In order to find a new way to improve the dispersion ability of nanometer material, an investigation on preparation of thin film with low surface energy on the surface of nanometer material by means of plasma polymeri...In order to find a new way to improve the dispersion ability of nanometer material, an investigation on preparation of thin film with low surface energy on the surface of nanometer material by means of plasma polymerization has been done. Some physical behaviors and chemical constitution of prepared film as well as the influence of polymerized film on nanometer material were tested. All the experimental results showed that this is a possible way to improve the dispersion ability of nanometer materials.展开更多
A study has been made on the plasma polymerization of acetylene/CO_2/H_2 in a capacitively coupled RF plasma. The monomer mixture yielded a crosslinked film with light brown color. A kinetic study is reported for the ...A study has been made on the plasma polymerization of acetylene/CO_2/H_2 in a capacitively coupled RF plasma. The monomer mixture yielded a crosslinked film with light brown color. A kinetic study is reported for the plasma polymer ization of acetylene/CO_2/H_2. The effects of discharge power level and reactor geometry on the rate of polymer formation are reported. The structure of the plasma polymer is investigated by IR study.展开更多
Surface modification of nucle-microporous membrane by plasma polymerization of HEMA, NVP and D_4 has been studied. The hydrophilicity of membranes was increased with increasing of plasma polymerization time of hydroph...Surface modification of nucle-microporous membrane by plasma polymerization of HEMA, NVP and D_4 has been studied. The hydrophilicity of membranes was increased with increasing of plasma polymerization time of hydrophilic monomers HEMA and NVP. The flow rate of water through the membrane was increased remarkably after plasma polymerization of HEMA on it.展开更多
In a capacitively coupled RF discharge system with external electrodes ,hexamethyicyclotrisiloxane was polymerized, and the effects of discharge power and plasma gas on polymer deposition rate were studied. The polyme...In a capacitively coupled RF discharge system with external electrodes ,hexamethyicyclotrisiloxane was polymerized, and the effects of discharge power and plasma gas on polymer deposition rate were studied. The polymer structures and properties were studied by IR spectroscopy, XPS measurement, PGC/MS combined technique, TG analysis and contact angle measuring. The results showed that the polymers prepared in H_2 or O_2 have higher C/Si ratio in comparison with those prepared in inert gases. PGC/MS results revealed the existence of many short carbon chains in the polymer structure .TG analysis suggested that the polymers prepared in the inert gas would possess better thermal stabilities.展开更多
Polymeric polypyrrole-like （PPy-llke） nanocrystallines were fast synthesized through oriented plasma polymerization at atmospheric pressure and room temperature. The effects of discharge power on the nanocrystalline...Polymeric polypyrrole-like （PPy-llke） nanocrystallines were fast synthesized through oriented plasma polymerization at atmospheric pressure and room temperature. The effects of discharge power on the nanocrystalline morphology were investigated. Larger power tends to produce longer nanocrystallines. 3 mm long nanowires were produced at the largest power in our experiment. TEM image and the sharp electronic diffraction spots in SAD suggest that the nanoparticles have a single crystal phase. The chemical structure of the nanocrystalline has been studied through FTIR, EDX etc. This novel polymerization method could have great applications in fabricating functional polymeric nanocrystallines.展开更多
The PVC/EBBA ultrathin composite membranes with thickness of about 100 nm were prepared by spreading the solution on water surface. The overlapped composite membrane showed a characteristic aggregation structure in wh...The PVC/EBBA ultrathin composite membranes with thickness of about 100 nm were prepared by spreading the solution on water surface. The overlapped composite membrane showed a characteristic aggregation structure in which the polymer matrix exists as a three-dimensional spongy network and the liquid crystal domains werc observed. Tne surface modification for the overlapped membranes was carried out by means of plasma-polymerization with the monomers of fluorocarbon compounds. Both Arrhenius plots of permeability coefficients for oxygen ((?)_O_2) in the membrane samples before and after modification showed significant increase in the vicinity of the T_(KN) of EBBA.展开更多
The surface of polypropylene （iPP） is modified with glow discharge plasma of Ar, so that the modified surfaces of iPP films are obtained. The studies of scanning electron microscopy （SEM） show the surface etching ...The surface of polypropylene （iPP） is modified with glow discharge plasma of Ar, so that the modified surfaces of iPP films are obtained. The studies of scanning electron microscopy （SEM） show the surface etching pattern of iPP films. The chemical structures of iPP films are confirmed by X-ray photoelectron spectroscopy （XPS） and Fourier transform infrared （FTIR） spectroscopy. The wetting properties of modified surfaces of iPP films are characterized by contact angle, and the free energy of surfaces is calculated. The free radical of modification surfaces of iPP is measured by chemical method. The surfaces of iPP are achieved with Ar plasma treatment followed by grafting copolymerization with styrene （St） in St. The grafting polymer of St onto iPP is characterized by FTIR. The grafting rate is dependent on plasma exposure time and discharge voltage. The studies show that homopolymerization of St is undergone at the sane time during the graftingcopolymerization of St onto/PP.展开更多
