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Noodles at Coffee Garden——Weekend Life Picks for as little as RMB68
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《China Today》 2002年第4期76-77,共2页
关键词 Office Weekend Life picks for as little as RMB68 Noodles at Coffee Garden
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Flooded County Picks Up the Pieces
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《Beijing Review》 2008年第35期5-9,共5页
Local residents in Xiahe County, Gansu Province, clear up debris left by floodwaters on August 20. People’s Daily Online reported that rains triggered mudrock flows that hit seven villages in three towns on August 19... Local residents in Xiahe County, Gansu Province, clear up debris left by floodwaters on August 20. People’s Daily Online reported that rains triggered mudrock flows that hit seven villages in three towns on August 19. About 3,000 rooms in the county’s houses are reported to have collapsed and more than 11,400 were flooded. Three people were killed and one was missing. A 30-meter section of highway linking Xiahe and other regions was blocked by falling rocks and mud. The report said the county government had mobilized staff for disaster-relief work. 展开更多
关键词 Flooded County picks Up the Pieces
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Auto Industry Picks Electronic Technology for Speedy Expansion
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作者 Dong Yang, AIB of MMI 《中国汽车(英文版)》 1996年第1期9-11,共3页
Ⅰ. The Development Plan for Auto-electronic technology in China 1. The Status Quo of China’s Auto-electronic Technology Application There is a clear disparity between China and developed countries in the field of au... Ⅰ. The Development Plan for Auto-electronic technology in China 1. The Status Quo of China’s Auto-electronic Technology Application There is a clear disparity between China and developed countries in the field of auto-electronic technology. The comprehensive level of China today’s auto-electronic 展开更多
关键词 Auto Industry picks Electronic Technology for Speedy Expansion In
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The structural optimization of roadheader conical picks based on fatigue life
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作者 Zhenguo Lu Lirong Wan +2 位作者 Qingliang Zeng Xin Zhang Kuidong Gao 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2018年第2期70-86,共17页
Conical picks are the key cutting components used on roadheaders,and they are replaced frequently because of the bad working conditions.Picks did not meet the fatigue life when they were damaged by abrasion,so the pic... Conical picks are the key cutting components used on roadheaders,and they are replaced frequently because of the bad working conditions.Picks did not meet the fatigue life when they were damaged by abrasion,so the pick fatigue life and strength are excessive.In the paper,in order to reduce the abrasion and save the materials,structure optimization was carried out.For static analysis and fatigue life prediction,the simulation program was proposed based on mathematical models to obtain the cutting resistance.Furthermore,the finite element models for static analysis and fatigue life analysis were proposed.The results indicated that fatigue life damage and strength failure of the cutting pick would never happen.Subsequently,the initial optimization model and the finite element model of picks were developed.According to the optimized results,a new type of pick was developed based on the working and installing conditions of the traditional pick.Finally,the previous analysis methods used for traditional methods were carried out again for the new type picks.The results show that new type of pick can satisfy the strength and fatigue life requirements. 展开更多
关键词 Structure optimization static analysis fatigue life prediction the new type of pick.
