Large populations with multi-modal biomedical phenotypes are crucial for investigating the potential causes of human diseases.In particular,large population-based imaging studies can provide detailed imaging-derived p...Large populations with multi-modal biomedical phenotypes are crucial for investigating the potential causes of human diseases.In particular,large population-based imaging studies can provide detailed imaging-derived phenotypes(IDPs)to quantitatively describe the anatomical structure and function for assessing their associations with genetics,life-style factors and disease outcomes.However,it is not a trivial task to initiate a large population-based imaging study,considering the challenges of logistics,cost,standardisation of the image acquisition protocol,robust image analysis pipelines for IDP extraction and quality control etc.Published in Phenomics,Wang et al.describe the brain image acquisition and phenotyping protocol for the China Phenobank Project(CHPP)(Wang et al.2023),an effort to assess and understand the current health status of a Chinese population,as well as to investigate the causes and progression of common diseases in China.展开更多
Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anato...Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.展开更多
文摘Large populations with multi-modal biomedical phenotypes are crucial for investigating the potential causes of human diseases.In particular,large population-based imaging studies can provide detailed imaging-derived phenotypes(IDPs)to quantitatively describe the anatomical structure and function for assessing their associations with genetics,life-style factors and disease outcomes.However,it is not a trivial task to initiate a large population-based imaging study,considering the challenges of logistics,cost,standardisation of the image acquisition protocol,robust image analysis pipelines for IDP extraction and quality control etc.Published in Phenomics,Wang et al.describe the brain image acquisition and phenotyping protocol for the China Phenobank Project(CHPP)(Wang et al.2023),an effort to assess and understand the current health status of a Chinese population,as well as to investigate the causes and progression of common diseases in China.
基金the Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01).
文摘Imaging-derived phenotypes(IDPs)have been increasingly used in population-based cohort studies in recent years.As widely reported,magnetic resonance imaging(MRI)is an important imaging modality for assessing the anatomical structure and function of the brain with high resolution and excellent soft-tissue contrast.The purpose of this article was to describe the imaging protocol of the brain MRI in the China Phenobank Project(CHPP).Each participant underwent a 30-min brain MRI scan as part of a 2-h whole-body imaging protocol in CHPP.The brain imaging sequences included T1-magnetization that prepared rapid gradient echo,T2 fuid-attenuated inversion-recovery,magnetic resonance angiography,difusion MRI,and resting-state functional MRI.The detailed descriptions of image acquisition,interpretation,and post-processing were provided in this article.The measured IDPs included volumes of brain subregions,cerebral vessel geometrical parameters,microstructural tracts,and function connectivity metrics.
