Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds （QAs） have been develop...Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds （QAs） have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs. In this study, we investigated the development of S. mutans persistence induced by a novel dental caries defensive agent, dimethylaminododecyl methacrylate （DMADDM）, for the first time. Typical biphasic killing kinetics for persisters were observed in both S. mutans planktonic and biofilm cultures challenged by DMADDM at concentrations of 20 and 200 pg.mL- z respectively. The persisters tolerated six other antibiotics with different antibacterial mechanisms, while only daptomycin and vancomycin could slightly reduce the persister numbers in planktonic cultures. The distribution of persisters in DMADDM-treated biofilms was similar to that in the untreated control, except that the total biomass and biofilm height were significantly reduced. A higher exopolysaccharides （EPS）：bacteria ratio was observed in DMADDM-treated biofilms. Persisters in biofilms significantly upregulated gtf gene expression, indicating an increase in the bacteria＇s ability to produce EPS and an elevated capability of cariogenic virulence. Carbon source metabolism was significantly reduced, as related metabolic genes were all downregulated in persisters. Concentrations of 0.1 mM, 1 mM and 10 mM of extra glucose significantly reduced the number of persisters both in planktonic and biofilm conditions. The formation of non- inheritable and multidrug tolerant persisters induced by DMADDM suggested that drug tolerance and new persistent eradication strategies should be considered for oral antibacterial agents.展开更多
本文研究了肉桂醛对酿酒酵母persister细胞形成的影响。通过96孔板微量法测定肉桂醛对酿酒酵母生长的最小抑制浓度(MIC)为0.4 m M;采用流式细胞仪以及梯度稀释滴平板计数法研究了肉桂醛处理后酿酒酵母persister细胞的形成情况。结果表明...本文研究了肉桂醛对酿酒酵母persister细胞形成的影响。通过96孔板微量法测定肉桂醛对酿酒酵母生长的最小抑制浓度(MIC)为0.4 m M;采用流式细胞仪以及梯度稀释滴平板计数法研究了肉桂醛处理后酿酒酵母persister细胞的形成情况。结果表明,肉桂醛可以抑制酿酒酵母生长,且能够诱导酿酒酵母细胞形成persister状态,该状态下的细胞对两性霉素B产生耐药性。进一步研究发现肉桂醛处理后可以使酿酒酵母细胞停滞在细胞周期的任何阶段,而雷帕霉素诱导的细胞自噬只能停留在G1期,所以酿酒酵母perisister与自噬状态存在区别。目前,对于Persister的研究集中在原核微生物,对真核生物persister的研究非常有限。由于persister群体通常占总群体极小一部分,这就给基因水平上研究persister的形成机制带来很大的挑战。本研究发现肉桂醛处理酿酒酵母细胞后,可以促使其大部分细胞形成persister。这就为从基因水平上认识真核生物persister的形成机制提供了方法,实验结果表明YGL基因也与酿酒酵母persister的形成有很大关系。展开更多
Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chron...Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed biofilms.Here,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and persisters.Even after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop resistance.Besides,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and persisters.Furthermore,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA cycle.Then,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein degradation.Furthermore,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory response.In conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters.展开更多
Glioblastoma(GBM)represents the main form of brain tumors in adults,and one of the most aggressive cancers overall.The treatment of GBM is a combination of surgery(when possible),chemotherapy(usually Temozolomide,TMZ)...Glioblastoma(GBM)represents the main form of brain tumors in adults,and one of the most aggressive cancers overall.The treatment of GBM is a combination of surgery(when possible),chemotherapy(usually Temozolomide,TMZ)and radiotherapy(RT).However,despite this heavy treatment,GBM invariably recur and the median length of survival following diagnosis is 12 to 15 months,with less than 10%of people surviving longer than five years.GBM is extremely resistant to most treatments because of its heterogeneous nature,which is associated with extreme clonal plasticity and the presence of cancer stem cells,refractory to TMZ-and RT-induced cell death.In this review,we explore the mechanisms by which cancer cells,and especially GBM,can acquire resistance to treatment.We describe and discuss the concept of persister/tolerant cells that precede and/or accompany the acquisition of resistance.Persister/tolerant cells are cancer cells that are not eliminated by treatment(s)because of different mechanisms ranging from dormancy/quiescence to senescence.We discuss the possibility of targeting these mechanisms in new therapeutic regimen.展开更多
AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV betwe...AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV between January 2014 and August 2021 were retrospectively reviewed.Corneal keratometry parameters were measured using IOLMaster or a handheld keratometer.Differences in CA between the affected and fellow eyes were analyzed in 52 unilateral PFV patients with available examination data.RESULTS:Totally 133 patients diagnosed with PFV were retrospectively reviewed.The male-to-female ratio was 73/60.Median age at surgery was 38.03mo(interquartile range 58.27mo).Among the PFV patients,32(24.06%)had anterior PFV,2(1.50%)had posterior PFV,and 99(74.44%)had combined anterior-posterior PFV.Mild combined PFV was the most common subtype.In unilateral PFV cases,the mean CA in the affected eye was 2.29±1.11 D,and 59.62%(31 eyes)had CA≥2.0 D.The mean CA in the affected eyes was significantly higher than in the fellow eyes(1.37±0.77 D;P<0.001).Among PFV-affected eyes with CA≥2.0 D,the steepest corneal meridian was vertically oriented in 30 cases(96.77%),while only 1 case(3.23%)had the steepest meridian oriented horizontally.CONCLUSION:In children with unilateral PFV,CA is significantly higher in the affected eyes than in the fellow eyes,and the steepest corneal meridian was predominantly oriented vertically.展开更多
Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address thes...Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address these challenges,we propose an Uncertainty-Driven Graph Embedding-Enhanced Lateral Movement Detection framework(UGEA-LMD).First,the framework employs event-level incremental encoding on a continuous-time graph to capture fine-grained behavioral evolution,enabling newly appearing nodes to retain temporal contextual awareness even in the absence of historical interactions and thereby fundamentally mitigating the cold-start problem.Second,in the embedding space,we model the dependency structure among feature dimensions using a Gaussian copula to quantify the uncertainty distribution,and generate augmented samples with consistent structural and semantic properties through adaptive sampling,thus expanding the representation space of sparse samples and enhancing the model’s generalization under sparse sample conditions.Unlike static graph methods that cannot model temporal dependencies or data augmentation techniques that depend on predefined structures,UGEA-LMD offers both superior temporaldynamic modeling and structural generalization.Experimental results on the large-scale LANL log dataset demonstrate that,under the transductive setting,UGEA-LMD achieves an AUC of 0.9254;even when 10%of nodes or edges are withheld during training,UGEA-LMD significantly outperforms baseline methods on metrics such as recall and AUC,confirming its robustness and generalization capability in sparse-sample and cold-start scenarios.展开更多
Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation conditions.These cells can regrow a...Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation conditions.These cells can regrow after stress removal and remain susceptible to the same stress.Persisters are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective treatments.Understanding the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent infections.Currently,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered questions.This article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and treatments.We hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.展开更多
Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmenta...Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.展开更多
Rare earth-doped inorganic compounds contribute mostly to the family of persistent luminescent materials due to the versatile energy levels of rare earth ions.One of the key research aims is to match the trap level st...Rare earth-doped inorganic compounds contribute mostly to the family of persistent luminescent materials due to the versatile energy levels of rare earth ions.One of the key research aims is to match the trap level stemming from the doped rare earth ion or intrinsic defects to the electronic structure of the host,and therefore thermoluminescence measurement becomes a radical technology in studying trap depth,which is one of the significant parameters that determine the properties of persistent luminescence and photostimulated luminescence.However,the results of trap depth obtained by different thermoluminescence methods are quite different so that they are not comparable.Herein,we analyzed different thermoluminescence methods,selected and improved the traditional peak position method of T_(m)/500 to be E=(-0.94Inβ+30.09)kT_(m).Only the experimental heating rate(β)is needed additionally,but the accuracy is improved greatly in most cases.This convenient and accurate method will accelerate the discovery of novel rare earth-doped materials.展开更多
Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous brom...Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.展开更多
A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,t...A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.展开更多
BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevanc...BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains uncertain.AIM To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic shock.METHODS In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were analyzed.Patients were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with normonatremia.Moreover,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of IAH.Notably,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the ICU.It is highly recommended that hypernatremia be considered a potentially important prognostic indicator for the outcome of septic shock.展开更多
Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent lumine...Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent luminescent material applications.At present,YAGG:Ce^(3+),Cr^(3+)powders exhibit good persistent performance,but their persistent performance of ceramics still needs to be further improved to meet the new requirements.In this work,(Y_(0.998)Ce_(0.002))_(3)(Al_(1-x)Cr_(x))_(2)Ga_(3)O_(12) ceramics with different Cr^(3+)doping concentrations were prepared by solid-state reaction,including air pre-sintering,hot isostatic pressing(HIP)post-treatment and air annealing,to investigate the effects of Cr^(3+)doping concentration on the microstructure,optical properties and persistent performance of the ceramics.The results showed that as the doping concentration of Cr^(3+)increased from 0.025%to 0.2%(in atom),no significant effect of Cr^(3+)concentration on the morphology of pre-sintered ceramics or HIP post-treatment ceramics was observed,but the in-line transmittance gradually increased while the persistent performance gradually decreased.Among them,YAGG:Ce^(3+),Cr^(3+)ceramics doped with 0.025%Cr^(3+)showed the strongest initial luminescence intensity exceeding 6055 mcd/m^(2) and a persistent time of 1030 min after air pre-sintering combined with HIP post-treatment and air annealing.By optimizing the Cr^(3+)doping concentration and the fabrication process,the persistent luminescence(PersL)performance of the YAGG:Ce^(3+),Cr^(3+)ceramics was obviously improved.展开更多
Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of ima...Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of imaging[1].Among numerous persistent luminescence materials,lanthanide-doped fluoride nanoparticles have shown tunable persistent luminescence across the UV-vis-NIR spectrum(200-1700 nm)under X-ray excitation and adjustable size,promising significant applications in deep-tissue imaging[2,3],security encryption,and data storage[4].In particular,those exhibiting NIR-II luminescence(1000-1700 nm)provide key advantages such as deeper tissue penetration,higher contrast,and minimal interference from biological autofluorescence.However,challenges such as low brightness and rapid signal decay,especially in the NIR-II region,limit their effectiveness in long-term monitoring,including tumor theranostics[5].Traditional approaches like size control and surface passivation yield only marginal improvements,underscoring the need for next-generation nanoparticles with superior NIR-II brightness.展开更多
