Porphyrin-based photodynamic therapy(PDT)has emerged as a promising approach in clinic.However,its therapeutic efficacy is remarkedly constrained due to the intrinsic hydrophobicity of porphyrins and their limited abs...Porphyrin-based photodynamic therapy(PDT)has emerged as a promising approach in clinic.However,its therapeutic efficacy is remarkedly constrained due to the intrinsic hydrophobicity of porphyrins and their limited absorption in the near-infrared(NIR)region.Inspired by the unique supramolecular structures and optical properties of pigment-binding proteins during photosynthesis,we herein developed a carbon dot derived from porphyrin and amino acid mixture(TPP-AA-CDs)for efficient PDT.Having precisely tuned the optical properties of TPP-AA-CDs in the range of visible to NIR region,such a pigment-binding protein-mimicking system leveraged the hydrophilic amino acid-hybrid framework as a light-harvesting scaffold to support the hydrophobic porphyrin centre.TPP-AA-CDs exhibited enhanced light-harvesting efficiency in the presence of amino and hydroxyl residues from amino acid side chains,which facilitate the incorporation of porphyrin within the framework.Among the variants,histidine-derived carbon dots(TPP-H-CDs)performed markedly improved PDT efficiency with high biocompatibility,leading to accelerated wound healing and boosted antitumor effects under NIR light irradiation.This light-harvesting pigment-binding protein-mimicking framework that scaffolded the porphyrin,offered a promising strategy for developing the next-generation of efficient NIR-absorbing materials with potential clinical translations.展开更多
基金supported by the Key Research and Development Joint Fund of the Department of Science and Technology of Liaoning Province(No.2021JH2/1030005)the General Program of the Education Department of Liaoning Province(No.JYTMS20230101)。
文摘Porphyrin-based photodynamic therapy(PDT)has emerged as a promising approach in clinic.However,its therapeutic efficacy is remarkedly constrained due to the intrinsic hydrophobicity of porphyrins and their limited absorption in the near-infrared(NIR)region.Inspired by the unique supramolecular structures and optical properties of pigment-binding proteins during photosynthesis,we herein developed a carbon dot derived from porphyrin and amino acid mixture(TPP-AA-CDs)for efficient PDT.Having precisely tuned the optical properties of TPP-AA-CDs in the range of visible to NIR region,such a pigment-binding protein-mimicking system leveraged the hydrophilic amino acid-hybrid framework as a light-harvesting scaffold to support the hydrophobic porphyrin centre.TPP-AA-CDs exhibited enhanced light-harvesting efficiency in the presence of amino and hydroxyl residues from amino acid side chains,which facilitate the incorporation of porphyrin within the framework.Among the variants,histidine-derived carbon dots(TPP-H-CDs)performed markedly improved PDT efficiency with high biocompatibility,leading to accelerated wound healing and boosted antitumor effects under NIR light irradiation.This light-harvesting pigment-binding protein-mimicking framework that scaffolded the porphyrin,offered a promising strategy for developing the next-generation of efficient NIR-absorbing materials with potential clinical translations.