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Strength prediction and cuttability identification of rock based on monitoring while cutting(MWC)using a conical pick
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作者 Shaofeng Wang Yumeng Wu +2 位作者 Xinlei Shi Xin Cai Zilong Zhou 《International Journal of Minerals,Metallurgy and Materials》 2025年第5期1025-1043,共19页
Real-time identification of rock strength and cuttability based on monitoring while cutting during excavation is essential for key procedures such as the precise adjustment of excavation parameters and the in-situ mod... Real-time identification of rock strength and cuttability based on monitoring while cutting during excavation is essential for key procedures such as the precise adjustment of excavation parameters and the in-situ modification of hard rocks.This study proposes an in-telligent approach for predicting rock strength and cuttability.A database comprising 132 data sets is established,containing cutting para-meters(such as cutting depth and pick angle),cutting responses(such as specific energy and instantaneous cutting rate),and rock mech-anical parameters collected from conical pick-cutting experiments.These parameters serve as input features for predicting the uniaxial compressive strength and tensile strength of rocks using regression fitting and machine learning methodologies.In addition,rock cuttabil-ity is classified using a combination of the analytic hierarchy process and fuzzy comprehensive evaluation method,and subsequently iden-tified through machine learning approaches.Various models are compared to determine the optimal predictive and classification models.The results indicate that the optimal model for uniaxial compressive strength and tensile strength prediction is the genetic algorithm-optimized backpropagation neural network model,and the optimal model for rock cuttability classification is the radial basis neural network model. 展开更多
关键词 conical picks strength prediction cuttability identification machine learning monitoring while cutting
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Managing cotton canopy architecture for machine picking cotton via high plant density and plant growth retardants 被引量:1
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作者 LAKSHMANAN Sankar SOMASUNDARAM Selvaraj +4 位作者 SHRI RANGASAMI Silambiah ANANTHARAJU Pokkharu VIJAYALAKSHMI Dhashnamurthi RAGAVAN Thiruvengadam DHAMODHARAN Paramasivam 《Journal of Cotton Research》 2025年第1期102-114,共13页