A novel atmospheric plasma device developed in this paper, which is more effective and convenient to study the plasma-initiated polymerization (PIP) than conventional setup. The structure and mechanism of the device i...A novel atmospheric plasma device developed in this paper, which is more effective and convenient to study the plasma-initiated polymerization (PIP) than conventional setup. The structure and mechanism of the device is introduced. Some plasma-initiated polymerization experiments are carried out on the device, and the conversion of AA (Acrylic acid) and AM (Acryl amide) atmospheric (N2) plasma polymerization are respectively 89% and 94% after 120 h post polymerization, whereby IR spectra of the product (AA, AM). Our PIP result are confirmed.展开更多
Plasma initiated polymerization is a kind of well-known radical polymerization mechanism, but it has the ＇living＇ polymerization feature and produces ultra-high molecular weight polymer. In order to explain such phe...Plasma initiated polymerization is a kind of well-known radical polymerization mechanism, but it has the ＇living＇ polymerization feature and produces ultra-high molecular weight polymer. In order to explain such phenomena, we calculate the basic data of plasma initiated polymerization of methylmethacrylate （MMA） according to the principle of polymer physics and chemistry. It results in that the radical concentration ranges from 10^-12mol/L to 10^-16mol/L corresponding to the radical life in 10^4s to 10^8s, which means the radicals have a long lifetime. Moreover because of the long lifetime radicals it causes a unique feature rather than the common radical polymerization, and also shows no ＂living polymerization＂. It is noticed in experiments that there are two key factors playing important roles. One is the effective radical amount produced during the plasma discharging while the another is the diffusion factor.展开更多
This study aims to investigate the chemical structure and morphology of plasmapolymers produced by deposition of ethylene on the surface of polypropylene. The deposition films（sediments） of ethylene plasma on the su...This study aims to investigate the chemical structure and morphology of plasmapolymers produced by deposition of ethylene on the surface of polypropylene. The deposition films（sediments） of ethylene plasma on the surface of polypropylene are nonuniform, and the characterization results indicate the existence of hydroxyl groups and aldehyde（or ketone） groups in the sediments. The sediment of ethylene plasma on the polypropylene surface could induce the growth of β-form crystals in the surface layer of polypropylene.展开更多
We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated scaffold.We designed a culture chamber where a radial flow of culture medi-um was conti...We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated scaffold.We designed a culture chamber where a radial flow of culture medi-um was continuously delivered through it.Once this system was established,flow was simulated using flow dy-namics software based on numeric methods to solve Navier-Stockes flow equations.Perfusion within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor chamber.Afterwards,the bioreactor was built according to the simulated design and was tested with liver carcinoma cells(HepG2)cultured over an L-polylactic acid scaffold whose surface was modified with iodine-doped polypyrrole.The bioreactor was tested under non-flow and in radial flow condi-tions.Cell density under radial flow conditions was almost double than that under static conditions and both total protein and albumin output was also increased under radial flow conditions.展开更多
Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both cases.They were polymerized on glass substrates under the same reacti...Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both cases.They were polymerized on glass substrates under the same reaction conditions.Polymerization of allylamine was also studied at different operating powers.These thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human hepatoma.The proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.展开更多
Poly（ethylene glycol） methyl ether methacrylate（PEGMA） was grafted on fluorosilicone acrylate rigid gas permissible contact lens surface by means of argon plasma induced polymerization to improve surface hydrophil...Poly（ethylene glycol） methyl ether methacrylate（PEGMA） was grafted on fluorosilicone acrylate rigid gas permissible contact lens surface by means of argon plasma induced polymerization to improve surface hydrophilicity and reduce protein adsorption.The surface properties were characterized by contact angle measurement,x-ray photoelectron spectroscopy（XPS） and atomic force microscopy respectively.The surface protein adsorption was evaluated by lysozyme solution immersion and XPS analysis.The results indicated that a thin layer of PEGMA was successfully grafted.The surface hydrophilicity was bettered and surface free energy increased.The lysozyme adsorption on the lens surface was reduced greatly.展开更多
