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A Comparison of the Practical Predictability of Hail with Initial Perturbations of Climatological and Flow-Dependent Uncertainty in Ensembles
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作者 Xiaofei LI 《Advances in Atmospheric Sciences》 2025年第7期1349-1364,共16页
The practical predictability of hail precipitation rates is significantly influenced by initial meteorological perturbations,stemming from various uncertainty sources.This study thoroughly assessed the predictability ... The practical predictability of hail precipitation rates is significantly influenced by initial meteorological perturbations,stemming from various uncertainty sources.This study thoroughly assessed the predictability of hail precipitation rates in both climatologically and flow-dependent perturbed ensembles(CEns and FEns).These ensembles incorporated initial meteorological uncertainties derived separately from two operational ensembles.Leveraging the Weather Research and Forecasting model,we conducted cloud-resolving simulations of an idealized hailstorm.The practical predictability of hail responded comparably to both climatological and flow-dependent uncertainties,which was revealed across the entire ensemble of 50 members.However,a notable difference emerged when comparing the peak hail precipitation rates among the top 10 and bottom 10 members.From a thermodynamic perspective,the primary source of uncertainty in hail precipitation lay in the significant variations in temperature stratification,particularly at-20℃and-40℃.On the microphysical front,perturbations within CEns generated greater uncertainty in the process of rainwater collection by hail,contributing significantly to the microphysical growth mechanisms of hail.Furthermore,the findings reveal a stronger dependency of hail precipitation uncertainty on thermodynamic perturbations compared to kinematic perturbations.These insights enhance the comprehension of the practical predictability of hail and contribute significantly to the understanding of ensemble forecasting for hail events. 展开更多
关键词 HAIL PREDICTABILITY UNCERTAINTY climatological perturbation flow-dependent perturbation
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Perturbation response scanning of drug-target networks:Drug repurposing for multiple sclerosis 被引量:1
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作者 Yitan Lu Ziyun Zhou +10 位作者 Qi Li Bin Yang Xing Xu Yu Zhu Mengjun Xie Yuwan Qi Fei Xiao Wenying Yan Zhongjie Liang Qifei Cong Guang Hu 《Journal of Pharmaceutical Analysis》 2025年第6期1277-1290,共14页
Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-targe... Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases. 展开更多
关键词 Network perturbations Mechanism of action Multiple sclerosis HTR2B
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Global Ensemble Weather Prediction from a Deep Learning–Based Model(Pangu-Weather)with the Initial Condition Perturbations of CMA-GEPS
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作者 Xin LIU Jing CHEN +6 位作者 Yuejian ZHU Yongzhu LIU Fajing CHEN Zhenhua HUO Fei PENG Yanan MA Yuhang GONG 《Advances in Atmospheric Sciences》 2025年第8期1636-1660,共25页
Pangu-Weather(PGW),trained with deep learning–based methods(DL-based model),shows significant potential for global medium-range weather forecasting.However,the interpretability and trustworthiness of global medium-ra... Pangu-Weather(PGW),trained with deep learning–based methods(DL-based model),shows significant potential for global medium-range weather forecasting.However,the interpretability and trustworthiness of global medium-range DLbased models raise many concerns.This study uses the singular vector(SV)initial condition(IC)perturbations of the China Meteorological Administration's Global Ensemble Prediction System(CMA-GEPS)as inputs of PGW for global ensemble prediction(PGW-GEPS)to investigate the ensemble forecast sensitivity of DL-based models to the IC errors.Meanwhile,the CMA-GEPS forecasts serve as benchmarks for comparison and verification.The spatial structures and prediction performance of PGW-GEPS are discussed and compared to CMA-GEPS based on seasonal ensemble experiments.The results show that the ensemble mean and dispersion of PGW-GEPS are similar to those of CMA-GEPS in the medium range but with smoother forecasts.Meanwhile,PGW-GEPS is sensitive to the SV IC perturbations.Specifically,PGWGEPS can generate realistic ensemble spread beyond the sub-synoptic scale(wavenumbers≤64)with SV IC perturbations.However,PGW's kinetic energy is significantly reduced at the sub-synoptic scale,leading to error growth behavior inconsistent with CMA-GEPS at that scale.Thus,this behavior indicates that the effective resolution of PGW-GEPS is beyond the sub-synoptic scale and is limited to predicting mesoscale atmospheric motions.In terms of the global mediumrange ensemble prediction performance,the probability prediction skill of PGW-GEPS is comparable to CMA-GEPS in the extratropic when they use the same IC perturbations.That means that PGW has a general ability to provide skillful global medium-range forecasts with different ICs from numerical weather prediction. 展开更多
