO)and enhanced with bisphenol A-type benzoxazine(BZ).In this study,the synthesis process,reactionmechanism,and application performance of this novelmaterial are systematically presented,explored and optimized.It is shown that the optimal formulation of BEOPA includes 41.4 wt%ESO,24.8 wt%BZ,24.8 wt%methylhexahydrophthalic anhydride(MHHPA),8.2 wt%styrene(ST),and 0.8 wt%N,N-dimethylbenzylamine(BDMA),yielding an impressive compressive strength of 93.7 MPa.The integration of ESO and BZ creates an intricate and robust double crosslinking network,significantly enhancing material strength and durability.BEOPA exhibits a tunable curing time,ranging from 0.5 to 15 h,with viscosities below 300 mPa⋅s at 25℃and 75mPa⋅s at 50℃.Furthermore,it demonstrates exceptional thermal stability within the 100℃-150℃range,even in environments with mineral salt concentrations as high as 43,330 mg/L.Remarkably,BEOPA achieves superior plugging performance,sustaining breakthrough pressures exceeding 29.7 MPa in 1 mm crack cores. 展开更多
关键词 Casing damage epoxidized soybean oil BENZOXAZINE mechanical properties plugging properties
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Experimental study of a circulation agent dynamic plugging for multi-scale natural fractures
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作者 Zhao-Wen Hu Yi-Qun Zhang +3 位作者 Jin-Shan Wang Xin-Yu Wang Yu Qin Ya Liu 《Petroleum Science》 2025年第9期3641-3654,共14页
Lost circulation critically jeopardizes drilling safety and efficiency,and remains an unresolved challenge in oil and gas engineering.In this paper,by utilizing the self-developed dynamic plugging apparatus and synthe... Lost circulation critically jeopardizes drilling safety and efficiency,and remains an unresolved challenge in oil and gas engineering.In this paper,by utilizing the self-developed dynamic plugging apparatus and synthetic cores containing large-scale fractures,experimental research on the circulation plugging of different materials was conducted.Based on the D90 rule and fracture mechanical aperture model,we analyze the location of plugging layer under dynamic plugging mechanism.By setting different parameters of fracture width and injection pressure,the laws of cyclic plugging time,pressure bearing capacity and plugging layers formation were investigated.The results show that the comprehensive analysis of particle size and fracture aperture provides an accurate judgment of the entrance-plugging phenomenon.The bridging of solid materials in the leakage channel is a gradual process,and the formation of a stable plug requires 2–3 plug-leakage cycles.The first and second cyclic plugging time was positively correlated with the fracture width.Different scales of fractures were successfully plugged with the bearing pressure greater than 6 MPa,but there were significant differences in the composition of the plugging layer.The experimental results can effectively prove that the utilized plugging agent is effective and provides an effective reference for dynamic plugging operation. 展开更多
关键词 Dynamic plugging Large scale fracture Lost circulation material Laboratory experiments Fracture aperture
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Enhancing uniformity of multi-fracture propagation by temporary plugging and diversion fracturing in a horizontal well with multicluster perforations
