A capacity calculation method of High Altitude Platform System(HAPS) is proposed in which TD-CDMA multiple access schemes are applied.With the influence of both power limit and bandwidth limit on capacity integrated,t...A capacity calculation method of High Altitude Platform System(HAPS) is proposed in which TD-CDMA multiple access schemes are applied.With the influence of both power limit and bandwidth limit on capacity integrated,the paper derives the equations by which the capacity of TD-CDMA systems can be calculated,and performs calculation on a practical system.This calculation method is quite simple and effective with a comparatively small error,which is essential to the de-signing and research on HAPS.展开更多
The aim is to solve the problem that how to share dispersive and heterogeneous data inside business information system or some other information source. On the basis of Web service, this paper adopts the notion of Dat...The aim is to solve the problem that how to share dispersive and heterogeneous data inside business information system or some other information source. On the basis of Web service, this paper adopts the notion of Data As ,Service to build service-oriented data integration architecture. According to this architecture, we develop data collection system which effectively integrates data from heterogeneous informa tion source and present a uniform data view to end users by implementing sharing data from heterogeneous systems and information source . At last, this paper gives an example of a compositive information collection platform system.展开更多
Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Ch...Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Chinese medicine”,“chemotherapy”and“diarrhea”as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to November 2020 was conduct-ed.The formulas of external treatment of traditional Chinese medicine for chemotherapy-induced diarrhea were included and the association rule,clustering and factor analysis were carried out.Results:A total of 145 papers,57 prescriptions meeting the inclusion criteria were collected,among which high-frequency drugs including Baizhu(Atractylodis macrocephalae rhizoma),Fuling(Poria),Dangshen(Codonopsisradix),Huanglian(Coptidis rhizoma),Zhigancao(Glycyrrhizae radix et rhizoma praeparata cum melle)were the most commonly used.The confidence level was set as 0.7 and the support level was set as 10,12 core compatibility groups were obtained,and 6 categories were cluster analyzed.Conclusion:The principle of external treatment of chemotherapy-induced diarrhea is mainly“restore deficiency and benefiting qi”,“benefiting water infiltration and dampness”,“clearing heat”and“inducing astringency”.Prescription combination and new prescription combination based on traditional Chinese medicine(TCM)inheritance computing platform system can be used as reference for clinicians and applied in primary hospitals.展开更多
According to the known sequence of iron stress-induced gene (isiAB operon), wecloned its 1. 5 kb fragment by PCR, and used this Fragment as integration homologous fragment. Afterseveral steps of subcloning donor DNA i...According to the known sequence of iron stress-induced gene (isiAB operon), wecloned its 1. 5 kb fragment by PCR, and used this Fragment as integration homologous fragment. Afterseveral steps of subcloning donor DNA into the isiAB fragment, a donor plasmid pZL which could be inte-grated into the chromosomal DNA of Synechococcus sp. PCC7942 was constructed. In order to express theheterologous gene at a high level through the integration platform system, we constructed the donor DNAby the following steps. We cloned the strong promoter (240 bp) of heat shock gene groESL operon fromSynechococcus sp. PCC7942 by PCR. Then subcloned the multiple cloning sites (MCS), rbcS polyA intothe downstream of the groESL promoter. The kanamycin resistance gene, as the marker gene, was alsosubcloned into the donor DNA. Thus, in the donor plasmid pZL, the integration homologous fragment andseveral expression elements, such as groESL promoter, MCS, rbcS polyA teminator and kanamycin re-sistance gene, were all included.After naturally transformed and introduced the donor plasmid pZL into Synechococcus sp. PCC7942,as in the pZL, the donor DNA sequence is flanked by two DNA fragments (0.4 kb and 0.7 kb) homolo-gous to the isiAB fragment of Synechococcus sp. PCC7942, the homologous DNA can recombine with thechromosomal DNA. After screening by kanamycin, the transformants which integrated the heterologousDNA were selected. The efficiency of transformation is about 1×10-6. By southem blot analysis, it wasconfirmed that the donor DNA had been integrated into the chromosomal DNA of Synechococcus sp.PCC7942, located on the site of the isiAB gene, and can be replicated with the chromosomal DNA.展开更多
Stability analysis plays a central role in nonlinear system theory and engineering application. Over the past few years, the stability analysis of fuzzy systems has been proposed and there are many successful applicat...Stability analysis plays a central role in nonlinear system theory and engineering application. Over the past few years, the stability analysis of fuzzy systems has been proposed and there are many successful applications in practical engineering. Therefore, in this paper firstly proposed is the stability analysis on oceanic structure by fuzzy models. In the present study, Takagi-Sugeno （T-S） fuzzy model is proposed for a time delay tension leg platform （TLP） system subjected to an external wave force. In terms of stability analysis, linear matrix inequality （LMI） conditions are derived via Lyapunov theory to guarantee the stability of the TLP system.展开更多
