The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitte...The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.展开更多
Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July ...Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July 2024 to July 2025 were selected and randomly divided into the experimental group and the control group,with 34 cases in each group.The control group received routine blood glucose management,while the experimental group,on this basis,implemented individualized intervention 3 days before the operation,real-time regulation during the operation,dynamic management 7 days after the operation,and self-management training.Result:The blood glucose control in the experimental group was more stable 7 days after the operation.The total incidence of complications(2.9%)was significantly lower than that in the control group(38.2%),and the average hospital stay(5.1±1.0 days)was shorter than that in the control group(7.3±1.4 days).One week after the operation,the proportions of uncorrected visual acuity and visual acuity≥0.6(67.6%)were both better than those of the control group(p<0.001).Conclusion:The whole-course management of perioperative blood glucose can enhance the stability of blood glucose control,reduce the risk of complications,shorten the length of hospital stay,promote visual recovery,and has high clinical promotion value.展开更多
The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccin...The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccines.Taking these key elements into consideration,an almost periodic SVEIR warning model in the patch environment is here proposed.First,in terms of reproduction numbers,our results imply that if the effective reproduction numbers are R_(e)<1,then the disease dies out;if R_(e)>1,then the disease spreads and leads to local outbreaks.Second,the relationships between R_(e)and C_(s1),C_(a1)(see Section 2)are given by numerical simulations.The numerical results show that even if all people are vaccinated,NPIs are still needed because of the potentially low efficacy of vaccines.Furthermore,the numerical results suggest that NPIs and the strengthening of the effective rate of vaccination are essential in order to achieve herd immunity.Theories involving this model effectively explain the transmission mechanism of most infectious diseases,and provide a valuable theoretical basis for analyzing new infectious diseases in the future.Moreover,this model is helpful for the prevention and control of infectious diseases and the formulation of public health safety policies.展开更多
Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before...Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before surgery to 1 day after surgery),and to provide a basis for optimizing clinical nursing plans for elderly cataract surgery.Methods:A retrospective selection of 90 elderly patients(aged≥60 years)who underwent cataract surgery in the Ophthalmology Department of our hospital from August 2024 to December 2024 was conducted.They were divided into an observation group(n=45)and a control group(n=45)using a random number table method.The control group received routine nursing for cataract surgery,while the observation group implemented evidence-based predictive nursing intervention(including the establishment of a multidisciplinary evidence-based team,hierarchical psychological intervention,perioperative environment optimization,intraoperative personalized cooperation,and video-based health education).Psychological stress indicators[Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),General Self-Efficacy Scale(GSES)]on the 1st day before surgery and 1st day after surgery,and fluctuations of physiological indicators[Heart Rate(HR),Systolic Blood Pressure(SBP),Diastolic Blood Pressure(DBP)]on the 1st day before surgery and during surgery were compared between the two groups.Results:Before intervention,there were no statistically significant differences in SAS,SDS,GSES scores,HR,SBP,or DBP between the two groups(p>0.05);after intervention,the SAS score(33.62±5.72)and SDS score(32.14±4.86)of the observation group on the 1st day after surgery were significantly lower than those of the control group[(41.05±5.56),(43.59±4.75)],and the GSES score(31.15±3.28)was significantly higher than that of the control group(24.84±3.52)(all p<0.05);during surgery,the fluctuations of HR(74.0±6.0)beats/min,SBP(127.0±15.8)mmHg,and DBP(75.0±5.9)mmHg in the observation group were significantly smaller than those in the control group(all p<0.05).Conclusion:Evidence-based predictive nursing intervention can effectively alleviate anxiety and depression in elderly cataract patients during the perioperative period,improve self-efficacy,stabilize intraoperative physiological status,and enhance surgical cooperation,which is worthy of clinical promotion.展开更多
This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the...This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.展开更多
Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we sy...Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we systematically investigate the structure-activity relationship of four representative Fe-based metal-organic frameworks(Fe-MOFs)-MIL-101(Fe),MIL-88B(Fe),MIL-88A(Fe),and MIL-53(Fe)-as PI activators for tetracycline(TC)degradation.Among them,MIL-101(Fe)exhibited the highest catalytic performance,owing to its unique Fe3O-OH nodes and mesoporous architecture.The MIL-101(Fe)/PI system achieved 93.3%TC degradation and 55.9%mineralization rate within 60 min.Mechanistic studies combining scavenger quenching,sulfoxide probe transformation,X-ray photoelectron spectroscopy,and X-ray absorption fine structure confirmed the generation of multiple reactive oxygen species,and high-valent Fe(IV)]O and O_(2)^(·-)played major roles in the tetracycline degradation process.Density functional theory calculations further revealed that MIL-101(Fe)and MIL-88B(Fe)effectively interact with PI to form Fe(Ⅲ)-superoxide(Fe(Ⅲ)-O-O^(·-)),a key intermediate in Fe(IV)]O generation.In contrast,the adsorption energy of MIL-53(Fe)and MIL-88A(Fe)was relatively weak,with fewer binding sites,resulting in poor performance.The synergy between Fe(Ⅲ)-O-O^(·-)formation and the pore accessibility of MIL-101(Fe)accounted for its superior catalytic efficiency.This work not only clarifies the structural factors governing PI activation in Fe-MOFs,but also proposes a mechanistically informed strategy for designing high-performance catalysts for antibiotic degradation.展开更多
In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of t...In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of the considered neural networks with more relaxed conditions imposed on the amplification functions is analyzed by using set-valued mapping and Kakutani's fixed point theorem,which has rarely been used to study such problem.Secondly,the fixed-time synchronization of the error system of the considered neural networks is also investigated by designing a novel control strategy,which can improve not only the previous ones with sign function greatly,but also can reduce the chattering phenomenon.Finally,two numerical examples are presented to further illustrate the validity of the obtained results.展开更多
We used hydrodynamic simulations and shock wave propagation theories to analyze the behavior of shock waves within Ti/Pt periodically modulated graded structures and their integration layers.The effects of the total n...We used hydrodynamic simulations and shock wave propagation theories to analyze the behavior of shock waves within Ti/Pt periodically modulated graded structures and their integration layers.The effects of the total number of periodic layers,the total thickness of graded materials and loading velocity on the integration layer thickness and behavior of pressure-strain rate were systematically investigated.The results reveal that,by adjusting the total number of periodically modulated layers,the total thickness of graded materials and loading velocity the pressure amplitudes of the reflected compressive and rarefaction waves at different interfaces of Ti/Pt periodically modulated graded materials can be precisely controlled.Furthermore,empirical structural design criteria for Ti/Pt periodically modulated graded materials are established.The thickness ratio variation between adjacent Ti/Pt layers in the periodic structure must exceed 0.32.After the collaborative design of the integration layer,Ti/Pt periodically modulated graded materials can achieve a controllable loading function with pressures ranging from 1.4 to 144 GPa and strain rates from 3.8×10^(4) to 1.7×10^(7) s^(–1).The outcomes of this research provide a theoretical and simulation basis for the optimized design of periodically modulated graded materials to be utilized in ramp compression experiments.展开更多
To investigate the eco-economic thresholds of weeds and the critical period for their control,combining economic and ecological perspectives to achieve scientific weed management,four dominant weeds,Echinochloa crus-g...To investigate the eco-economic thresholds of weeds and the critical period for their control,combining economic and ecological perspectives to achieve scientific weed management,four dominant weeds,Echinochloa crus-galli(L.)P.Beauv,Chenopodium album L.,Digitaria sanguinalis(L.)Scop,and Commelina communis L.,were selected as experimental subjects,based on their common occurrence in spring maize planting areas in Northern China.A predictive model for maize yield loss caused by mixed weed populations was established.The study analyzed the eco-economic thresholds of weeds under different control measures and determined the optimal period for weed control by combining the critical control period.A logarithmic function model was developed to describe the relationship between mixed weed density and maize yield loss:y=5.9875ln(x)-6.5407(R^(2)=0.949,F=131.244,P=0.000).The optimal model for the critical period of competition between weeds and maize in maize fields was:y=-0.0027x^(2)+0.5624x-10.064(R2=0.968,F=30.513,P=0.032).When the weed density in maize fields reached 5.57 plants·m^(-2),manual weeding should be conducted promptly.When the weed density was 3.41 plants·m^(-2) or 3.48 plants·m^(-2),soil or foliar treatments should be applied,respectively.If the weed density reached 3.93 plants·m^(-2),a combination of soil and foliar treatment should be implemented.The critical period for manual weeding was 28.4 days after sowing,for soil treatment it was 19.9 days,for foliar treatment it was 21.8 days,and for the combined treatment of soil and foliar methods,it was 23.5 days after sowing.Retaining weeds for up to 15 days after maize sowing did not result in a yield loss and could even have a positive effect on maize yield.展开更多
Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently so...Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently solving linear systems Aα=b.The objective of this paper is to provide one new iterative algorithm based on BCR method to find the symmetric periodic solutions of linear periodic matrix equations.This kind of periodic matrix equations has not been dealt with yet.This iterative method is guaranteed to converge in a finite number of steps in the absence of round-off errors.Some numerical results are performed to illustrate the efficiency and feasibility of new method.展开更多
Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the...Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.展开更多
Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift w...Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift work-related circadian disruption functions in periodontitis remains unknown.Herein,we employed a simulated shift work model constructed by controlling the environmental light-dark cycles and revealed that shift work-related circadian disruption exacerbated the progression of experimental periodontitis.RNA sequencing and in vitro experiments indicated that downregulation of the core circadian protein brain and muscle ARNT-like protein 1(BMAL1)and activation of the Gasdermin D(GSDMD)-mediated pyroptosis were involved in the pathogenesis of that.Mechanically,BMAL1 regulated GSDMD-mediated pyroptosis by suppressing NOD-like receptor protein 3(NLRP3)inflammasome signaling through modulating nuclear receptor subfamily 1 group D member 1(NR1D1),and inhibiting Gsdmd transcription via directly binding to the E-box elements in its promoter.GSDMD-mediated pyroptosis accelerated periodontitis progression,whereas downregulated BMAL1 under circadian disruption further aggravated periodontal destruction by increasing GSDMD activity.And restoring the level of BMAL1 by circadian recovery and SR8278 injection alleviated simulated shift work-exacerbated periodontitis via lessening GSDMD-mediated pyroptosis.These findings provide new evidence and potential interventional targets for circadian disruption-accelerated periodontitis.展开更多
In this paper, we investigate the pseudo almost periodicity of the unique bounded solution for a nonlinear hyperbolic equation with piecewise constant argument. The equation under consideration is a mathematical model...In this paper, we investigate the pseudo almost periodicity of the unique bounded solution for a nonlinear hyperbolic equation with piecewise constant argument. The equation under consideration is a mathematical model for the dynamics of gas absorption,展开更多
The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall hea...The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall health.Studies have demonstrated a significant association between aging and the dysfunction of neutrophils,critical cells in the early stages of periodontitis,and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion.Neutrophils differentiate and mature in the bone marrow before entering the circulation;during an infection,they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens.Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues.The impacts of aging on neutrophils'chemotaxis,anti-microbial function,cell activation,and lifespan result in impaired neutrophil functions and excessive neutrophil activation,which could influence periodontitis course.We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses.We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging.This review could help us better understand the pathogenesis of periodontitis,which could offer novel therapeutic targets for periodontitis.展开更多
The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits ...The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.展开更多
Phase classification has a clear guiding significance for the design of high entropy alloys.For mutually exclusive and non-mutually exclusive classifications,the composition descriptors,commonly used physical paramete...Phase classification has a clear guiding significance for the design of high entropy alloys.For mutually exclusive and non-mutually exclusive classifications,the composition descriptors,commonly used physical parameter descriptors,elemental-property descriptors,and descriptors extracted from the periodic table representation(PTR)by the convolutional neural network were collected.Appropriate selection among features with rich information is helpful for phase classification.Based on random forest,the accuracy of the four-label classification and balanced accuracy of the five-label classification were improved to be 0.907 and 0.876,respectively.The roles of the four important features were summarized by interpretability analysis,and a new important feature was found.The model extrapolation ability and the influence of Mo were demonstrated by phase prediction in(CoFeNiMn)_(1-x)Mo_(x).The phase information is helpful for the hardness prediction,the classification results were coupled with the PTR of hardness data,and the prediction error(the root mean square error)was reduced to 56.69.展开更多
BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue...BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.展开更多
The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding sto...The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.展开更多
With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation wind...With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation window period is crucial for navigating in the Arctic route,which is of great significance to the selection of the route and the optimization of navigation.This paper introduces the establishment of a risk index system,determination of risk index weight,establishment of a risk evaluation model,and prediction algorithm for the window period.In addition,data sources of both environmental factors and ship factors are introducted,and their shortcomings are analyzed,followed by introduction of various methods involved in window prediction and analysis of their advantages and disadvantages.The quantitative risk evaluation and window period algorithm can provide a reference for the research of polar navigation window period prediction.展开更多
基金supported by the Center for Cognition and Sociality,Institute for Basic Science(IBS)(IBS-R001-D2)(to WK).