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作者 Xin Chang Shi-Long Teng +2 位作者 Xing-Yi Wang Yin-Tong Guo Chun-He Yang 《Petroleum Science》 2025年第9期3688-3708,共21页
Multi-stage and multi-cluster fracturing(MMF)is a crucial technology in unconventional oil and gas development,aiming to enhance production by creating extensive fracture networks.However,achieving uniform expansion o... Multi-stage and multi-cluster fracturing(MMF)is a crucial technology in unconventional oil and gas development,aiming to enhance production by creating extensive fracture networks.However,achieving uniform expansion of multi-cluster hydraulic fractures(HFs)in MMF remains a significant challenge.Field practice has shown that the use of temporary plugging and diversion fracturing(TPDF)can promote the balanced expansion of multi-cluster HFs.This study conducted TPDF experiments using a true triaxial fracturing simulation system setting a horizontal well completion with multi-cluster jetting perforations to investigate the equilibrium initiation and extension of multi-cluster fractures.The influence of key parameters,including cluster spacing,fracturing fluid viscosity,differential stress,and fracturing fluid injection rate,on fracture initiation and propagation was systematically examined.The results indicate that while close-spaced multi-cluster fracturing significantly increases the number of HFs,it also leads to uneven extension of HFs in their propagation.In contrast,TPDF demonstrates effectiveness in mitigating uneven HF extension,increasing the number of HFs,and creating a larger stimulated reservoir volume,ultimately leading to improved oil and gas well productivity.Moreover,under conditions of high differential stress,the differential stress within the formation exerts a stronger guiding effect in HFs,which are more closely aligned with the minimum principal stress.Low-viscosity fluids facilitate rapid and extensive fracture propagation within the rock formation.High-volume fluid injection,on the other hand,more comprehensively fills the formation.Therefore,employing lowviscosity and high-volume fracturing is advantageous for the initiation and extension of multi-cluster HFs. 展开更多
关键词 Non-uniformity of fracture propagation Temporary plugging and diversion FRACTURING Multi-cluster hydraulic fracturing Fracture propagation
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Single-image super-resolution of gamma-ray imaging system using deep denoiser prior based on plug-and-play framework
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作者 Guo-Guang Li Liang Sheng +6 位作者 Bao-Jun Duan Yang Li Yan Song Zi-Jian Zhu Wei-Peng Yan Dong-Wei Hei Qing-Zi Xing 《Matter and Radiation at Extremes》 2025年第2期56-70,共15页