Remote sensing and web-based platforms have emerged as vital tools in the effective monitoring of mangrove ecosystems, which are crucial for coastal protection, biodiversity, and carbon sequestration. Utilizing satell...Remote sensing and web-based platforms have emerged as vital tools in the effective monitoring of mangrove ecosystems, which are crucial for coastal protection, biodiversity, and carbon sequestration. Utilizing satellite imagery and aerial data, remote sensing allows researchers to assess the health and extent of mangrove forests over large areas and time periods, providing insights into changes due to environmental stressors like climate change, urbanization, and deforestation. Coupled with web-based platforms, this technology facilitates real-time data sharing and collaborative research efforts among scientists, policymakers, and conservationists. Thus, there is a need to grow this research interest among experts working in this kind of ecosystem. The aim of this paper is to provide a comprehensive literature review on the effective role of remote sensing and web-based platform in monitoring mangrove ecosystem. The research paper utilized the thematic approach to extract specific information to use in the discussion which helped realize the efficiency of digital monitoring for the environment. Web-based platforms and remote sensing represent a powerful tool for environmental monitoring, particularly in the context of forest ecosystems. They facilitate the accessibility of vital data, promote collaboration among stakeholders, support evidence-based policymaking, and engage communities in conservation efforts. As experts confront the urgent challenges posed by climate change and environmental degradation, leveraging technology through web-based platforms is essential for fostering a sustainable future for the forests of the world.展开更多
Platform-style construction is a widely recognized and well-established approach among engineers and developers for multi-story mass timber buildings.This construction method offers many advantages,such as rapid assem...Platform-style construction is a widely recognized and well-established approach among engineers and developers for multi-story mass timber buildings.This construction method offers many advantages,such as rapid assembly,an excellent strength-to-weight ratio,and appealing aesthetic features.In a platform-type construction,each story is constructed by placing the floor panels on top of the load-bearing wall,creating a platform for the level above.Although this method offers numerous advantages,recent research findings have revealed that cross-laminated(CLT)platform buildings with conventional connections,such as wall-to-floor hold-down brackets and shear connectors with nails and screws,are prone to experience a high degree of damage under design-level earthquakes.Consequently,conventional connections in platform-type construction are vulnerable to more damage under aftershocks and do not meet the damage avoidance requirements of seismic design.This paper introduces an innovative floor-to-wall connection for a platform-type low-rise mass timber building that mitigates the limitations of conventional connections.The effectiveness of the proposed connection has been investigated,and the seismic performance of the system,which incorporates the proposed connection,has been outlined in this paper.A numerical model with an innovative inter-story isolation system is developed in ETABS,and the seismic performance of the isolated structure was evaluated using Response Spectrum Analysis(RSA)and Nonlinear Time History Analysis(NLTHA).This study revealed that inter-story isolation systems significantly reduced the seismic demands on the mass timber components,demonstrating the system’s ability to dissipate seismic energy.Additionally,the system displayed effective energy dissipation while exhibiting self-centering behaviour.展开更多
With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare re...With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.展开更多
Installing annular wave-energy converters(WECs)on the columns of floating wind platforms in the form of a coaxial-cylinder provides a convenient means of integration.Extant coaxial-cylinder-type wind-wave hybrid syste...Installing annular wave-energy converters(WECs)on the columns of floating wind platforms in the form of a coaxial-cylinder provides a convenient means of integration.Extant coaxial-cylinder-type wind-wave hybrid systems are mostly based on single-column platforms such as spars(single coaxial-cylinder hybrid system'hereafter).Systems based on multiple-column platforms such as semi-submersible platforms('multiple coaxial-cylinder hybrid systems'hereafter)are rarely seen or studied,despite their superiority in wave-power absorption due to the use of multiple WECs as well as in dynamic stability.This paper proposes a novel WindFloat-annular-WEC hybrid system,based on our study investigating its dynamic and power features,and optimizing the geometry and power take-off of the WECs.Our results show that the dynamic and power features of a multiple coaxial-cylinder hybrid system are different from those of a single coaxial-cylinder hybrid system,so the same optimization parameters cannot be directly applied.Flatter annular WECs absorb slightly more power in a wider wave-period range,but their geometry is confined by limitations in installation and structural strength.The overall effect of an oblique incident wave is greater intensity in the motions of the hybrid system in yaw and the direction perpendicular to propagation,although the difference is small and maybe negligible.展开更多
白银有色集团是中国大型国有有色金属企业,在AVEVA剑维软件及白银蓝鸟的助力下,顺利完成了全面的数字化转型,从而显著提升了其生产设施的运营效率和安全水平。从传统冶炼到智能制造:新质生产力的典型案例自2020年起,白银有色以“顶层设...白银有色集团是中国大型国有有色金属企业,在AVEVA剑维软件及白银蓝鸟的助力下,顺利完成了全面的数字化转型,从而显著提升了其生产设施的运营效率和安全水平。从传统冶炼到智能制造:新质生产力的典型案例自2020年起,白银有色以“顶层设计引领、平台架构先行、分步实施推进”为指导方针,成立专业数字化公司“白银蓝鸟数智科技”,全面启动数字化转型战略。面对白银集团核心产业链与生产工艺流程及工况的复杂业态和场景、设备老旧、数据分散等行业共性难题,集团选择了AVEVA System Platform作为统一数据底座,构建了白银蓝鸟智能管控一体化BBMCI平台(以下简称BBMCI平台)迈出了转型的关键一步。展开更多
