The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with...The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with limited studies on fog,particularly those that examine the combined influences of all key physical processes and their roles during fog evolution.As such,this study aims to conduct a comprehensive investigation by examining the relationships between relative dispersion and other microphysical variables,as well as the underlying microphysical and dynamic processes,based on field fog campaigns in polluted and clean conditions.In polluted fog,droplet concentrations are higher,leading to smaller droplets and increased dispersion.The correlation between dispersion and droplet volume-mean radius is positive in the polluted fog,but shifts to negative in clean fog.We attribute the difference to various microphysical processes like aerosol activation,condensation,collision-coalescence,and entrainment-mixing.In polluted fog,high aerosol concentrations,low supersaturations,and strong turbulence(entrainment-mixing)provide suitable conditions for the simultaneous occurrence of droplet condensation and aerosol activation,resulting in a positive correlation between dispersion and volume-mean radius,especially during the fog formation stage.In contrast,during the mature stage in clean fog,condensation is dominant with weak aerosol activation leading to a negative correlation between relative dispersion and volume-mean radius.The collision-coalescence process is more active in the mature stage,increasing radii and leading to the negative correlation between dispersion and volume-mean radius.This result sheds new light on understanding the relative dispersion and mechanisms in fog under different aerosol backgrounds.展开更多
Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced su...Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced substantial deformation and transition into the residual stage remain insufficiently understood.To elucidate the relationship between grouting effectiveness and pre-cracking strain,grouting and subsequent re-fracturing tests were conducted on sandy mudstone specimens with varying levels of pre-cracking strain.Additionally,a model was developed to determine the optimal grouting timing during the residual stage.The results indicate that the failure mode of specimens in the residual stage exhibits banded and localized distribution patterns.As pre-cracking strain increases,both the maximum fracture aperture and the relative grout injection ratio increase,with the increases becoming more pronounced at higher strain levels.After grouting,the consolidation coefficient and strength enhancement coefficient exhibit a positive correlation with pre-cracking strain,although the rate of increase gradually decreases.Grouting does not alter the initial failure mode of residual-stage fractured specimens but effectively suppresses secondary crack propagation in regions distant from primary fractures.At the microscale,grout bonds within the rock matrix form cavity structures that delay tensile failure and generate an interconnected network,thereby enhancing crack resistance.Based on the evolution of rock damage and the efficiency of grouting materials utilization,a method is proposed to determine the optimal grouting timing for fractured specimens in the residual stage.At the optimal timing,specimens exhibit moderate damage while maintaining high reinforcement efficiency per unit mass of grout.展开更多
Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve bette...Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients.Methods:We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy(CCRT)or sequential chemoradiotherapy(SCRT)(Group A)and immunotherapy combined with CCRT/SCRT followed by immunotherapy(Group B),to assess the objective response rate(ORR),disease control rate(DCR),and progression-free survival(PFS).Factors affecting prognosis were also explored using Cox analysis.The prognosis of patients with type 2 diabetes and patients with different TNM stages was compared to guide the selection of clinical regimens.Results:The overall ORR was 55.93%.The overall DCR was 98.31%.The DCR was 100%in Group A and 96.61%in Group B.There was no statistical difference in ORR and DCR.The overall median PFS was 9.86 months(95%CI,8.62-11.10),and the difference in median PFS between the two groups was statistically significant(8.94 vs.11.89 months,p=0.03).The Cox regression analysis showed type 2 diabetes was associated with the survival prognosis.Patients with type 2 diabetes tended to choose immunotherapy combined with CCRT/SCRT.Patients in TNM stage IIIB had a significantly worse prognosis than those in stage I+II+IIIA.Conclusion:We suggest that LS-SCLC patients who receive immunotherapy combined with CCRT/SCRT can achieve longer PFS than those with CCRT/SCRT.Type 2 diabetes and TNM stage affect the survival prognosis.Patients with type 2 diabetes may benefit from immunotherapy combination treatments.展开更多
The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the...The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the patterns of change in community R/S ratios during forest succession and their response to moisture levels across broad geographic gradients remains unclear.Based on forest biomass data from a national field inventory of 5,825 plots conducted across China between 2011 and 2015,this study looked into allocating biomass shoots and roots at the early,middle,and late stages of growth in plantations and succession in natural forests,and evaluated how moisture availability influences this allocation.The results revealed a significant decline in R/S ratios from early to late stages for both plantations and natural forests.Shoot and root biomass in plantations grew isometrically during the early and middle succession stages but shifted to allometric growth in the late stage,with the slope of the log-transformed shoot-root biomass relationship differing significantly across growth stages.Natural forests,in contrast,maintained isometric growth across successional stages,showing no significant variation in the slope of the log-transformed shoot-root biomass relationship.Environmental factors,particularly moisture levels,strongly influenced R/S ratios.Moisture levels significantly affected size-corrected R/S ratios,particularly in the middle stage of plantations and the early and middle stages of natural forests,supporting the hypothesis of optimal allocation.These findings suggest that in water-limited regions,forest management should prioritize drought-tolerant,deep-rooted native species,encourage mixed-species planting in the early stage,and reduce logging intensity in mature plantations.Conserving natural forests to maintain successional dynamics is essential for long-term ecological resilience.These findings emphasize the importance of balancing productivity with ecological sustainability by adapting practices to specific environments and forest types under climate change.展开更多
Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hyperten...Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.展开更多
The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspective...The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.展开更多
Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have...Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have largely failed to halt or reverse disease progression.This has prompted a critical shift in focus toward the earlier,preclinical stages of AD,where interventions may hold greater promise for altering the disease trajectory.展开更多
The wheat above-ground biomass(AGB)is an important index that shows the life activity of vegetation,which is of great significance for wheat growth monitoring and yield prediction.Traditional biomass estimation method...The wheat above-ground biomass(AGB)is an important index that shows the life activity of vegetation,which is of great significance for wheat growth monitoring and yield prediction.Traditional biomass estimation methods specifically include sample surveys and harvesting statistics.Although these methods have high estimation accuracy,they are time-consuming,destructive,and difficult to implement to monitor the biomass at a large scale.The main objective of this study is to optimize the traditional remote sensing methods to estimate the wheat AGBbased on improved convolutional features(CFs).Low-cost unmanned aerial vehicles(UAV)were used as the main data acquisition equipment.This study acquired image data acquired by RGB camera(RGB)and multi-spectral(MS)image data of the wheat population canopy for two wheat varieties and five key growth stages.Then,field measurements were conducted to obtain the actual wheat biomass data for validation.Based on the remote sensing indices(RSIs),structural features(SFs),and CFs,this study proposed a new feature named AUR-50(multi-source combination based on convolutional feature optimization)to estimate the wheat AGB.The results show that AUR-50 could estimate the wheat AGB more accurately than RSIs and SFs,and the average R^(2) exceeded 0.77.In the overwintering period,AUR-50_(MS)(multi-source combination with convolutional feature optimization using multispectral imagery)had the highest estimation accuracy(R^(2) of 0.88).In addition,AUR-50 reduced the effect of the vegetation index saturation on the biomass estimation accuracy by adding CFs,where the highest R^(2) was 0.69 at the flowering stage.The results of this study provide an effective method to evaluate the AGB in wheat with high throughput and a research reference for the phenotypic parameters of other crops.展开更多
The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur batteries.Herein,we propose a dual-action strategy to address the lithiu...The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur batteries.Herein,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene (PP) separator.The uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition stage.Most importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance(145.88 MPa) of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium dendrite.The Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm^(-2)with a polarization voltage of only 29.3 mV.Additionally,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity attenuation.The improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.展开更多
Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-ter...Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health.Currently,several surgical techniques have been validated for their effectiveness in increasing PIKM.However,the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques,variations in clinical scenarios,and anatomical differences.Therefore,clear guidelines and considerations for PIKM augmentation are needed.This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery.It aims to establish a standardized framework for assessing,planning,and executing PIKM augmentation procedures,with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.展开更多
Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate...Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.展开更多
Osteoarthritis(OA)is one of the most common degenerative joint diseases in the elderly,increasing in prevalence and posing a substantial socioeconomic challenge,while no disease-modifying treatments available.Better u...Osteoarthritis(OA)is one of the most common degenerative joint diseases in the elderly,increasing in prevalence and posing a substantial socioeconomic challenge,while no disease-modifying treatments available.Better understanding of the early molecular events will benefit the early-stage diagnosis and clinical therapy.Here,we observed the nucleus accumulation of ZBTB20,a member of ZBTB-protein family,in the chondrocytes of early-stage OA.Chondrocytes-specific depletion of Zbtb20 in adult mice attenuated DMM-induced OA progress,restored the balance of extracellular matrix anabolism and catabolism.The NF-κB signaling mediated disturbance of ECM maintenance by ZBTB20 requires its suppression of Pten and consequent PI3K-Akt signaling activation.Furthermore,the subcellular localization of ZBTB20 was modulated by the kinase LATS1.Independent approaches to modulating ZBTB20 via utilizing TRULI and DAPA can restore ECM homeostasis,improving the abnormal behavior and moderating cartilage degeneration.The compounds TRULI and DAPA modulating ZBTB20 may serve as anti-OA drugs.展开更多