Gamma-ray imaging systems are powerful tools in radiographic diagnosis.However,the recorded images suffer from degradations such as noise,blurring,and downsampling,consequently failing to meet high-precision diagnosti... Gamma-ray imaging systems are powerful tools in radiographic diagnosis.However,the recorded images suffer from degradations such as noise,blurring,and downsampling,consequently failing to meet high-precision diagnostic requirements.In this paper,we propose a novel single-image super-resolution algorithm to enhance the spatial resolution of gamma-ray imaging systems.A mathematical model of the gamma-ray imaging system is established based on maximum a posteriori estimation.Within the plug-and-play framework,the half-quadratic splitting method is employed to decouple the data fidelit term and the regularization term.An image denoiser using convolutional neural networks is adopted as an implicit image prior,referred to as a deep denoiser prior,eliminating the need to explicitly design a regularization term.Furthermore,the impact of the image boundary condition on reconstruction results is considered,and a method for estimating image boundaries is introduced.The results show that the proposed algorithm can effectively addresses boundary artifacts.By increasing the pixel number of the reconstructed images,the proposed algorithm is capable of recovering more details.Notably,in both simulation and real experiments,the proposed algorithm is demonstrated to achieve subpixel resolution,surpassing the Nyquist sampling limit determined by the camera pixel size. 展开更多
关键词 deep denoiser prior enhance spatial resolution maximum posteriori estimationwithin radiographic diagnosishoweverthe maximum posteriori estimation gamma ray imaging plug play framework recorded images
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Soil Plug Effect Prediction and Pile Driveability Analysis for Large-Diameter Steel Piles in Ocean Engineering 被引量:18
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作者 刘润 闫澍旺 李志华 《China Ocean Engineering》 SCIE EI 2009年第1期107-118,共12页
Long steel piles with large diameters have been more widely used in the field of ocean engineering. Owing to the pile with a large diameter, soil plug development during pile driving has great influences on pile drive... Long steel piles with large diameters have been more widely used in the field of ocean engineering. Owing to the pile with a large diameter, soil plug development during pile driving has great influences on pile driveability and bearing capacity. The response of soil plug developed inside the open-ended pipe pile during the dynamic condition of pile-driving is different from the response under the static condition of loading during service. This paper addresses the former aspect. A numerical procedure for soil plug effect prediction and pile driveabihty analysis is proposed and described. By taking into consideration of the pile dimension effect on side and tip resistance, this approach introduces a dimensional coefficient to the conventional static eqnihbrium equations for the plug differential unit and proposes an improved static equity method for the plug effect prediction. At the same time, this approach introduces a simplified model by use of one-dimensional stress wave equation to simulate the interaction between soil plug and pile inner wall. The proposed approach has been applied in practical engineering analyses. Results show that the calculated plug effect and pile driveabihty based on the proposed approach agree well with the observed data. 展开更多
关键词 large diameter steel piles soil plug plug effect static equity method interaction between the plug and pile inner wall driveability analysis
