Several bis（trifluoromethylsulfonyl）phenylamines have been synthesized and used as internal donors for the preparation of heterogeneous Ziegler-Natta catalysts for propylene polymerization. These new cata- lysts are...Several bis（trifluoromethylsulfonyl）phenylamines have been synthesized and used as internal donors for the preparation of heterogeneous Ziegler-Natta catalysts for propylene polymerization. These new cata- lysts are highly active and stereospecific in combination with an external donor for the polymerization of propylene. The activity of these catalysts is dramatically influenced by the electronic capability of the phenyl substituents on the sulfonyl phenylamines. Therefore, the performances of the catalysts can be modified by adjusting the electronic property of the phenyl substituents of the sulfonyl phenylamines.展开更多
The reaction mechanism of phenylamine reacting with 1,4-butanediol to give N- phenylpyrrolidine was investigated with traditional transition state theory. Based on the experimental results, two reaction channels were ...The reaction mechanism of phenylamine reacting with 1,4-butanediol to give N- phenylpyrrolidine was investigated with traditional transition state theory. Based on the experimental results, two reaction channels were discussed. The geometries of their reactants, products, intermediates and transition states were optimized. The possible transition State and activation energy were determined by vibrational analysis and IRC verification. And finally, the main reaction channel was given.展开更多
A novel （4-ferrocenylethyne） phenylamine functionalized graphene sheets （FEPA-GR）, coupling with chitosan （CS） were used as a signal amplification platform for simultaneous and sensitive determination of dopami...A novel （4-ferrocenylethyne） phenylamine functionalized graphene sheets （FEPA-GR）, coupling with chitosan （CS） were used as a signal amplification platform for simultaneous and sensitive determination of dopamine （DA） and acetaminophen （AC）. In this work, FEPA used as electron transfer mediator can be immobilized on GR surface via strong π-π stacking interaction between the conjugate chain of FEPA and GR, which effectively prevents FEPA electron mediator leaking from the electrode surface and amplified the signal. Transmission electron microscopy, FT-IR spectroscopy, UV-vis spectroscopy and electrochemical experiments results are all demonstrated the strong π-π stacking interaction between FEPA and GR. The resulted biosensor exhibited a fast response, remarkable electrocatalytic activity, perfect anti-interference ability and good stability for simultaneous detection of DA and AC. Under the optimum conditions, the oxidation peak currents of DA and AC were linearly correlated to their concentrations in the range of 2.0-135.0 μmol·L-1 and 0.3--80.0μmol·L 1, respectively. The lower detection limits for DA and AC were 0.30 and 0.05 μmol·L-1, respectively. The feasibility of the proposed method was validated by successfully applied to the simultaneous determination of DA and AC in serum samples with the standard addition method.展开更多
Halogen substituents play a crucial role in the structural diversity and biological activity of natural products,and the synthesis of halogenated molecules remains an area of significant research interest.This study d...Halogen substituents play a crucial role in the structural diversity and biological activity of natural products,and the synthesis of halogenated molecules remains an area of significant research interest.This study describes the generation of 15 new halogenated angucyclinones through the incorporation of halogen-containing phenylamines into a biosynthetic C-ringcleaved angucyclinone under mild conditions.The newly synthesized compounds feature halogen substituents encompassing all four halogen atoms(F,Cl,Br,I),with some compounds containing multiple halogen types.Structural elucidation was accomplished through ultraviolet(UV),infrared spectroscopy(IR),mass spectrometry(MS),and nuclear magnetic resonance(NMR)spectroscopic analyses,expanding the structural diversity of angucyclinonetype polyketides.Cytotoxicity evaluations revealed that eight compounds demonstrated moderate cytotoxic activities against four human tumor cell lines,with half maximal inhibitory concentration(IC_(50))values ranging from 3.35±0.37 to 16.02±6.60μmol·L-1.These findings highlight the significant potential of combining biosynthetic and chemical approaches in generating bioactive halogenated molecules.展开更多
