We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the pl...We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the plateau （PG）. The other was by progressively increasing the time of exposure to hypoxia with oxygen supplied in stages after radical plateau （RG）. By testing the blood oxygen saturation （SpO2）, heart rate （HR）, and quality of sleep after arriving at the 3800 m high plateau, results showed that the pre-acclimatization and radical groups performed better than the control group （CG）. Both strategies were equivalent in terms of effects and principles in providing more flexible choices for acclimatization.展开更多
Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that c...Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.展开更多
基金supported in part by the national basic research program of China 973 program(NO.2012CB518200-G)Army major issue of comprehensive medical security research of flight crew in the plateau(N0.AKJ11J005)
文摘We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the plateau （PG）. The other was by progressively increasing the time of exposure to hypoxia with oxygen supplied in stages after radical plateau （RG）. By testing the blood oxygen saturation （SpO2）, heart rate （HR）, and quality of sleep after arriving at the 3800 m high plateau, results showed that the pre-acclimatization and radical groups performed better than the control group （CG）. Both strategies were equivalent in terms of effects and principles in providing more flexible choices for acclimatization.
基金supported by the Financial Special Fund,grant number XZ202401JD0027National Barley Industry Technology System(CARS-05-01A-08)+3 种基金the Xizang Agri-Tech Innovation Project(XZNKY-2025-CXGC-T01)the Joint Funds of the National Natural Science Foundation of China(No.U20A2026)the Financial Special Fund,grant number(32401784,2017CZZX001/2,XZNKY-2018-C-021 and NYSTC202401)the China Agriculture Research System of Barley(CARS-05).
文摘Qingke,a staple crop grown on the high-altitude Tibetan Plateau,has evolved a metabolomic profile providing both environmental stress resilience and human nutrition.We review the hypothesis that the metabolites that confer cold and UV resistance on the crop also facilitate human adaptation to high-altitude stresses.Specifically,β-glucans regulate blood glucose primarily via short-chain fatty acids(SCFAs)produced through gut microbiota fermentation,which directly mediate glucose homeostasis.Phenolamides accumulate via the phenylpropanoid pathway,with chalcone isomerase(CHI)serving as a key enzyme in flavonoid biosynthesis and enhancing UV-B resistance.Under low temperatures,β-glucans improve frost tolerance by modulating osmotic balance and inhibiting ice-nucleating proteins,while lipids maintain membrane fluidity to sustain cellular function during cold stress.Importantly,we explore the hypothesis that these same metabolites,upon consumption,may facilitate human adaptation to high-altitude stresses.This hypothesis is supported by preliminary epidemiological associations between Qingke consumption and favorable health outcomes in high-altitude populations,as well as established bioactivities of the implicated metabolites in vitro and in animal models.However,direct causal evidence in humans and a comprehensive understanding of the underlying molecular mechanisms remain key knowledge gaps that warrant future investigation.Qingke as a unique resource at the interface of agricultural resilience and human nutrition.Understanding its metabolic blueprint will inform the development of functional foods and climate-resilient crops.