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Plugging behaviors of temporary plugging particles in hydraulic fractures 被引量:4
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作者 GUO Jianchun ZHAN Li +5 位作者 LU Qianli QI Tianjun LIU Yuxuan WANG Xin CHEN Chi GOU Xinghao 《Petroleum Exploration and Development》 SCIE 2023年第2期464-472,共9页
Using the visualized experimental device of temporary plugging in hydraulic fractures, the plugging behaviors of temporary plugging particles with different sizes and concentrations in hydraulic fractures were experim... Using the visualized experimental device of temporary plugging in hydraulic fractures, the plugging behaviors of temporary plugging particles with different sizes and concentrations in hydraulic fractures were experimentally analyzed under the conditions of different carrier fluid displacements and viscosities. The results show that the greater the carrier fluid viscosity and displacement, the more difficult it is to form a plugging layer, and that the larger the size and concentration of the temporary plugging particle, the less difficult it is to form a plugging layer. When the ratio of particle size to fracture width is 0.45, the formation of the plugging layer is mainly controlled by the mass concentration of the temporary plugging particle and the viscosity of the carrier fluid, and a stable plugging layer cannot form if the mass concentration of the temporary plugging particle is less than 20 kg/m^(3)or the viscosity of the carrier fluid is greater than 3 mPa·s. When the ratio of particle size to fracture width is 0.60, the formation of the plugging layer is mainly controlled by the mass concentration of the temporary plugging particle, and a stable plugging layer cannot form if the mass concentration of the temporary plugging particle is less than 10 kg/m^(3). When the ratio of particle size to fracture width is 0.75, the formation of the plugging layer is basically not affected by other parameters, and a stable plugging layer can form within the experimental conditions. The formation process of plugging layer includes two stages and four modes. The main controlling factors affecting the formation mode are the ratio of particle size to fracture width, carrier fluid displacement and carrier fluid viscosity. 展开更多
关键词 hydraulic fracture temporary plugging and diversion temporary plugging particle plugging characteristics construction parameters combination
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Formation mechanisms of fracture plugging zone and optimization of plugging particles 被引量:2
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作者 LEI Shaofei SUN Jinsheng +5 位作者 BAI Yingrui LYU Kaihe ZHANG Shupei XU Chengyuan CHENG Rongchao LIU Fan 《Petroleum Exploration and Development》 CSCD 2022年第3期684-693,共10页
