Preformed albumin corona of albumin-nonselective nanoparticles(NPs)is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration.However,very few studies have concerned the preforme...Preformed albumin corona of albumin-nonselective nanoparticles(NPs)is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration.However,very few studies have concerned the preformed albumin corona of albumin-selective NPs.Herein,we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate(SA)onto PLGA NPs(SP NPs)surface,taking albuminnonselective PLGA NPs as control.PLGA NPs and SP NPs were prepared by emulsion-solvent evaporation method and the resultant NPs were in spherical shape with an average diameter around 180 nm.The corresponding albumin-coating PLGA NPs(PLGA@BSA NPs)and albumin-coating SP NPs(SP@BSA NPs)were formulated by incubating SP NPs or PLGA NPs with bovine serum albumin solution,respectively.The impact of albumin corona on particle characteristics,stability,photothermal effect,cytotoxicity,cell uptake,spheroid penetration and pharmacokinetics was investigated.In line with previous findings of preformed albumin coating,PLGA@BSA NPs exhibited higher stability,cytotoxicity,cell internalization and spheroid penetration performances in vitro,and longer blood circulation time in vivo than those of albumin-nonselective PLGA NPs,but albumin-selective SP NPs is capable of achieving a comparable in vitro and in vivo performances with both SP@BSA NPs and PLGA@BSA NPs.Our results demonstrate that SA decorated albumin-selective NPs pave a versatile avenue for optimizing nanoparticulate delivery without preformed albumin corona.展开更多
Recently it is a hot topic to make full use of high abundant Y element in Nd_(2)Fe_(14)B-type permanent magnets.In contrast to Pr and Nd elements,Y shows different metallurgical behaviors during preparation process.In...Recently it is a hot topic to make full use of high abundant Y element in Nd_(2)Fe_(14)B-type permanent magnets.In contrast to Pr and Nd elements,Y shows different metallurgical behaviors during preparation process.In this paper,we have explored the magnetic properties,microstructures and corrosion performance of Pr-Nd-Y-Fe-B magnets fabricated by spark plasma sintering(SPS)technique from the ribbons of nanocrystalline and amorphous precursors,respectively.The coercivity and maximum energy product were improved for the magnets prepared from amorphous precursor materials(denoted as SPS-A hereafter)compared with the magnets prepared from crystalline precursor materials(denoted as SPS-C hereafter).Magnetic properties of Jr=0.79 T,Hci=864 k A/m,and(BH)_(max)=102 k J/m^(3)were obtained for SPS-A magnets.In contrast with SPS-C magnets,the magnetic properties of SPS-A magnets are not so sensitive to the preparation conditions,which is quite beneficial to the homogeneity of microstructure and enhancement of coercivity for large-scale production of the designated magnets.Aggregated(Pr,Nd,Y)-rich phase was found out in SPS-C magnets.Pr and Nd elements are rich at grain boundary while Y is distributed uniformly at main phase and grain boundary phase.The strip grains and equiaxed grains exist in SPS-C and SPS-A magnets,respectively.The enhanced magnetic properties for SPS-A magnets are accredited to the uniform distribution of rare-earth-rich phase and low demagnetization factor.It is revealed by electrochemical test and dipping test that the corrosion potential is more positive and the corrosion rate is slower for the SPS-A magnets in 3.5 wt.%Na Cl solution.The work is also expected to shed light on developing the nanocrystalline Pr-Nd-Y-Fe-B SPSed high-performance magnets in industry.展开更多
Production of quality wood is a big problem in forestry plantation since trees grown in plantation of some high value temperate and tropical hardwood species tend to produce low value, short butt logs and bolts due to...Production of quality wood is a big problem in forestry plantation since trees grown in plantation of some high value temperate and tropical hardwood species tend to produce low value, short butt logs and bolts due to crooked stems, low fork heights and delayed shedding of lower branches. Result from existing Acacia plantation in Malaysia indicated that most existing Acacia plantation trees especially Acacia auriculiformis and Acacia mangium, fork very heavily which leads to the formation of multiple leaders more than one and some are fork so close to the ground that they will produce little to no merchantable wood. In this context, a research study was initiated to select and recommend the best performing tree species or provenance suited for timber production in Malaysia with respect to growth and other characteristics. Species/provenance/progeny test was conducted on four species of Acacia namely, A. mangium, A. auriculiformis, A. crassicarpa and A. aulococarpa, each with 4 provenances originated from Papua New Guinea (PNG) and Queensland (QL). The growth performance of the provenances was monitored in terms of some quantitative and qualitative characteristics to evaluate the genetic variation and growth performance of a base breeding population. 