A Kind of homogeneous resin , which can be used as thermal resistant adhesive and matrix for composite, was prepared by bis (4-maleimidophenyl) methane ( BMI), 4,4’ -diaminodiphenylmethane( DDM), aniline (An), phenol...A Kind of homogeneous resin , which can be used as thermal resistant adhesive and matrix for composite, was prepared by bis (4-maleimidophenyl) methane ( BMI), 4,4’ -diaminodiphenylmethane( DDM), aniline (An), phenol type epoxy resin ( F-51 ) and nitrile -butadiene rubber ( NRR) through solution copolymer-ization . The reaction from prepolymerization to curing of the resin system was studied. And the factors such as raw material ratio and curing temperature, which affect thermal resistance and adhesives of cured product, were also analyzed. SEM and IR spectra were utilized to discuss the mechanisms of toughness and reaction of modified BMI.展开更多
The reaction of acenaphthene with nitrobenzene was investigated in the presence of AlCl3. The results showed that the reaction proceeded via carboncation-electrophilic substitution reaction and free radical substituti...The reaction of acenaphthene with nitrobenzene was investigated in the presence of AlCl3. The results showed that the reaction proceeded via carboncation-electrophilic substitution reaction and free radical substitution reaction pathway. The products of acenaphthenyl phenylamine and biacenaphthyl could be synthesized by this reaction. The influence of the amount of AlCl3 and the temperature on the components of products were also studied in this reaction.展开更多
A novel approach to the synthesis of 6, 7-disubstituted-1H-quinoxalin-2-ones is described.The title compounds were regioselectively prepared by starting from substituted phenylamines andchloroacetyl chloride through t...A novel approach to the synthesis of 6, 7-disubstituted-1H-quinoxalin-2-ones is described.The title compounds were regioselectively prepared by starting from substituted phenylamines andchloroacetyl chloride through the efficient sequence of acylation, nitration, reduction, intramolecular alkylation, and oxidation.展开更多
Electro-oxidation of phenylamine derivatives（1a and 1b） have been studied in the presence of pyrazolidine-3,5-dione（3） as a nucleophile in phosphate buffer solution mixed with ethanol,using voltammetric and spectr...Electro-oxidation of phenylamine derivatives（1a and 1b） have been studied in the presence of pyrazolidine-3,5-dione（3） as a nucleophile in phosphate buffer solution mixed with ethanol,using voltammetric and spectroscopic techniques.The obtained results indicated that the oxidized form of phenylamines（2a and 2b） participate in Michael addition type reactions with pyrazolidine-3,5-dione（3） and via ECECCCCC mechanisms convert to the corresponding new polycyclic indoles（12a and 12b）.In the present study,new polycyclic indole derivatives were synthesized with good yields and high purity using a facile,one-pot and environmentally friendly electrochemical method,without any chemical catalysts,toxic solvents and hard conditions.展开更多
文摘Several bis（trifluoromethylsulfonyl）phenylamines have been synthesized and used as internal donors for the preparation of heterogeneous Ziegler-Natta catalysts for propylene polymerization. These new cata- lysts are highly active and stereospecific in combination with an external donor for the polymerization of propylene. The activity of these catalysts is dramatically influenced by the electronic capability of the phenyl substituents on the sulfonyl phenylamines. Therefore, the performances of the catalysts can be modified by adjusting the electronic property of the phenyl substituents of the sulfonyl phenylamines.
基金supported by the Foundation of Liaoning Provincial Department of Education (990321076)
文摘The reaction mechanism of phenylamine reacting with 1,4-butanediol to give N- phenylpyrrolidine was investigated with traditional transition state theory. Based on the experimental results, two reaction channels were discussed. The geometries of their reactants, products, intermediates and transition states were optimized. The possible transition State and activation energy were determined by vibrational analysis and IRC verification. And finally, the main reaction channel was given.