文摘The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.
文摘Objective:To explore the intervention effect of comprehensive perioperative blood glucose management on patients with diabetes complicated with cataract surgery.Method:A total of 68 patients in our hospital from July 2024 to July 2025 were selected and randomly divided into the experimental group and the control group,with 34 cases in each group.The control group received routine blood glucose management,while the experimental group,on this basis,implemented individualized intervention 3 days before the operation,real-time regulation during the operation,dynamic management 7 days after the operation,and self-management training.Result:The blood glucose control in the experimental group was more stable 7 days after the operation.The total incidence of complications(2.9%)was significantly lower than that in the control group(38.2%),and the average hospital stay(5.1±1.0 days)was shorter than that in the control group(7.3±1.4 days).One week after the operation,the proportions of uncorrected visual acuity and visual acuity≥0.6(67.6%)were both better than those of the control group(p<0.001).Conclusion:The whole-course management of perioperative blood glucose can enhance the stability of blood glucose control,reduce the risk of complications,shorten the length of hospital stay,promote visual recovery,and has high clinical promotion value.
基金supported by the NSFC(11501269)and the Natural Science Foundation of Gansu Province(23JRRA1041).
文摘The outbreak of infectious diseases is the result of a combination of various factors,including season,the movement of individuals,non-pharmaceutical interventions(NPIs)and the effectiveness and availability of vaccines.Taking these key elements into consideration,an almost periodic SVEIR warning model in the patch environment is here proposed.First,in terms of reproduction numbers,our results imply that if the effective reproduction numbers are R_(e)<1,then the disease dies out;if R_(e)>1,then the disease spreads and leads to local outbreaks.Second,the relationships between R_(e)and C_(s1),C_(a1)(see Section 2)are given by numerical simulations.The numerical results show that even if all people are vaccinated,NPIs are still needed because of the potentially low efficacy of vaccines.Furthermore,the numerical results suggest that NPIs and the strengthening of the effective rate of vaccination are essential in order to achieve herd immunity.Theories involving this model effectively explain the transmission mechanism of most infectious diseases,and provide a valuable theoretical basis for analyzing new infectious diseases in the future.Moreover,this model is helpful for the prevention and control of infectious diseases and the formulation of public health safety policies.
基金Hospital Quality Management Research Fund Project of China Medical Quality Management Association(Project No.:YLZG202511)。
文摘Objective:To explore the impact of evidence-based predictive nursing intervention on psychological stress and physiological indicator stability of elderly cataract patients during the perioperative period(1 day before surgery to 1 day after surgery),and to provide a basis for optimizing clinical nursing plans for elderly cataract surgery.Methods:A retrospective selection of 90 elderly patients(aged≥60 years)who underwent cataract surgery in the Ophthalmology Department of our hospital from August 2024 to December 2024 was conducted.They were divided into an observation group(n=45)and a control group(n=45)using a random number table method.The control group received routine nursing for cataract surgery,while the observation group implemented evidence-based predictive nursing intervention(including the establishment of a multidisciplinary evidence-based team,hierarchical psychological intervention,perioperative environment optimization,intraoperative personalized cooperation,and video-based health education).Psychological stress indicators[Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),General Self-Efficacy Scale(GSES)]on the 1st day before surgery and 1st day after surgery,and fluctuations of physiological indicators[Heart Rate(HR),Systolic Blood Pressure(SBP),Diastolic Blood Pressure(DBP)]on the 1st day before surgery and during surgery were compared between the two groups.Results:Before intervention,there were no statistically significant differences in SAS,SDS,GSES scores,HR,SBP,or DBP between the two groups(p>0.05);after intervention,the SAS score(33.62±5.72)and SDS score(32.14±4.86)of the observation group on the 1st day after surgery were significantly lower than those of the control group[(41.05±5.56),(43.59±4.75)],and the GSES score(31.15±3.28)was significantly higher than that of the control group(24.84±3.52)(all p<0.05);during surgery,the fluctuations of HR(74.0±6.0)beats/min,SBP(127.0±15.8)mmHg,and DBP(75.0±5.9)mmHg in the observation group were significantly smaller than those in the control group(all p<0.05).Conclusion:Evidence-based predictive nursing intervention can effectively alleviate anxiety and depression in elderly cataract patients during the perioperative period,improve self-efficacy,stabilize intraoperative physiological status,and enhance surgical cooperation,which is worthy of clinical promotion.