关键词 deep learning ensemble prediction forecast uncertainty initial condition perturbations CMA-GEPS Pangu-Weather
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Bridging the Gap Between Individual and Universal Adversarial Perturbations
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作者 Li Yanchun Li Zemin +2 位作者 Zeng Li Zhu Jiang Song Jingkuan 《China Communications》 2025年第9期244-263,共20页
In recent years,universal adversarial per-turbation(UAP)has attracted the attention of many re-searchers due to its good generalization.However,in order to generate an appropriate UAP,current methods usually require e... In recent years,universal adversarial per-turbation(UAP)has attracted the attention of many re-searchers due to its good generalization.However,in order to generate an appropriate UAP,current methods usually require either accessing the original dataset or meticulously constructing optimization functions and proxy datasets.In this paper,we aim to elimi-nate any dependency on proxy datasets and explore a method for generating Universal Adversarial Pertur-bations(UAP)on a single image.After revisiting re-search on UAP,we discovered that the key to gener-ating UAP lies in the accumulation of Individual Ad-versarial Perturbation(IAP)gradient,which prompted us to study the method of accumulating gradients from an IAP.We designed a simple and effective process to generate UAP,which only includes three steps:pre-cessing,generating an IAP and scaling the perturba-tions.Through our proposed process,any IAP gener-ated on an image can be constructed into a UAP with comparable performance,indicating that UAP can be generated free of data.Extensive experiments on var-ious classifiers and attack approaches demonstrate the superiority of our method on efficiency and aggressiveness. 展开更多
关键词 black-box attack data-independent transferability universal adversarial perturbation
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Thermoporoelastic stress perturbations from hydraulic fracturing and thermal depletion in enhanced geothermal systems(EGS)and implications for fault reactivation and seismicity
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作者 Mengke An Rui Huang +2 位作者 Derek Elsworth Fengshou Zhang Egor Dontsov 《Journal of Rock Mechanics and Geotechnical Engineering》 2025年第5期2893-2903,共11页
Hydraulic fracturing then fluid circulation in enhanced geothermal system(EGS)reservoirs have been shown to induce seismicity remote from the stimulation-potentially generated by the distal projection of thermoporoela... Hydraulic fracturing then fluid circulation in enhanced geothermal system(EGS)reservoirs have been shown to induce seismicity remote from the stimulation-potentially generated by the distal projection of thermoporoelastic stresses.We explore this phenomenon by evaluating stress perturbations resulting from stimulation of a single stage of hydraulic fracturing that is followed by thermal depletion of a prismatic zone adjacent to the hydraulic fracture.We use Coulomb failure stress to assess the effect of resulting stress perturbations on instability on adjacent critically-stressed faults.Results show that hydraulic fracturing in a single stage is capable of creating stress perturbations at distances to 1000 m that reach 10^(-5)-10^(-4)MPa.At a closer distance,the magnitude of stress perturbations increases even further.The stress perturbation induced by temperature depletion could also reach 10^(-3)-10^(-2)MPa within 1000 m-much higher than that by hydraulic fracturing.Considering that a critical change in Coulomb failure stress for fault instability is 10^(-2)MPa,a single stage of hydraulic fracturing and thermal drawdown are capable of reactivating critically-stressed faults at distances within 200 m and 1000 m,respectively.These results have important implications for understanding the distribution and magnitudes of stress perturbations driven by thermoporoelastic effects and the associated seismicity during the simulation and early production of EGS reservoirs. 展开更多
关键词 Thermoporoelastic stress perturbations Hot-dry rock Enhanced geothermal system Hydraulic fracturing Thermal depletion Fault instability
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Numerical Simulation via Homotopy Perturbation Approach of a Dissipative Squeezed Carreau Fluid Flow Due to a Sensor Surface
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作者 Sara I.Abdelsalam W.Abbas +2 位作者 Ahmed M.Megahed Hassan M.H.Sadek M.S.Emam 《Frontiers in Heat and Mass Transfer》 2025年第5期1511-1527,共17页