Mitigating vortex-induced vibrations(VIV)in flexible risers represents a critical concern in offshore oil and gas production,considering its potential impact on operational safety and efficiency.The accurate predictio...Mitigating vortex-induced vibrations(VIV)in flexible risers represents a critical concern in offshore oil and gas production,considering its potential impact on operational safety and efficiency.The accurate prediction of displacement and position of VIV in flexible risers remains challenging under actual marine conditions.This study presents a data-driven model for riser displacement prediction that corresponds to field conditions.Experimental data analysis reveals that the XGBoost algorithm predicts the maximum displacement and position with superior accuracy compared with Support vector regression(SVR),considering both computational efficiency and precision.Platform displacement in the Y-direction demonstrates a significant positive correlation with both axial depth and maximum displacement magnitude.The fourth point displacement exhibits the highest contribution to model prediction outcomes,showing a positive influence on maximum displacement while negatively affecting the axial depth of maximum displacement.Platform displacement in the X-and Y-directions exhibits competitive effects on both the riser’s maximum displacement and its axial depth.Through the implementation of XGBoost algorithm and SHapley Additive exPlanation(SHAP)analysis,the model effectively estimates the riser’s maximum displacement and its precise location.This data-driven approach achieves predictions using minimal,readily available data points,enhancing its practical field applications and demonstrating clear relevance to academic and professional communities.展开更多
This study examines the Big Data Collection and Preprocessing course at Anhui Institute of Information Engineering,implementing a hybrid teaching reform using the Bosi Smart Learning Platform.The proposed hybrid model...This study examines the Big Data Collection and Preprocessing course at Anhui Institute of Information Engineering,implementing a hybrid teaching reform using the Bosi Smart Learning Platform.The proposed hybrid model follows a“three-stage”and“two-subject”framework,incorporating a structured design for teaching content and assessment methods before,during,and after class.Practical results indicate that this approach significantly enhances teaching effectiveness and improves students’learning autonomy.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Fibrosis is a pathological outcome of a dysregulated repair response to injury,which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide.However,challenges remain in delin...Fibrosis is a pathological outcome of a dysregulated repair response to injury,which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide.However,challenges remain in delineating the complex and dynamic network regulating fibrosis,as well as translating this information into effective anti-fibrotic treatments.A comprehensive understanding of existing methodologies and the development of new research tools are essential for ensuring the transferability of findings from bench to bedside.In this review,we present a framework consisting of a large biospecimen repository that integrates diverse patient cohorts with corresponding clinical data,and a systematic research platform incorporating multiple layers of experimental strategies,primarily focused on skin fibrosis.We summarize current advancements and the applications of various tools for preclinical fibrosis research and examine the limitations of traditional methods used to simulate and investigate biomechanical signals in the fibrotic environment.Importantly,we highlight the strengths of research techniques and translational approaches of varying physiological relevance developed by us over the past decade.Collectively,we emphasize a trend toward more faithfully replicating the functional,structural,and biological complexity of fibrosis while providing high spatio-temporal control over soluble cues and intricate interactions.Our comprehensive overview of methodology paves the way for minimizing batch-to-batch variation and improving the reproducibility of experimental systems.展开更多
Leveraging the Baidu Qianfan model platform,this paper designs and implements a highly efficient and accurate scoring system for subjective questions,focusing primarily on questions in the field of computer network te...Leveraging the Baidu Qianfan model platform,this paper designs and implements a highly efficient and accurate scoring system for subjective questions,focusing primarily on questions in the field of computer network technology.The system enhances the foundational model by utilizing Qianfan’s training tools and integrating advanced techniques,such as supervised fine-tuning.In the data preparation phase,a comprehensive collection of subjective data related to computer network technology is gathered,cleaned,and labeled.During model training and evaluation,optimal hyperparameters and tuning strategies are applied,resulting in a model capable of scoring with high accuracy.Evaluation results demonstrate that the proposed model performs well across multiple dimensions-content,expression,and development scores-yielding results comparable to those of manual scoring.展开更多
Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data...Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data that mooring system designers aim to acquire.To address the need for long-term continuous monitoring of mooring tension in deep-sea marine environments,this paper presents a mooring cable tension monitoring method based on the principle of direct mechanical measurement.The developed tension monitoring sensors were installed and applied in the mooring system of the"Yongle"scientific experimental platform.Over the course of one year,a substantial amount of in-situ tension monitoring data was obtained.Under wave heights of up to 1.24 m,the mooring tension on the floating platform reached 16.5 tons.Through frequency domain and time domain analysis,the spectral characteristics of mooring tension,including waveinduced force,slow drift force,and mooring cable elastic restoring force,were determined.The mooring cable elastic restoring force frequency was approximately half of that of the wave signal.Due to the characteristics of the hinge connection structure of the dual module floating platform,under some specific working conditions the wave-induced force was the maximum of the three different frequency forces,and restoring force was the smallest.展开更多