Water existing in water-absorbing plasma polymerized N-vinyl-2-pyrrolidone(PPNVP) include pure bulk water, freezable water and non-freezing, or bound, water. The C-N bond of N, N-disubstituted amides in PPNVP was cons...Water existing in water-absorbing plasma polymerized N-vinyl-2-pyrrolidone(PPNVP) include pure bulk water, freezable water and non-freezing, or bound, water. The C-N bond of N, N-disubstituted amides in PPNVP was considered as an active binding site for bound water.展开更多
The effects of oxygen on the chemical structure, morphology, hydrophilicity and drug release behavior of radio-frequency plasma poly n- butyl methacrylate （PPBMA） thin film were carded out for the first time. ATR-FT...The effects of oxygen on the chemical structure, morphology, hydrophilicity and drug release behavior of radio-frequency plasma poly n- butyl methacrylate （PPBMA） thin film were carded out for the first time. ATR-FTIR and XPS showed that oxygen had little influence on the chemical structure and composition of PPBMAs, which did not agree with the thought that the presence of oxygen gas would increase the oxidized carbon functionalities in the plasma polymer. SEM and static contact angle measurement indicated that in case of deposition with oxygen, the smoothness and hydrophilicity of PPBMA were dramatically improved. The drug release behavior showed that drug release from the PPBMA coating without oxygen was biphasic patterns, while from PPBMA coating with oxygen was Higuchi release. These results were helpful for the design and tailoring of the PPBMA polymer film and other of plasma polymers film, but could provide a new idea for the drug release controlled form.展开更多
Organosilicone thin films were prepared through plasma polymerization(pp)in a plasma enhance chemical vapour deposition(PECVD)system,utilizing hexamethyldisilazane(HMDSN)as a monomer precursor,at varying distances(25 ...Organosilicone thin films were prepared through plasma polymerization(pp)in a plasma enhance chemical vapour deposition(PECVD)system,utilizing hexamethyldisilazane(HMDSN)as a monomer precursor,at varying distances(25 mm,35 mm,45 mm,55 mm,and 65 mm)from the plasma source to the substrate.Research has examined how the distance between the substrate and plasma source impacts the properties of thin films,including their thickness,surface morphology,and photoluminescence(PL).It was discovered that as the distance increased,both film thickness and PL intensity also increased.Additionally,the film was observed to be more uniform and smoother when deposited 45 mm below the plasma source.展开更多
Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of ...Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte patch.Plasma polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)monomers.Human pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization determined.The AA surface provided the superior transfer of the cells to de-epidermized dermis.Excisional murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the wounds.Pericyte delivery also enhanced angiogenesis through a mechanism independent of VEGF signalling.Pericytes,when delivered to wounds,improved healing responses by dampening inflammation and promoting angiogenesis.Delivery of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into wounds.Pericyte-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.展开更多
The increasing demand for potable water is never-ending.Freshwater resources are scarce and stress is accumulating on other alternatives.Therefore,new technologies and novel optimization methods are developed for the ...The increasing demand for potable water is never-ending.Freshwater resources are scarce and stress is accumulating on other alternatives.Therefore,new technologies and novel optimization methods are developed for the existing processes.Membrane-based processes are among the most efficient methods for water treatment.Yet,membranes suffer from severe operational problems,namely fouling and temperature polarization.These effects can harm the membrane’s permeability,permeate recovery,and lifetime.To mitigate such effects,membranes can be treated through two techniques:plasma treatment(a surface modification technique),and treatment through the use of plasmonic materials(surface and bulk modification).This article showcases plasma-and plasmonic-based treatments in the context of water desalination/purification.It aims to offer a comprehensive review of the current developments in membrane-based water treatment technologies along with suggested directions to enhance its overall efficiency through careful selection of material and system design.Moreover,basic guidelines and strategies are outlined on the different membrane modification techniques to evaluate its prerequisites.Besides,we discuss the challenges and future developments about these membrane modification methods.展开更多
文摘In order to find a new way to improve the dispersion ability of nanometer material, an investigation on preparation of thin film with low surface energy on the surface of nanometer material by means of plasma polymerization has been done. Some physical behaviors and chemical constitution of prepared film as well as the influence of polymerized film on nanometer material were tested. All the experimental results showed that this is a possible way to improve the dispersion ability of nanometer materials.