Machine picking in cotton is an emerging practice in India,to solve the problems of labour shortages and production costs increasing.Cotton production has been declining in recent years;however,the high density planti... Machine picking in cotton is an emerging practice in India,to solve the problems of labour shortages and production costs increasing.Cotton production has been declining in recent years;however,the high density planting system(HDPS)offers a viable method to enhance productivity by increasing plant populations per unit area,optimizing resource utilization,and facilitating machine picking.Cotton is an indeterminate plant that produce excessive vegeta-tive growth in favorable soil fertility and moisture conditions,which posing challenges for efficient machine picking.To address this issue,the application of plant growth retardants(PGRs)is essential for controlling canopy architecture.PGRs reduce internode elongation,promote regulated branching,and increase plant compactness,making cotton plants better suited for machine picking.PGRs application also optimizes photosynthates distribution between veg-etative and reproductive growth,resulting in higher yields and improved fibre quality.The integration of HDPS and PGRs applications results in an optimal plant architecture for improving machine picking efficiency.However,the success of this integration is determined by some factors,including cotton variety,environmental conditions,and geographical variations.These approaches not only address yield stagnation and labour shortages but also help to establish more effective and sustainable cotton farming practices,resulting in higher cotton productivity. 展开更多
关键词 COTTON High density planting system Plant growth retardant Canopy management Defoliators Machine picking Yield improvement
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基于靶点筛选探讨京尼平龙胆双糖苷抗抑郁的作用机制
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作者 肖洋 杨琴 +3 位作者 谢肖瑶 荆继虎 江玉翠 陈飞燕 《中草药》 北大核心 2025年第21期7772-7782,共11页
目的基于药物亲和反应的靶点稳定性(drug affinity responsive target stability,DARTS)技术筛选京尼平龙胆双糖苷(genipin-1-β-D-gentiobioside,GG)脑内抗抑郁靶点,并探讨GG基于靶点发挥抗抑郁作用的潜在机制。方法通过DARTS联合无标... 目的基于药物亲和反应的靶点稳定性(drug affinity responsive target stability,DARTS)技术筛选京尼平龙胆双糖苷(genipin-1-β-D-gentiobioside,GG)脑内抗抑郁靶点,并探讨GG基于靶点发挥抗抑郁作用的潜在机制。方法通过DARTS联合无标记液相色谱质谱联用(liquid chromatography-mass spectrometry,LC-MS)蛋白质组学筛选GG在脑组织内潜在蛋白质靶点,再将给药组特有的差异表达基因与抑郁症疾病靶点数据库取交集,共交集出1个潜在抗抑郁靶点蛋白激酶C相互作用蛋白1(protein interacting with C kinase 1,PICK1)。通过生物层干涉技术(biolayer interferometry,BLI)、分子对接和氨基酸定点突变对潜在靶标PICK1与GG之间的亲和力和结合位点进行分析。通过qRT-PCR和Western blotting考察GG对慢性不可预见性轻度应激(chronic unpredictable mild stress,CUMS)小鼠海马组织PICK1、谷氨酸受体A2(glutamate receptor A2,GluA2)和突触后致密蛋白95(postsynaptic density protein 95,PSD95)表达的影响,阐释GG基于靶点PICK1发挥抗抑郁作用的潜在机制。结果基于DARTS联合无标记LC-MS蛋白质组学共获得29个潜在靶点,将29个潜在靶点与抑郁症靶点数据库交集获得1个GG在脑内的潜在抗抑郁靶标PICK1。BLI结果显示,GG与PICK1存在相互作用,亲和力(KD)值为1.915×10^(-5)mol/L。分子对接结果显示,GG与PICK1存在相互作用,GLN91、LYS83、ILE37、SER36和ILE35与GG形成的氢键为主要作用力。氨基酸定点突变结果显示,突变SER36、GLN91、LYS83后GG与PICK1之间的亲和力变化显著,SER36、GLN91、LYS83为GG与PICK1结合的关键位点。qRT-PCR和Western blotting结果显示,GG显著下调抑郁模型小鼠海马组织中PICK1、GluA2和PSD95的m RNA和蛋白表达(P<0.05、0.01)。结论GG可能通过结合PICK1影响突触可塑性相关蛋白的表达水平,进而改善CUMS小鼠海马突触可塑性,发挥抗抑郁作用。 展开更多