As formation mechanisms of plugging zone and criteria for fracture plugging remain unclear,plugging experiments and methods testing granular material mechanical properties are used to study the formation process of th... As formation mechanisms of plugging zone and criteria for fracture plugging remain unclear,plugging experiments and methods testing granular material mechanical properties are used to study the formation process of the plugging zone in fractured formations,analyze composition and ratios of different sizes of particles in the plugging zone,and reveal the essence and driving energy of the formation and damage of the plugging zone.New criteria for selecting lost circulation materials are proposed.The research results show that the formation of the plugging zone has undergone a process from inertial flow,elastic flow,to quasi-static flow.The plugging zone is composed of fracture mouth plugging particles,bridging particles and filling particles,and the proportion of the three types of particles is an important basis for designing drilling fluid loss control formula.The essence of the construction of the plugging zone is non-equilibrium Jamming phase transition.The response of the plugging zone particle system to pressure is driven by entropy force;the greater the entropy,the more stable the plugging zone.Lost circulation control formula optimized according to the new criteria has better plugging effect than the formula made according to conventional plugging rules and effectively improves the pressure-bearing capacity of the plugging zone.The research results provide a theoretical and technical basis for the lost circulation control of fractured formations. 展开更多
关键词 fractured formation drilling fluid loss plugging zone plugging mechanism plugging particles optimization criterion
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Plug-in混合动力汽车能量管理策略全局优化研究 被引量:33
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作者 张博 李君 +2 位作者 高莹 杨成宏 尹雪峰 《中国机械工程》 EI CAS CSCD 北大核心 2010年第6期715-720,共6页
应用动态规划全局优化算法,针对并联式Plug-in混合动力汽车在不同行驶里程下的能量管理策略进行了全局优化研究。结果表明:车辆的行驶里程小于55km时应使用电动机为主的能量管理策略,当车辆的行驶里程大于55km时应使用发动机为主的能量... 应用动态规划全局优化算法,针对并联式Plug-in混合动力汽车在不同行驶里程下的能量管理策略进行了全局优化研究。结果表明:车辆的行驶里程小于55km时应使用电动机为主的能量管理策略,当车辆的行驶里程大于55km时应使用发动机为主的能量管理策略;在动态规划最优控制下,车辆行驶里程为55km时整车经济性能最佳,行驶里程小于110km时整车平均等价油耗为2.7L/100km,相对于原型车经济性提高了近58%。 展开更多
关键词 plug—in混合动力汽车 能量管理策略 动态规划 优化设计
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Smart Plug泪小管塞治疗水液缺乏型干眼症临床初步观察 被引量:8
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作者 陈晓莉 张世华 廖润斌 《国际眼科杂志》 CAS 2015年第4期723-724,共2页
目的:探讨Smart Plug泪小管塞治疗水液缺乏型干眼症临床疗效。方法:选取2012-05/2013-04期间我院收治的48例水液缺乏型干眼症患者为研究对象,进行Smart Plug泪小管塞治疗,观察术后临床疗效、基础泪液分泌试验(SchirmerⅠtest,SⅠt)、泪... 目的:探讨Smart Plug泪小管塞治疗水液缺乏型干眼症临床疗效。方法:选取2012-05/2013-04期间我院收治的48例水液缺乏型干眼症患者为研究对象,进行Smart Plug泪小管塞治疗,观察术后临床疗效、基础泪液分泌试验(SchirmerⅠtest,SⅠt)、泪膜破裂时间(tear break up time,BUT)、角膜荧光素染色(fluoreseein staining,FL)变化。结果:本组48例患者,显效31例(65%),有效14例(29%),无效3例(6%),总有效率为94%。治疗前,患者SⅠt,BUT,FL分别为3.49±1.24mm/5min,3.15±1.07s,2.52±0.11分。治疗后,患者SⅠt,BUT,FL均明显改善,与治疗前比较,差异具有统计学意义(P<0.05)。1例患者术后有异物感,8h后栓子脱落;1例患者于术后8mo出现肉芽组织,泪小管塞脱落。其余病例无下泪小管感染或肉芽肿。结论:Smart Plug泪小管塞治疗水液缺乏型干眼症疗效确切,能够有效缓解临床症状,值得临床推广。 展开更多
关键词 SMART plug 泪小管塞 水液缺乏型干眼症 疗效 并发症
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Plug-in结构应用程序设计 被引量:18
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作者 刘毅 陈慧蓉 荣钢 《计算机应用》 CSCD 北大核心 2002年第4期9-11,14,共4页
插件 (Plug in)结构使软件可以动态地寻找和加载特定的代码模块 ,因此被越来越广泛地采用。文中分析了Plug in程序应当具有的主要特性 ,介绍了运用标准DLL方式和COM标准两种方式实现Plug in结构的界面的方法 。
关键词 程序设计 应用程序 plug-in结构 代码模块 计算机
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PLUG引物和IT引物在顶芒山羊草分子标记建立中的通用性分析 被引量:6
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作者 宫文萍 李凯 +6 位作者 程敦公 武智民 李洪振 韩冉 李豪圣 刘成 刘建军 《山东农业科学》 2019年第7期10-16,共7页