This study rigorously examines the interplay between viscous dissipation,magnetic effects,and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro... This study rigorously examines the interplay between viscous dissipation,magnetic effects,and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro cantilever channel,aiming to deepen our understanding of heat transport processes in complex fluid dynamics scenarios.The primary objective is to elucidate how physical operational parameters influence both the velocity of fluid flow and its temperature distribution,utilizing a comprehensive numerical approach.Employing a combination of mathematical modeling techniques,including similarity transformation,this investigation transforms complex partial differential equations into more manageable ordinary ones,subsequently solving them using the homotopy perturbation method.By analyzing the obtained solutions and presenting them graphically,alongside detailed analysis,the study sheds light on the pivotal role of significant parameters in shaping fluid movement and energy distribution.Noteworthy observations reveal a substantial increase in fluid velocity with escalating magnetic parameters,while conversely,a contrasting trend emerges in the temperature distribution,highlighting the intricate relationship between magnetic effects,flow dynamics,and thermal behavior in non-Newtonian fluids.Further,the suction velocity enhance both the local skin friction and Nusselt numbers,whereas theWeissenberg number reduces them,opposite to the effect of the power-law index. 展开更多
关键词 Homotopy perturbation method squeezed flow Carreau fluid sensor surface magnetic field viscous dissipation
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Adversarial Perturbation for Sensor Data Anonymization: Balancing Privacy and Utility
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作者 Tatsuhito Hasegawa Kyosuke Fujino 《Computers, Materials & Continua》 2025年第8期2429-2454,共26页
Recent advances in wearable devices have enabled large-scale collection of sensor data across healthcare,sports,and other domains but this has also raised critical privacy concerns,especially under tightening regulati... Recent advances in wearable devices have enabled large-scale collection of sensor data across healthcare,sports,and other domains but this has also raised critical privacy concerns,especially under tightening regulations such as the General Data Protection Regulation(GDPR),which explicitly restrict the processing of data that can re-identify individuals.Although existing anonymization approaches such as the AnonymizingAutoEncoder(AAE)can reduce the risk of re-identification,they often introduce substantial waveform distortions and fail to preserve information beyond a single classification task(e.g.,human activity recognition).This study proposes a novel sensor data anonymization method based onAdversarial Perturbations(AP)to address these limitations.By generating minimal yet targeted noise,the proposed method significantly degrades the accuracy of identity classification while retaining essential features for multiple tasks such as activity,gender,or device-position recognition.Moreover,to enhance robustness against frequency-domain analysis,additional models trained on transformed(e.g.,short-time Fourier transform(STFT))representations are incorporated into the perturbation process.A multi-task formulation is introduced that selectively suppresses person-identifying features while reinforcing those relevant to other desired tasks without retraining large autoencoder-based architectures.The proposed framework is,to our knowledge,the first AP-based anonymization technique that(i)defends simultaneously against time-and frequency-domain attacks and(ii)allows per-task trade-off control on a single forward-back-propagation run,enabling real-time,on-device deployment on commodity hardware.On three public datasets,the proposed method reduces person-identification accuracy from 60–90%to near-chance levels(≤5%)while preserving the original activity-recognition F1 both in the time and frequency domains.Compared with the baseline AAE,the proposed method improves downstream task F1 and lowers waveform mean squared error,demonstrating a better privacy-utility trade-off without additional model retraining.These findings underscore the effectiveness and flexibility of AP in privacy-preserving sensor-data processing,offering a practical solution that safeguards user identity while retaining rich,application-critical information. 展开更多
关键词 Human activity recognition privacy-aware IoT adversarial perturbation
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A New Method to Calculate Nonlinear Optimal Perturbations for Ensemble Forecasting
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作者 Junjie MA Wansuo DUAN +1 位作者 Zhuomin LIU Ye WANG 《Advances in Atmospheric Sciences》 2025年第5期952-967,共16页