关键词 药物亲和反应的靶点稳定性 京尼平龙胆双糖苷 抑郁 PICK1 突触可塑性
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Water-induced changes in mechanical response and fragmentation behavior of rocks exposed to conical pick indentation:Implications for rock cuttability improvement
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作者 Xin Cai Jifeng Yuan +5 位作者 Zilong Zhou Shaofeng Wang Yunming Wang Jixiong Zhang Dan Ma Lu Chen 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第9期5465-5478,共14页
Water-weakening presents a promising strategy for the in-situ improvement of rock cuttability.This study unveils the influences of water saturation on the mechanical response and fragmentation characteristics of rock ... Water-weakening presents a promising strategy for the in-situ improvement of rock cuttability.This study unveils the influences of water saturation on the mechanical response and fragmentation characteristics of rock samples.A series of rock-cutting tests using conical pick indentation was conducted on three types of sandstone samples under both dry and water-saturated conditions.The relationships between cutting force and indentation depth,as well as typical cuttability indices are determined and compared for dry and water-saturated samples.The experimental results reveal that the presence of water facilitates shearing failure in rock samples,as well as alleviates the fluctuations in the cutting force-indentation depth curve Furthermore,the peak cutting force(F_(p)),cutting work(W_(p)),and specific energy(SE)undergo apparent decrease after water saturation,whereas the trend in the indentation depth at rock failure(D_(f))varies across different rock types.Additionally,the water-induced percentage reductions in F_(p)and SE correlate positively with the quartz and swelling clay content within the rocks,suggesting that the cuttability improvement due to water saturation is attributed to the combined effects of stress corrosion and frictional reduction.These findings carry significant implications for improving rock cuttability in mechanized excavation of hard rock formations. 展开更多
关键词 Rock-cutting Water-weakening effects Conical pick Peak cutting force Specific energy Rock cuttability improvement
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Intelligent phase picking of microseismic signals based on ResUNet in underground engineering
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作者 OU Li-yuan HUANG Lin-qi +3 位作者 ZHAO Yun-ge WANG Zhao-wei SHEN Hui-ming LI Xi-bing 《Journal of Central South University》 2025年第9期3314-3335,共22页