In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide r...In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide radiation quantum energy range of 0.62–3.1 eV both at T=4.2 K and at T=77 K.Common features of the PPC spectra for all structures were revealed,and their relation to the presence of a CdTe cap layer in all structures and the appropriate cadmium fraction in the CdHgTe barrier layers was shown.One of the features was associated with the presence of a deep level in the CdTe layer.In addition,the oscillatory behavior of the PPC spectra in the region from 0.8–1.1 eV to 1.2–1.5 eV was observed.It is associated with the cascade emission of longitudinal optical phonons in CdHgTe barrier.展开更多
BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum ...BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum months,with notably high incidence rates even one year after childbirth.Persistent PPD has been associated with poor developmental outcomes in infants,highlighting the need for continued monitoring and support during this critical period.Understanding the broader impacts of persistent PPD is essential for developing effective interventions to improve maternal and infant well-being.AIM To explore the impact of persistent PPD on infant developmental behavior and maternal self-efficacy.METHODS We recruited 60 postpartum women who experienced persistent depression after childbirth in our hospital from January 2020 to December 2024 as the research subjects.The study collected basic characteristics of both infants and mothers,analyzed the self-efficacy of the mothers and the developmental behaviors of the infants,and conducted a correlation analysis to examine the relationship between postpartum persistent depression in mothers and the developmental behaviors and self-efficacy of infants.The Bootstrap method was used to verify the significance of the mediating effect.RESULTS The basic characteristics of infants and mothers show that 53.33%are male,58.33%are born via vaginal delivery,88.33%have a normal body mass index,51.67%are aged between 25 and 29 years,70%are non-agricultural workers,51.67%have a per capita household income over 4000 yuan,96.67%are full-term births,and 58.33%of the fathers are aged between 26 and 32 years.In terms of infant development behavior,the gross motor skills score is relatively low(38.44±12.15).Regarding maternal self-efficacy,the skill score(45.68±5.49)and mental activity score(46.37±3.72)are both at a low level.Correlation analysis reveals that postpartum persistent depression is significantly negatively correlated with maternal self-efficacy and infant development behavior(β=-0.439,-0.657,P<0.001),while self-efficacy is positively correlated with infant development behavior(β=0.728,P<0.001).The path coefficient and Bootstrap method test indicate that self-efficacy acts as a mediator between postpartum persistent depression and infant development behavior,accounting for 54.80%of the effect(P<0.05),while the direct effect of postpartum persistent depression on infant development behavior is 45.20%(P<0.05).CONCLUSION Persistent PPD significantly negatively impacts infant developmental outcomes,with maternal self-efficacy serving as a partial mediator.These findings suggest that interventions targeting both depressive symptoms and selfenhancement may effectively promote infant health development.展开更多
Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a ra...Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a rare phenomenon.In the general population,the incidence of this condition is reported to be between 0.3%and 2.1%.[1]While this anatomical variation is often asymptomatic and discovered incidentally,it becomes relevant in certain clinical scenarios.Indeed,the presence of a PLSVC and double superior vena cava can pose challenges as incorrect positioning and result in failure.展开更多
The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these s...The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.展开更多
Artificial intelligence(AI)is a revolutionizing problem-solver across various domains,including scientific research.Its application to chemical processes holds remarkable potential for rapid optimization of protocols ...Artificial intelligence(AI)is a revolutionizing problem-solver across various domains,including scientific research.Its application to chemical processes holds remarkable potential for rapid optimization of protocols and methods.A notable application of AI is in the photoFenton degradation of organic compounds.Despite the high novelty and recent surge of interest in this area,a comprehensive synthesis of existing literature on AI applications in the photo-Fenton process is lacking.This review aims to bridge this gap by providing an in-depth summary of the state-of-the-art use of artificial neural networks(ANN)in the photo-Fenton process,with the goal of aiding researchers in the water treatment field to identify the most crucial and relevant variables.It examines the types and architectures of ANNs,input and output variables,and the efficiency of these networks.The findings reveal a rapidly expanding field with increasing publications highlighting AI's potential to optimize the photo-Fenton process.This review also discusses the benefits and drawbacks of using ANNs,emphasizing the need for further research to advance this promising area.展开更多
Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algo...Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.展开更多
基金supported by the National Key Research and Development Program of China 2016YFC1102700(X.Z.)the National Natural Science Foundation of China grants 81372889(LC)+2 种基金81600858(BR)and 81430011(XZ)the Recruitment Program for Young Professionals(MF)the Youth Grant of the Science and Technology Department of Sichuan Province,China2017JQ0028(L.C.)