Teacher education at the foundational and preparatory stages plays a crucial role in shaping early childhood learning experiences.The National Curriculum Framework for School Education(NCFSE)2023 provides a structured...Teacher education at the foundational and preparatory stages plays a crucial role in shaping early childhood learning experiences.The National Curriculum Framework for School Education(NCFSE)2023 provides a structured pedagogical approach to address challenges in these stages.However,despite these policy frameworks,teachers in Kendriya Vidyalayas(KVs)continue to face numerous pedagogical challenges.This paper aims to explore and analyze the pedagogical challenges encountered by KV teachers in foundational and preparatory stage classrooms and compare them with the challenges addressed in NCFSE 2023.Using qualitative research methods,data were collected through structured online interviews with 10 KV teachers from different campuses.This paper investigated various challenges,including classroom management,language barriers,a lack of inclusive education strategies,insufficient infrastructure,limited parental involvement,and difficulties in integrating technology into teaching practices.The findings highlight the gap between policy recommendations and ground-level implementation.Based on these insights,the study suggests recommendations such as specialized teacher training,recruitment of special educators,improved infrastructure,enhanced parental engagement,and policy-driven interventions to bridge the gap between policy frameworks and real-world classroom experiences.The study concludes that addressing these challenges through targeted reforms can create a more inclusive and effective learning environment,fostering holistic student development at the foundational and preparatory stages.展开更多
Objective The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer(AJCC)anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for imp...Objective The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer(AJCC)anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for improvement.Methods The clinical and histopathologic data from 16 centers between January 2000 and December 2021 were assessed according to the 8th AJCC anatomic and prognostic stage groups.Kaplan–Meier plots were used to estimate the disease-specific survival(DSS)of the patients.The accuracy of the staging systems was investigated using the Harrell's concordance index(C-index).Results According to the 8th AJCC anatomic and prognostic stage groups,the 5-year DSS rates for patients with stages 0is/a,I,IIA,IIB,IIIA,IIIB,and IV disease were 100%,99%,86%,81%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–IIA)<0.001,p_(IIA–IIB)=0.5,p_(IIB–IIIA)<0.001,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).According to the modified model 1 system,the 5-year DSS rates without survivorship overlap for patients with stages 0is/a,I,II,IIIA,IIIB,and IV disease were 100%,99%,88%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–II)<0.001,p_(II–IIIA)=0.002,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).Similarly,according to the modified model 2 system,the 5-year DSS rates without survivorship overlap for patients with stages 0is/a,I,II,IIIA,IIIB,and IV disease were 100%,99%,86%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–II)<0.001,p_(II–IIIA)=0.008,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).The C-index scores of the simple modified staging systems were not inferior to those of the AJCC anatomic and prognostic stage groups.These results were confirmed by the bootstrap internal validation.Conclusion There is still room for improvement about the 8th AJCC anatomic and prognostic stage groups.The improved models,which are more concise and convenient,have similar prediction accuracy.展开更多
This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise inten...This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise intensity.Scientific and reasonable sports protection measures and training plans are formulated,including correcting sports postures and reasonably controlling exercise intensity and frequency.Rehabilitation training is carried out in stages,and the training intensity and frequency are gradually adjusted according to the recovery situation.Through scientific protection and training,the risk of re-injury to athletes can be reduced,and they can be helped to restore their best sports conditions.At the same time,future research directions are prospected,covering personalized rehabilitation programs,application of new technologies,and research on psychological factors.展开更多
Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perc...Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perception and its predictive factors among young football players from Poland and Türkiye.Methods The study involved 171 players aged 15–18 years,recruited from football academies in Poland and Türkiye.The Polish and Turkish versions of the Body-Esteem Scale for Adolescents and Adults(BESAA)were administered to assess body image perception,while the Düsseldorf Orthorexia Scale(DOS)was used to measure ON risk.Anthropometric measurements were taken to calculate Body Mass Index(BMI),which was then referenced to centile charts to determine nutritional status.Results Results indicated that 13%of participants exhibited characteristics of ON,with an additional 26%classified as at elevated risk.Comparative analysis revealed no significant differences in ON prevalence between Polish and Turkish players(p=0.938)and no age-related differences(p=0.694).Among Polish players,a significant positive association emerged between BMI(relative to centile charts)and overall appearance evaluation(BE-Appearance)(p=0.008,partialη^(2)=0.10).This relationship was not observed in Turkish players.Moreover,analysis of ON risk predictors—including age,nationality,nutritional status,and body image—did not identify any single variable as a definitive predictor(all p-values>0.05),with a low predictive capacity(McFadden’s R^(2)=0.03).Conclusion The study revealed a significant risk of ON among young footballers with no clear predictors.展开更多
基金supported by the Chinese National Natural Science Foundation under Grant Nos.(41975181,42325503,42375197,42575207,42205090)Y.LIU is supported by the U.S.Department of Energy’s Atmospheric System Research(ASR)program.