Orthogonal conditional nonlinear optimal perturbations(O-CNOPs)have been used to generate ensemble forecasting members for achieving high forecasting skill of high-impact weather and climate events.However,highly effi... Orthogonal conditional nonlinear optimal perturbations(O-CNOPs)have been used to generate ensemble forecasting members for achieving high forecasting skill of high-impact weather and climate events.However,highly efficient calculations for O-CNOPs are still challenging in the field of ensemble forecasting.In this study,we combine a gradient-based iterative idea with the Gram‒Schmidt orthogonalization,and propose an iterative optimization method to compute O-CNOPs.This method is different from the original sequential optimization method,and allows parallel computations of O-CNOPs,thus saving a large amount of computational time.We evaluate this method by using the Lorenz-96 model on the basis of the ensemble forecasting ability achieved and on the time consumed for computing O-CNOPs.The results demonstrate that the parallel iterative method causes O-CNOPs to yield reliable ensemble members and to achieve ensemble forecasting skills similar to or even slightly higher than those produced by the sequential method.Moreover,the parallel method significantly reduces the computational time for O-CNOPs.Therefore,the parallel iterative method provides a highly effective and efficient approach for calculating O-CNOPs for ensemble forecasts.Expectedly,it can play an important role in the application of the O-CNOPs to realistic ensemble forecasts for high-impact weather and climate events. 展开更多
关键词 initial uncertainty conditional nonlinear optimal perturbation optimization method ensemble forecasting
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Toroidal torques due to n=1 magnetic perturbations in ITER baseline scenario
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作者 Jingwei LI Li LI +5 位作者 Yueqiang LIU Yunfeng LIANG Yanfei WANG Lu TIAN Zhongqing LIU Fangchuan ZHONG 《Plasma Science and Technology》 2025年第1期39-51,共13页
Toroidal torques,generated by the resonant magnetic perturbation(RMP)and acting on the plasma column,are numerically systematically investigated for an ITER baseline scenario.The neoclassical toroidal viscosity(NTV),i... Toroidal torques,generated by the resonant magnetic perturbation(RMP)and acting on the plasma column,are numerically systematically investigated for an ITER baseline scenario.The neoclassical toroidal viscosity(NTV),in particular the resonant portion,is found to provide the dominant contribution to the total toroidal torque under the slow plasma flow regime in ITER.While the electromagnetic torque always opposes the plasma flow,the toroidal torque associated with the Reynolds stress enhances the plasma flow independent of the flow direction.A peculiar double-peak structure for the net NTV torque is robustly computed for ITER,as the toroidal rotation frequency is scanned near the zero value.This structure is found to be ultimately due to a non-monotonic behavior of the wave-particle resonance integral(over the particle pitch angle)in the superbanana plateau NTV regime in ITER.These findings are qualitatively insensitive to variations of a range of factors including the wall resistivity,the plasma pedestal flow and the assumed frequency of the rotating RMP field. 展开更多
关键词 toroidal torques resonant magnetic perturbation fieds plasma flow ITER baseline scenario
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An Extension of Conditional Nonlinear Optimal Perturbation in the Time Dimension and Its Applications in Targeted Observations
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作者 Ziqing ZU Mu MU +1 位作者 Jiangjiang XIA Qiang WANG 《Advances in Atmospheric Sciences》 2025年第9期1783-1797,共15页
The Conditional Nonlinear Optimal Perturbation(CNOP)method works essentially for conventional numerical models;however,it is not fully applicable to the commonly used deep-learning forecasting models(DLMs),which typic... The Conditional Nonlinear Optimal Perturbation(CNOP)method works essentially for conventional numerical models;however,it is not fully applicable to the commonly used deep-learning forecasting models(DLMs),which typically input multiple time slices without deterministic dependencies.In this study,the CNOP for DLMs(CNOP-DL)is proposed as an extension of the CNOP in the time dimension.This method is useful for targeted observations as it indicates not only where but also when to deploy additional observations.The CNOP-DL is calculated for a forecast case of sea surface temperature in the South China Sea with a DLM.The CNOP-DL identifies a sensitive area northwest of Palawan Island at the last input time.Sensitivity experiments demonstrate that the sensitive area identified by the CNOP-DL is effective not only for the CNOP-DL itself,but also for random perturbations.Therefore,this approach holds potential for guiding practical field campaigns.Notably,forecast errors are more sensitive to time than to location in the sensitive area.It highlights the crucial role of identifying the time of the sensitive area in targeted observations,corroborating the usefulness of extending the CNOP in the time dimension. 展开更多
关键词 deep-learning forecasting model conditional nonlinear optimal perturbation targeted observation sensitive area
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Influence of 3D helical magnetic perturbations on runaway electron generation in J-TEXT tokamak
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作者 Wei YAN Guinan ZOU +22 位作者 Zhongyong CHEN You LI Jiangang FANG Zhifang LIN Zhonghe JIANG Nengchao WANG Bo RAO Yangbo LI Zhengkang REN Chuanxu ZHAO Yu ZHONG Fanxi LIU Yinlong YU Zisen NIE Xun ZHOU Yuan SHENG Yuwei SUN Song ZHOU Xiaoqing ZHANG Zhoujun YANG Zhipeng CHEN Yonghua DING the J-TEXT Team 《Plasma Science and Technology》 2025年第3期36-44,共9页