文摘This study aims to explore the Qing court’s emphasis on traditional Chinese medicine(TCM)culture and technology,as well as the role of ingots as a carrier of imperial medical culture.By systematically sorting out the types,quantities,and shapes of medicinal ingots recorded in Huo Ji Dang(活计档Archives of Imperial Workshops)during the 13-year Yongzheng reign,and by combining these records with existing ingot-related molds,physical specimens,and other collections in the Palace Museum,this research finds that:the Yongzheng Emperor incorporated ingots into the production list of the Imperial Workshop and established standardized preparation procedures,making them a technical practice for displaying imperial power;the fixed system of rewarding ingots during the Dragon Boat Festival turned ingots into a product of Manchu-Han cultural integration and formed a custom;the evolution of ingot equipment was dynamically related to military activities in the mid-Qing dynasty,confirming its function in court politics;and the integration of the preparation and packaging process of ingots into the power operation system,and transforming TCM-related knowledge and technology into means of exercising power,constructed a materialized path for imperial power to regulate the bureaucratic system and social order.The conclusion reveals the inherent logic of the Qing court:establishing authoritative identity through material culture.
基金National Natural Science Foundation of China(Nos.42177405,42377359,12075152)Energy Science and Technology discipline under the Shanghai Class IV Peak Disciplinary Development Program for the financial support.W.Y.Huang thanks the China Scholarship Council(CSC)for funding.
文摘Antibiotics are emerging pollutants that pose significant risks to environmental and human health.Periodate(PI)-based advanced oxidation processes have shown promise for their effective degradation.In this study,we systematically investigate the structure-activity relationship of four representative Fe-based metal-organic frameworks(Fe-MOFs)-MIL-101(Fe),MIL-88B(Fe),MIL-88A(Fe),and MIL-53(Fe)-as PI activators for tetracycline(TC)degradation.Among them,MIL-101(Fe)exhibited the highest catalytic performance,owing to its unique Fe3O-OH nodes and mesoporous architecture.The MIL-101(Fe)/PI system achieved 93.3%TC degradation and 55.9%mineralization rate within 60 min.Mechanistic studies combining scavenger quenching,sulfoxide probe transformation,X-ray photoelectron spectroscopy,and X-ray absorption fine structure confirmed the generation of multiple reactive oxygen species,and high-valent Fe(IV)]O and O_(2)^(·-)played major roles in the tetracycline degradation process.Density functional theory calculations further revealed that MIL-101(Fe)and MIL-88B(Fe)effectively interact with PI to form Fe(Ⅲ)-superoxide(Fe(Ⅲ)-O-O^(·-)),a key intermediate in Fe(IV)]O generation.In contrast,the adsorption energy of MIL-53(Fe)and MIL-88A(Fe)was relatively weak,with fewer binding sites,resulting in poor performance.The synergy between Fe(Ⅲ)-O-O^(·-)formation and the pore accessibility of MIL-101(Fe)accounted for its superior catalytic efficiency.This work not only clarifies the structural factors governing PI activation in Fe-MOFs,but also proposes a mechanistically informed strategy for designing high-performance catalysts for antibiotic degradation.
