Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an un...Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure.Periplocymarin is a secondary alpha cardiac glycoside,which is produced by removing one molecule of glucose from periplocin,and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.These three cardiac glycosides,by virtue of their unique pharmacological activities and mechanisms of action,mediate signaling pathways,mainly the retinoblastoma and p53 signaling pathways,and regulate cell cycle proteins,thereby hindering the proliferation of cancer cells and altering the cell cycle process.These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways,thereby inducing the apoptosis of cancer cells.This minireview focuses on the inhibitory effects of periplocin,periplocymarin and periplogenin on cancer,and explores their potential antitumor mechanisms.展开更多
基金Supported by Traditional Chinese Medicine Science and Technology Project of Shandong Province,China,No.M-2023131The Science and Technology Development Fund Project of the Affiliated Hospital of Xuzhou Medical University,China,No.XYFM202348.
文摘Periplocin,periplocymarin and periplogenin are the main active components of Cortex Periplocae.The most cytotoxic constituent of Cortex Periplocae,periplocin is an alpha cardiac glycoside with a steroid core and an unsaturated five-membered lactone ring structure.Periplocymarin is a secondary alpha cardiac glycoside,which is produced by removing one molecule of glucose from periplocin,and periplogenin is the glycosidic portion and the basic unit of periplocin and periplocymarin.These three cardiac glycosides,by virtue of their unique pharmacological activities and mechanisms of action,mediate signaling pathways,mainly the retinoblastoma and p53 signaling pathways,and regulate cell cycle proteins,thereby hindering the proliferation of cancer cells and altering the cell cycle process.These glycosides also regulate caspase proteins by mediating endogenous and exogenous pathways,thereby inducing the apoptosis of cancer cells.This minireview focuses on the inhibitory effects of periplocin,periplocymarin and periplogenin on cancer,and explores their potential antitumor mechanisms.