A large number of runaway electrons(REs)generated during disruption can cause significant damage to next-generation large-scale tokamaks.The influence of three-dimensional(3D)helical magnetic perturbations on the supp... A large number of runaway electrons(REs)generated during disruption can cause significant damage to next-generation large-scale tokamaks.The influence of three-dimensional(3D)helical magnetic perturbations on the suppression of RE generation was explored using a set of 3D helical coils in J-TEXT tokamak,which can excite m/n=-2/2 helical magnetic perturbations.Experimental evidence shows that the-2/2 magnetic perturbations caused by the opposite coil current direct plasma toward the high-field side,simultaneously enhancing the magnetic fluctuations,which would enhance the radial loss of REs and even prevent RE generation.On the other hand,-2/2 magnetic perturbations can also reduce the cooling time during the disruption phase and generate a population of high-energy REs,which can interact with high-frequency magnetic fluctuations and in turn suppress RE generation.The critical helical coil current was found to correlate with electron density,requiring higher coil currents at higher densities.According to the statistical analysis of RE generation at different electron densities,the applied-2/2 magnetic perturbations can increase the magnetic fluctuations to the same level at lower electron densities,which can decrease the threshold electron density for RE suppression.This will be beneficial for RE mitigation in future large tokamak devices. 展开更多
关键词 3D helical magnetic perturbations runaway electron J-TEXT tokamak
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On the monotonicity of limit wave speed to a perturbed gKdV equation
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作者 WEN Zhen-shu SHI Tian-yu 《Applied Mathematics(A Journal of Chinese Universities)》 2025年第1期207-212,共6页
This paper deals with the monotonicity of limit wave speed c0(h)to a perturbed g KdV equation.We show the decrease of c0(h)by combining the analytic method and the numerical technique.Our results solve a special case ... This paper deals with the monotonicity of limit wave speed c0(h)to a perturbed g KdV equation.We show the decrease of c0(h)by combining the analytic method and the numerical technique.Our results solve a special case of the open question presented by Yan et al.,and the method potentially provides a way to study the monotonicity of c0(h)for general m∈N^(+). 展开更多
关键词 the perturbed gKdV equation with m=5 traveling waves limit wave speed MONOTONICITY
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Alternative Methods of Regular and Singular Perturbation Problems
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作者 Boampong Asare Manohar Sah Ram Krishna Hona 《Applied Mathematics》 2024年第10期687-708,共22页
Making exact approximations to solve equations distinguishes applied mathematicians from pure mathematicians, physicists, and engineers. Perturbation problems, both regular and singular, are pervasive in diverse field... Making exact approximations to solve equations distinguishes applied mathematicians from pure mathematicians, physicists, and engineers. Perturbation problems, both regular and singular, are pervasive in diverse fields of applied mathematics and engineering. This research paper provides a comprehensive overview of algebraic methods for solving perturbation problems, featuring a comparative analysis of their strengths and limitations. Serving as a valuable resource for researchers and practitioners, it offers insights and guidance for tackling perturbation problems in various disciplines, facilitating the advancement of applied mathematics and engineering. 展开更多
关键词 perturbATION Regular perturbation Singular perturbation Asymptotic Expansion Matched Asymptotic Strained Coordinates Multiple Scales
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An Initial Perturbation Method for the Multiscale Singular Vector in Global Ensemble Prediction 被引量:5
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作者 Xin LIU Jing CHEN +6 位作者 Yongzhu LIU Zhenhua HUO Zhizhen XU Fajing CHEN Jing WANG Yanan MA Yumeng HAN 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第3期545-563,共19页
Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial pertur... Ensemble prediction is widely used to represent the uncertainty of single deterministic Numerical Weather Prediction(NWP) caused by errors in initial conditions(ICs). The traditional Singular Vector(SV) initial perturbation method tends only to capture synoptic scale initial uncertainty rather than mesoscale uncertainty in global ensemble prediction. To address this issue, a multiscale SV initial perturbation method based on the China Meteorological Administration Global Ensemble Prediction System(CMA-GEPS) is proposed to quantify multiscale initial uncertainty. The multiscale SV initial perturbation approach entails calculating multiscale SVs at different resolutions with multiple linearized physical processes to capture