The integrated system composed of wave energy converters and floating wind turbines offers substantial potential for reducing the levelized cost of energy(LCOE) by sharing the infrastructure, mooring system, substatio...The integrated system composed of wave energy converters and floating wind turbines offers substantial potential for reducing the levelized cost of energy(LCOE) by sharing the infrastructure, mooring system, substations and cables.This paper proposes an integrated system consisting of a semi-submersible wind turbine platform and three Wave Star flap-type wave energy converters. The coupled motion model of the integrated system is established and validated on the basis of viscously corrected potential flow theory. This study investigates the influence of two key parameters,the arm length and hinge points of flap-type wave energy converters, on system performance. The results reveal that variations in the arm length of flap-type wave energy converters(WECs) are the primary determinants of the integrated system's dynamic characteristics, whereas changes in hinge points predominantly affect device power generation.Additionally, incorporating WECs reduces the pitch and heave motions of the platform within a specific wave frequency range, thereby enhancing the energy output of the integrated system at the operational sea site. The performance of this hybrid system at a selected sea site is further assessed via the proposed aero-hydroservo coupling simulations.展开更多
1Introduction Embodied Artificial Intelligence(Embodied AI)has recently become a key research focus[1].It emphasizes agents'abilities to perceive,comprehend,and act in physical worlds to complete tasks.Simulation ...1Introduction Embodied Artificial Intelligence(Embodied AI)has recently become a key research focus[1].It emphasizes agents'abilities to perceive,comprehend,and act in physical worlds to complete tasks.Simulation platforms are essential in this area,as they simulate agent behaviors in set environments and tasks,thereby accelerating algorithm validation and optimization.However,constructing such a platform presents several challenges.展开更多
In the process of developing oil and gas resources in the Arctic,the impact of icebergs can pose a considerable threat to the structural safety of semi-submersible mooring platforms in ice regions.On the basis of the ...In the process of developing oil and gas resources in the Arctic,the impact of icebergs can pose a considerable threat to the structural safety of semi-submersible mooring platforms in ice regions.On the basis of the arbitrary Lagrangian Eulerian(ALE)algorithm,a numerical model for the interaction between an iceberg and a semi-submersible mooring platform is built in this work.First,a mooring system with a link element is designed and validated.An ice material model for the target iceberg is built and validated.A numerical model for the interaction between an iceberg and a semi-submersible mooring platform is then built.A parametric study(cable angle,tension angle and number of cables)is carried out to study the performance of the mooring system.The collision process between the semi-submersible mooring platform and the iceberg in the polar marine environment can be predicted by the present numerical model,and then the optimal mooring arrangement scheme can be obtained.The research results in this work can provide a reference for the design of mooring systems.展开更多
As a high-value eudicot family,many famous horticultural crop genomes have been deciphered in Oleaceae.However,there are currently no bioinformatics platforms focused on empowering genome research in Oleaceae.Herein,w...As a high-value eudicot family,many famous horticultural crop genomes have been deciphered in Oleaceae.However,there are currently no bioinformatics platforms focused on empowering genome research in Oleaceae.Herein,we developed the first comprehensive Oleaceae Genome Research Platform(OGRP,https://oleaceae.cgrpoee.top/).In OGRP,70 genomes of 10 Oleaceae species and 46 eudicots and 366 transcriptomes involving 18 Oleaceae plant tissues can be obtained.We built 34 window-operated bioinformatics tools,collected 38 professional practical software programs,and proposed 3 new pipelines,namely ancient polyploidization identification,ancestral karyotype reconstruction,and gene family evolution.Employing these pipelines to reanalyze the Oleaceae genomes,we clarified the polyploidization,reconstructed the ancestral karyotypes,and explored the effects of paleogenome evolution on genes with specific biological regulatory roles.Significantly,we generated a series of comparative genomic resources focusing on the Oleaceae,comprising 108 genomic synteny dot plots,1952225 collinear gene pairs,multiple genome alignments,and imprints of paleochromosome rearrangements.Moreover,in Oleaceae genomes,researchers can efficiently search for 1785987 functional annotations,22584 orthogroups,29582 important trait genes from 74 gene families,12664 transcription factor-related genes,9178872 transposable elements,and all involved regulatory pathways.In addition,we provided downloads and usage instructions for the tools,a species encyclopedia,ecological resources,relevant literatures,and external database links.In short,ORGP integrates rich data resources and powerful analytical tools with the characteristic of continuous updating,which can efficiently empower genome research and agricultural breeding in Oleaceae and other plants.展开更多
文摘A capacity calculation method of High Altitude Platform System(HAPS) is proposed in which TD-CDMA multiple access schemes are applied.With the influence of both power limit and bandwidth limit on capacity integrated,the paper derives the equations by which the capacity of TD-CDMA systems can be calculated,and performs calculation on a practical system.This calculation method is quite simple and effective with a comparatively small error,which is essential to the de-signing and research on HAPS.
