A perilymphatic fistula(PLF)is a rare condition in which perilymph leaks from the cochlea or vestibule into the surrounding cavities,most commonly through round and oval windows,and causes cochlear and vestibular symp...A perilymphatic fistula(PLF)is a rare condition in which perilymph leaks from the cochlea or vestibule into the surrounding cavities,most commonly through round and oval windows,and causes cochlear and vestibular symptoms.However,vague symptoms and the lack of a clear diagnostic test have made the existence of PLF a controversial subject for decades.Here,we report a case of definite PLF confirmed by surgery in a patient who underwent mastoidectomy 20 years prior,revealing a specific sign of missing perilymph on MRI.T2-weighted MRI revealed a nodular bright signal in the cochlea and vestibule and a large area of bright signal in the middle ear cavity with a long tail running toward the vestibule in the left ear.MRI via T2-sampling perfection with application-optimized contrasts by using a flip angle evolution sequence revealed a bright signal in the cochlear endolymph but not in the perilymph.The specific sign of a missing perilymph on MRI has a diagnostic role for PLF.展开更多
Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.954000...Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.9540001 proposing the"missing perilymph"sign on MRI as a novel radiological indicator of perilymphatic fistula(PLF).This study adds to the growing body of work seeking objective,non-invasive diagnostic methods for PLF,a condition that has long eluded definitive radiological confirmation.The avoidance of gadolinium contrast in the imaging technique is an additional strength,given increasing awareness of gadoliniumassociated risks (Starekova et al.,2024).展开更多
Objective To study effects of adenosine 5’-triphosphate (ATP) on cochlear function of guineapig. Methods After perfusion of ATP into perilymphatic spaces of the guinea pig cochlea, summating potential(SP) , cochlear ...Objective To study effects of adenosine 5’-triphosphate (ATP) on cochlear function of guineapig. Methods After perfusion of ATP into perilymphatic spaces of the guinea pig cochlea, summating potential(SP) , cochlear microphonic ( CM) , auditory nerve compound action potential ( CAP) , distortion product otoa-coustic emission (DPOAE) and auditory brainstem response (ABR) were measured. Results The resultsshowed concentration-dependent effect of ATP on the response alterations of bioelectric activity in cochlea. Adminis-tration of Immol/L ATP caused an increase both in the amplitude of the SP and in the threshold of ABR, a decreasein amplitude of the CAP and DPOAE. In addition, response alterations of the CAP and DPOAE showed in an inten-sity- and frequency-dependent manner, respectively. At levels of 20 - 70dB nHL sound intensity, lmmol/L ATPcaused a significant decrease in the CAP amplitude, while at moderate and high frequency ranges of 2 -8kHz it re-duced DPOAE amplitude significantly. 330μmol/L ATP also increased the threshold of ABR. Conclusion ATPthrough perilymphatic perfusion could inhibit cochlear function of guinea pig.展开更多
基金supported by the National Natural Science Foundation of China(81771006).
文摘A perilymphatic fistula(PLF)is a rare condition in which perilymph leaks from the cochlea or vestibule into the surrounding cavities,most commonly through round and oval windows,and causes cochlear and vestibular symptoms.However,vague symptoms and the lack of a clear diagnostic test have made the existence of PLF a controversial subject for decades.Here,we report a case of definite PLF confirmed by surgery in a patient who underwent mastoidectomy 20 years prior,revealing a specific sign of missing perilymph on MRI.T2-weighted MRI revealed a nodular bright signal in the cochlea and vestibule and a large area of bright signal in the middle ear cavity with a long tail running toward the vestibule in the left ear.MRI via T2-sampling perfection with application-optimized contrasts by using a flip angle evolution sequence revealed a bright signal in the cochlear endolymph but not in the perilymph.The specific sign of a missing perilymph on MRI has a diagnostic role for PLF.
文摘Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.9540001 proposing the"missing perilymph"sign on MRI as a novel radiological indicator of perilymphatic fistula(PLF).This study adds to the growing body of work seeking objective,non-invasive diagnostic methods for PLF,a condition that has long eluded definitive radiological confirmation.The avoidance of gadolinium contrast in the imaging technique is an additional strength,given increasing awareness of gadoliniumassociated risks (Starekova et al.,2024).
基金Supported by National Natural Science Foundation of China (30100206).
文摘Objective To study effects of adenosine 5’-triphosphate (ATP) on cochlear function of guineapig. Methods After perfusion of ATP into perilymphatic spaces of the guinea pig cochlea, summating potential(SP) , cochlear microphonic ( CM) , auditory nerve compound action potential ( CAP) , distortion product otoa-coustic emission (DPOAE) and auditory brainstem response (ABR) were measured. Results The resultsshowed concentration-dependent effect of ATP on the response alterations of bioelectric activity in cochlea. Adminis-tration of Immol/L ATP caused an increase both in the amplitude of the SP and in the threshold of ABR, a decreasein amplitude of the CAP and DPOAE. In addition, response alterations of the CAP and DPOAE showed in an inten-sity- and frequency-dependent manner, respectively. At levels of 20 - 70dB nHL sound intensity, lmmol/L ATPcaused a significant decrease in the CAP amplitude, while at moderate and high frequency ranges of 2 -8kHz it re-duced DPOAE amplitude significantly. 330μmol/L ATP also increased the threshold of ABR. Conclusion ATPthrough perilymphatic perfusion could inhibit cochlear function of guinea pig.