文摘The relative dispersion of cloud and fog droplets has significant impacts on aerosol indirect effects,radiative transfer,and microphysical processes.However,previous studies have been mostly concerned with clouds,with limited studies on fog,particularly those that examine the combined influences of all key physical processes and their roles during fog evolution.As such,this study aims to conduct a comprehensive investigation by examining the relationships between relative dispersion and other microphysical variables,as well as the underlying microphysical and dynamic processes,based on field fog campaigns in polluted and clean conditions.In polluted fog,droplet concentrations are higher,leading to smaller droplets and increased dispersion.The correlation between dispersion and droplet volume-mean radius is positive in the polluted fog,but shifts to negative in clean fog.We attribute the difference to various microphysical processes like aerosol activation,condensation,collision-coalescence,and entrainment-mixing.In polluted fog,high aerosol concentrations,low supersaturations,and strong turbulence(entrainment-mixing)provide suitable conditions for the simultaneous occurrence of droplet condensation and aerosol activation,resulting in a positive correlation between dispersion and volume-mean radius,especially during the fog formation stage.In contrast,during the mature stage in clean fog,condensation is dominant with weak aerosol activation leading to a negative correlation between relative dispersion and volume-mean radius.The collision-coalescence process is more active in the mature stage,increasing radii and leading to the negative correlation between dispersion and volume-mean radius.This result sheds new light on understanding the relative dispersion and mechanisms in fog under different aerosol backgrounds.
基金supported by the National Natural Science Foundation of China(Grant Nos.52274091 and 51974193).
文摘Grouting is an essential technique for reinforcing tunnel rock masses following deformation and failure.However,the mechanisms and effectiveness evaluation of grouting in fractured rock masses that have experienced substantial deformation and transition into the residual stage remain insufficiently understood.To elucidate the relationship between grouting effectiveness and pre-cracking strain,grouting and subsequent re-fracturing tests were conducted on sandy mudstone specimens with varying levels of pre-cracking strain.Additionally,a model was developed to determine the optimal grouting timing during the residual stage.The results indicate that the failure mode of specimens in the residual stage exhibits banded and localized distribution patterns.As pre-cracking strain increases,both the maximum fracture aperture and the relative grout injection ratio increase,with the increases becoming more pronounced at higher strain levels.After grouting,the consolidation coefficient and strength enhancement coefficient exhibit a positive correlation with pre-cracking strain,although the rate of increase gradually decreases.Grouting does not alter the initial failure mode of residual-stage fractured specimens but effectively suppresses secondary crack propagation in regions distant from primary fractures.At the microscale,grout bonds within the rock matrix form cavity structures that delay tensile failure and generate an interconnected network,thereby enhancing crack resistance.Based on the evolution of rock damage and the efficiency of grouting materials utilization,a method is proposed to determine the optimal grouting timing for fractured specimens in the residual stage.At the optimal timing,specimens exhibit moderate damage while maintaining high reinforcement efficiency per unit mass of grout.
基金funded by the National Natural Science Foundation of China(grant no.82273162)the National Natural Science Foundation of China(grant no.82203272)the Science and Technology Development Foundation of Nanjing Medical University(grant NMUB20240119)。
文摘Objective:To determine whether immunotherapy can bring new hope for patients with limited-stage small-cell lung cancer(LS-SCLC).We conducted this retrospective study to evaluate whether immunotherapy can achieve better efficacy in LS-SCLC patients.Methods:We evaluated 122 LS-SCLC patients who received concurrent chemoradiotherapy(CCRT)or sequential chemoradiotherapy(SCRT)(Group A)and immunotherapy combined with CCRT/SCRT followed by immunotherapy(Group B),to assess the objective response rate(ORR),disease control rate(DCR),and progression-free survival(PFS).Factors affecting prognosis were also explored using Cox analysis.The prognosis of patients with type 2 diabetes and patients with different TNM stages was compared to guide the selection of clinical regimens.Results:The overall ORR was 55.93%.The overall DCR was 98.31%.The DCR was 100%in Group A and 96.61%in Group B.There was no statistical difference in ORR and DCR.The overall median PFS was 9.86 months(95%CI,8.62-11.10),and the difference in median PFS between the two groups was statistically significant(8.94 vs.11.89 months,p=0.03).The Cox regression analysis showed type 2 diabetes was associated with the survival prognosis.Patients with type 2 diabetes tended to choose immunotherapy combined with CCRT/SCRT.Patients in TNM stage IIIB had a significantly worse prognosis than those in stage I+II+IIIA.Conclusion:We suggest that LS-SCLC patients who receive immunotherapy combined with CCRT/SCRT can achieve longer PFS than those with CCRT/SCRT.Type 2 diabetes and TNM stage affect the survival prognosis.Patients with type 2 diabetes may benefit from immunotherapy combination treatments.