With the continuous expansion of deep underground engineering and the growing demand for safety monitoring,microseismic monitoring has become a core method for early warning of rock mass fracture and engineering stabi... With the continuous expansion of deep underground engineering and the growing demand for safety monitoring,microseismic monitoring has become a core method for early warning of rock mass fracture and engineering stability assessment.To address problems in existing methods,such as low data processing efficiency and poor phase recognition accuracy under low signal-to-noise ratio(SNR)conditions in complex geological environments,this study proposes an intelligent phase picking model based on ResUNet.The model integrates the residual learning mechanism of ResNet with the multi-scale feature extraction capability of UNet,effectively mitigating the vanishing gradient problem in deep networks.It also achieves cross-layer fusion of shallow detail features and deep semantic features through skip connections in the encoder-decoder structure.Compared with traditional short-time average/long-time average(STA/LTA)algorithms and advanced neural network models such as PhaseNet and EQTransformer,ResUNet shows superior performance in picking P-and S-wave phases.The model was trained on 400000 labeled microseismic signals from the Stanford earthquake dataset(STEAD)and was successfully applied to the Shizhuyuan polymetallic mine in Hunan Province,China.The results demonstrate that ResUNet achieves high picking accuracy and robustness in complex geological conditions,offering reliable technical support for early warning of disasters such as rockburst in deep underground engineering. 展开更多
关键词 underground engineering microseismic monitoring phase picking deep learning ResUNet architecture rock fracture early warning
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Applying deep learning to teleseismic phase detection and picking:PcP and PKiKP cases
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作者 Congcong Yuan Jie Zhang 《Artificial Intelligence in Geosciences》 2025年第1期25-32,共8页
The availability of a tremendous amount of seismic data demands seismological researchers to analyze seismic phases efficiently.Recently,deep learning algorithms exhibit a powerful capability of detecting and picking ... The availability of a tremendous amount of seismic data demands seismological researchers to analyze seismic phases efficiently.Recently,deep learning algorithms exhibit a powerful capability of detecting and picking on P-and S-wave phases.However,it remains a challenge to effeciently process enormous teleseismic phases,which are crucial to probe Earth’s interior structures and their dynamics.In this study,we propose a scheme to detect and pick teleseismic phases,such as seismic phase that reflects off the core-mantle boundary(i.e.,PcP)and that reflects off the inner-core boundary(i.e.,PKiKP),from a seismic dataset in Japan.The scheme consists of three steps:1)latent phase traces are truncated from the whole seismogram with theoretical