fast-growing perturbations from mesoscale to synoptic scale in target areas and combining these SVs by using a Gaussian sampling method with amplitude coefficients to generate initial perturbations. Following that, the energy norm,energy spectrum, and structure of multiscale SVs and their impact on GEPS are analyzed based on a batch experiment in different seasons. The results show that the multiscale SV initial perturbations can possess more energy and capture more mesoscale uncertainties than the traditional single-SV method. Meanwhile, multiscale SV initial perturbations can reflect the strongest dynamical instability in target areas. Their performances in global ensemble prediction when compared to single-scale SVs are shown to(i) improve the relationship between the ensemble spread and the root-mean-square error and(ii) provide a better probability forecast skill for atmospheric circulation during the late forecast period and for short-to medium-range precipitation. This study provides scientific evidence and application foundations for the design and development of a multiscale SV initial perturbation method for the GEPS. 展开更多
关键词 multiscale uncertainty singular vector initial perturbation global ensemble prediction system
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Perturbation to Symmetries and Adiabatic Invariants for Generalized Birkhoffian Systems on Time Scales 被引量:2
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作者 HOU Shuang SONG Chuanjing 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2024年第3期263-272,共10页
Time scale is a new and powerful tool for dealing with complex dynamics problems. The main result of this study is the exact invariants and adiabatic invariants of the generalized Birkhoffian system and the constraine... Time scale is a new and powerful tool for dealing with complex dynamics problems. The main result of this study is the exact invariants and adiabatic invariants of the generalized Birkhoffian system and the constrained Birkhoffian system on time scales. Firstly, we establish the differential equations of motion for the above two systems and give the corresponding Noether symmetries and exact invariants. Then, the perturbation to the Noether symmetries and the adiabatic invariants for the systems mentioned above under the action of slight disturbance are investigated, respectively. Finally, two examples are provided to show the practicality of the findings. 展开更多
关键词 time scale generalized Birkhoffian system Noether symmetry perturbation and adiabatic invariants
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Chien-physics-informed neural networks for solving singularly perturbed boundary-layer problems 被引量:1
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作者 Long WANG Lei ZHANG Guowei HE 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第9期1467-1480,共14页
A physics-informed neural network(PINN)is a powerful tool for solving differential equations in solid and fluid mechanics.However,it suffers from singularly perturbed boundary-layer problems in which there exist sharp... A physics-informed neural network(PINN)is a powerful tool for solving differential equations in solid and fluid mechanics.However,it suffers from singularly perturbed boundary-layer problems in which there exist sharp changes caused by a small perturbation parameter multiplying the highest-order derivatives.In this paper,we introduce Chien's composite expansion method into PINNs,and propose a novel architecture for the PINNs,namely,the Chien-PINN(C-PINN)method.This novel PINN method is validated by singularly perturbed differential equations,and successfully solves the wellknown thin plate bending problems.In particular,no cumbersome matching conditions are needed for the C-PINN method,compared with the previous studies based on matched asymptotic expansions. 展开更多
关键词 physics-informed neural network(PINN) singular perturbation boundarylayer problem composite asymptotic expansion
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Maximum Power Point Tracking Based on Improved Kepler Optimization Algorithm and Optimized Perturb&Observe under Partial Shading Conditions 被引量:1
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作者 Zhaoqiang Wang Fuyin Ni 《Energy Engineering》 EI 2024年第12期3779-3799,共21页
Under the partial shading conditions(PSC)of Photovoltaic(PV)modules in a PV hybrid system,the power output curve exhibits multiple peaks.This often causes traditional maximum power point tracking(MPPT)methods to fall ... Under the partial shading conditions(PSC)of Photovoltaic(PV)modules in a PV hybrid system,the power output curve exhibits multiple peaks.This often causes traditional maximum power point tracking(MPPT)methods to fall into local optima and fail to find the global optimum.To address this issue,a composite MPPT algorithm is proposed.It combines the improved kepler optimization algorithm(IKOA)with the optimized variable-step perturb and observe(OIP&O).The update probabilities,planetary velocity and position step coefficients of IKOA are nonlinearly and adaptively optimized.This adaptation meets the varying needs of the initial and later stages of the iterative process and accelerates convergence.During stochastic exploration,the refined position update formulas enhance diversity and global search capability.The improvements in the algorithmreduces the likelihood of falling into local optima.In the later stages,the OIP&O algorithm decreases oscillation and increases accuracy.compared with cuckoo search(CS)and gray wolf optimization(GWO),simulation tests of the PV hybrid inverter demonstrate that the proposed IKOA-OIP&O algorithm achieves faster convergence and greater stability under static,local and dynamic shading conditions.These results can confirm the feasibility and effectiveness of the proposed PV MPPT algorithm for PV hybrid systems. 展开更多
