Photolysis of 4-acetyl-4-ethoxyformylcyclohexanone, 4-acetyl-4-phenylcyclohexanone and 1-acetyl-1-phenylcyclohexane in deuteriochloroform using a high pressure Hg-Xe lamp showed unusual polarizations. The results are ...Photolysis of 4-acetyl-4-ethoxyformylcyclohexanone, 4-acetyl-4-phenylcyclohexanone and 1-acetyl-1-phenylcyclohexane in deuteriochloroform using a high pressure Hg-Xe lamp showed unusual polarizations. The results are explained by the formation of a singlet exciplex of the ketone with deuteriochloroform and the photoaddition of deuteriochloroform to the ketone.展开更多
Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and...Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry.Radical-mediated cycloaddition strategies,which recycle radical character,are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy.This review focuses on recent developments and synthetic applications in RCRs,with an emphasis on visible lightinduced radical photocycloaddition reactions(RPCRs),transition metal-catalyzed approaches,and small molecule-catalyzed methods.By highlighting some outstanding innovations and addressing current challenges,this review aims to identify potential areas for improvement.These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies.展开更多
基金This work was supported by the National Natural Science Foundati on of China.
文摘Photolysis of 4-acetyl-4-ethoxyformylcyclohexanone, 4-acetyl-4-phenylcyclohexanone and 1-acetyl-1-phenylcyclohexane in deuteriochloroform using a high pressure Hg-Xe lamp showed unusual polarizations. The results are explained by the formation of a singlet exciplex of the ketone with deuteriochloroform and the photoaddition of deuteriochloroform to the ketone.
基金The financial support from the National Natural Science Foundation of China (Nos.22150410339,W2432012,22301237 and 22171218)the Ministry of Science and Technology China (No.wgxz2022188) is greatly acknowledged。
文摘Radical cycloaddition reactions(RCRs) are highly effective methods for constructing complex carbo-and heterocycles,which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry.Radical-mediated cycloaddition strategies,which recycle radical character,are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy.This review focuses on recent developments and synthetic applications in RCRs,with an emphasis on visible lightinduced radical photocycloaddition reactions(RPCRs),transition metal-catalyzed approaches,and small molecule-catalyzed methods.By highlighting some outstanding innovations and addressing current challenges,this review aims to identify potential areas for improvement.These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies.