基金Supported by the Plan of Research on Science andTechnology and Development in Hebei Province (04213534)
文摘The aim is to solve the problem that how to share dispersive and heterogeneous data inside business information system or some other information source. On the basis of Web service, this paper adopts the notion of Data As ,Service to build service-oriented data integration architecture. According to this architecture, we develop data collection system which effectively integrates data from heterogeneous informa tion source and present a uniform data view to end users by implementing sharing data from heterogeneous systems and information source . At last, this paper gives an example of a compositive information collection platform system.
基金National Natural Science Foundation of China Youth Science Foundation Project(No.81904001)Capital Health Development Scientific Research Project(No.first issue 2018-1-4061)+1 种基金State Administration of Traditional Chinese Medicine Clinical Collaboration Project of TCM and Western Medicine for Major and Intractable Diseases(No.2019-ZX-005)In-Hospital Project of China-Japan Friendship Hospital(No.2019-1-QN-56)。
文摘Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Chinese medicine”,“chemotherapy”and“diarrhea”as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to November 2020 was conduct-ed.The formulas of external treatment of traditional Chinese medicine for chemotherapy-induced diarrhea were included and the association rule,clustering and factor analysis were carried out.Results:A total of 145 papers,57 prescriptions meeting the inclusion criteria were collected,among which high-frequency drugs including Baizhu(Atractylodis macrocephalae rhizoma),Fuling(Poria),Dangshen(Codonopsisradix),Huanglian(Coptidis rhizoma),Zhigancao(Glycyrrhizae radix et rhizoma praeparata cum melle)were the most commonly used.The confidence level was set as 0.7 and the support level was set as 10,12 core compatibility groups were obtained,and 6 categories were cluster analyzed.Conclusion:The principle of external treatment of chemotherapy-induced diarrhea is mainly“restore deficiency and benefiting qi”,“benefiting water infiltration and dampness”,“clearing heat”and“inducing astringency”.Prescription combination and new prescription combination based on traditional Chinese medicine(TCM)inheritance computing platform system can be used as reference for clinicians and applied in primary hospitals.
文摘According to the known sequence of iron stress-induced gene (isiAB operon), wecloned its 1. 5 kb fragment by PCR, and used this Fragment as integration homologous fragment. Afterseveral steps of subcloning donor DNA into the isiAB fragment, a donor plasmid pZL which could be inte-grated into the chromosomal DNA of Synechococcus sp. PCC7942 was constructed. In order to express theheterologous gene at a high level through the integration platform system, we constructed the donor DNAby the following steps. We cloned the strong promoter (240 bp) of heat shock gene groESL operon fromSynechococcus sp. PCC7942 by PCR. Then subcloned the multiple cloning sites (MCS), rbcS polyA intothe downstream of the groESL promoter. The kanamycin resistance gene, as the marker gene, was alsosubcloned into the donor DNA. Thus, in the donor plasmid pZL, the integration homologous fragment andseveral expression elements, such as groESL promoter, MCS, rbcS polyA teminator and kanamycin re-sistance gene, were all included.After naturally transformed and introduced the donor plasmid pZL into Synechococcus sp. PCC7942,as in the pZL, the donor DNA sequence is flanked by two DNA fragments (0.4 kb and 0.7 kb) homolo-gous to the isiAB fragment of Synechococcus sp. PCC7942, the homologous DNA can recombine with thechromosomal DNA. After screening by kanamycin, the transformants which integrated the heterologousDNA were selected. The efficiency of transformation is about 1×10-6. By southem blot analysis, it wasconfirmed that the donor DNA had been integrated into the chromosomal DNA of Synechococcus sp.PCC7942, located on the site of the isiAB gene, and can be replicated with the chromosomal DNA.
基金supported by the Science Council under Contract Nos.NSC 96-2628-E-366-004-MY2 and NSC96-2628-E-132-001-MY2
文摘Stability analysis plays a central role in nonlinear system theory and engineering application. Over the past few years, the stability analysis of fuzzy systems has been proposed and there are many successful applications in practical engineering. Therefore, in this paper firstly proposed is the stability analysis on oceanic structure by fuzzy models. In the present study, Takagi-Sugeno （T-S） fuzzy model is proposed for a time delay tension leg platform （TLP） system subjected to an external wave force. In terms of stability analysis, linear matrix inequality （LMI） conditions are derived via Lyapunov theory to guarantee the stability of the TLP system.
文摘Remote sensing and web-based platforms have emerged as vital tools in the effective monitoring of mangrove ecosystems, which are crucial for coastal protection, biodiversity, and carbon sequestration. Utilizing satellite imagery and aerial data, remote sensing allows researchers to assess the health and extent of mangrove forests over large areas and time periods, providing insights into changes due to environmental stressors like climate change, urbanization, and deforestation. Coupled with web-based platforms, this technology facilitates real-time data sharing and collaborative research efforts among scientists, policymakers, and conservationists. Thus, there is a need to grow this research interest among experts working in this kind of ecosystem. The aim of this paper is to provide a comprehensive literature review on the effective role of remote sensing and web-based platform in monitoring mangrove ecosystem. The research paper utilized the thematic approach to extract specific information to use in the discussion which helped realize the efficiency of digital monitoring for the environment. Web-based platforms and remote sensing represent a powerful tool for environmental monitoring, particularly in the context of forest ecosystems. They facilitate the accessibility of vital data, promote collaboration among stakeholders, support evidence-based policymaking, and engage communities in conservation efforts. As experts confront the urgent challenges posed by climate change and environmental degradation, leveraging technology through web-based platforms is essential for fostering a sustainable future for the forests of the world.