文摘Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds （QAs） have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs. In this study, we investigated the development of S. mutans persistence induced by a novel dental caries defensive agent, dimethylaminododecyl methacrylate （DMADDM）, for the first time. Typical biphasic killing kinetics for persisters were observed in both S. mutans planktonic and biofilm cultures challenged by DMADDM at concentrations of 20 and 200 pg.mL- z respectively. The persisters tolerated six other antibiotics with different antibacterial mechanisms, while only daptomycin and vancomycin could slightly reduce the persister numbers in planktonic cultures. The distribution of persisters in DMADDM-treated biofilms was similar to that in the untreated control, except that the total biomass and biofilm height were significantly reduced. A higher exopolysaccharides （EPS）：bacteria ratio was observed in DMADDM-treated biofilms. Persisters in biofilms significantly upregulated gtf gene expression, indicating an increase in the bacteria＇s ability to produce EPS and an elevated capability of cariogenic virulence. Carbon source metabolism was significantly reduced, as related metabolic genes were all downregulated in persisters. Concentrations of 0.1 mM, 1 mM and 10 mM of extra glucose significantly reduced the number of persisters both in planktonic and biofilm conditions. The formation of non- inheritable and multidrug tolerant persisters induced by DMADDM suggested that drug tolerance and new persistent eradication strategies should be considered for oral antibacterial agents.
文摘本文研究了肉桂醛对酿酒酵母persister细胞形成的影响。通过96孔板微量法测定肉桂醛对酿酒酵母生长的最小抑制浓度(MIC)为0.4 m M;采用流式细胞仪以及梯度稀释滴平板计数法研究了肉桂醛处理后酿酒酵母persister细胞的形成情况。结果表明,肉桂醛可以抑制酿酒酵母生长,且能够诱导酿酒酵母细胞形成persister状态,该状态下的细胞对两性霉素B产生耐药性。进一步研究发现肉桂醛处理后可以使酿酒酵母细胞停滞在细胞周期的任何阶段,而雷帕霉素诱导的细胞自噬只能停留在G1期,所以酿酒酵母perisister与自噬状态存在区别。目前,对于Persister的研究集中在原核微生物,对真核生物persister的研究非常有限。由于persister群体通常占总群体极小一部分,这就给基因水平上研究persister的形成机制带来很大的挑战。本研究发现肉桂醛处理酿酒酵母细胞后,可以促使其大部分细胞形成persister。这就为从基因水平上认识真核生物persister的形成机制提供了方法,实验结果表明YGL基因也与酿酒酵母persister的形成有很大关系。
基金supported by the National Natural Science Foundation of China(Grant No.82172464,82172453,81972086)National Key Research and Development Project of China(Grant No.2020YFC1107500,2020YFC1107503)+4 种基金The Shanghai Rising-Star Program(21QA1405500)Shanghai“Rising Stars of Medical Talent”Youth Development Program(Youth Medical Talents-Specialist Program)(Grant No.2019-72)“Technology Innovation Action Plan”Key Project of Shanghai Science and Technology Commission(Grant No.19411962800)Shanghai municipal education commission-Gaofeng clinical medicine grant support(Grant No.20161423)NSFC Advancing Targeted Projects(RJTJ-JX-005,RJTJ22-RC-011).
文摘Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chronic implant infections in clinical,only few drugs are effective in clearing persisters and formed biofilms.Here,felodipine,a dihydropyridine calcium channel blocker,was reported for the first time to have antibacterial effects against MRSA,biofilm,and persisters.Even after continuous exposure to sub-lethal concentrations of felodipine,bacteria are less likely to develop resistance.Besides,low doses of felodipine enhances the antibacterial activity of gentamicin by inhibiting the expression of protein associated with aminoglycoside resistance(aacA-aphD).Next,biofilm eradication test and persisters killing assay suggested felodipine has an excellent bactericidal effect against formed biofilms and persisters.Furthermore,the result of protein profiling,and quantitative metabonomics analysis indicated felodipine reduce MRSA virulence(agrABC),biofilm formation and TCA cycle.Then,molecular docking showed felodipine inhibit the growth of persisters by binding to the H pocket of ClpP protease,which could lead to substantial protein degradation.Furthermore,murine infection models suggested felodipine in combination with gentamicin alleviate bacterial burden and inflammatory response.In conclusion,low dose of felodipine might be a promising agent for biomaterial delivery to enhance aminoglycosides efficacy against implant infections caused by MRSA,biofilm,and persisters.