基金supported by the China National Science Foundation(No.42130506,42071031)the Special Technology Innovation Fund of Carbon Peak and Carbon Neutrality in Jiangsu Province(BK20231515)+1 种基金the Spanish Government grant PID2022-140808NB-I00 funded by MICIU/AEI/https://doi.org/10.13039/501100011033the Catalan Government grants SGR 2021-1333 and AGAUR2023 CLIMA 00118.
文摘The root-to-shoot(R/S)ratio is a critical indicator of the balance between root biomass and shoot biomass,representing the ecological strategies and adaptive responses of plants to environmental conditions.However,the patterns of change in community R/S ratios during forest succession and their response to moisture levels across broad geographic gradients remains unclear.Based on forest biomass data from a national field inventory of 5,825 plots conducted across China between 2011 and 2015,this study looked into allocating biomass shoots and roots at the early,middle,and late stages of growth in plantations and succession in natural forests,and evaluated how moisture availability influences this allocation.The results revealed a significant decline in R/S ratios from early to late stages for both plantations and natural forests.Shoot and root biomass in plantations grew isometrically during the early and middle succession stages but shifted to allometric growth in the late stage,with the slope of the log-transformed shoot-root biomass relationship differing significantly across growth stages.Natural forests,in contrast,maintained isometric growth across successional stages,showing no significant variation in the slope of the log-transformed shoot-root biomass relationship.Environmental factors,particularly moisture levels,strongly influenced R/S ratios.Moisture levels significantly affected size-corrected R/S ratios,particularly in the middle stage of plantations and the early and middle stages of natural forests,supporting the hypothesis of optimal allocation.These findings suggest that in water-limited regions,forest management should prioritize drought-tolerant,deep-rooted native species,encourage mixed-species planting in the early stage,and reduce logging intensity in mature plantations.Conserving natural forests to maintain successional dynamics is essential for long-term ecological resilience.These findings emphasize the importance of balancing productivity with ecological sustainability by adapting practices to specific environments and forest types under climate change.
基金supported by grants from the Sichuan Science and Technology Program(2023YFQ0094)the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(25HXJS028).
文摘Background:According to the 2022 update of the BCLC strategy,laparoscopic liver resection(LLR)is considered feasible for BCLC stage 0-A hepatocellular carcinoma(HCC)patients with clinically significant portal hypertension(CSPH).However,there is still no research to explore the outcomes of laparoscopic versus open liver resection(OLR)in the specific patients with BCLC stage 0-A HCC and CSPH.Methods:Patients diagnosed with BCLC stage 0-A HCC and CSPH who underwent liver resection at West China Hospital of Sichuan University from February 2018 to December 2022 were analyzed.Demographic characteristics,pathological findings and postoperative outcomes were compared using propensity score matching(PSM).Long-term outcomes after surgery were analyzed using Kaplan-Meier analysis both before and after PSM.Results:A total of 409 patients,including 261 LLRs and 148 OLRs,were enrolled in this study.There were imbalances between the groups in baseline information.After 1:1 PSM,118 patients were included in each group with comparable baseline characteristics.Patients in the LLR group had significantly less intraoperative blood loss compared to those in the OLR group(median 223 vs.318 mL,P<0.001),and fewer postoperative complications(33.9%vs.57.6%,P<0.001),including lower rates of postoperative liver decompensation(16.9%vs.28.0%,P=0.043),postoperative ascites(18.6%vs.31.4%,P=0.024)and pulmonary infections(12.7%vs.29.7%,P=0.001).The long-term follow-up showed that overall survival(P=0.154)and recurrence-free survival(P=0.376)were comparable between the two groups.In subgroup analysis,patients with PLT≤75×10^(9)/L suffered more postoperative liver decompensation(PLD)and ascites than patiens with PLT>75×10^(9)/L.Conclusions:Compared with OLR,LLR had less intraoperative blood loss,fewer postoperative complications and comparable oncological outcomes for patients with BCLC stage 0/A HCC and CSPH.