基金the National Natural Science Foundation of China，the Scientific Research Fund of Hunan Provincial Education Department，the Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
文摘A novel （4-ferrocenylethyne） phenylamine functionalized graphene sheets （FEPA-GR）, coupling with chitosan （CS） were used as a signal amplification platform for simultaneous and sensitive determination of dopamine （DA） and acetaminophen （AC）. In this work, FEPA used as electron transfer mediator can be immobilized on GR surface via strong π-π stacking interaction between the conjugate chain of FEPA and GR, which effectively prevents FEPA electron mediator leaking from the electrode surface and amplified the signal. Transmission electron microscopy, FT-IR spectroscopy, UV-vis spectroscopy and electrochemical experiments results are all demonstrated the strong π-π stacking interaction between FEPA and GR. The resulted biosensor exhibited a fast response, remarkable electrocatalytic activity, perfect anti-interference ability and good stability for simultaneous detection of DA and AC. Under the optimum conditions, the oxidation peak currents of DA and AC were linearly correlated to their concentrations in the range of 2.0-135.0 μmol·L-1 and 0.3--80.0μmol·L 1, respectively. The lower detection limits for DA and AC were 0.30 and 0.05 μmol·L-1, respectively. The feasibility of the proposed method was validated by successfully applied to the simultaneous determination of DA and AC in serum samples with the standard addition method.
基金supported by the National Key Research and Development Program of China(Nos.2023YFC3503900,2023YFA0914102)National Natural Science Foundation of China(Nos.82325046,82273829,92357305,22377004,22077007)the key project at central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302-2201-17)。
文摘Halogen substituents play a crucial role in the structural diversity and biological activity of natural products,and the synthesis of halogenated molecules remains an area of significant research interest.This study describes the generation of 15 new halogenated angucyclinones through the incorporation of halogen-containing phenylamines into a biosynthetic C-ringcleaved angucyclinone under mild conditions.The newly synthesized compounds feature halogen substituents encompassing all four halogen atoms(F,Cl,Br,I),with some compounds containing multiple halogen types.Structural elucidation was accomplished through ultraviolet(UV),infrared spectroscopy(IR),mass spectrometry(MS),and nuclear magnetic resonance(NMR)spectroscopic analyses,expanding the structural diversity of angucyclinonetype polyketides.Cytotoxicity evaluations revealed that eight compounds demonstrated moderate cytotoxic activities against four human tumor cell lines,with half maximal inhibitory concentration(IC_(50))values ranging from 3.35±0.37 to 16.02±6.60μmol·L-1.These findings highlight the significant potential of combining biosynthetic and chemical approaches in generating bioactive halogenated molecules.
文摘A Kind of homogeneous resin , which can be used as thermal resistant adhesive and matrix for composite, was prepared by bis (4-maleimidophenyl) methane ( BMI), 4,4’ -diaminodiphenylmethane( DDM), aniline (An), phenol type epoxy resin ( F-51 ) and nitrile -butadiene rubber ( NRR) through solution copolymer-ization . The reaction from prepolymerization to curing of the resin system was studied. And the factors such as raw material ratio and curing temperature, which affect thermal resistance and adhesives of cured product, were also analyzed. SEM and IR spectra were utilized to discuss the mechanisms of toughness and reaction of modified BMI.
文摘The reaction of acenaphthene with nitrobenzene was investigated in the presence of AlCl3. The results showed that the reaction proceeded via carboncation-electrophilic substitution reaction and free radical substitution reaction pathway. The products of acenaphthenyl phenylamine and biacenaphthyl could be synthesized by this reaction. The influence of the amount of AlCl3 and the temperature on the components of products were also studied in this reaction.
文摘A novel approach to the synthesis of 6, 7-disubstituted-1H-quinoxalin-2-ones is described.The title compounds were regioselectively prepared by starting from substituted phenylamines andchloroacetyl chloride through the efficient sequence of acylation, nitration, reduction, intramolecular alkylation, and oxidation.
基金Semnan University Research Council for financial support of this work
文摘Electro-oxidation of phenylamine derivatives（1a and 1b） have been studied in the presence of pyrazolidine-3,5-dione（3） as a nucleophile in phosphate buffer solution mixed with ethanol,using voltammetric and spectroscopic techniques.The obtained results indicated that the oxidized form of phenylamines（2a and 2b） participate in Michael addition type reactions with pyrazolidine-3,5-dione（3） and via ECECCCCC mechanisms convert to the corresponding new polycyclic indoles（12a and 12b）.In the present study,new polycyclic indole derivatives were synthesized with good yields and high purity using a facile,one-pot and environmentally friendly electrochemical method,without any chemical catalysts,toxic solvents and hard conditions.