文摘Glioblastoma(GBM)represents the main form of brain tumors in adults,and one of the most aggressive cancers overall.The treatment of GBM is a combination of surgery(when possible),chemotherapy(usually Temozolomide,TMZ)and radiotherapy(RT).However,despite this heavy treatment,GBM invariably recur and the median length of survival following diagnosis is 12 to 15 months,with less than 10%of people surviving longer than five years.GBM is extremely resistant to most treatments because of its heterogeneous nature,which is associated with extreme clonal plasticity and the presence of cancer stem cells,refractory to TMZ-and RT-induced cell death.In this review,we explore the mechanisms by which cancer cells,and especially GBM,can acquire resistance to treatment.We describe and discuss the concept of persister/tolerant cells that precede and/or accompany the acquisition of resistance.Persister/tolerant cells are cancer cells that are not eliminated by treatment(s)because of different mechanisms ranging from dormancy/quiescence to senescence.We discuss the possibility of targeting these mechanisms in new therapeutic regimen.
基金Supported by the National Natural Science Foundation of China(No.82070942,No.81970780,No.81770907,No.81670835).
文摘AIM:To characterize the distribution of persistent fetal vasculature(PFV)subtypes and to evaluate corneal astigmatism(CA)in children with unilateral PFV.METHODS:The medical records of patients diagnosed with PFV between January 2014 and August 2021 were retrospectively reviewed.Corneal keratometry parameters were measured using IOLMaster or a handheld keratometer.Differences in CA between the affected and fellow eyes were analyzed in 52 unilateral PFV patients with available examination data.RESULTS:Totally 133 patients diagnosed with PFV were retrospectively reviewed.The male-to-female ratio was 73/60.Median age at surgery was 38.03mo(interquartile range 58.27mo).Among the PFV patients,32(24.06%)had anterior PFV,2(1.50%)had posterior PFV,and 99(74.44%)had combined anterior-posterior PFV.Mild combined PFV was the most common subtype.In unilateral PFV cases,the mean CA in the affected eye was 2.29±1.11 D,and 59.62%(31 eyes)had CA≥2.0 D.The mean CA in the affected eyes was significantly higher than in the fellow eyes(1.37±0.77 D;P<0.001).Among PFV-affected eyes with CA≥2.0 D,the steepest corneal meridian was vertically oriented in 30 cases(96.77%),while only 1 case(3.23%)had the steepest meridian oriented horizontally.CONCLUSION:In children with unilateral PFV,CA is significantly higher in the affected eyes than in the fellow eyes,and the steepest corneal meridian was predominantly oriented vertically.
基金supported by the Zhongyuan University of Technology Discipline Backbone Teacher Support Program Project(No.GG202417)the Key Research and Development Program of Henan under Grant 251111212000.
文摘Lateral movement represents the most covert and critical phase of Advanced Persistent Threats(APTs),and its detection still faces two primary challenges:sample scarcity and“cold start”of new entities.To address these challenges,we propose an Uncertainty-Driven Graph Embedding-Enhanced Lateral Movement Detection framework(UGEA-LMD).First,the framework employs event-level incremental encoding on a continuous-time graph to capture fine-grained behavioral evolution,enabling newly appearing nodes to retain temporal contextual awareness even in the absence of historical interactions and thereby fundamentally mitigating the cold-start problem.Second,in the embedding space,we model the dependency structure among feature dimensions using a Gaussian copula to quantify the uncertainty distribution,and generate augmented samples with consistent structural and semantic properties through adaptive sampling,thus expanding the representation space of sparse samples and enhancing the model’s generalization under sparse sample conditions.Unlike static graph methods that cannot model temporal dependencies or data augmentation techniques that depend on predefined structures,UGEA-LMD offers both superior temporaldynamic modeling and structural generalization.Experimental results on the large-scale LANL log dataset demonstrate that,under the transductive setting,UGEA-LMD achieves an AUC of 0.9254;even when 10%of nodes or edges are withheld during training,UGEA-LMD significantly outperforms baseline methods on metrics such as recall and AUC,confirming its robustness and generalization capability in sparse-sample and cold-start scenarios.
基金We acknowledge the support by Zhejiang Provincial Natural Science Foundation of China(LY24H290004)National Natural Science Foundation of China Youth Foundation(81701969)+4 种基金Natural Science Youth Exploration Program(2022JKZKTS03)Open fund for the State Key Laboratory of Pathogenic Biology of Animal Diseases(SKLVEB2021KFKT002)for HXNNational Center for Infectious Disease startup fund(B2022011-1)Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2021R01012)Jinan Microecological Biomedicine Shandong Laboratory project(UNL-2022050B)for YZ.
文摘Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation conditions.These cells can regrow after stress removal and remain susceptible to the same stress.Persisters are underlying the problems of treating chronic and persistent infections and relapse infections after treatment,drug resistance development,and biofilm infections,and pose significant challenges for effective treatments.Understanding the characteristics and the exact mechanisms of persister formation,especially the key molecules that affect the formation and survival of the persisters is critical to more effective treatment of chronic and persistent infections.Currently,genes related to persister formation and survival are being discovered and confirmed,but the mechanisms by which bacteria form persisters are very complex,and there are still many unanswered questions.This article comprehensively summarizes the historical background of bacterial persisters,details their complex characteristics and their relationship with antibiotic tolerant and resistant bacteria,systematically elucidates the interplay between various bacterial biological processes and the formation of persister cells,as well as consolidates the diverse anti-persister compounds and treatments.We hope to provide theoretical background for in-depth research on mechanisms of persisters and suggest new ideas for choosing strategies for more effective treatmentofpersistent infections.