基金Supported by the National Natural Science Foundation of China(62576008)University Annual Scientific Research Plan of Anhui Province(2022AH030023)。
文摘In this paper,a class of discontinuous Cohen-Grossberg neural networks with timevarying delays is considered.Firstly,under the extended Filippov differential inclusions framework,the problem of periodic solutions of the considered neural networks with more relaxed conditions imposed on the amplification functions is analyzed by using set-valued mapping and Kakutani's fixed point theorem,which has rarely been used to study such problem.Secondly,the fixed-time synchronization of the error system of the considered neural networks is also investigated by designing a novel control strategy,which can improve not only the previous ones with sign function greatly,but also can reduce the chattering phenomenon.Finally,two numerical examples are presented to further illustrate the validity of the obtained results.
基金Funded by the Guangdong Major Project of Basic and Applied Basic Research(No.2021B0301030001)the Foundation of National Key Laboratory of Shock Wave and Detonation Physics(No.JCKYS2022212004)。
文摘We used hydrodynamic simulations and shock wave propagation theories to analyze the behavior of shock waves within Ti/Pt periodically modulated graded structures and their integration layers.The effects of the total number of periodic layers,the total thickness of graded materials and loading velocity on the integration layer thickness and behavior of pressure-strain rate were systematically investigated.The results reveal that,by adjusting the total number of periodically modulated layers,the total thickness of graded materials and loading velocity the pressure amplitudes of the reflected compressive and rarefaction waves at different interfaces of Ti/Pt periodically modulated graded materials can be precisely controlled.Furthermore,empirical structural design criteria for Ti/Pt periodically modulated graded materials are established.The thickness ratio variation between adjacent Ti/Pt layers in the periodic structure must exceed 0.32.After the collaborative design of the integration layer,Ti/Pt periodically modulated graded materials can achieve a controllable loading function with pressures ranging from 1.4 to 144 GPa and strain rates from 3.8×10^(4) to 1.7×10^(7) s^(–1).The outcomes of this research provide a theoretical and simulation basis for the optimized design of periodically modulated graded materials to be utilized in ramp compression experiments.
基金Supported by the National Key Research and Development Program of China(2023YFD1400502)。
文摘To investigate the eco-economic thresholds of weeds and the critical period for their control,combining economic and ecological perspectives to achieve scientific weed management,four dominant weeds,Echinochloa crus-galli(L.)P.Beauv,Chenopodium album L.,Digitaria sanguinalis(L.)Scop,and Commelina communis L.,were selected as experimental subjects,based on their common occurrence in spring maize planting areas in Northern China.A predictive model for maize yield loss caused by mixed weed populations was established.The study analyzed the eco-economic thresholds of weeds under different control measures and determined the optimal period for weed control by combining the critical control period.A logarithmic function model was developed to describe the relationship between mixed weed density and maize yield loss:y=5.9875ln(x)-6.5407(R^(2)=0.949,F=131.244,P=0.000).The optimal model for the critical period of competition between weeds and maize in maize fields was:y=-0.0027x^(2)+0.5624x-10.064(R2=0.968,F=30.513,P=0.032).When the weed density in maize fields reached 5.57 plants·m^(-2),manual weeding should be conducted promptly.When the weed density was 3.41 plants·m^(-2) or 3.48 plants·m^(-2),soil or foliar treatments should be applied,respectively.If the weed density reached 3.93 plants·m^(-2),a combination of soil and foliar treatment should be implemented.The critical period for manual weeding was 28.4 days after sowing,for soil treatment it was 19.9 days,for foliar treatment it was 21.8 days,and for the combined treatment of soil and foliar methods,it was 23.5 days after sowing.Retaining weeds for up to 15 days after maize sowing did not result in a yield loss and could even have a positive effect on maize yield.
基金Supported by NSFC (No.12371378)NSF of Fujian Province (Nos.2024J01980,2023J01955)。
文摘Analysis and design of linear periodic control systems are closely related to the periodic matrix equations.The biconjugate residual method(BCR for short)have been introduced by Vespucci and Broyden for efficiently solving linear systems Aα=b.The objective of this paper is to provide one new iterative algorithm based on BCR method to find the symmetric periodic solutions of linear periodic matrix equations.This kind of periodic matrix equations has not been dealt with yet.This iterative method is guaranteed to converge in a finite number of steps in the absence of round-off errors.Some numerical results are performed to illustrate the efficiency and feasibility of new method.
