This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progressi...This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progression.A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were included.Patients were divided into two groups according to the median value of PPFT:high(PPFT>4.35 mm)PPFT group and low(PPFT<4.35 mm)PPFT group.After the initial evaluation,all patients received a combination drug treatment of tamsulosin and finasteride for 12 months.Of the 286 enrolled patients,244 completed the drug treatment course.Patients with high PPFT had larger prostate volume(PV;P=0.013),higher International Prostate Symptom Score(IPSS;P-0.008),and lower five-item version of the International Index of Erectile Function(IIEF-5)score(P=0.002)than those with low PPFT.Both high and low PPFT groups showed significant improvements in PV,maximum flow rate,IPSS,and quality of life score and a decrease of IIEF-5 score after the combination drug treatment.The decrease of IIEF-5 score was more obvious in the high PPFT group than that in the low PPFT group.In addition,more patients in the high PPFT group underwent prostate surgery than those in the low PPFT group.Moreover,Pearson’s correlation coefficient analysis indicated that PPFT was positively correlated with age,PV,and IPSS and negatively correlated with IIEF-5 score;however,body mass index was only negatively correlated with IIEF-5 score.展开更多
The prevalence of overweight and obesity and their health-related problems have been increasing.Obesity is increasingly recognized as a risk factor in different types of cancer in humans.The mechanisms supporting the ...The prevalence of overweight and obesity and their health-related problems have been increasing.Obesity is increasingly recognized as a risk factor in different types of cancer in humans.The mechanisms supporting the link between obesity and cancer development have not been fully understood.Leptin,a circulating cytokine produced by adipocytes,may influence prostate cancer(PCa)progression in different ways.Body mass index seems to be an unreliable predictor for the development of PCa,but its influence on progression and poor oncological outcomes seems to be clear.Given the fact that abdominal fat is the most metabolically active fat,with different metabolic and paracrine effects,related anthropometric measurements may lead to a better estimation of PCa risk.Metabolically active periprostatic abdominal fat may also play an important role in releasing cytokines and growth factors that may promote tumor cell proliferation or even create a favorable environment for aggressive tumor biology.Different imaging measurements,e.g.,periprostatic adipose tissue(PPAT)thickness,may be significant predictors of PCa.Several genes in the PPAT of obese men have been identified to contribute to chronic immuno-inflammatory responses which eventually lead to cell cycle alterationwith oncological potential.In vitro studies showed the importance of PCa and its interaction with its microenvironment particularly in patients with aggressive PCa.Different types of cytokines,such as interleukin-6,may promote a tumorigenic microenvironment.This article endeavors to review the current literature on the association of PPAT with aggressive tumor biology in PCa.展开更多
文摘This study investigated the correlation between periprostatic fat thickness(PPFT)measured on magnetic resonance imaging and lower urinary tract symptoms,erectile function,and benign prostatic hyperplasia(BPH)progression.A total of 286 treatment-naive men diagnosed with BPH in our department between March 2017 and February 2019 were included.Patients were divided into two groups according to the median value of PPFT:high(PPFT>4.35 mm)PPFT group and low(PPFT<4.35 mm)PPFT group.After the initial evaluation,all patients received a combination drug treatment of tamsulosin and finasteride for 12 months.Of the 286 enrolled patients,244 completed the drug treatment course.Patients with high PPFT had larger prostate volume(PV;P=0.013),higher International Prostate Symptom Score(IPSS;P-0.008),and lower five-item version of the International Index of Erectile Function(IIEF-5)score(P=0.002)than those with low PPFT.Both high and low PPFT groups showed significant improvements in PV,maximum flow rate,IPSS,and quality of life score and a decrease of IIEF-5 score after the combination drug treatment.The decrease of IIEF-5 score was more obvious in the high PPFT group than that in the low PPFT group.In addition,more patients in the high PPFT group underwent prostate surgery than those in the low PPFT group.Moreover,Pearson’s correlation coefficient analysis indicated that PPFT was positively correlated with age,PV,and IPSS and negatively correlated with IIEF-5 score;however,body mass index was only negatively correlated with IIEF-5 score.
文摘The prevalence of overweight and obesity and their health-related problems have been increasing.Obesity is increasingly recognized as a risk factor in different types of cancer in humans.The mechanisms supporting the link between obesity and cancer development have not been fully understood.Leptin,a circulating cytokine produced by adipocytes,may influence prostate cancer(PCa)progression in different ways.Body mass index seems to be an unreliable predictor for the development of PCa,but its influence on progression and poor oncological outcomes seems to be clear.Given the fact that abdominal fat is the most metabolically active fat,with different metabolic and paracrine effects,related anthropometric measurements may lead to a better estimation of PCa risk.Metabolically active periprostatic abdominal fat may also play an important role in releasing cytokines and growth factors that may promote tumor cell proliferation or even create a favorable environment for aggressive tumor biology.Different imaging measurements,e.g.,periprostatic adipose tissue(PPAT)thickness,may be significant predictors of PCa.Several genes in the PPAT of obese men have been identified to contribute to chronic immuno-inflammatory responses which eventually lead to cell cycle alterationwith oncological potential.In vitro studies showed the importance of PCa and its interaction with its microenvironment particularly in patients with aggressive PCa.Different types of cytokines,such as interleukin-6,may promote a tumorigenic microenvironment.This article endeavors to review the current literature on the association of PPAT with aggressive tumor biology in PCa.