基金gratitude to WIDE Trust New Zealand for providing the opportunity and funding for this research,as well as QuakeCoRE,a New Zealand Tertiary Education Commission-funded Centre,for partially funding this research.This is QuakeCoRE,publication number 1013.
文摘Platform-style construction is a widely recognized and well-established approach among engineers and developers for multi-story mass timber buildings.This construction method offers many advantages,such as rapid assembly,an excellent strength-to-weight ratio,and appealing aesthetic features.In a platform-type construction,each story is constructed by placing the floor panels on top of the load-bearing wall,creating a platform for the level above.Although this method offers numerous advantages,recent research findings have revealed that cross-laminated(CLT)platform buildings with conventional connections,such as wall-to-floor hold-down brackets and shear connectors with nails and screws,are prone to experience a high degree of damage under design-level earthquakes.Consequently,conventional connections in platform-type construction are vulnerable to more damage under aftershocks and do not meet the damage avoidance requirements of seismic design.This paper introduces an innovative floor-to-wall connection for a platform-type low-rise mass timber building that mitigates the limitations of conventional connections.The effectiveness of the proposed connection has been investigated,and the seismic performance of the system,which incorporates the proposed connection,has been outlined in this paper.A numerical model with an innovative inter-story isolation system is developed in ETABS,and the seismic performance of the isolated structure was evaluated using Response Spectrum Analysis(RSA)and Nonlinear Time History Analysis(NLTHA).This study revealed that inter-story isolation systems significantly reduced the seismic demands on the mass timber components,demonstrating the system’s ability to dissipate seismic energy.Additionally,the system displayed effective energy dissipation while exhibiting self-centering behaviour.
文摘With the continuous advancement of the tiered diagnosis and treatment system,the medical consortium model has gained increasing attention as an important approach to promoting the vertical integration of healthcare resources.Within this context,laboratory data,as a key component of healthcare information systems,urgently requires efficient sharing and intelligent analysis.This paper designs and constructs an intelligent early warning system for laboratory data based on a cloud platform tailored to the medical consortium model.Through standardized data formats and unified access interfaces,the system enables the integration and cleaning of laboratory data across multiple healthcare institutions.By combining medical rule sets with machine learning models,the system achieves graded alerts and rapid responses to abnormal key indicators and potential outbreaks of infectious diseases.Practical deployment results demonstrate that the system significantly improves the utilization efficiency of laboratory data,strengthens public health event monitoring,and optimizes inter-institutional collaboration.The paper also discusses challenges encountered during system implementation,such as inconsistent data standards,security and compliance concerns,and model interpretability,and proposes corresponding optimization strategies.These findings provide a reference for the broader application of intelligent medical early warning systems.
基金supported by the National Natural Science Foundation of China(Nos.52201322,52222109,and 52071096)the Guangdong Basic and Applied Basic Research Foundation(Nos.2022B1515020036 and 2023A1515012144)the Natural Science Foundation of Guangzhou City(No.202201010055),China.
文摘Installing annular wave-energy converters(WECs)on the columns of floating wind platforms in the form of a coaxial-cylinder provides a convenient means of integration.Extant coaxial-cylinder-type wind-wave hybrid systems are mostly based on single-column platforms such as spars(single coaxial-cylinder hybrid system'hereafter).Systems based on multiple-column platforms such as semi-submersible platforms('multiple coaxial-cylinder hybrid systems'hereafter)are rarely seen or studied,despite their superiority in wave-power absorption due to the use of multiple WECs as well as in dynamic stability.This paper proposes a novel WindFloat-annular-WEC hybrid system,based on our study investigating its dynamic and power features,and optimizing the geometry and power take-off of the WECs.Our results show that the dynamic and power features of a multiple coaxial-cylinder hybrid system are different from those of a single coaxial-cylinder hybrid system,so the same optimization parameters cannot be directly applied.Flatter annular WECs absorb slightly more power in a wider wave-period range,but their geometry is confined by limitations in installation and structural strength.The overall effect of an oblique incident wave is greater intensity in the motions of the hybrid system in yaw and the direction perpendicular to propagation,although the difference is small and maybe negligible.
文摘白银有色集团是中国大型国有有色金属企业,在AVEVA剑维软件及白银蓝鸟的助力下,顺利完成了全面的数字化转型,从而显著提升了其生产设施的运营效率和安全水平。从传统冶炼到智能制造:新质生产力的典型案例自2020年起,白银有色以“顶层设计引领、平台架构先行、分步实施推进”为指导方针,成立专业数字化公司“白银蓝鸟数智科技”,全面启动数字化转型战略。面对白银集团核心产业链与生产工艺流程及工况的复杂业态和场景、设备老旧、数据分散等行业共性难题,集团选择了AVEVA System Platform作为统一数据底座,构建了白银蓝鸟智能管控一体化BBMCI平台(以下简称BBMCI平台)迈出了转型的关键一步。
基金The research work was financially supported by the National Natural Science Foundation of China(Grant Nos.51979238 and 52301338)the Sichuan Science and Technology Program(Grant Nos.2023NSFSC1953 and 2023ZYD0140).