基金The National Natural Science Foundation of China under contract No.41821004the Basic Scientific Fund for National Public Research Institutes of China under contract No.2020Q08the Fund of Laoshan Laboratory under contract No.LSKJ202201600.
文摘Significant wave period is an important parameter in coastal and offshore engineering design.Traditional spectral wave models do not directly calculate this parameter,which means that it needs to be estimated from the spectral periods using empirical formulas.The wave energy period is one of the wave periods directly output by many wave models and is often used in studies of wave energy.This study investigated the relationship between significant wave period and wave energy period using wave data measured at three stations in the coastal waters of China.The observations recorded at these stations in the South China Sea,the East China Sea,and the Bohai Sea covered a wide range of surface wave conditions.Analysis indicated that the ratio of significant wave period to wave energy period is closely related to the Goda peakedness parameter of the wave spectra.Therefore,we proposed an empirical formula in which significant wave period is a function of wave energy period and the Goda peakedness parameter.Evaluation results showed that the performance of this formula is substantially better than that of fitting formulas that use constant coefficients.
基金supported by the National Natural Science Foundation of China(Nos.82170955,82101064)the Xinfei Program funded by Fourth Military Medical University。
文摘Approximately 20%to 30%of the global workforce is engaged in shift work.As a significant cause of circadian disruption,shift work is closely associated with an increased risk for periodontitis.Nevertheless,how shift work-related circadian disruption functions in periodontitis remains unknown.Herein,we employed a simulated shift work model constructed by controlling the environmental light-dark cycles and revealed that shift work-related circadian disruption exacerbated the progression of experimental periodontitis.RNA sequencing and in vitro experiments indicated that downregulation of the core circadian protein brain and muscle ARNT-like protein 1(BMAL1)and activation of the Gasdermin D(GSDMD)-mediated pyroptosis were involved in the pathogenesis of that.Mechanically,BMAL1 regulated GSDMD-mediated pyroptosis by suppressing NOD-like receptor protein 3(NLRP3)inflammasome signaling through modulating nuclear receptor subfamily 1 group D member 1(NR1D1),and inhibiting Gsdmd transcription via directly binding to the E-box elements in its promoter.GSDMD-mediated pyroptosis accelerated periodontitis progression,whereas downregulated BMAL1 under circadian disruption further aggravated periodontal destruction by increasing GSDMD activity.And restoring the level of BMAL1 by circadian recovery and SR8278 injection alleviated simulated shift work-exacerbated periodontitis via lessening GSDMD-mediated pyroptosis.These findings provide new evidence and potential interventional targets for circadian disruption-accelerated periodontitis.
基金The NSF(001084)of Liaoning Provincethe Science Foundation of OUC and the NSF(10371010)of China
文摘In this paper, we investigate the pseudo almost periodicity of the unique bounded solution for a nonlinear hyperbolic equation with piecewise constant argument. The equation under consideration is a mathematical model for the dynamics of gas absorption,
文摘The increasing aging population and aging-associated diseases have become a global issue for decades.People over 65 show an increased prevalence and greater severity of periodontitis,which poses threats to overall health.Studies have demonstrated a significant association between aging and the dysfunction of neutrophils,critical cells in the early stages of periodontitis,and their crosstalk with macrophages and T and B lymphocytes to establish the periodontal lesion.Neutrophils differentiate and mature in the bone marrow before entering the circulation;during an infection,they are recruited to infected tissues guided by the signal from chemokines and cytokines to eliminate invading pathogens.Neutrophils are crucial in maintaining a balanced response between host and microbes to prevent periodontal diseases in periodontal tissues.The impacts of aging on neutrophils'chemotaxis,anti-microbial function,cell activation,and lifespan result in impaired neutrophil functions and excessive neutrophil activation,which could influence periodontitis course.We summarize the roles of neutrophils in periodontal diseases and the aging-related impacts on neutrophil functional responses.We also explore the underlying mechanisms that can contribute to periodontitis manifestation in aging.This review could help us better understand the pathogenesis of periodontitis,which could offer novel therapeutic targets for periodontitis.