基金supported by the National Natural Science Foundation of China(Nos.42077299,and U21A20290)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750400)the Ordos Key Research and Development Program(No.YF20240037).
文摘Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.
基金Project supported by the National Natural Science Foundation of China(52372134,12274023)the Fundamental Re search Funds for the Central Universities(FRF-EYIT-23-04)。
文摘Rare earth-doped inorganic compounds contribute mostly to the family of persistent luminescent materials due to the versatile energy levels of rare earth ions.One of the key research aims is to match the trap level stemming from the doped rare earth ion or intrinsic defects to the electronic structure of the host,and therefore thermoluminescence measurement becomes a radical technology in studying trap depth,which is one of the significant parameters that determine the properties of persistent luminescence and photostimulated luminescence.However,the results of trap depth obtained by different thermoluminescence methods are quite different so that they are not comparable.Herein,we analyzed different thermoluminescence methods,selected and improved the traditional peak position method of T_(m)/500 to be E=(-0.94Inβ+30.09)kT_(m).Only the experimental heating rate(β)is needed additionally,but the accuracy is improved greatly in most cases.This convenient and accurate method will accelerate the discovery of novel rare earth-doped materials.
文摘Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.
基金Supported by National Natural Science Foundation of China(61911530398,12231012)Consultancy Project by the Chinese Academy of Engineering(2022-JB-06,2023-JB-12)+3 种基金the Natural Science Foundation of Fujian Province of China(2021J01621)Special Projects of the Central Government Guiding Local Science and Technology Development(2021L3018)Royal Society of Edinburgh(RSE1832)Engineering and Physical Sciences Research Council(EP/W522521/1).
文摘A stochastic epidemic model with two age groups is established in this study,in which the susceptible(S),the exposed(E),the infected(I),the hospitalized(H)and the recovered(R)are involved within the total population,the aging rates between two age groups are set to be constant.The existence-and-uniqueness of global positive solution is firstly showed.Then,by constructing several appropriate Lyapunov functions and using the high-dimensional Itô’s formula,the sufficient conditions for the stochastic extinction and stochastic persistence of the exposed individuals and the infected individuals are obtained.The stochastic extinction indicator and the stochastic persistence indicator are less-valued expressions compared with the basic reproduction number.Meanwhile,the main results of this study are modified into multi-age groups.Furthermore,by using the surveillance data for Fujian Provincial Center for Disease Control and Prevention,Fuzhou COVID-19 epidemic is chosen to carry out the numerical simulations,which show that the age group of the population plays the vital role when studying infectious diseases.
基金Supported by The National Natural Science Foundation of China,No.82072130Key Medical Research Projects in Jiangsu Province,No.ZD2022021Suzhou Clinical Medical Center for Anesthesiology,No.Szlcyxzxj202102。
文摘BACKGROUND Hypernatremia represents a significant electrolyte imbalance associated with numerous adverse outcomes,particularly in cases of intensive care unit(ICU)-acquired hypernatremia(IAH).Nevertheless,its relevance in patients with septic shock remains uncertain.AIM To identify independent risk factors and their predictive efficacy for IAH to improve outcomes in patients with septic shock.METHODS In the present retrospective single-center study,a cohort of 157 septic shock patients with concurrent hypernatremia in the ICU at The First Affiliated Hospital of Soochow University,between August 1,2018,and May 31,2023,were analyzed.Patients were categorized based on the timing of hypernatremia occurrence into the IAH group(n=62),the non-IAH group(n=41),and the normonatremia group(n=54).RESULTS In the present study,there was a significant association between the high serum sodium concentrations,excessive persistent inflammation,immunosuppression and catabolism syndrome and chronic critical illness,while rapid recovery had an apparent association with normonatremia.Moreover,multivariable analyses revealed the following independent risk factors for IAH:Total urinary output over the preceding three days[odds ratio(OR)=1.09;95%CI:1.02–1.17;P=0.014],enteral nutrition(EN)sodium content of 500 mg(OR=2.93;95%CI:1.13–7.60;P=0.027),and EN sodium content of 670 mg(OR=6.19;95%CI:1.75–21.98;P=0.005)were positively correlated with the development of IAH.Notably,the area under the curve for total urinary output over the preceding three days was 0.800(95%CI:0.678–0.922,P=0.001).Furthermore,maximum serum sodium levels,the duration of hypernatremia,and varying sodium correction rates were significantly associated with 28-day in-hospital mortality in septic shock patients(P<0.05).CONCLUSION The present findings illustrate that elevated serum sodium level was significantly associated with a poor prognosis in septic shock patients in the ICU.It is highly recommended that hypernatremia be considered a potentially important prognostic indicator for the outcome of septic shock.