基金jointly supported by the National Natural Science Foundation of China (Nos.42272075,42302083,and 92162323)Guangdong Province Introduced Innovative R&D Team of Big Data-Mathematical Earth Sciences and Extreme Geological Events Team (No.2021ZT09H399)+1 种基金the National Key R&D Program of China (Nos.2017YFC0601201,2018YFC0604002)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University (No.22qntd2101)。
文摘The role of ore metals in magmatic fluids during the magmatic-hydrothermal transition in porphyry systems remains unclear,and their contributions to porphyry ore genesis are unclear.This study offers fresh perspectives on the ore-forming process during this critical transition,focusing on the Hongyuan porphyry Mo(Cu) deposit(PMCD) in West Junggar,China.We find that sulfide-quartz-rich miarolitic cavities(MCs),characterized by micrographic quartz and feldspar,indicate the formation of initial mineralizing fluids from magmatic fluids.This conclusion is supported by three key observations: the simultaneous formation of feldspar and sulfides in the micrographic zones of MCs,the high formation temperatures(approaching 750 ℃) suggested by the sectorzoned bright CL cores of quartz phenocrysts,and the magmatic sulfur source indicated by the narrow sulfur isotopic composition ranges(+0.18‰ to +4.63‰).LA-ICP-MS analyses reveal distinct trace element distribution patterns between the early magmatic and transition stages and the later hydrothermal stage.Chalcopyrite from the early stages has higher Cd and lower Zn contents,while molybdenite has higher Re contents,and pyrite has higher Co and Ni contents than its counterparts in the hydrothermal stage.The decrease in sulfur concentrations at sulfide saturation from granite porphyry to micrographic quartz-feldspar melts(from 200 ppm to 100 ppm) suggests that nearly half of the sulfur was exsolved during the formation of feldspar and quartz intergrowths from fractionated granitic magma.These findings indicate that the initial mineralizing fluids of the porphyry deposit were high-temperature,melt-bearing,and ore-rich and originated from magma.The transition from initial melt-bearing,metal-rich fluids to hydrothermal ore-forming fluids is marked by decreasing temperatures and logf_(S2) values,underscoring the critical role of sulfide formation during the magmatic-hydrothermal transition in the development of porphyry deposits.
基金supported by the Canadian Institutes of Health Research Project grant (PJT-169197) to QYsupported by a CGS-M fellowship from the Canadian Institutes of Health Research
文摘Alzheimer’s disease(AD)remains an incurable neurodegenerative disorder with devastating societal and personal impacts.Despite decades of intensive research,therapeutic efforts targeting the clinical stages of AD have largely failed to halt or reverse disease progression.This has prompted a critical shift in focus toward the earlier,preclinical stages of AD,where interventions may hold greater promise for altering the disease trajectory.
基金supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(SJCX23_1973)the National Natural Science Foundation of China(32172110,32071945)+7 种基金the Key Research and Development Program(Modern Agriculture)of Jiangsu Province,China(BE2022342-2,BE2020319)the Anhui Province Crop Intelligent Planting and Processing Technology Engineering Research Center Open Project,China(ZHKF04)the National Key Research and Development Program of China(2023YFD2300201,2023YFD1202200)the Special Funds for Scientific and Technological Innovation of Jiangsu Province,China(BE2022425)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China(PAPD)the Central Publicinterest Scientific Institution Basal Research Fund,China(JBYW-AII-2023-08)the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences(CAAS-CS-202201)the Special Fund for Independent Innovation of Agriculture Science and Technology in Jiangsu Province,China(CX(22)3112)。
文摘The wheat above-ground biomass(AGB)is an important index that shows the life activity of vegetation,which is of great significance for wheat growth monitoring and yield prediction.Traditional biomass estimation methods specifically include sample surveys and harvesting statistics.Although these methods have high estimation accuracy,they are time-consuming,destructive,and difficult to implement to monitor the biomass at a large scale.The main objective of this study is to optimize the traditional remote sensing methods to estimate the wheat AGBbased on improved convolutional features(CFs).Low-cost unmanned aerial vehicles(UAV)were used as the main data acquisition equipment.This study acquired image data acquired by RGB camera(RGB)and multi-spectral(MS)image data of the wheat population canopy for two wheat varieties and five key growth stages.Then,field measurements were conducted to obtain the actual wheat biomass data for validation.Based on the remote sensing indices(RSIs),structural features(SFs),and CFs,this study proposed a new feature named AUR-50(multi-source combination based on convolutional feature optimization)to estimate the wheat AGB.The results show that AUR-50 could estimate the wheat AGB more accurately than RSIs and SFs,and the average R^(2) exceeded 0.77.In the overwintering period,AUR-50_(MS)(multi-source combination with convolutional feature optimization using multispectral imagery)had the highest estimation accuracy(R^(2) of 0.88).In addition,AUR-50 reduced the effect of the vegetation index saturation on the biomass estimation accuracy by adding CFs,where the highest R^(2) was 0.69 at the flowering stage.The results of this study provide an effective method to evaluate the AGB in wheat with high throughput and a research reference for the phenotypic parameters of other crops.