文摘Mitigating vortex-induced vibrations(VIV)in flexible risers represents a critical concern in offshore oil and gas production,considering its potential impact on operational safety and efficiency.The accurate prediction of displacement and position of VIV in flexible risers remains challenging under actual marine conditions.This study presents a data-driven model for riser displacement prediction that corresponds to field conditions.Experimental data analysis reveals that the XGBoost algorithm predicts the maximum displacement and position with superior accuracy compared with Support vector regression(SVR),considering both computational efficiency and precision.Platform displacement in the Y-direction demonstrates a significant positive correlation with both axial depth and maximum displacement magnitude.The fourth point displacement exhibits the highest contribution to model prediction outcomes,showing a positive influence on maximum displacement while negatively affecting the axial depth of maximum displacement.Platform displacement in the X-and Y-directions exhibits competitive effects on both the riser’s maximum displacement and its axial depth.Through the implementation of XGBoost algorithm and SHapley Additive exPlanation(SHAP)analysis,the model effectively estimates the riser’s maximum displacement and its precise location.This data-driven approach achieves predictions using minimal,readily available data points,enhancing its practical field applications and demonstrating clear relevance to academic and professional communities.
基金2024 Anqing Normal University University-Level Key Project(ZK2024062D)。
文摘This study examines the Big Data Collection and Preprocessing course at Anhui Institute of Information Engineering,implementing a hybrid teaching reform using the Bosi Smart Learning Platform.The proposed hybrid model follows a“three-stage”and“two-subject”framework,incorporating a structured design for teaching content and assessment methods before,during,and after class.Practical results indicate that this approach significantly enhances teaching effectiveness and improves students’learning autonomy.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
基金supported by grants from the National Natural Science Foundation of China(grant nos.82472554 and 82202449)the Fund for Excellent Young Scholars of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(grant no.JYYQ006)the Shanghai Clinical Research Center of Plastic and Reconstructive Surgery(grant no.22MC1940300).
文摘Fibrosis is a pathological outcome of a dysregulated repair response to injury,which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide.However,challenges remain in delineating the complex and dynamic network regulating fibrosis,as well as translating this information into effective anti-fibrotic treatments.A comprehensive understanding of existing methodologies and the development of new research tools are essential for ensuring the transferability of findings from bench to bedside.In this review,we present a framework consisting of a large biospecimen repository that integrates diverse patient cohorts with corresponding clinical data,and a systematic research platform incorporating multiple layers of experimental strategies,primarily focused on skin fibrosis.We summarize current advancements and the applications of various tools for preclinical fibrosis research and examine the limitations of traditional methods used to simulate and investigate biomechanical signals in the fibrotic environment.Importantly,we highlight the strengths of research techniques and translational approaches of varying physiological relevance developed by us over the past decade.Collectively,we emphasize a trend toward more faithfully replicating the functional,structural,and biological complexity of fibrosis while providing high spatio-temporal control over soluble cues and intricate interactions.Our comprehensive overview of methodology paves the way for minimizing batch-to-batch variation and improving the reproducibility of experimental systems.
文摘Leveraging the Baidu Qianfan model platform,this paper designs and implements a highly efficient and accurate scoring system for subjective questions,focusing primarily on questions in the field of computer network technology.The system enhances the foundational model by utilizing Qianfan’s training tools and integrating advanced techniques,such as supervised fine-tuning.In the data preparation phase,a comprehensive collection of subjective data related to computer network technology is gathered,cleaned,and labeled.During model training and evaluation,optimal hyperparameters and tuning strategies are applied,resulting in a model capable of scoring with high accuracy.Evaluation results demonstrate that the proposed model performs well across multiple dimensions-content,expression,and development scores-yielding results comparable to those of manual scoring.
文摘Mooring cable tension is a crucial parameter for evaluating the safety and reliability of a floating platform mooring system.The real-time mooring tension in an actual marine environment has always been essential data that mooring system designers aim to acquire.To address the need for long-term continuous monitoring of mooring tension in deep-sea marine environments,this paper presents a mooring cable tension monitoring method based on the principle of direct mechanical measurement.The developed tension monitoring sensors were installed and applied in the mooring system of the"Yongle"scientific experimental platform.Over the course of one year,a substantial amount of in-situ tension monitoring data was obtained.Under wave heights of up to 1.24 m,the mooring tension on the floating platform reached 16.5 tons.Through frequency domain and time domain analysis,the spectral characteristics of mooring tension,including waveinduced force,slow drift force,and mooring cable elastic restoring force,were determined.The mooring cable elastic restoring force frequency was approximately half of that of the wave signal.Due to the characteristics of the hinge connection structure of the dual module floating platform,under some specific working conditions the wave-induced force was the maximum of the three different frequency forces,and restoring force was the smallest.
