Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding dril...Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.展开更多
Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive ...Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive drilling simulation tools has the potential to be transformative.Such tools must accurately capture the rock’s response to enable an effective analysis of the fragmentation process.Traditional continuum numerical methods,such as the finite element method(FEM),do not simulate discrete cracks or the contact interaction between rock fragments.The finite-discrete element method(FDEM)is a three-dimensional hybrid method that combines FEM with the discrete element method(DEM)that addresses these limitations.New FDEM simulation results of impacts on Kuru Grey granite show good agreement with published experimental data.The interpretation focuses on two significant processes in percussive drilling:crack propagation and chipping generation.FDEM successfully simulates the evolution of cracks,including radial,side,and inclined cracks,as well as crushed and cracked zones.The simulation also reproduces the coalescence of adjacent craters to generate more chippings.Additionally,the stress state,velocity field and discrete fractures simulated by FDEM provide detailed insights into the different fracture patterns for Kuru Grey granite,enhancing understanding of the fundamental underlying mechanisms.展开更多
With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychologic...With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychological factors in percussion performance impact stage expressiveness and to propose corresponding psychological training strategies.By analyzing relevant domestic and international literature,we found that psychological training not only enhances performers’confidence and alleviates performance anxiety but also contributes to an overall improvement in performance quality.This study shows that methods such as emotional management and cognitive restructuring exhibit promising application potential in practice.Therefore,exploring a systematic psychological training program is significant for improving the stage expressiveness of percussion performers.展开更多
In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electric...In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electrical interactions between charged microparticles (MPs), which develop as fundamental vibrations (FVs) in ether, producing the vibrational strains εand γand the resulting stresses σand τ, as percussions of ether cells (ECs) upon the MP surface. The stresses σ?and?τproduce a resultant force FP, due to the percussions which constitute the real electric force FCC. The spatial effect of ether on FP is demonstrated by an analytical method, considering the electrical interaction between MPs through various equidistant spatial paths li of FVs, modelled on the basis of the Huygens principle for waves. For this issue, we utilized a numerical calculation, which could be generalized. But this spatial effect of the ether leads at a very slow decreasing of the FP forces ratio rF when doubling the distance l, in contrast to Coulomb’s FC forces whose ratio rF?decreases accentuate with doubling l. Accordingly, the necessity of including the term ln r in the FCC force, which is limited to 1.0 for doubling l, at long distances, was justified.展开更多
Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the mod...Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.展开更多
The process of DTH（down-the-hole） hammer drilling has been characterized as a very complex phenomenon due to its high nonlinearity,large deformation and damage behaviors.Taking brittle materials（concrete,granite an...The process of DTH（down-the-hole） hammer drilling has been characterized as a very complex phenomenon due to its high nonlinearity,large deformation and damage behaviors.Taking brittle materials（concrete,granite and sandstone） as impact specimens,the explicit time integration nonlinear finite element code LS-DYNA was employed to analyze the impact process and the penetration boundary conditions of DTH hammer percussive drilling system.Compared with previous studies,the present model contains several new features.One is that the 3D effects of DTH hammer drilling system were considered.Another important feature is that it took the coupling effects of brittle materials into account to the bit-specimen boundary of the drilling system.This distinguishes it from the traditional approaches to the bit-rock intersection,in which nonlinear spring models are usually imposed.The impact forces,bit insert penetrations and force-penetration curves of concrete,granite and sandstone under DTH hammer impact have been recorded;the formation of craters and fractures has been also investigated.The impact loads of piston-bit interaction appear to be relatively sensitive to piston impact velocity.The impact between piston-bit interaction occurs at two times larger forces,whereas the duration of the first impact doesn＇t change with respect to the piston velocity.The material properties of impact specimen do not affect the first impact process between the piston and bit.However,the period between the two impacts and the magnitudes of the second impact forces greatly depend on the specimen material properties.It is found that the penetration depth of specimen is dependent on the impact force magnitude and the macro-mechanical properties of the brittle materials.展开更多
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve...Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016.展开更多
Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the...Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.展开更多
Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptos...Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.展开更多