基金National Natural Science Foundation of China (Grant 52372083, 52173255)Opening Project of the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials (JSKC24025)+1 种基金Special Funds for the Trans-formation of Scientific and Technological Achievements in Jiangsu Province(BA2023003)Collaborative Innovation Center for Advanced Micro/nanomaterials and Equipment (Co-constructed by Jiangsu Province and Ministry of Education)。
文摘The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur batteries.Herein,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene (PP) separator.The uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition stage.Most importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance(145.88 MPa) of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium dendrite.The Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm^(-2)with a polarization voltage of only 29.3 mV.Additionally,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity attenuation.The improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.
基金supported by the Natural Science Foundation of Sichuan Province(grant number:25NSFSC0265).
文摘Peri-implant keratinized mucosa(PIKM)augmentation refers to surgical procedures aimed at increasing the width of PIKM.Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health.Currently,several surgical techniques have been validated for their effectiveness in increasing PIKM.However,the selection and application of PIKM augmentation methods may present challenges for dental practitioners due to heterogeneity in surgical techniques,variations in clinical scenarios,and anatomical differences.Therefore,clear guidelines and considerations for PIKM augmentation are needed.This expert consensus focuses on the commonly employed surgical techniques for PIKM augmentation and the factors influencing their selection at second-stage surgery.It aims to establish a standardized framework for assessing,planning,and executing PIKM augmentation procedures,with the goal of offering evidence-based guidance to enhance the predictability and success of PIKM augmentation.
基金supported in part by the National Natural Science Foundation of China(62173051)the Fundamental Research Funds for the Central Universities(2024CDJCGJ012,2023CDJXY-010)+1 种基金the Chongqing Technology Innovation and Application Development Special Key Project(CSTB2022TIADCUX0015,CSTB2022TIAD-KPX0162)the China Postdoctoral Science Foundation(2024M763865)
文摘Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.
基金supported by grants from the National Natural Science Foundation of China(82002351,82394442,82130070,82272442)funded by the Innovation Capability Support Program of Shaanxi Province(2024SF-LCZX-16)+2 种基金the Shaanxi Province Health Scientific Research Innovation Ability Promotion Plan(2024PT-12)the Independent Exploration and Innovation Project of Xi’an Jiaotong University(xzy012023121)the project of Xi’an Postdoctoral Innovation Base.
文摘Osteoarthritis(OA)is one of the most common degenerative joint diseases in the elderly,increasing in prevalence and posing a substantial socioeconomic challenge,while no disease-modifying treatments available.Better understanding of the early molecular events will benefit the early-stage diagnosis and clinical therapy.Here,we observed the nucleus accumulation of ZBTB20,a member of ZBTB-protein family,in the chondrocytes of early-stage OA.Chondrocytes-specific depletion of Zbtb20 in adult mice attenuated DMM-induced OA progress,restored the balance of extracellular matrix anabolism and catabolism.The NF-κB signaling mediated disturbance of ECM maintenance by ZBTB20 requires its suppression of Pten and consequent PI3K-Akt signaling activation.Furthermore,the subcellular localization of ZBTB20 was modulated by the kinase LATS1.Independent approaches to modulating ZBTB20 via utilizing TRULI and DAPA can restore ECM homeostasis,improving the abnormal behavior and moderating cartilage degeneration.The compounds TRULI and DAPA modulating ZBTB20 may serve as anti-OA drugs.
文摘Teacher education at the foundational and preparatory stages plays a crucial role in shaping early childhood learning experiences.The National Curriculum Framework for School Education(NCFSE)2023 provides a structured pedagogical approach to address challenges in these stages.However,despite these policy frameworks,teachers in Kendriya Vidyalayas(KVs)continue to face numerous pedagogical challenges.This paper aims to explore and analyze the pedagogical challenges encountered by KV teachers in foundational and preparatory stage classrooms and compare them with the challenges addressed in NCFSE 2023.Using qualitative research methods,data were collected through structured online interviews with 10 KV teachers from different campuses.This paper investigated various challenges,including classroom management,language barriers,a lack of inclusive education strategies,insufficient infrastructure,limited parental involvement,and difficulties in integrating technology into teaching practices.The findings highlight the gap between policy recommendations and ground-level implementation.Based on these insights,the study suggests recommendations such as specialized teacher training,recruitment of special educators,improved infrastructure,enhanced parental engagement,and policy-driven interventions to bridge the gap between policy frameworks and real-world classroom experiences.The study concludes that addressing these challenges through targeted reforms can create a more inclusive and effective learning environment,fostering holistic student development at the foundational and preparatory stages.