基金financially supported by the National Natural Science Foundation of China National Outstanding Youth Science Fund Project (Grant No. 52222109)the National Natural Science Foundation of China (Grant No. 52201322)+1 种基金Guangdong Basic and Applied Basic Research Foundation (Grant Nos. 2024A1515240006, 2022B1515020036 and 2023A1515012144)the Project of State Key Laboratory of Subtropical Building and Urban Science (Grant No. 2023ZB14)。
文摘The integrated system composed of wave energy converters and floating wind turbines offers substantial potential for reducing the levelized cost of energy(LCOE) by sharing the infrastructure, mooring system, substations and cables.This paper proposes an integrated system consisting of a semi-submersible wind turbine platform and three Wave Star flap-type wave energy converters. The coupled motion model of the integrated system is established and validated on the basis of viscously corrected potential flow theory. This study investigates the influence of two key parameters,the arm length and hinge points of flap-type wave energy converters, on system performance. The results reveal that variations in the arm length of flap-type wave energy converters(WECs) are the primary determinants of the integrated system's dynamic characteristics, whereas changes in hinge points predominantly affect device power generation.Additionally, incorporating WECs reduces the pitch and heave motions of the platform within a specific wave frequency range, thereby enhancing the energy output of the integrated system at the operational sea site. The performance of this hybrid system at a selected sea site is further assessed via the proposed aero-hydroservo coupling simulations.
基金supported by the National Natural Science Foundation of China(Grant No.62322601).
文摘1Introduction Embodied Artificial Intelligence(Embodied AI)has recently become a key research focus[1].It emphasizes agents'abilities to perceive,comprehend,and act in physical worlds to complete tasks.Simulation platforms are essential in this area,as they simulate agent behaviors in set environments and tasks,thereby accelerating algorithm validation and optimization.However,constructing such a platform presents several challenges.
基金financially supported by the Open Project Program of Shandong Marine Aerospace Equipment Technological Innovation Center,Ludong University(Grant Nos.MAETIC202209 and MAETIC202201)Shandong Provincial Natural Science Foundation(Grant No.ZR2022QE092)+2 种基金China Postdoctoral Science Foundation(Grant No.2023M730829)Open Fund of the State Key Laboratory of Industrial Equipment Structural Analysis(Grant No.GZ23109)the National Natural Science Foundation of China(Grant Nos.52001284 and 52192694).
文摘In the process of developing oil and gas resources in the Arctic,the impact of icebergs can pose a considerable threat to the structural safety of semi-submersible mooring platforms in ice regions.On the basis of the arbitrary Lagrangian Eulerian(ALE)algorithm,a numerical model for the interaction between an iceberg and a semi-submersible mooring platform is built in this work.First,a mooring system with a link element is designed and validated.An ice material model for the target iceberg is built and validated.A numerical model for the interaction between an iceberg and a semi-submersible mooring platform is then built.A parametric study(cable angle,tension angle and number of cables)is carried out to study the performance of the mooring system.The collision process between the semi-submersible mooring platform and the iceberg in the polar marine environment can be predicted by the present numerical model,and then the optimal mooring arrangement scheme can be obtained.The research results in this work can provide a reference for the design of mooring systems.
基金supported by the National Natural Science Foundation of China(32470676 and 32170236)Central Guidance on Local Science and Technology Development Fund of Hebei Province(246Z2508G)+2 种基金Hebei Natural Science Foundation(C2020209064)Tangshan Science and Technology Program Project(21130217C)Key research project of North China University of Science and Technology(ZD-YG-202313-23).
文摘As a high-value eudicot family,many famous horticultural crop genomes have been deciphered in Oleaceae.However,there are currently no bioinformatics platforms focused on empowering genome research in Oleaceae.Herein,we developed the first comprehensive Oleaceae Genome Research Platform(OGRP,https://oleaceae.cgrpoee.top/).In OGRP,70 genomes of 10 Oleaceae species and 46 eudicots and 366 transcriptomes involving 18 Oleaceae plant tissues can be obtained.We built 34 window-operated bioinformatics tools,collected 38 professional practical software programs,and proposed 3 new pipelines,namely ancient polyploidization identification,ancestral karyotype reconstruction,and gene family evolution.Employing these pipelines to reanalyze the Oleaceae genomes,we clarified the polyploidization,reconstructed the ancestral karyotypes,and explored the effects of paleogenome evolution on genes with specific biological regulatory roles.Significantly,we generated a series of comparative genomic resources focusing on the Oleaceae,comprising 108 genomic synteny dot plots,1952225 collinear gene pairs,multiple genome alignments,and imprints of paleochromosome rearrangements.Moreover,in Oleaceae genomes,researchers can efficiently search for 1785987 functional annotations,22584 orthogroups,29582 important trait genes from 74 gene families,12664 transcription factor-related genes,9178872 transposable elements,and all involved regulatory pathways.In addition,we provided downloads and usage instructions for the tools,a species encyclopedia,ecological resources,relevant literatures,and external database links.In short,ORGP integrates rich data resources and powerful analytical tools with the characteristic of continuous updating,which can efficiently empower genome research and agricultural breeding in Oleaceae and other plants.