基金supported bythe National Natural Science Foundation of China(Nos.U23A20523,82272504,and 82072456)the Department of Science and Technology of Jilin Province,China(Nos.20210101439JC,20210101321JC,20220204119YY,202201ZYTS131,202201ZYTS129,20230204114YY,YDZJ202201ZYTS505,and YDZJ202301ZYTS076)+4 种基金the Special Program for Science and Technology Personnel of Changchun(No.ZKICKJJ2023015)the Key Training Plan for Outstanding Youth of Jilin University(No.419070623036)the Research Fund of the First Hospital of Jilin University(No.2021-zl-01)the Graduate Innovation Fund of Jilin University(No.2024CX125)the Foun-dation of National Center for Translational Medicine(Shanghai)SHU Branch,China(No.SUITM-202405).
文摘The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.
基金supported by the National Natural Science Foundation of China(Nos.51671075,51971086)the Natural Science Foundation of Heilongjiang Province,China(No.LH2022E081)。
文摘Phase classification has a clear guiding significance for the design of high entropy alloys.For mutually exclusive and non-mutually exclusive classifications,the composition descriptors,commonly used physical parameter descriptors,elemental-property descriptors,and descriptors extracted from the periodic table representation(PTR)by the convolutional neural network were collected.Appropriate selection among features with rich information is helpful for phase classification.Based on random forest,the accuracy of the four-label classification and balanced accuracy of the five-label classification were improved to be 0.907 and 0.876,respectively.The roles of the four important features were summarized by interpretability analysis,and a new important feature was found.The model extrapolation ability and the influence of Mo were demonstrated by phase prediction in(CoFeNiMn)_(1-x)Mo_(x).The phase information is helpful for the hardness prediction,the classification results were coupled with the PTR of hardness data,and the prediction error(the root mean square error)was reduced to 56.69.
文摘BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,strenuous exercise,alcohol abuse,high carbohydrate intake and insulin injections are common triggers of paralysis.This article reports a case of severe TPP induced by insulin injection,elucidates the characteristics and pathogenesis of the disease,analyses the risk factors for triggering TPP,and hopefully provides more clinical data for TPP patients.CASE SUMMARY A 38-year-old Asian man presented to the emergency department with a oneweek history of limb weakness and worsening half-day.His medical history included poorly controlled type 2 diabetes and he had been switched to Aspart50 a week earlier.He was alert and oriented with upper extremity strength grade 3 and lower extremity strength grade 1.Emergency department tests showed hypokalemia of 1.6 mmol/L.The paramedics administered 1.5 g of potassium intravenously,followed by 4.0 g orally.Weakness in the arms and legs improved.He was referred to endocrinology where he was diagnosed with Graves'disease,with suboptimal control and insulin injections possibly causing TPP.We stopped his insulin and he was discharged with a potassium level of 4.0 mmol/L.CONCLUSION Insulin is a trigger for TPP and should be avoided in patients with hyperthyroidism.Early recognition and treatment of TPP is crucial,especially in patients presenting with hypokalemic periodic paralysis.
基金Supported by the National Natural Science Foundation of China(10671182)。
文摘The article studies the evolutionary dynamics of two-population two-strategy game models with and without impulses. First, the payment matrix is given and two evolutionary dynamics models are established by adding stochastic and impulse. For the stochastic model without impulses, the existence and uniqueness of solution, and the existence of positive periodic solutions are proved, and a sufficient condition for strategy extinction is given. For the stochastic model with impulses, the existence of positive periodic solutions is proved. Numerical results show that noise and impulses directly affect the model, but the periodicity of the model does not change.
文摘With the increase of international trade activities and the gradual melting of the polar ice cap,the importance of the Arctic route for marine transportation has been emphasized.Prediction of the polar navigation window period is crucial for navigating in the Arctic route,which is of great significance to the selection of the route and the optimization of navigation.This paper introduces the establishment of a risk index system,determination of risk index weight,establishment of a risk evaluation model,and prediction algorithm for the window period.In addition,data sources of both environmental factors and ship factors are introducted,and their shortcomings are analyzed,followed by introduction of various methods involved in window prediction and analysis of their advantages and disadvantages.The quantitative risk evaluation and window period algorithm can provide a reference for the research of polar navigation window period prediction.