arrival times;2)latent phases are recognized and evaluated by convolutional neural network(CNN)models;3)arrivals of good or fair phase are picked with another CNN models.The testing detection result on 7386 seismograms shows that the scheme recognizes 92.15%and 94.13%of PcP and PKiKP phases.The testing picking result has a mean absolute error of 0.0742 s and 0.0636 s for the PcP and PKiKP phases,respectively.These seismograms were processed in just 5 min for phase detection and picking,demonstrating the efficiency of the proposed scheme in automatic teleseismic phase analysis. 展开更多
关键词 Earth’s interior Teleseismic phases Phase detection Phase picking Deep learning
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AMPA受体和相关蛋白在束缚应激大鼠相关脑区的表达变化及逍遥散对其影响 被引量:11
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作者 岳广欣 王竹风 +4 位作者 张巧丽 赵歆 岳利峰 丁杰 陈家旭 《中国应用生理学杂志》 CAS CSCD 北大核心 2008年第2期129-132,共4页
目的:观察海马及杏仁核α-氨基羟甲基恶唑丙酸(AMPA)受体亚基和相关调节蛋白在束缚应激状态下蛋白表达变化及逍遥散的调节作用。方法:使用每天捆绑3 h的方法制作慢性束缚应激动物模型,并用逍遥散进行干预,分别于7 d后和21 d后用Western ... 目的:观察海马及杏仁核α-氨基羟甲基恶唑丙酸(AMPA)受体亚基和相关调节蛋白在束缚应激状态下蛋白表达变化及逍遥散的调节作用。方法:使用每天捆绑3 h的方法制作慢性束缚应激动物模型,并用逍遥散进行干预,分别于7 d后和21 d后用Western blot方法检测各组大鼠海马CA1区、CA3区、齿状回(DG)和杏仁核的AMPA受体亚基GluR2/3及N-乙基顺丁烯二酰亚胺敏感性的融合蛋白(NSF)、PKC作用蛋白1(PICK1)蛋白表达的情况。结果:7 d应激可使DG和杏仁核的GluR2/3、NSF表达显著降低(P均<0.05),使PICK1在CA1区的表达量显著增多(P<0.05),逍遥散对PICK1变化显示出一定调节作用。21 d应激可使CA1区的GluR2/3、NSF表达升高,其中GluR2/3有显著性差异(P<0.01),而在杏仁核表达有降低趋势,逍遥散对其均有显著调节作用(均为P<0.05),21 d应激使杏仁核PICK1表达量出现升高趋势,逍遥散可显著降低其表达(P<0.05)。结论:AMPA受体在短期重复应激和慢性应激状态下反应不同,海马和杏仁核反应相反,逍遥散对慢性应激状态下AMPA受体表达的调节作用较短期重复应激强。 展开更多
关键词 束缚应激 突触可塑性 Western blot AMPA受体 NSF PICK1 逍遥散
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实行BOPS模式是否总是有益的?与传统双渠道的对比研究 被引量:39
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作者 刘咏梅 周笛 《运筹与管理》 CSSCI CSCD 北大核心 2018年第2期168-177,共10页
针对企业线上线下渠道融合战略中提出的BOPS(buy-online-and-pick-up-in-store)模式,在集中式和分散式两情境下分别构建并对比了BOPS和传统双渠道模型,探讨了在传统双渠道基础之上引入BOPS服务是否对企业而言总是有好处的,并分析了传统... 针对企业线上线下渠道融合战略中提出的BOPS(buy-online-and-pick-up-in-store)模式,在集中式和分散式两情境下分别构建并对比了BOPS和传统双渠道模型,探讨了在传统双渠道基础之上引入BOPS服务是否对企业而言总是有好处的,并分析了传统型消费者占比和消费者的服务敏感性程度对企业实施BOPS的影响。研究表明,企业是否在传统双渠道模式基础上增设BOPS服务,取决于市场中传统型消费者占比规模(即偏好传统零售的消费者)以及各类型消费者对线下服务的敏感性程度;BOPS模式下,当消费者BOPS行为的真正动机是出于欲体验线下零售服务时,对实施BOPS的制造商企业而言更为有利;同时,企业的产品定价和线下服务水平不仅需要考量生产、服务成本,同样需对消费者的服务敏感性有准确的了解和定位。 展开更多
关键词 BUY ONLINE and PICK up in STORE 渠道整合 传统双渠道 服务
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圆头精子症患者的遗传学检测与成功辅助育孕 被引量:4
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作者 郑灵燕 袁萍 +4 位作者 张宁峰 梁中锟 王文军 张清学 杨冬梓 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2015年第6期955-960,共6页
