Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertensi...Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertension,jaundice,dysmenorrheal,gastrointestinal disorders and malaria.In order to reveal its full pharmacological and therapeutic potentials,die present review focuses on the current medicinal uses,phytochemistry,pharmacological and toxicological activities of this species.Literature survey on scientific journals,books as well as electronic sources have shown the isolation of alkaloids,tannins,polyphenols and steroids from different parts of the plant,pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic,anti-inflammatory,hypoglyceamic,hypotensive,antiplasmodial,antimicrobial,antiulcer and antitumorigenic activities.Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases.However,further studies on the extracts and pure compounds from this species is required to completely assess its phytoc-hemical,pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species.展开更多
Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionat...Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction.They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.Results:Oral administration of the methanol extract,chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%,40.0%and 56.3%,respectively;and the fractions of the extract significantly(P【0.05) reduced gastric emptying time when compared to the control.Gastric acidity was significandy decreased when compared with saline group,40.25 mEq/ L in methanol extract,50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fration but had no significant effect on the gastric secretion volume.Conclusions:These findings showed that methanol extract,chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.展开更多
基金supported by a US-Senior Fulbright Award granted to Dr.A.Falodun for study at University of Mississippi,USA,CIESCs for the Fulbright awardthe University of Benin(Nigeria)and Institute of Chemistry(University of Rostock,Germany),for their support
文摘Picralima nitida Durand and Hook,(fam.Apocynaceae)is a West African plant with varied applications in African folk medicine.Various parts of the plant have been employed ethnomedicinally as remedy for fever,hypertension,jaundice,dysmenorrheal,gastrointestinal disorders and malaria.In order to reveal its full pharmacological and therapeutic potentials,die present review focuses on the current medicinal uses,phytochemistry,pharmacological and toxicological activities of this species.Literature survey on scientific journals,books as well as electronic sources have shown the isolation of alkaloids,tannins,polyphenols and steroids from different parts of the plant,pharmacological studies revealed that the extract or isolated compounds from this species posses analgesic,anti-inflammatory,hypoglyceamic,hypotensive,antiplasmodial,antimicrobial,antiulcer and antitumorigenic activities.Results from various scientific investigations to date have revealed the potential of the extract from the plant or isolated compounds for use in the treatment and prevention of various kinds of human diseases.However,further studies on the extracts and pure compounds from this species is required to completely assess its phytoc-hemical,pharmacological and toxicological profile as well as the mechanism of action behind these pharmacological activities exhibited by the compounds isolated from this species.
文摘Objective:To investigated the antisecrectory activities of the methanol extract,chloroform fraction and methanol fraction of Picralima nitida seeds.Methods:The methanol extract of Picralima nitida seeds was fractionated into chloroform fraction and methanol fraction.They were evaluated for antiulcer activity and gastric emptying time in rats using aspirin-pylorus-ligation model.Results:Oral administration of the methanol extract,chloroform fraction and methanol fraction at 1 000 mg/kg reduced gastric ulcer by 56.4%,40.0%and 56.3%,respectively;and the fractions of the extract significantly(P【0.05) reduced gastric emptying time when compared to the control.Gastric acidity was significandy decreased when compared with saline group,40.25 mEq/ L in methanol extract,50.0 mEq/L in chloroform fraction 51.25 mEq/L in methanol fration but had no significant effect on the gastric secretion volume.Conclusions:These findings showed that methanol extract,chloroform fraction and methanol fraction of the seeds of Picralima possessed potent antiulcer properties and some antisecretory properties.
