BACKGROUND： Hepatic lymphoma （HL） is categorized as primary and secondary hepatic lymphoma （PHL and SHL）. This disorder can present as hepatic mass or mass-like lesion. Chemotherapy often is the first line treatm...BACKGROUND： Hepatic lymphoma （HL） is categorized as primary and secondary hepatic lymphoma （PHL and SHL）. This disorder can present as hepatic mass or mass-like lesion. Chemotherapy often is the first line treatment for patients with HL. Thus, an accurate pre-management histological diagnosis is essential to potentially improve clinical outcomes. The present study was to explore the prevalence of HL in ultrasound guided liver biopsies for hepatic mass or mass-like lesions, to investigate HL associated clinicopathological features, to raise the awareness of early recognition and proper diagnosis of this entity, and to assess specimen adequacy in needle core biopsy. METHODS： Twenty-one cases of HL were enrolled. Clinical and pathological characteristics were evaluated, quality of biopsies was assessed and pertinent literature was reviewed. RESULTS： HL was diagnosed in 0.94% of 2242 liver biopsy cases with ambiguous clinical presentation, laboratory tests and image studies. There were two cases of PHL （0.09%）, and nineteen cases of SHL （0.85%）. Histopathologically, diffuse large B-cell lymphoma was the most common type, followed by B-cell lymphoma not otherwise specified, T-ceU lymphoma, Hodgkin＇s lymphoma, and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Additionally, three lym- phocytic infiltration patterns were documented microscopically. The nodular infiltration was the most common type. CONCLUSIONS： HL is a rare entity and histopathology along with ancillary tests remains the only way to make the diagnosis.Clinicians＇ awareness of this entity and early liver biopsy are essential in patient management.展开更多
New technologies that combine standard procedures for tissue sample extraction and analysis with optical spectroscopy and imaging represent a new step in the development of tumour tissue diagnostics.Optical percutaneo...New technologies that combine standard procedures for tissue sample extraction and analysis with optical spectroscopy and imaging represent a new step in the development of tumour tissue diagnostics.Optical percutaneous needle biopsy is a promising method for increasing the diagnostic efficiency of the procedure by selecting the area for sample extraction and obtaining information about vascular changes and the metabolism of biological tissues at the needle tip.This study provides a comprehensive analysis of existing technical solutions to address various diagnostic tasks:studying the metabolic status of tissues for the adjustment of treatment protocols,differentiating healthy and tumour tissues for navigating puncture needles,and obtaining preliminary diagnoses of the nature of neoplasms.Technical systems for assessing the perfusion and metabolic characteristics of biological tissues using fine-needle probes have been described.Fine-needle probe designs for biopsies of various organs are also presented.The results of using optical percutaneous needle biopsy in liver and breast cancers are demonstrated.展开更多
Purpose:To retrospectively evaluate the diagnostic performance and complications of CT-guided percutaneous core needle biopsy(PCNB)for tuberculosis,analysis the influence factors of the diagnostic accuracy.Methods:Fro...Purpose:To retrospectively evaluate the diagnostic performance and complications of CT-guided percutaneous core needle biopsy(PCNB)for tuberculosis,analysis the influence factors of the diagnostic accuracy.Methods:From November 2005 to December 2015,through a retrospective review,283 CT-guided PCNBs performed in 270 patients were identified.Final results were confirmed by definitive surgery or the clinical course.Influence factor,complication rate,diagnostic performance was investigated.Influencing factors of the diagnostic accuracy were analyzed by uni-and multivariate logistic regression analyses.Results:283 CT-guided PCNBs performed in 270 patients(181 men,102 women;mean age,53.6 years)were included.The diagnostic accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of CT-guided PCNB were 90.00%,79.63%,100.00%,100.00%,88.89%%respectively.Significant factors affecting accuracy was age(p<0.05).Multivariate logistic regression analysis revealed that the risk of TB lesions receiving a false-negative diagnosis decreased for each additional year of subject age[OR=0.96;P<0.001].The incidences of complications such as pneumothorax,needle bleeding and hemoptysis were 9.3%,11.1%and 8.3%,respectively.Conclusion:CT-guided PCNB is efficient for the diagnosis of tuberculosis and is a safe diagnostic method.展开更多
BACKGROUND Acute fibrinous and organizing pneumonia(AFOP)is a rare,noninfective lung disease,histologically characterized by a patchy distribution of intra-alveolar fibrin“balls”and organizing pneumonia.The clinical...BACKGROUND Acute fibrinous and organizing pneumonia(AFOP)is a rare,noninfective lung disease,histologically characterized by a patchy distribution of intra-alveolar fibrin“balls”and organizing pneumonia.The clinical manifestations of AFOP are nonspecific.Diagnosis depends on pathology.Surgical lung biopsy is optimal for tissue sampling to diagnose AFOP.However,many patients have no tolerance to the operation,including mentally and physically.There is still no standard therapy for AFOP and the methods remain controversial.Therefore,further clinical attention and discussion are warranted.CASE SUMMARY A 53-year-old woman presented with fever,cough and dyspnea for 15 d.Antiinfective therapy was ineffective.Chest computed tomography showed bilateral patchy consolidation,especially in the lower lobes.We performed both ultrasound-guided transbronchial lung biopsy and ultrasound-guided percutaneous fine needle puncture at different lung lesion locations.Both samples supported the diagnosis of AFOP.The patient had a good clinical course after treatment with methylprednisolone,and no side effects of steroids.CONCLUSION Percutaneous needle biopsy combined with transbronchial lung biopsies may be a good choice in the absence of surgical biopsy.Methylprednisolone alone is effective in the treatment of idiopathic AFOP.展开更多