文摘A study has been made on the plasma polymerization of acetylene/CO_2/H_2 in a capacitively coupled RF plasma. The monomer mixture yielded a crosslinked film with light brown color. A kinetic study is reported for the plasma polymer ization of acetylene/CO_2/H_2. The effects of discharge power level and reactor geometry on the rate of polymer formation are reported. The structure of the plasma polymer is investigated by IR study.
文摘Surface modification of nucle-microporous membrane by plasma polymerization of HEMA, NVP and D_4 has been studied. The hydrophilicity of membranes was increased with increasing of plasma polymerization time of hydrophilic monomers HEMA and NVP. The flow rate of water through the membrane was increased remarkably after plasma polymerization of HEMA on it.
基金The project is supported by the National Natural Science Foundation of PRC
文摘In a capacitively coupled RF discharge system with external electrodes ,hexamethyicyclotrisiloxane was polymerized, and the effects of discharge power and plasma gas on polymer deposition rate were studied. The polymer structures and properties were studied by IR spectroscopy, XPS measurement, PGC/MS combined technique, TG analysis and contact angle measuring. The results showed that the polymers prepared in H_2 or O_2 have higher C/Si ratio in comparison with those prepared in inert gases. PGC/MS results revealed the existence of many short carbon chains in the polymer structure .TG analysis suggested that the polymers prepared in the inert gas would possess better thermal stabilities.
基金Supported by the Natural Science Foundation of China (No.50473003) and Shanghai Nano Science and Technology Promotion Center(No.0352nm035)
文摘Polymeric polypyrrole-like （PPy-llke） nanocrystallines were fast synthesized through oriented plasma polymerization at atmospheric pressure and room temperature. The effects of discharge power on the nanocrystalline morphology were investigated. Larger power tends to produce longer nanocrystallines. 3 mm long nanowires were produced at the largest power in our experiment. TEM image and the sharp electronic diffraction spots in SAD suggest that the nanoparticles have a single crystal phase. The chemical structure of the nanocrystalline has been studied through FTIR, EDX etc. This novel polymerization method could have great applications in fabricating functional polymeric nanocrystallines.
基金Supported by the Science Fund of Academia Sinica and the National Natural Science Foundation of China
文摘The PVC/EBBA ultrathin composite membranes with thickness of about 100 nm were prepared by spreading the solution on water surface. The overlapped composite membrane showed a characteristic aggregation structure in which the polymer matrix exists as a three-dimensional spongy network and the liquid crystal domains werc observed. Tne surface modification for the overlapped membranes was carried out by means of plasma-polymerization with the monomers of fluorocarbon compounds. Both Arrhenius plots of permeability coefficients for oxygen ((?)_O_2) in the membrane samples before and after modification showed significant increase in the vicinity of the T_(KN) of EBBA.