基金National Key R&D Program of China(2023YFB3506600)。
文摘Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+),Cr^(3+)(YAGG:Ce^(3+),Cr^(3+)),as a persistent luminescent material,has advantages of high initial luminescence intensity and long persistent time,which is promising in persistent luminescent material applications.At present,YAGG:Ce^(3+),Cr^(3+)powders exhibit good persistent performance,but their persistent performance of ceramics still needs to be further improved to meet the new requirements.In this work,(Y_(0.998)Ce_(0.002))_(3)(Al_(1-x)Cr_(x))_(2)Ga_(3)O_(12) ceramics with different Cr^(3+)doping concentrations were prepared by solid-state reaction,including air pre-sintering,hot isostatic pressing(HIP)post-treatment and air annealing,to investigate the effects of Cr^(3+)doping concentration on the microstructure,optical properties and persistent performance of the ceramics.The results showed that as the doping concentration of Cr^(3+)increased from 0.025%to 0.2%(in atom),no significant effect of Cr^(3+)concentration on the morphology of pre-sintered ceramics or HIP post-treatment ceramics was observed,but the in-line transmittance gradually increased while the persistent performance gradually decreased.Among them,YAGG:Ce^(3+),Cr^(3+)ceramics doped with 0.025%Cr^(3+)showed the strongest initial luminescence intensity exceeding 6055 mcd/m^(2) and a persistent time of 1030 min after air pre-sintering combined with HIP post-treatment and air annealing.By optimizing the Cr^(3+)doping concentration and the fabrication process,the persistent luminescence(PersL)performance of the YAGG:Ce^(3+),Cr^(3+)ceramics was obviously improved.
基金supported by the Major Research Plan of the National Natural Science Foundation of China(No.92361202)National Natural Science Foundation of China(No.12204481).
文摘Persistent luminescence is a unique optical phenomenon that continues to emit light for minutes or even hours after the excitation stops,which can significantly enhance the sensitivity and signal-to-noise ratio of imaging[1].Among numerous persistent luminescence materials,lanthanide-doped fluoride nanoparticles have shown tunable persistent luminescence across the UV-vis-NIR spectrum(200-1700 nm)under X-ray excitation and adjustable size,promising significant applications in deep-tissue imaging[2,3],security encryption,and data storage[4].In particular,those exhibiting NIR-II luminescence(1000-1700 nm)provide key advantages such as deeper tissue penetration,higher contrast,and minimal interference from biological autofluorescence.However,challenges such as low brightness and rapid signal decay,especially in the NIR-II region,limit their effectiveness in long-term monitoring,including tumor theranostics[5].Traditional approaches like size control and surface passivation yield only marginal improvements,underscoring the need for next-generation nanoparticles with superior NIR-II brightness.
基金supported by the Russian Science Foundation (Grant No. 22-12-00298)supported by the Center of Excellence "Center of Photonics" funded by the Ministry of Science and Higher Education of the Russian Federation, Contract #075-15-2022-316the Theoretical Physics and Mathematics Advancement Foundation "BASIS" scholarship for the support.
文摘In this work,we studied the persistent photoconductivity(PPC)spectra in single HgTe/CdHgTe quantum wells with different growth parameters and different types of dark conductivity.The studies were performed in a wide radiation quantum energy range of 0.62–3.1 eV both at T=4.2 K and at T=77 K.Common features of the PPC spectra for all structures were revealed,and their relation to the presence of a CdTe cap layer in all structures and the appropriate cadmium fraction in the CdHgTe barrier layers was shown.One of the features was associated with the presence of a deep level in the CdTe layer.In addition,the oscillatory behavior of the PPC spectra in the region from 0.8–1.1 eV to 1.2–1.5 eV was observed.It is associated with the cascade emission of longitudinal optical phonons in CdHgTe barrier.
基金Supported by the Key Medical Research Project of Hebei Province in 2020,No.20201360.