基金supported by the Guangdong Province Nature Foundation of China Project (No. 2022A1515012200 to Li Z)Shenzhen Science and Technology Program (No. RCYX20221008093032008 to Li Z)Shenzhen People's Hospital Clinician Scientist Training Program (No. SYWGSJCYJ202405 to Li Z).
文摘Objective The aim of this study was to investigate the value of the 8th American Joint Committee on Cancer(AJCC)anatomic and prognostic stage groups for penile cancer patients and explore whether there is room for improvement.Methods The clinical and histopathologic data from 16 centers between January 2000 and December 2021 were assessed according to the 8th AJCC anatomic and prognostic stage groups.Kaplan–Meier plots were used to estimate the disease-specific survival(DSS)of the patients.The accuracy of the staging systems was investigated using the Harrell's concordance index(C-index).Results According to the 8th AJCC anatomic and prognostic stage groups,the 5-year DSS rates for patients with stages 0is/a,I,IIA,IIB,IIIA,IIIB,and IV disease were 100%,99%,86%,81%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–IIA)<0.001,p_(IIA–IIB)=0.5,p_(IIB–IIIA)<0.001,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).According to the modified model 1 system,the 5-year DSS rates without survivorship overlap for patients with stages 0is/a,I,II,IIIA,IIIB,and IV disease were 100%,99%,88%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–II)<0.001,p_(II–IIIA)=0.002,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).Similarly,according to the modified model 2 system,the 5-year DSS rates without survivorship overlap for patients with stages 0is/a,I,II,IIIA,IIIB,and IV disease were 100%,99%,86%,66%,34%,and 23%,respectively(p_(0is/a–I)=0.8,p_(I–II)<0.001,p_(II–IIIA)=0.008,p_(IIIA–IIIB)<0.001,p_(IIIB–IV)=0.004,and p_(Total)<0.001).The C-index scores of the simple modified staging systems were not inferior to those of the AJCC anatomic and prognostic stage groups.These results were confirmed by the bootstrap internal validation.Conclusion There is still room for improvement about the 8th AJCC anatomic and prognostic stage groups.The improved models,which are more concise and convenient,have similar prediction accuracy.
文摘This study examines on badminton players following anterior cruciate ligament(ACL)surgery.It analyses the risk factors in badminton that may cause re-injury to the knee joint,such as sports postures and exercise intensity.Scientific and reasonable sports protection measures and training plans are formulated,including correcting sports postures and reasonably controlling exercise intensity and frequency.Rehabilitation training is carried out in stages,and the training intensity and frequency are gradually adjusted according to the recovery situation.Through scientific protection and training,the risk of re-injury to athletes can be reduced,and they can be helped to restore their best sports conditions.At the same time,future research directions are prospected,covering personalized rehabilitation programs,application of new technologies,and research on psychological factors.
文摘Background In light of growing concern over eating disorders among young athletes amid cultural and social pressures,this study aimed to assess the prevalence of orthorexia nervosa(ON)risk and evaluate body image perception and its predictive factors among young football players from Poland and Türkiye.Methods The study involved 171 players aged 15–18 years,recruited from football academies in Poland and Türkiye.The Polish and Turkish versions of the Body-Esteem Scale for Adolescents and Adults(BESAA)were administered to assess body image perception,while the Düsseldorf Orthorexia Scale(DOS)was used to measure ON risk.Anthropometric measurements were taken to calculate Body Mass Index(BMI),which was then referenced to centile charts to determine nutritional status.Results Results indicated that 13%of participants exhibited characteristics of ON,with an additional 26%classified as at elevated risk.Comparative analysis revealed no significant differences in ON prevalence between Polish and Turkish players(p=0.938)and no age-related differences(p=0.694).Among Polish players,a significant positive association emerged between BMI(relative to centile charts)and overall appearance evaluation(BE-Appearance)(p=0.008,partialη^(2)=0.10).This relationship was not observed in Turkish players.Moreover,analysis of ON risk predictors—including age,nationality,nutritional status,and body image—did not identify any single variable as a definitive predictor(all p-values>0.05),with a low predictive capacity(McFadden’s R^(2)=0.03).Conclusion The study revealed a significant risk of ON among young footballers with no clear predictors.