基金supported by a grant from the major research and development plan of the National Natural Science Foundation of China(91542205)
文摘BACKGROUND： Hepatic lymphoma （HL） is categorized as primary and secondary hepatic lymphoma （PHL and SHL）. This disorder can present as hepatic mass or mass-like lesion. Chemotherapy often is the first line treatment for patients with HL. Thus, an accurate pre-management histological diagnosis is essential to potentially improve clinical outcomes. The present study was to explore the prevalence of HL in ultrasound guided liver biopsies for hepatic mass or mass-like lesions, to investigate HL associated clinicopathological features, to raise the awareness of early recognition and proper diagnosis of this entity, and to assess specimen adequacy in needle core biopsy. METHODS： Twenty-one cases of HL were enrolled. Clinical and pathological characteristics were evaluated, quality of biopsies was assessed and pertinent literature was reviewed. RESULTS： HL was diagnosed in 0.94% of 2242 liver biopsy cases with ambiguous clinical presentation, laboratory tests and image studies. There were two cases of PHL （0.09%）, and nineteen cases of SHL （0.85%）. Histopathologically, diffuse large B-cell lymphoma was the most common type, followed by B-cell lymphoma not otherwise specified, T-ceU lymphoma, Hodgkin＇s lymphoma, and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Additionally, three lym- phocytic infiltration patterns were documented microscopically. The nodular infiltration was the most common type. CONCLUSIONS： HL is a rare entity and histopathology along with ancillary tests remains the only way to make the diagnosis.Clinicians＇ awareness of this entity and early liver biopsy are essential in patient management.
基金support of the Russian Science Foundation under Project No.21-15-00325。
文摘New technologies that combine standard procedures for tissue sample extraction and analysis with optical spectroscopy and imaging represent a new step in the development of tumour tissue diagnostics.Optical percutaneous needle biopsy is a promising method for increasing the diagnostic efficiency of the procedure by selecting the area for sample extraction and obtaining information about vascular changes and the metabolism of biological tissues at the needle tip.This study provides a comprehensive analysis of existing technical solutions to address various diagnostic tasks:studying the metabolic status of tissues for the adjustment of treatment protocols,differentiating healthy and tumour tissues for navigating puncture needles,and obtaining preliminary diagnoses of the nature of neoplasms.Technical systems for assessing the perfusion and metabolic characteristics of biological tissues using fine-needle probes have been described.Fine-needle probe designs for biopsies of various organs are also presented.The results of using optical percutaneous needle biopsy in liver and breast cancers are demonstrated.
基金supported by the Key Foundation of Hubei Nature Scientific Funds(grant no.2014CFB481).
文摘Purpose:To retrospectively evaluate the diagnostic performance and complications of CT-guided percutaneous core needle biopsy(PCNB)for tuberculosis,analysis the influence factors of the diagnostic accuracy.Methods:From November 2005 to December 2015,through a retrospective review,283 CT-guided PCNBs performed in 270 patients were identified.Final results were confirmed by definitive surgery or the clinical course.Influence factor,complication rate,diagnostic performance was investigated.Influencing factors of the diagnostic accuracy were analyzed by uni-and multivariate logistic regression analyses.Results:283 CT-guided PCNBs performed in 270 patients(181 men,102 women;mean age,53.6 years)were included.The diagnostic accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of CT-guided PCNB were 90.00%,79.63%,100.00%,100.00%,88.89%%respectively.Significant factors affecting accuracy was age(p<0.05).Multivariate logistic regression analysis revealed that the risk of TB lesions receiving a false-negative diagnosis decreased for each additional year of subject age[OR=0.96;P<0.001].The incidences of complications such as pneumothorax,needle bleeding and hemoptysis were 9.3%,11.1%and 8.3%,respectively.Conclusion:CT-guided PCNB is efficient for the diagnosis of tuberculosis and is a safe diagnostic method.
基金Supported by Natural Science Foundation of Liaoning Province,No.2021-MS-287。
文摘BACKGROUND Acute fibrinous and organizing pneumonia(AFOP)is a rare,noninfective lung disease,histologically characterized by a patchy distribution of intra-alveolar fibrin“balls”and organizing pneumonia.The clinical manifestations of AFOP are nonspecific.Diagnosis depends on pathology.Surgical lung biopsy is optimal for tissue sampling to diagnose AFOP.However,many patients have no tolerance to the operation,including mentally and physically.There is still no standard therapy for AFOP and the methods remain controversial.Therefore,further clinical attention and discussion are warranted.CASE SUMMARY A 53-year-old woman presented with fever,cough and dyspnea for 15 d.Antiinfective therapy was ineffective.Chest computed tomography showed bilateral patchy consolidation,especially in the lower lobes.We performed both ultrasound-guided transbronchial lung biopsy and ultrasound-guided percutaneous fine needle puncture at different lung lesion locations.Both samples supported the diagnosis of AFOP.The patient had a good clinical course after treatment with methylprednisolone,and no side effects of steroids.CONCLUSION Percutaneous needle biopsy combined with transbronchial lung biopsies may be a good choice in the absence of surgical biopsy.Methylprednisolone alone is effective in the treatment of idiopathic AFOP.