基金financially supported by the National Natural Science Foundation of China(No.50673073)the Doctoral Foundation of Ministry of Education of China(No.20060056043)
文摘The surface of polypropylene （iPP） is modified with glow discharge plasma of Ar, so that the modified surfaces of iPP films are obtained. The studies of scanning electron microscopy （SEM） show the surface etching pattern of iPP films. The chemical structures of iPP films are confirmed by X-ray photoelectron spectroscopy （XPS） and Fourier transform infrared （FTIR） spectroscopy. The wetting properties of modified surfaces of iPP films are characterized by contact angle, and the free energy of surfaces is calculated. The free radical of modification surfaces of iPP is measured by chemical method. The surfaces of iPP are achieved with Ar plasma treatment followed by grafting copolymerization with styrene （St） in St. The grafting polymer of St onto iPP is characterized by FTIR. The grafting rate is dependent on plasma exposure time and discharge voltage. The studies show that homopolymerization of St is undergone at the sane time during the graftingcopolymerization of St onto/PP.
文摘A novel atmospheric plasma device developed in this paper, which is more effective and convenient to study the plasma-initiated polymerization (PIP) than conventional setup. The structure and mechanism of the device is introduced. Some plasma-initiated polymerization experiments are carried out on the device, and the conversion of AA (Acrylic acid) and AM (Acryl amide) atmospheric (N2) plasma polymerization are respectively 89% and 94% after 120 h post polymerization, whereby IR spectra of the product (AA, AM). Our PIP result are confirmed.
文摘Plasma initiated polymerization is a kind of well-known radical polymerization mechanism, but it has the ＇living＇ polymerization feature and produces ultra-high molecular weight polymer. In order to explain such phenomena, we calculate the basic data of plasma initiated polymerization of methylmethacrylate （MMA） according to the principle of polymer physics and chemistry. It results in that the radical concentration ranges from 10^-12mol/L to 10^-16mol/L corresponding to the radical life in 10^4s to 10^8s, which means the radicals have a long lifetime. Moreover because of the long lifetime radicals it causes a unique feature rather than the common radical polymerization, and also shows no ＂living polymerization＂. It is noticed in experiments that there are two key factors playing important roles. One is the effective radical amount produced during the plasma discharging while the another is the diffusion factor.
基金financially supported by the National Natural Science Foundation of China(Nos.51033004 and 51473113)the Natural Science Foundation of Tianjin(No.12JCYBJC11900)
文摘This study aims to investigate the chemical structure and morphology of plasmapolymers produced by deposition of ethylene on the surface of polypropylene. The deposition films（sediments） of ethylene plasma on the surface of polypropylene are nonuniform, and the characterization results indicate the existence of hydroxyl groups and aldehyde（or ketone） groups in the sediments. The sediment of ethylene plasma on the polypropylene surface could induce the growth of β-form crystals in the surface layer of polypropylene.
基金Universidad Autónoma Metropolitana(UAM),Consejo Nacional de Ciencia y Tecnología(CONACYT)(project 155239)Instituto de Ciencia y Tecnología del Distrito Federal(ICyT-DF)(PIUTE 10-63276/2010)y(PICSA 11-14/2011)for funding.
文摘We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated scaffold.We designed a culture chamber where a radial flow of culture medi-um was continuously delivered through it.Once this system was established,flow was simulated using flow dy-namics software based on numeric methods to solve Navier-Stockes flow equations.Perfusion within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor chamber.Afterwards,the bioreactor was built according to the simulated design and was tested with liver carcinoma cells(HepG2)cultured over an L-polylactic acid scaffold whose surface was modified with iodine-doped polypyrrole.The bioreactor was tested under non-flow and in radial flow condi-tions.Cell density under radial flow conditions was almost double than that under static conditions and both total protein and albumin output was also increased under radial flow conditions.
文摘Low pressure plasma polymer films were synthesized using pyrrole and allylamine monomers and adding iodine was used(or not)for the reaction in both cases.They were polymerized on glass substrates under the same reaction conditions.Polymerization of allylamine was also studied at different operating powers.These thin polymer films were used as culture surfaces for HepG2 cells,a cell line derived from a human hepatoma.The proliferation,differentiation and two-dimensional propagation until obtaining monolayer of the cells was studied on the different synthetized films and correlations were established between the conditions of synthesis,the physicochemical characteristics obtained and the performance as substrates for the cellular growth.