分子标记是检测和追踪小麦背景中近缘物种染色体的重要手段。依据禾本科物种基因共线性原则,基于基因序列设计的引物在不同物种中可能具有通用性。本研究对水稻PLUG引物和簇毛麦IT引物在顶芒山羊草中的通用性进行了分析,并建立了顶芒山... 分子标记是检测和追踪小麦背景中近缘物种染色体的重要手段。依据禾本科物种基因共线性原则,基于基因序列设计的引物在不同物种中可能具有通用性。本研究对水稻PLUG引物和簇毛麦IT引物在顶芒山羊草中的通用性进行了分析,并建立了顶芒山羊草染色体特异IT标记。供试的397对PLUG引物和841对IT引物对小麦-顶芒山羊草双二倍体与中国春的扩增结果显示,377对(95.0%)PLUG引物和593对(70.5%)IT引物可以在供试材料中扩增出清晰条带。因此,PLUG引物在顶芒山羊草中的通用性优于IT引物。相比小麦对照,PLUG引物和IT引物能在小麦-顶芒山羊草双二倍体中扩增出多态性条带的引物数分别有17对和5对,分别占供试PLUG引物和IT引物的4.3%和0.6%。利用获得的IT多态性引物对一套小麦-顶芒山羊草附加系和一套小麦-卵穗山羊草附加系进行扩增,结果发现仅引物CINAU1060、CINAU1465和CINAU1517能在相应附加系中扩增出大小分别约为300、480bp和320bp的多态性标记,为小麦背景中顶芒山羊草染色质的鉴定提供了新的检测手段。然而,本研究中IT引物建立顶芒山羊草分子标记的比率仅为0.4%,低于我们之前用PLUG引物建立顶芒山羊草分子标记的比率(8.9%)。 展开更多
关键词 顶芒山羊草 分子标记 plug引物 IT引物 通用性
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Plug-in混合动力汽车能量管理策略优化设计 被引量:15
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作者 张博 李君 +3 位作者 高莹 杨世春 杨成宏 陈华艳 《农业机械学报》 EI CAS CSCD 北大核心 2009年第9期20-25,共6页
应用PSAT前向仿真软件及矩阵分割全局优化算法,对并联式Plug-in混合动力汽车(PHEV)在不同电能消耗续驶里程(CDR)下的能量管理策略进行了优化设计研究。结果表明:PHEV电能消耗续驶里程越大,优化控制参数对整车经济性影响越小;小CDR优化... 应用PSAT前向仿真软件及矩阵分割全局优化算法,对并联式Plug-in混合动力汽车(PHEV)在不同电能消耗续驶里程(CDR)下的能量管理策略进行了优化设计研究。结果表明:PHEV电能消耗续驶里程越大,优化控制参数对整车经济性影响越小;小CDR优化控制参数的整车平均经济性能好于大CDR优化控制参数;利用优化设计得到的PHEV能量管理策略可以使整车平均等价油耗降至2.70 L/(100 km),相对于原型车经济性提高了近58%。 展开更多
关键词 plug-IN混合动力汽车 能量管理策略 优化 仿真
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用Plug-in实现对PDF文件的信息提取 被引量:16
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作者 李贵林 李建中 杨艳 《计算机应用》 CSCD 北大核心 2003年第2期110-112,共3页
利用AdobeAcrobat提供的编程接口编写Plug in插件,实现对PDF文件信息的提取。
关键词 PDF文件 信息提取 程序设计 plug-in插件
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Visiplug~泪小管塞栓治疗中度以上干眼的临床疗效分析 被引量:2
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作者 黄俊 石珂 +3 位作者 金奇芳 游志鹏 张倩 毛新帮 《眼科新进展》 CAS 北大核心 2018年第9期876-879,共4页
目的探讨应用眼表综合分析仪评估Visi Plug泪小管塞栓治疗中度以上干眼的临床疗效。方法选择2015年1月至2016年3月于我院诊断为干眼并使用人工泪液及普拉洛芬滴眼液4周后仍有症状并再次评分为中度以上干眼的患者32例(64眼),分成治疗... 目的探讨应用眼表综合分析仪评估Visi Plug泪小管塞栓治疗中度以上干眼的临床疗效。方法选择2015年1月至2016年3月于我院诊断为干眼并使用人工泪液及普拉洛芬滴眼液4周后仍有症状并再次评分为中度以上干眼的患者32例(64眼),分成治疗组和对照组,每组各16例32眼,治疗组使用泪小管塞栓联合人工泪液及普拉洛芬滴眼液进行治疗,对照组继续使用人工泪液和普拉洛芬滴眼液治疗,随访6~12个月,分别观察治疗前及治疗后2周、1个月、3个月、6个月、末次随访时干眼主观症状问卷调查得分、眼表综合分析仪中泪膜破裂时间、泪河高度、眼红指数及角膜荧光素染色检查情况并评估临床疗效。结果治疗后1 a,主观症状问卷调查评分治疗组由术前(16.95±5.12)分降至(4.36±0.16)分,对照组由术前(17.22±5.20)分降至(5.50±0.29)分,两组治疗前差异无统计学意义(P>0.05),治疗后1 a差异有统计学意义(P<0.01)。治疗组、对照组治疗前与治疗后不同时间点的泪膜破裂时间、泪河高度、眼红指数、角膜荧光素染色评分的差异均有统计学意义(均为P<0.05)。两组在治疗后泪膜破裂时间均较治疗前显著延长、泪河高度均较治疗前显著增加,眼红指数评分和角膜荧光素染色评分均较治疗前显著降低,差异均有统计学意义(均为P<0.05),但治疗组与对照组相比,泪膜破裂时间更长,泪河高度改善更为明显,眼红指数评分与角膜荧光素染色评分更低。结论 Visi Plug泪小管塞栓治疗中度以上干眼具有良好的临床效果。应用眼表综合分析仪评估Visi Plug~泪小管塞栓治疗中度以上干眼的临床疗效更加客观、简便。 展开更多
关键词 眼表综合分析仪 Visi plug泪小管塞栓 干眼 临床疗效
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Plug-in混合动力汽车动力总成优化设计研究 被引量:11
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作者 张博 李君 +2 位作者 杨世春 高莹 尹雪峰 《汽车工程》 EI CSCD 北大核心 2009年第7期592-596,共5页
应用PSAT前向仿真软件,建立了双离合器式并联PHEV仿真模型。在确定了PHEV整车性能约束条件并对动力总成主要部件进行了成本分析之后,对不同全电力续驶里程和动力电池类型的PHEV动力总成进行了优化。结果表明:动力电池设计容量对整车成... 应用PSAT前向仿真软件,建立了双离合器式并联PHEV仿真模型。在确定了PHEV整车性能约束条件并对动力总成主要部件进行了成本分析之后,对不同全电力续驶里程和动力电池类型的PHEV动力总成进行了优化。结果表明:动力电池设计容量对整车成本影响最大,而它主要取决于所要求的全电力续驶里程;随着所要求的全电力续驶里程的增大,所需电机最大输出功率升高,而发动机最大输出功率则降低。 展开更多
关键词 plug-IN混合动力汽车 动力总成 优化设计 PSAT仿真软件
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