An efficient and accurate analytical method was developed for the simultaneous determination of 20 synthetic food additives, including three sweeteners,seven food colorants,nine synthetic preservatives and caffeine,by...An efficient and accurate analytical method was developed for the simultaneous determination of 20 synthetic food additives, including three sweeteners,seven food colorants,nine synthetic preservatives and caffeine,by high performance liquid chromatography （HPLC） with photodiode array detector（PDA）.This method permits the detection of food additives at very low concentrations（0.005-0.150μg/mL）.The applicability was verified by the determination of food additives present in various foodstuffs.展开更多
The contents of indapamide and related impurities in generic indapamide sustained-release tablets were simultaneously detected by a single-run high performance liquid chromatography equipped with photodiode array dete...The contents of indapamide and related impurities in generic indapamide sustained-release tablets were simultaneously detected by a single-run high performance liquid chromatography equipped with photodiode array detector(HPLC-PDA)method for the quality control in this paper.The results showed the method had a good selectivity and was validated through linearity,limits of detection and quantification,recovery,and precision.The linear ranges of indapamide,2-methyl-1-nitroso-2,3-dihydro-1H-indole(impurity A,ImA),4-chloro-N-(2-methyl-1H-indol-1-yl)-3-sulphamoyl-benzamide(impurity B,ImB)and 4-chloro-3-sulfamoylbenzoic acid(impurity 1,Im1)were 0.028-1.80μg/mL(R=0.99995),0.060-1.20μg/mL(R=0.9996),0.0324-1.20μg/mL(R=0.99985)and 0.060-1.20μg/mL(R=0.9997)with detection limits of 0.0093,0.012,0.012 and 0.006μg/mL,respectively.ImA and Im1 were not detectable in the generic drug.The content of indapamide was 96.7%of the labeled amount with a relative standard deviation(RSD)of 1.30%,and the percentage of ImB relative to the labeled amounts of indapamide was 0.106%with an RSD of 1.82%.The content of other unspecified impurities all met the reference quality standards.The results provided references for the quality control and the quality standard study of generic indapamide sustained-release tablets.展开更多
A rapid and effective analytical method was developed for the detection of triclosan in wastewater samples using a hydrophobic deep eutectic solvent thymol-lidocaine(Thy-Lid,molar ratio of 1:1)and dispersive liquid-li...A rapid and effective analytical method was developed for the detection of triclosan in wastewater samples using a hydrophobic deep eutectic solvent thymol-lidocaine(Thy-Lid,molar ratio of 1:1)and dispersive liquid-liquid microextraction(DLLME).The analyte was determined by high-performance liquid chromatography with a photodiode array detector(HPLC-PDA),obtaining a detection limit of 0.38μg/L,a recovery rate of 99%,and an enrichment factor of the analyte in the water of 80.A factorial design was used to optimize the analytical signal to improve the time and reduce the cost of the method.Combining this chemometric optimization tool with a green solvent and DLLME allows for obtaining an analytical methodology aligned with the principles of green analytical chemistry,enabling the inexpensive,selective,and rapid analysis of triclosan in real wastewater.展开更多
基金the financial support by the Food Safety Fund of General Administration of Quality Supervision,Inspection and Quarantine of Chinathe Key Scientific Program of National Institute of Metrology of China(Nos.ASPAQ201010 and AJDYX1116)
文摘An efficient and accurate analytical method was developed for the simultaneous determination of 20 synthetic food additives, including three sweeteners,seven food colorants,nine synthetic preservatives and caffeine,by high performance liquid chromatography （HPLC） with photodiode array detector（PDA）.This method permits the detection of food additives at very low concentrations（0.005-0.150μg/mL）.The applicability was verified by the determination of food additives present in various foodstuffs.
基金the Natural Science Foundation of Anhui Province,China(11040606M41)the Natural Science Project in Colleges and Universities of Anhui Province,China(kj2016A683)the Natural Science Project of Huangshan University,China(hxkt20190042,xdhz202007)。
文摘The contents of indapamide and related impurities in generic indapamide sustained-release tablets were simultaneously detected by a single-run high performance liquid chromatography equipped with photodiode array detector(HPLC-PDA)method for the quality control in this paper.The results showed the method had a good selectivity and was validated through linearity,limits of detection and quantification,recovery,and precision.The linear ranges of indapamide,2-methyl-1-nitroso-2,3-dihydro-1H-indole(impurity A,ImA),4-chloro-N-(2-methyl-1H-indol-1-yl)-3-sulphamoyl-benzamide(impurity B,ImB)and 4-chloro-3-sulfamoylbenzoic acid(impurity 1,Im1)were 0.028-1.80μg/mL(R=0.99995),0.060-1.20μg/mL(R=0.9996),0.0324-1.20μg/mL(R=0.99985)and 0.060-1.20μg/mL(R=0.9997)with detection limits of 0.0093,0.012,0.012 and 0.006μg/mL,respectively.ImA and Im1 were not detectable in the generic drug.The content of indapamide was 96.7%of the labeled amount with a relative standard deviation(RSD)of 1.30%,and the percentage of ImB relative to the labeled amounts of indapamide was 0.106%with an RSD of 1.82%.The content of other unspecified impurities all met the reference quality standards.The results provided references for the quality control and the quality standard study of generic indapamide sustained-release tablets.
基金financially supported by ANID-FONDECYT No.1201978DICYT Asociativo USACH 022242TN_DAS。
文摘A rapid and effective analytical method was developed for the detection of triclosan in wastewater samples using a hydrophobic deep eutectic solvent thymol-lidocaine(Thy-Lid,molar ratio of 1:1)and dispersive liquid-liquid microextraction(DLLME).The analyte was determined by high-performance liquid chromatography with a photodiode array detector(HPLC-PDA),obtaining a detection limit of 0.38μg/L,a recovery rate of 99%,and an enrichment factor of the analyte in the water of 80.A factorial design was used to optimize the analytical signal to improve the time and reduce the cost of the method.Combining this chemometric optimization tool with a green solvent and DLLME allows for obtaining an analytical methodology aligned with the principles of green analytical chemistry,enabling the inexpensive,selective,and rapid analysis of triclosan in real wastewater.