基金supported by National Natural Science Foundation of China(No.51273072)
文摘Poly（ethylene glycol） methyl ether methacrylate（PEGMA） was grafted on fluorosilicone acrylate rigid gas permissible contact lens surface by means of argon plasma induced polymerization to improve surface hydrophilicity and reduce protein adsorption.The surface properties were characterized by contact angle measurement,x-ray photoelectron spectroscopy（XPS） and atomic force microscopy respectively.The surface protein adsorption was evaluated by lysozyme solution immersion and XPS analysis.The results indicated that a thin layer of PEGMA was successfully grafted.The surface hydrophilicity was bettered and surface free energy increased.The lysozyme adsorption on the lens surface was reduced greatly.
文摘Water existing in water-absorbing plasma polymerized N-vinyl-2-pyrrolidone(PPNVP) include pure bulk water, freezable water and non-freezing, or bound, water. The C-N bond of N, N-disubstituted amides in PPNVP was considered as an active binding site for bound water.
文摘The effects of oxygen on the chemical structure, morphology, hydrophilicity and drug release behavior of radio-frequency plasma poly n- butyl methacrylate （PPBMA） thin film were carded out for the first time. ATR-FTIR and XPS showed that oxygen had little influence on the chemical structure and composition of PPBMAs, which did not agree with the thought that the presence of oxygen gas would increase the oxidized carbon functionalities in the plasma polymer. SEM and static contact angle measurement indicated that in case of deposition with oxygen, the smoothness and hydrophilicity of PPBMA were dramatically improved. The drug release behavior showed that drug release from the PPBMA coating without oxygen was biphasic patterns, while from PPBMA coating with oxygen was Higuchi release. These results were helpful for the design and tailoring of the PPBMA polymer film and other of plasma polymers film, but could provide a new idea for the drug release controlled form.
基金the AECS for its financial support of this study
文摘Organosilicone thin films were prepared through plasma polymerization(pp)in a plasma enhance chemical vapour deposition(PECVD)system,utilizing hexamethyldisilazane(HMDSN)as a monomer precursor,at varying distances(25 mm,35 mm,45 mm,55 mm,and 65 mm)from the plasma source to the substrate.Research has examined how the distance between the substrate and plasma source impacts the properties of thin films,including their thickness,surface morphology,and photoluminescence(PL).It was discovered that as the distance increased,both film thickness and PL intensity also increased.Additionally,the film was observed to be more uniform and smoother when deposited 45 mm below the plasma source.
基金This research was supported by the Cell Therapy Manufacturing Cooperative Research Centre(CTM CRC).Additionally,H.M.T.was supported through an Australian Post-Graduate Award scholarship and a top-up scholarship from the Playford Trust.P.A.received a University of South Australia President’s Postgraduate Scholarship,and A.J.C.is supported by a National Health and Medical Research Council(NHMRC)Senior Research Fellowship(GNT#1102617).
文摘Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte patch.Plasma polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)monomers.Human pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization determined.The AA surface provided the superior transfer of the cells to de-epidermized dermis.Excisional murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the wounds.Pericyte delivery also enhanced angiogenesis through a mechanism independent of VEGF signalling.Pericytes,when delivered to wounds,improved healing responses by dampening inflammation and promoting angiogenesis.Delivery of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into wounds.Pericyte-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.
基金the Center for Membranes and Advanced Water Technology(CMAT)at Khalifa University for the support(Award No.RC2-2018-009).
文摘The increasing demand for potable water is never-ending.Freshwater resources are scarce and stress is accumulating on other alternatives.Therefore,new technologies and novel optimization methods are developed for the existing processes.Membrane-based processes are among the most efficient methods for water treatment.Yet,membranes suffer from severe operational problems,namely fouling and temperature polarization.These effects can harm the membrane’s permeability,permeate recovery,and lifetime.To mitigate such effects,membranes can be treated through two techniques:plasma treatment(a surface modification technique),and treatment through the use of plasmonic materials(surface and bulk modification).This article showcases plasma-and plasmonic-based treatments in the context of water desalination/purification.It aims to offer a comprehensive review of the current developments in membrane-based water treatment technologies along with suggested directions to enhance its overall efficiency through careful selection of material and system design.Moreover,basic guidelines and strategies are outlined on the different membrane modification techniques to evaluate its prerequisites.Besides,we discuss the challenges and future developments about these membrane modification methods.