关键词 PV hybrid inverter kepler optimization algorithm maximum power point tracking perturb and observe
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A proteomic landscape of pharmacologic perturbations for functional relevance
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作者 Zhiwei Liu Shangwen Jiang +8 位作者 Bingbing Hao Shuyu Xie Yingluo Liu Yuqi Huang Heng Xu Cheng Luo Min Huang Minjia Tan Jun-Yu Xu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第1期128-139,共12页
Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome ... Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine. 展开更多
关键词 PROTEOMICS Drug perturbATION Drug target Drug combination
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THE SUPERCLOSENESS OF THE FINITE ELEMENT METHOD FOR A SINGULARLY PERTURBED CONVECTION-DIFFUSION PROBLEM ON A BAKHVALOV-TYPE MESH IN 2D
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作者 Chunxiao ZHANG Jin ZHANG 《Acta Mathematica Scientia》 SCIE CSCD 2024年第4期1572-1593,共22页
For singularly perturbed convection-diffusion problems,supercloseness analysis of the finite element method is still open on Bakhvalov-type meshes,especially in the case of 2D.The difficulties arise from the width of ... For singularly perturbed convection-diffusion problems,supercloseness analysis of the finite element method is still open on Bakhvalov-type meshes,especially in the case of 2D.The difficulties arise from the width of the mesh in the layer adjacent to the transition point,resulting in a suboptimal estimate for convergence.Existing analysis techniques cannot handle these difficulties well.To fill this gap,here a novel interpolation is designed delicately for the smooth part of the solution,bringing about the optimal supercloseness result of almost order 2 under an energy norm for the finite element method.Our theoretical result is uniform in the singular perturbation parameterεand is supported by the numerical experiments. 展开更多
关键词 singularly perturbed CONVECTION-DIFFUSION finite element method SUPERCLOSENESS Bakhvalov-type mesh
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Volcanically Driven Terrestrial Environmental Perturbations during the Carnian Pluvial Episode in the Eastern Tethys
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作者 Naveed Ur RAHMAN XIAN Benzhong +4 位作者 FANG Linhao CHEN Sirui CHEN Peng Zaheen ULLAH WANG Pengyu 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第3期753-770,共18页
The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlat... The Carnian Pluvial Episode(CPE)fingerprints global environmental perturbations and biological extinction on land and oceans and is potentially linked to the Wrangellia Large Igneous Province(LIP).However,the correlation between terrestrial environmental changes and Wrangellia volcanism in the Ordos Basin during the CPE remains poorly understood.Records of negative carbon isotopic excursions(NCIEs),mercury(Hg),Hg/TOC,and Hg enrichment factor(HgEF)from oil shales in a large-scale terrestrial Ordos Basin in the Eastern Tethys were correlated with marine and other terrestrial successions.The three significant NCIEs in the study section were consistently correlated with those in the CPE successions of Europe,the UK,and South and North China.The U-Pb geochronology indicates a Ladinian-Carnian age for the Chang 7 Member.A comprehensive overview of the geochronology,NCIE correlation,and previous bio-and chronostratigraphic frameworks shows that the Ladinian-Carnian boundary is located in the lower part of Chang 7 in the Yishicun section.HgEF may be a more reliable proxy for tracing volcanic eruptions than the Hg/TOC ratio because the accumulation rates of TOC content largely vary in terrestrial and marine successions.The records of Hg,Hg/TOC,HgEF,and NCIEs in the Ordos Basin aligned with Carnian successions worldwide and were marked by similar anomalies,indicating a global response to the Wrangellia LIP during the CPE.Anoxia,a warm-humid climate,enhancement of detrital input,and NCIEs are synchronous with the CPE interval in the Ordos Basin,which suggests that the CPE combined with the regional Qinling Orogeny should dominate the enhanced rate of terrigenous input and paleoenvironmental evolution in the Ordos Basin. 展开更多
关键词 Chang 7 Member oil shale Carnian Pluvial Episode VOLCANISM environmental perturbations
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