Precise and spatiotemporal control over the pesticide remains to be a challenge.More efficient controlled release systems(CRSs)have been developed to support the precise delivery of active ingredients.Herein,we incorp...Precise and spatiotemporal control over the pesticide remains to be a challenge.More efficient controlled release systems(CRSs)have been developed to support the precise delivery of active ingredients.Herein,we incorporated the photoremovable protecting groups(PRPGs)into phenamacril(PHE)and obtained two photo-responsive fungicides of NV-PHE and DEACM-PHE.The 4,5-dimethoxy-o-nitrobenzyl(NV)or 7-diethylaminocoumarin(DEACM)-caged PHE could release the active molecule PHE after irradiation of UV light and blue light,respectively.Optical properties and in-vitro/vivo fungicidal activities of NV-PHE and DEACM-PHE demonstrated the feasibility for light controlled release of PHE.DEACM-PHE could release 98%PHE by illumination of blue light.The irradiated DEACM-PHE could preserve the similar bioactivity of PHE,and significantly improve the in-vitro/vivo fungicidal activities compared to the non-irradiated DEACM-PHE.The optical controlled release of PHE from DEACM-PHE enabled the precise and spatiotemporal delivery of PHE,diversifying the development of CRSs for pesticide,and providing environmentfriendly agricultural applications with high pesticide efficiency.展开更多
Photocages are a class of substances containing photosensitive groups,also known as“photoremovable protecting groups”,from which target substances are released upon exposure to specific wavelengths of light.The subs...Photocages are a class of substances containing photosensitive groups,also known as“photoremovable protecting groups”,from which target substances are released upon exposure to specific wavelengths of light.The substances released in the light-promoted processes have chemical or biological properties that enable them to carry specifically designed functions.As a result,photocages can be utilized in various fields such as chemistry,biology,and medicine.In this paper,progress made in research carried out in recent years aimed at developing photocage molecules with different photosensitive moieties is reviewed.展开更多
基金This work was financially supported by the Natural Science Foundation of China(Nos.21877039,32072441)National Key Research and Development Program of China(No.2018YFD0200100)Innovation Program of Shanghai Municipal Education Commission(No.2017-01-07-00-02-E00037).
文摘Precise and spatiotemporal control over the pesticide remains to be a challenge.More efficient controlled release systems(CRSs)have been developed to support the precise delivery of active ingredients.Herein,we incorporated the photoremovable protecting groups(PRPGs)into phenamacril(PHE)and obtained two photo-responsive fungicides of NV-PHE and DEACM-PHE.The 4,5-dimethoxy-o-nitrobenzyl(NV)or 7-diethylaminocoumarin(DEACM)-caged PHE could release the active molecule PHE after irradiation of UV light and blue light,respectively.Optical properties and in-vitro/vivo fungicidal activities of NV-PHE and DEACM-PHE demonstrated the feasibility for light controlled release of PHE.DEACM-PHE could release 98%PHE by illumination of blue light.The irradiated DEACM-PHE could preserve the similar bioactivity of PHE,and significantly improve the in-vitro/vivo fungicidal activities compared to the non-irradiated DEACM-PHE.The optical controlled release of PHE from DEACM-PHE enabled the precise and spatiotemporal delivery of PHE,diversifying the development of CRSs for pesticide,and providing environmentfriendly agricultural applications with high pesticide efficiency.
基金supported by the National Key R&D Program of China(2018YFA0902200)the National Natural Science Foundation of China(22278224,21978131 and 21878156)+1 种基金the Natural Science Foundation of Jiangsu Province(BK20200691)the Project of Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Photocages are a class of substances containing photosensitive groups,also known as“photoremovable protecting groups”,from which target substances are released upon exposure to specific wavelengths of light.The substances released in the light-promoted processes have chemical or biological properties that enable them to carry specifically designed functions.As a result,photocages can be utilized in various fields such as chemistry,biology,and medicine.In this paper,progress made in research carried out in recent years aimed at developing photocage molecules with different photosensitive moieties is reviewed.