【目的】分析圆头精子症患者的遗传学发病机制。【方法】回顾分析1例圆头精子症患者,对其进行多种遗传学方法的检测,包括染色体检查、Y染色体微缺失基因检测及通过array-CGH芯片技术和Sanger测序筛查候选基因DPY19L2、PICK1、SPATA16。... 【目的】分析圆头精子症患者的遗传学发病机制。【方法】回顾分析1例圆头精子症患者,对其进行多种遗传学方法的检测,包括染色体检查、Y染色体微缺失基因检测及通过array-CGH芯片技术和Sanger测序筛查候选基因DPY19L2、PICK1、SPATA16。【结果】该患者在我中心行两个卵胞浆内单精子显微注射(ICSI)周期后,其妻孕足月剖宫产一对异卵双胞胎女儿。患者染色体核型为46,XY、Y染色体微缺失基因检测未见异常,array-CGH芯片检测排除了DPY19L2、SPATA16和PICK1基因及其他该芯片所涵盖区域的100kb以上的片段重复或缺失。Sanger测序PICK1、SPATA16基因也未发现点突变和小片段插入缺失等病理性改变。【结论】圆头精子症患者可通过ICSI方式获得健康后代,本研究排除了已知的候选基因DPY19L2、PICK1、SPATA16与该圆头精子症患者的致病相关,可能存在其他致病基因。 展开更多
关键词 圆头精子 卵胞浆内单精子显微注射 DPY19L2 PICK1 SPATA16
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PICK1蛋白生理功能及其作为药物新靶点研究进展 被引量:2
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作者 段贤春 汪永忠 +9 位作者 高家荣 冯艺戎 李翔 吴健 刘晓闯 魏良兵 何云娇 朱红 李瑛 夏伦祝 《中国药理学通报》 CAS CSCD 北大核心 2013年第11期1606-1610,共5页
PICK1蛋白(protein interacting with C alpha kinase 1)是一种同时具有PDZ和BAR区域的支架蛋白,在哺乳动物体内与多种蛋白质相互作用,并被证明在多种生理过程中发挥重要的调节作用,同时参与了多种疾病病理过程。因此,PICK1蛋白可能成... PICK1蛋白(protein interacting with C alpha kinase 1)是一种同时具有PDZ和BAR区域的支架蛋白,在哺乳动物体内与多种蛋白质相互作用,并被证明在多种生理过程中发挥重要的调节作用,同时参与了多种疾病病理过程。因此,PICK1蛋白可能成为极具前景的疾病治疗靶点。该文通过对近年来国内外发表的相关文献进行整理与分析,综述了PICK1蛋白的生理功能与其作为药物靶点的研究新进展,旨在为PICK1蛋白的深入研究提供理论支持。 展开更多
关键词 PICK1 PDZ结构域 生理功能 中风 脑病 药物靶点
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EphB4/ephrinB2逆向信号对RAW264.7破骨细胞分化中PDZ结构域蛋白表达变化的研究 被引量:2
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作者 毛英杰 黄旭 +2 位作者 赵鹃 史月华 谷志远 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2011年第5期464-472,共9页
Eph受体是酪氨酸蛋白激酶受体家族中最大的亚家族,ephrin(Eph受体相互作用蛋白)是其配体,它们是膜结合蛋白,相互依赖进行信号转导.内居蛋白(syntenin)与Pick1属于PDZ结构域(PSD-95/Dlg-/Zo-1 domain)蛋白,报道称能与ephrinB配体结合,但... Eph受体是酪氨酸蛋白激酶受体家族中最大的亚家族,ephrin(Eph受体相互作用蛋白)是其配体,它们是膜结合蛋白,相互依赖进行信号转导.内居蛋白(syntenin)与Pick1属于PDZ结构域(PSD-95/Dlg-/Zo-1 domain)蛋白,报道称能与ephrinB配体结合,但是否受Eph受体调控尚未见报道.以RAW264.7细胞株为研究对象,通过蛋白质印迹及/或免疫荧光分析显示RAW264.7细胞经RANKL诱导的破骨细胞表达ephrinB2、内居蛋白(syntenin)和Pick1三个蛋白质.将提前成簇的可溶性EphB4蛋白加入培养液,与ephrinB2配体结合,用来研究EphB4/ephrinB2逆向信号对syntenin和Pick1表达水平变化的影响.免疫印迹及Real-time RT-PCR分析结果显示,在EphB4-Fc实验组中Pick1的蛋白质及mRNA水平都有明显增加,然而在EphB4-Fc实验组与Fc对照组别间syntenin的蛋白质及mRNA水平未见明显变化.免疫共沉淀结果显示,syntenin和Pick1不能与ephrinB2共沉淀.以上结果初步探索了体外破骨细胞分化过程中,EphB4/ephrinB2逆向信号对PDZ结构域蛋白(ephrinB2配体潜在的下游信号分子)表达变化的调控. 展开更多
关键词 EPHB4 EPHRINB2 内居蛋白(syntenin) Pick1 RAW264.7细胞株
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Pick病的诊断 被引量:3
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作者 贾建军 卢文甫 +2 位作者 王鲁宁 汤洪川 尹岭 《中国医学影像技术》 CSCD 2001年第4期318-320,共3页
目的 探讨Pick病 (Pickdisease)诊断的正确性。方法 分析 2例临床上曾诊断为阿尔茨海默病(Alzheimerdisease,AD) ,经核磁共振成像 (MRI)检查证实的Pick病 ,其中 1例经正电子发射型计算机断层扫描 (PET)得到进一步证实。结果 Pick病... 目的 探讨Pick病 (Pickdisease)诊断的正确性。方法 分析 2例临床上曾诊断为阿尔茨海默病(Alzheimerdisease,AD) ,经核磁共振成像 (MRI)检查证实的Pick病 ,其中 1例经正电子发射型计算机断层扫描 (PET)得到进一步证实。结果 Pick病与AD比较有如下特点 :①特殊的语言方式及语言改变 ;②临床上以缓慢进展的性格改变及社会活动能力衰退为主 ,而记忆力、理解判断力、计算力障碍等出现相对较晚 ;③病程中有不同程度的Kl櫣ver Bucy综合征表现 ;④脑MRI检查提示 :额和 (或 )颞叶萎缩 ,颞极为著 ;⑤PET检查提示 :双侧额、颞叶代谢减低 ,颞极明显。结论 根据Pick病临床表现及神经影像学特征 ,在排除AD及其它脑变性病的基础上 ,生前诊断Pick病是可能的。 展开更多
关键词 PICK病 阿尔茨海默病 磁共振成像 正电子发射型计算机断层扫描 诊断
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Pick病的脑MRI研究 被引量:1
