Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an impro...Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.展开更多
The porkchop plot is the porkchop-shaped,computer-generated contour plot that displays the launch date and arrival date characteristics of an interplanetary flight path for a given launch opportunity between two celes...The porkchop plot is the porkchop-shaped,computer-generated contour plot that displays the launch date and arrival date characteristics of an interplanetary flight path for a given launch opportunity between two celestial bodies.We found that,when the gravity assistance of a planet is taken into account of an interplanetary transfer trajectory,the classical porkchop plot cannot give enough information for the interplanetary mission.In this regard,we have generalized the classical porkchop plot into the 3D porkchop plot that gives the launch,flyby,and arrival opportunity of the interplanetary mission.This paper presents an alternative opportunity for the Psyche asteroid mission with Mars’s gravity assist.Psyche is a largest M-type asteroid in the solar system and may be a good source of Platinum group metals.This paper also presents the analytical solution of the gravity assist model,which is useful for obtaining the optimal flyby radius and the optimal thrust impulse during the planetary gravity assist.展开更多
基金This work was founded by the“AO Trauma Deutschland Nachwuchsf¨orderung”(PK)as well as the German Research Foundation(DFGproject no.449121904)(AL,MG).
文摘Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.
文摘The porkchop plot is the porkchop-shaped,computer-generated contour plot that displays the launch date and arrival date characteristics of an interplanetary flight path for a given launch opportunity between two celestial bodies.We found that,when the gravity assistance of a planet is taken into account of an interplanetary transfer trajectory,the classical porkchop plot cannot give enough information for the interplanetary mission.In this regard,we have generalized the classical porkchop plot into the 3D porkchop plot that gives the launch,flyby,and arrival opportunity of the interplanetary mission.This paper presents an alternative opportunity for the Psyche asteroid mission with Mars’s gravity assist.Psyche is a largest M-type asteroid in the solar system and may be a good source of Platinum group metals.This paper also presents the analytical solution of the gravity assist model,which is useful for obtaining the optimal flyby radius and the optimal thrust impulse during the planetary gravity assist.