20 progenies for each species were selected and randomly planted with 16 trees representing each progenies in a trial plot laid out in a randomized complete block design consisting of four blocks as replication. The study showed that there were significant different (p mangium performed better compared to other Acacia species in all of the aspect tested and it was followed by A. crassicarpa, A. aulococarpa and A. auriculiformis. There were also significant differences between provenance within regions and progenies within provenances in all quantitative and qualitative traits tested in this study. Generally, provenance and progenies selected from PNG excelled those from QL both in quantitative and qualitative characteristics. The top performing progenies of Acacia species are CG 1854 of (Bensbach WP) and KN000107 (SW of Boset WP) of A. mangium, BVG2609 (Bensbach WP) of A. crassicarpa, BVG 00835 (WP Morehead) and MM1016 (Arufi E Morehead WP) of A. aulococarpa and JSL363 (Wenlock River) and BVG 2657 (Bansbach) of A. auriculiformis.展开更多
The financial implication of the adoption of corporate social responsibility （CSR） practices is still an obscure field of study, because studies suggest controversial results. Thus, this research aimed to examine th...The financial implication of the adoption of corporate social responsibility （CSR） practices is still an obscure field of study, because studies suggest controversial results. Thus, this research aimed to examine the relationship CSR and economic performance of the companies of corporate sustainability index （ISE） of mercantile and futures exchange of Silo Paulo stock exchange （BM＆FBOVESPA）. The amount of companies allowing online access to their responses of the ISE questionnaire determined the sample of this research. Thus, for the study period from 2011 to 2012, it has been possible to access the responses of 12 companies, composing the overall sample of this research. The results of the regression analysis allow to statistically assert that for the sample used, environmental performance （EP） contributes to improving economic performance, measured by all financial metrics used： return on equity （ROE）, return on assets （ROA）, and net profit （NP）. Statistically, it is only possible to say that social performance （SP） contributes to improving NP. In terms of market metrics, none of the null hypothesis was rejected, i.e., in any cases, it has been possible to affirm, on a statistical base, that SP and EP contribute to improving the market value （MV） and systematic risk. Thus, it is understood that the stakeholder theory has potential to explain the Brazilian situation regarding the aspects of CSR and financial ones under the accounting and the shareholder theory explains this relation, when viewed with the aid of market measurements.展开更多
基金financially supported by the National Basic Research Program of China(973 Program,No.2015CB932100)National Natural Science Foundation of China(No.81703451,81573371,81473164)。
文摘Preformed albumin corona of albumin-nonselective nanoparticles(NPs)is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration.However,very few studies have concerned the preformed albumin corona of albumin-selective NPs.Herein,we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate(SA)onto PLGA NPs(SP NPs)surface,taking albuminnonselective PLGA NPs as control.PLGA NPs and SP NPs were prepared by emulsion-solvent evaporation method and the resultant NPs were in spherical shape with an average diameter around 180 nm.The corresponding albumin-coating PLGA NPs(PLGA@BSA NPs)and albumin-coating SP NPs(SP@BSA NPs)were formulated by incubating SP NPs or PLGA NPs with bovine serum albumin solution,respectively.The impact of albumin corona on particle characteristics,stability,photothermal effect,cytotoxicity,cell uptake,spheroid penetration and pharmacokinetics was investigated.In line with previous findings of preformed albumin coating,PLGA@BSA NPs exhibited higher stability,cytotoxicity,cell internalization and spheroid penetration performances in vitro,and longer blood circulation time in vivo than those of albumin-nonselective PLGA NPs,but albumin-selective SP NPs is capable of achieving a comparable in vitro and in vivo performances with both SP@BSA NPs and PLGA@BSA NPs.Our results demonstrate that SA decorated albumin-selective NPs pave a versatile avenue for optimizing nanoparticulate delivery without preformed albumin corona.