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作者 卢文甫 王鲁宁 +2 位作者 贾建军 汤洪川 蔡幼铨 《中国医学影像技术》 CSCD 2001年第10期945-947,共3页
目的 研究Pick病患者脑萎缩变化的特点 ,并动态研究脑萎缩变化的程度和病程及临床之间的相互相关系。方法  2例Pick病患者分别进行 5次和 7次脑MRI动态观察 ,并和 6例Alzheimer病患者进行对比分析。结果 Pick病早期以Kluver Bacy综... 目的 研究Pick病患者脑萎缩变化的特点 ,并动态研究脑萎缩变化的程度和病程及临床之间的相互相关系。方法  2例Pick病患者分别进行 5次和 7次脑MRI动态观察 ,并和 6例Alzheimer病患者进行对比分析。结果 Pick病早期以Kluver Bacy综合征和情感障碍为突出 ,人格改变、行为异常、语言障碍为显著 ,而智能减退相对较轻较晚 ,脑MRI以额或 /和颞极萎缩为主 ,尤其颞上回前 1/ 3为明显 ,其脑MRI的改变和临床特征及病程相一致。“刀片”状、“剪刀”像和“锥柱”样或“蘑菇”状脑萎缩改变可能是Pick病的特点。结论 充分认识这些特征 ,以利于Pick病的早期临床诊断。 展开更多
关键词 PICK病 MRI 诊断
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额颞叶痴呆合并运动神经元病2例报告 被引量:4
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作者 王文 张斯萌 沈雪莉 《中风与神经疾病杂志》 CAS CSCD 北大核心 2013年第1期77-79,共3页
额颞叶痴呆(FTD)为一组影响认知、语言、人格和社会能力的临床综合征,包括Pick病、额颞叶变性(frontotemperallobardegeneration,FTLD)、进行性失语(progressivenon-fluentaphasia,PNFA)、语义性痴呆(semanticdementia,SD)... 额颞叶痴呆(FTD)为一组影响认知、语言、人格和社会能力的临床综合征,包括Pick病、额颞叶变性(frontotemperallobardegeneration,FTLD)、进行性失语(progressivenon-fluentaphasia,PNFA)、语义性痴呆(semanticdementia,SD)。FTD发病在神经变性性痴呆中仅次于AD及路易体痴呆,占早老性痴呆的20%左右,占各种痴呆的10%左右。随着对神经系统变性性疾病的深入研究,发现痴呆尤其是额颞叶变性合并运动神经元病的患者不在少数。 展开更多
关键词 额颞叶痴呆 运动神经元病 神经系统变性性疾病 神经变性性 临床综合征 PICK病 语义性痴呆 路易体痴呆
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Pick病3例临床及病理分析 被引量:1
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作者 卢文甫 王鲁宁 +2 位作者 宋康兴 贾建华 汤洪川 《解放军医学杂志》 CAS CSCD 北大核心 2001年第11期847-849,共3页
通过分析 3例Pick病的临床、脑MRI、SPECT、PET和脑病理资料 ,发现和Alzheimer病相比 ,Pick病早期以人格变化、判断力改变较为特异 ,情感、情绪变化明显 ,Kl櫣ver Bucy综合征为特征 ,非流利性失语和语义性记忆障碍突出 ,而智能减退... 通过分析 3例Pick病的临床、脑MRI、SPECT、PET和脑病理资料 ,发现和Alzheimer病相比 ,Pick病早期以人格变化、判断力改变较为特异 ,情感、情绪变化明显 ,Kl櫣ver Bucy综合征为特征 ,非流利性失语和语义性记忆障碍突出 ,而智能减退及视觉空间定向能力受损相对较晚 ,脑MRI以颞极萎缩为重 ,SPECT和PET以额和 (或 )颞叶低灌流及低代谢为显著。提示应充分认识Pick病的特点 。 展开更多
关键词 临床病理学 脑皮克病 PICK病 早期诊断
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PICK1对人肝癌细胞HepG2增殖的影响 被引量:1
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作者 谢娟 周群 +3 位作者 刘雪姣 黄成 孟晓明 李俊 《安徽医科大学学报》 CAS 北大核心 2016年第5期615-619,共5页
目的检测蛋白激酶Cα相互作用蛋白1(PICKl)在肝癌、癌旁组织中的表达,初步探讨PICK1对人肝癌细胞HepG2增殖的作用及其可能机制。方法应用qRT-PCR、Western blot、HE和免疫组织化学染色法分析比较人肝癌和癌旁组织中PICK1蛋白的表达;培养... 目的检测蛋白激酶Cα相互作用蛋白1(PICKl)在肝癌、癌旁组织中的表达,初步探讨PICK1对人肝癌细胞HepG2增殖的作用及其可能机制。方法应用qRT-PCR、Western blot、HE和免疫组织化学染色法分析比较人肝癌和癌旁组织中PICK1蛋白的表达;培养HepG2细胞,体外给予不同浓度的FSC-231(PICK1的PDZ结构域小分子抑制剂),通过MTT法检测HepG2细胞的活力;采用流式细胞术检测HepG2细胞周期变化;进一步采用Western blot法检测G1/S-特异性周期蛋白-D1(CyclinD1)、原癌基因C-myc和Notch信号通路蛋白表达。结果肝脏病理组织学检测提示肝癌组织病变明显。免疫组化结果显示,肝癌组织中相比癌旁组织中的PICKl抗原阳性细胞显著增多(P<0.05),且多分布在肝实质细胞质区域;qRT-PCR和Western blot结果显示肝癌组织中PICK1 mRNA及蛋白水平与癌旁组相比显著升高(P<0.05);体外实验证明,与阴性对照组相比,FSC-231能够抑制HepG2细胞的增殖,并且明显抑制CyclinD1、C-myc和Notch1同源蛋白1(Notch1)、Hes-1蛋白表达(P<0.05)。结论提示PICK1可能参与肝癌的发生发展,PICK1的PDZ结构域抑制剂可以抑制肝癌细胞的增殖,此作用可能与Notch信号通路相关。 展开更多
关键词 PICK1 FSC-231 HEPG2细胞 肝癌 肝细胞增殖 CYCLIND1 NOTCH-1 Hes-1
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