Peri-intraventricular hemorrhage is one of the main causes of neurological impairment in premature newborns. </span><span style="font-family:Verdana;">To control</span><span style="...Peri-intraventricular hemorrhage is one of the main causes of neurological impairment in premature newborns. </span><span style="font-family:Verdana;">To control</span><span style="font-family:""><span style="font-family:Verdana;"> their risk factors is necessary </span><span style="font-family:Verdana;">in view of</span><span style="font-family:Verdana;"> the increasing survival of </span><span style="font-family:Verdana;">extreme</span><span style="font-family:Verdana;"> preterm infants</span></span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">Objective:</span><span style="font-family:""><span style="font-family:Verdana;"> To </span><span style="font-family:Verdana;">evaluate the prevalence of peri-intraventricular hemorrhage in premature newborns, identify the risk factors and observe the frequencies of intra-hospital </span><span style="font-family:Verdana;">outcomes of </span><span style="font-family:Verdana;">interests</span><span style="font-family:Verdana;">. </span><span><span style="font-family:Verdana;">Methods:</span><i> </i></span></span><span style="font-family:Verdana;">This study was done in Brazil</span><span style="font-family:""><span style="font-family:Verdana;">. This was an observational, analytical longitudinal </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> prospective study. The subjects inc</span><span style="font-family:Verdana;">luded were newborns of gestational age less than 34 weeks who were admitted to two public hospitals between May and November 2015. To assess possible</span><span style="font-family:Verdana;"> associated factors, obstetric, perinatal </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> neonatal data were analyzed (chorioamnionitis, antenatal corticosteroids, gestational age, newborn weight, Apgar score at 1 and 5 minutes, resuscitation in the delivery room, surfactant in the delivery room, newborn transferred from another hospital, respiratory distress syndrome</span></span><span style="font-family:Verdana;">:</span><span style="font-family:""><span style="font-family:Verdana;"> RDS, sepsis, umbilical vein catheterization, assisted ventilation, exogenous surfactant in the Neonatal ICU, use of sodium bicarbonate, inotropic agents, adrenaline, volume expanders </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> blood products). The hospital outcomes studied were assisted ventilation time, hospital stay </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> death. The data analysis was performed by chi-square test or Fisher’s test, with a significance level of 5%. </span><span><span style="font-family:Verdana;">Results:</span><i> </i></span><span style="font-family:Verdana;">Out of 156 newborns, 46 (29.9%) presented peri-intraventricular hemorrhage and 28.2% of these had a severe form of the disease. There were significant associations (p</span></span><span style="font-family:""> </span><span style="font-family:Verdana;"><</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.05) with the following risk factors: gestational age, birth weight, low Apgar score, delivery room resuscitation, RDS, surfactant use, sepsis, packed red blood cell transfusion, mechanical ventilation </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> umbilical vein catheterization</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> The newborns with peri-intraventricular hemorrhage presented longer times on assisted ventilation, longer hospital stays </span><span style="font-family:Verdana;">and</span> <span style="font-family:Verdana;">higher</span><span style="font-family:Verdana;"> risk of death. </span><span style="font-family:Verdana;">Conclusion:</span><span style="font-family:Verdana;"> The prevalence of peri-intraventricular hemorrhage was high in the population studied, especially </span><span style="font-family:Verdana;">the</span><span style="font-family:Verdana;"> severe form. Perinatal and neonatal risk factors were associated with a higher risk of developing the disease and the outcomes studied were more evident in these newborns.展开更多
文摘Peri-intraventricular hemorrhage is one of the main causes of neurological impairment in premature newborns. </span><span style="font-family:Verdana;">To control</span><span style="font-family:""><span style="font-family:Verdana;"> their risk factors is necessary </span><span style="font-family:Verdana;">in view of</span><span style="font-family:Verdana;"> the increasing survival of </span><span style="font-family:Verdana;">extreme</span><span style="font-family:Verdana;"> preterm infants</span></span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">Objective:</span><span style="font-family:""><span style="font-family:Verdana;"> To </span><span style="font-family:Verdana;">evaluate the prevalence of peri-intraventricular hemorrhage in premature newborns, identify the risk factors and observe the frequencies of intra-hospital </span><span style="font-family:Verdana;">outcomes of </span><span style="font-family:Verdana;">interests</span><span style="font-family:Verdana;">. </span><span><span style="font-family:Verdana;">Methods:</span><i> </i></span></span><span style="font-family:Verdana;">This study was done in Brazil</span><span style="font-family:""><span style="font-family:Verdana;">. This was an observational, analytical longitudinal </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> prospective study. The subjects inc</span><span style="font-family:Verdana;">luded were newborns of gestational age less than 34 weeks who were admitted to two public hospitals between May and November 2015. To assess possible</span><span style="font-family:Verdana;"> associated factors, obstetric, perinatal </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> neonatal data were analyzed (chorioamnionitis, antenatal corticosteroids, gestational age, newborn weight, Apgar score at 1 and 5 minutes, resuscitation in the delivery room, surfactant in the delivery room, newborn transferred from another hospital, respiratory distress syndrome</span></span><span style="font-family:Verdana;">:</span><span style="font-family:""><span style="font-family:Verdana;"> RDS, sepsis, umbilical vein catheterization, assisted ventilation, exogenous surfactant in the Neonatal ICU, use of sodium bicarbonate, inotropic agents, adrenaline, volume expanders </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> blood products). The hospital outcomes studied were assisted ventilation time, hospital stay </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> death. The data analysis was performed by chi-square test or Fisher’s test, with a significance level of 5%. </span><span><span style="font-family:Verdana;">Results:</span><i> </i></span><span style="font-family:Verdana;">Out of 156 newborns, 46 (29.9%) presented peri-intraventricular hemorrhage and 28.2% of these had a severe form of the disease. There were significant associations (p</span></span><span style="font-family:""> </span><span style="font-family:Verdana;"><</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">0.05) with the following risk factors: gestational age, birth weight, low Apgar score, delivery room resuscitation, RDS, surfactant use, sepsis, packed red blood cell transfusion, mechanical ventilation </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> umbilical vein catheterization</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> The newborns with peri-intraventricular hemorrhage presented longer times on assisted ventilation, longer hospital stays </span><span style="font-family:Verdana;">and</span> <span style="font-family:Verdana;">higher</span><span style="font-family:Verdana;"> risk of death. </span><span style="font-family:Verdana;">Conclusion:</span><span style="font-family:Verdana;"> The prevalence of peri-intraventricular hemorrhage was high in the population studied, especially </span><span style="font-family:Verdana;">the</span><span style="font-family:Verdana;"> severe form. Perinatal and neonatal risk factors were associated with a higher risk of developing the disease and the outcomes studied were more evident in these newborns.