基金supported by the National Natural Science Foundation of China(Nos.51901089 and 51671097)the Foundation of Jiangxi Educational Committee(No.GJJ180472)+2 种基金the Science and Technology Program of Fujian Province(No.2017T3001)the Key Research and Development Program of Jinagxi Province(No.20201BBE51010)the Ph D.Start-up Foundation of Jiangxi University of Science and Technology(No.JXXJBS18052)。
文摘Recently it is a hot topic to make full use of high abundant Y element in Nd_(2)Fe_(14)B-type permanent magnets.In contrast to Pr and Nd elements,Y shows different metallurgical behaviors during preparation process.In this paper,we have explored the magnetic properties,microstructures and corrosion performance of Pr-Nd-Y-Fe-B magnets fabricated by spark plasma sintering(SPS)technique from the ribbons of nanocrystalline and amorphous precursors,respectively.The coercivity and maximum energy product were improved for the magnets prepared from amorphous precursor materials(denoted as SPS-A hereafter)compared with the magnets prepared from crystalline precursor materials(denoted as SPS-C hereafter).Magnetic properties of Jr=0.79 T,Hci=864 k A/m,and(BH)_(max)=102 k J/m^(3)were obtained for SPS-A magnets.In contrast with SPS-C magnets,the magnetic properties of SPS-A magnets are not so sensitive to the preparation conditions,which is quite beneficial to the homogeneity of microstructure and enhancement of coercivity for large-scale production of the designated magnets.Aggregated(Pr,Nd,Y)-rich phase was found out in SPS-C magnets.Pr and Nd elements are rich at grain boundary while Y is distributed uniformly at main phase and grain boundary phase.The strip grains and equiaxed grains exist in SPS-C and SPS-A magnets,respectively.The enhanced magnetic properties for SPS-A magnets are accredited to the uniform distribution of rare-earth-rich phase and low demagnetization factor.It is revealed by electrochemical test and dipping test that the corrosion potential is more positive and the corrosion rate is slower for the SPS-A magnets in 3.5 wt.%Na Cl solution.The work is also expected to shed light on developing the nanocrystalline Pr-Nd-Y-Fe-B SPSed high-performance magnets in industry.
文摘Production of quality wood is a big problem in forestry plantation since trees grown in plantation of some high value temperate and tropical hardwood species tend to produce low value, short butt logs and bolts due to crooked stems, low fork heights and delayed shedding of lower branches. Result from existing Acacia plantation in Malaysia indicated that most existing Acacia plantation trees especially Acacia auriculiformis and Acacia mangium, fork very heavily which leads to the formation of multiple leaders more than one and some are fork so close to the ground that they will produce little to no merchantable wood. In this context, a research study was initiated to select and recommend the best performing tree species or provenance suited for timber production in Malaysia with respect to growth and other characteristics. Species/provenance/progeny test was conducted on four species of Acacia namely, A. mangium, A. auriculiformis, A. crassicarpa and A. aulococarpa, each with 4 provenances originated from Papua New Guinea (PNG) and Queensland (QL). The growth performance of the provenances was monitored in terms of some quantitative and qualitative characteristics to evaluate the genetic variation and growth performance of a base breeding population. 20 progenies for each species were selected and randomly planted with 16 trees representing each progenies in a trial plot laid out in a randomized complete block design consisting of four blocks as replication. The study showed that there were significant different (p mangium performed better compared to other Acacia species in all of the aspect tested and it was followed by A. crassicarpa, A. aulococarpa and A. auriculiformis. There were also significant differences between provenance within regions and progenies within provenances in all quantitative and qualitative traits tested in this study. Generally, provenance and progenies selected from PNG excelled those from QL both in quantitative and qualitative characteristics. The top performing progenies of Acacia species are CG 1854 of (Bensbach WP) and KN000107 (SW of Boset WP) of A. mangium, BVG2609 (Bensbach WP) of A. crassicarpa, BVG 00835 (WP Morehead) and MM1016 (Arufi E Morehead WP) of A. aulococarpa and JSL363 (Wenlock River) and BVG 2657 (Bansbach) of A. auriculiformis.
文摘The financial implication of the adoption of corporate social responsibility （CSR） practices is still an obscure field of study, because studies suggest controversial results. Thus, this research aimed to examine the relationship CSR and economic performance of the companies of corporate sustainability index （ISE） of mercantile and futures exchange of Silo Paulo stock exchange （BM＆FBOVESPA）. The amount of companies allowing online access to their responses of the ISE questionnaire determined the sample of this research. Thus, for the study period from 2011 to 2012, it has been possible to access the responses of 12 companies, composing the overall sample of this research. The results of the regression analysis allow to statistically assert that for the sample used, environmental performance （EP） contributes to improving economic performance, measured by all financial metrics used： return on equity （ROE）, return on assets （ROA）, and net profit （NP）. Statistically, it is only possible to say that social performance （SP） contributes to improving NP. In terms of market metrics, none of the null hypothesis was rejected, i.e., in any cases, it has been possible to affirm, on a statistical base, that SP and EP contribute to improving the market value （MV） and systematic risk. Thus, it is understood that the stakeholder theory has potential to explain the Brazilian situation regarding the aspects of CSR and financial ones under the accounting and the shareholder theory explains this relation, when viewed with the aid of market measurements.