文摘BACKGROUND Postpartum depression(PPD)represents a significant public health concern,adversely affecting both new mothers and their infants.Despite routine early screening,PPD can persist beyond the initial postpartum months,with notably high incidence rates even one year after childbirth.Persistent PPD has been associated with poor developmental outcomes in infants,highlighting the need for continued monitoring and support during this critical period.Understanding the broader impacts of persistent PPD is essential for developing effective interventions to improve maternal and infant well-being.AIM To explore the impact of persistent PPD on infant developmental behavior and maternal self-efficacy.METHODS We recruited 60 postpartum women who experienced persistent depression after childbirth in our hospital from January 2020 to December 2024 as the research subjects.The study collected basic characteristics of both infants and mothers,analyzed the self-efficacy of the mothers and the developmental behaviors of the infants,and conducted a correlation analysis to examine the relationship between postpartum persistent depression in mothers and the developmental behaviors and self-efficacy of infants.The Bootstrap method was used to verify the significance of the mediating effect.RESULTS The basic characteristics of infants and mothers show that 53.33%are male,58.33%are born via vaginal delivery,88.33%have a normal body mass index,51.67%are aged between 25 and 29 years,70%are non-agricultural workers,51.67%have a per capita household income over 4000 yuan,96.67%are full-term births,and 58.33%of the fathers are aged between 26 and 32 years.In terms of infant development behavior,the gross motor skills score is relatively low(38.44±12.15).Regarding maternal self-efficacy,the skill score(45.68±5.49)and mental activity score(46.37±3.72)are both at a low level.Correlation analysis reveals that postpartum persistent depression is significantly negatively correlated with maternal self-efficacy and infant development behavior(β=-0.439,-0.657,P<0.001),while self-efficacy is positively correlated with infant development behavior(β=0.728,P<0.001).The path coefficient and Bootstrap method test indicate that self-efficacy acts as a mediator between postpartum persistent depression and infant development behavior,accounting for 54.80%of the effect(P<0.05),while the direct effect of postpartum persistent depression on infant development behavior is 45.20%(P<0.05).CONCLUSION Persistent PPD significantly negatively impacts infant developmental outcomes,with maternal self-efficacy serving as a partial mediator.These findings suggest that interventions targeting both depressive symptoms and selfenhancement may effectively promote infant health development.
文摘Persistent left superior vena cava(PLSVC)is a congenital anomaly where the left-sided vena cava,which usually regresses during fetal development,persists.Double superior vena cava resulting from a PLSVC is indeed a rare phenomenon.In the general population,the incidence of this condition is reported to be between 0.3%and 2.1%.[1]While this anatomical variation is often asymptomatic and discovered incidentally,it becomes relevant in certain clinical scenarios.Indeed,the presence of a PLSVC and double superior vena cava can pose challenges as incorrect positioning and result in failure.
基金supported by grants from the National Key R&D Program of China(grant number 2021YFD1400900)the National Natural Science Foundation of China(grant numbers U1905201,32171805)+6 种基金the Forestry Key Program of Science and Technology in Fujian Province(grant number 2021FKJ03)the Natural Science Foundation of Fujian Province,China(grant number 2021J01056)the Forestry Programs of Science and Technology in Fujian Province[grant number Mincaizhi(2020)601]the Science and Technology Program of Fujian Province(grant number 2018N5002)the Forestry Science Research Project of Fujian Forestry Department[grant number Minlinke(2017)03]the National Major Emergency Science and Technology Program of China(grant number ZD202001)the Forestry Peak Discipline Construction Project of Fujian Agriculture and Forestry University(grant numbers 72202200205,71201800720).
文摘The effectiveness of fluopyram suspension concentrate against pine wilt disease(PWD)is limited by spraying efficiency and water dependence.A traditional dust formulation with strong dispersibility can overcome these shortcomings.However,its efficacy against PWD remains uncertain.This study evaluated the translocation of fluopyram dust within tree tissues,soil and water degradation,and its effective control against PWD.Nursery tests showed effective prevention;field tests showed dust absorption and translocation into pine tissues.Thirty days following application,residual concentrations in soil were low at 0.09 mg kg^(−1);no detectable residues were found in water samples.Three years after applying fluopyram,its effectiveness increased to approximately 87%.Based on this study,fluopyram had a half-life of 346 d with persistence lasting up to three years.This provides valuable insight for managing PWD through dust applications.
基金financial support provided by the Valencian Regional Governement(Grant No.CIPROM2023/037)Davide Palma and Alessandra Bianco Prevot acknowledge support from the Project CH4.0 under the MUR program"Dipartimenti di Eccellenza 2023-2027"(Grant No.CUP:D13C22003520001).
文摘Artificial intelligence(AI)is a revolutionizing problem-solver across various domains,including scientific research.Its application to chemical processes holds remarkable potential for rapid optimization of protocols and methods.A notable application of AI is in the photoFenton degradation of organic compounds.Despite the high novelty and recent surge of interest in this area,a comprehensive synthesis of existing literature on AI applications in the photo-Fenton process is lacking.This review aims to bridge this gap by providing an in-depth summary of the state-of-the-art use of artificial neural networks(ANN)in the photo-Fenton process,with the goal of aiding researchers in the water treatment field to identify the most crucial and relevant variables.It examines the types and architectures of ANNs,input and output variables,and the efficiency of these networks.The findings reveal a rapidly expanding field with increasing publications highlighting AI's potential to optimize the photo-Fenton process.This review also discusses the benefits and drawbacks of using ANNs,emphasizing the need for further research to advance this promising area.
文摘Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm(GKPA).Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network,and to identify high knowledge persistent patents(HKPP)of ginsenoside technology based on the GKPA,and extract its high knowledge persistence main path(HKPMP).Finally,the genetic forward and backward path(GFBP)was used to search the nodes on the main path,and draw the genetic forward and backward main path(GFBMP)of ginsenoside technology.Results and Conclusion The algorithm was applied to the field of ginsenosides.The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies,which points out the future direction for the technological development of ginsenosides.The results obtained by this algorithm are more interpretable,comprehensive and scientific.