In this paper, we investigate a low dimensional model of percussive drilling with vibro-impact to mimic the nonlinear dynamics of the bounded progression. Non- holonomity which arises in the stick-slip caused by the i...In this paper, we investigate a low dimensional model of percussive drilling with vibro-impact to mimic the nonlinear dynamics of the bounded progression. Non- holonomity which arises in the stick-slip caused by the impact during drilling fails to be correctly identified via the classical techniques. A reduced model without non-holono- mity is derived by the introduction of a new state variable, of which averaging technique is employed successfully to detect the periodic motions. Local bifurcations are presented directly by using C-L method. Numerical simulations and the penetrating rate analysis along different choices of parame- ters have been carried out to probe the nonlinear behaviour and the optimal penetrating rate of the drilling system.展开更多
In order to develop a rotary percussive bit with diamond enhanced cutters assisted by high pressure water jets, it is necessary to study the damage mechanism and the penetration properties of PDC cutters subject to di...In order to develop a rotary percussive bit with diamond enhanced cutters assisted by high pressure water jets, it is necessary to study the damage mechanism and the penetration properties of PDC cutters subject to different impact load level and rock types. Therefore the impact experiments of the single PDC cutters with different attack angles in four rocks: black basalt, Missouri red granite, Halston limestone, and a very soft (Roubidoux) sandstone were carried out, and the effects of rake angles of PDC cutters on both the penetration and impact resistance of PDC cutters have been discussed in detail. Test results show that a PDC insert can withstand a very strong impact in compression but is easily damaged by impact shearing, the PDC cutters are more easily damaged by shearing if the attack angles are relatively small, the 45? PDC cutters have the least penetration resistance among the cutters tested. Thus it is suggested that the attack angles of PDC cutters should be larger than 30? for bits which must withstand impact from a hammer.展开更多
This paper sets forth a geomechanics framework for assessing the energy efficiency of rotary percussive drilling using the energy criterion, which has been proposed by Victor Oparin for volumetric destruction of high-...This paper sets forth a geomechanics framework for assessing the energy efficiency of rotary percussive drilling using the energy criterion, which has been proposed by Victor Oparin for volumetric destruction of high-stress rocks having nonuniform physico-mechanical properties. We review the long-term research and development in the specified area of science and technology, including research and development projects implemented at the Institute of Mining, Siberian Branch of the Russian Academy of Sciences. A new modified expression of Oparin’s dimensionless energy criterion of volumetric rock destruction k is introduced. The range of in situ values is determined for the energy criterion of volumetric rock destruction at the optimized energy efficiency of rotary percussive drilling. The temporospatial intervals of geotechnical monitoring are found to control pneumatic drilling energy efficiency at subsoil use objects in Russia. The integrated experimental, theoretical and geotechnical approach to the comprehensive investigation of real-time processes of rock fracture in rotary percussive drilling using the energy concept possesses the necessary geomechanical performance-and-technology potential to create the next level geotechnical monitoring of drilling systems for various purposes, including determination of physico-mechanical properties and the stress-strain analysis of rock mass in full-scale drilling.展开更多
We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal ...We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal cumulative effects,we obtained crack-free holes of aspect ratios exceeding 30 in sodalime and 70 in fused silica.The results are discussed in terms of inner wall morphology,aspect ratio and drilling speed.展开更多
A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this...A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.展开更多
This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDP...This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDPW factors, which will affect aluminum and copper dissimilar bonding, are described and these parameters have also been optimized. The fracture pull, interface compounds, microstructure and hardness are all studied. The results show that aluminum wire welding to copper sheet can form a sound weld and in some conditions the fracture pull is similar to that of the pure aluminum wires. The capacitance, discharge voltage, wire taper angle and machine oil as welding assistant medium affect fracture pull. The intermetaUic compounds A12 Cu appears on the copper side of joint. Narrower heat-affected zone is observed.展开更多
The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard formations.Percussive drilling is the most potential approach to increase rock-breaking e...The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard formations.Percussive drilling is the most potential approach to increase rock-breaking efficiency and ROP.However,the rock-breaking mechanism of percussive drilling is still unclear enough,especially the micro-fracture mechanism of rock under confining pressure(under lateral pressure and hydraulic pressure).In this paper,the impact rock breaking experiments by four kinds of Polycrystalline Diamond Compact(PDC)cutters are carried out using a drop-weight impact testing machine and an acoustic emission(AE)recording system,the influence of parameters such as cutter shape,rake angle,and impact energy on rock-breaking are systematically analyzed.This study includes a numerical simulation to examine the process of crack initiation,propagation,and cuttings formation during the impact process with the consideration of confining pressure.The results show the conicalshaped cutter is the most aggressive with high breaking efficiency.The penetration depth of the cutter is mainly influenced by the impact energy and cutter shape than the rake angle of the cutter.There exists critical impact energy makes the rock breaking efficiency the highest.The critical impact energy is about 40 J when using the conical-shaped cutter with a rake angle of 15°.The rock mainly failed in tensile mode,and the inter-grain crack is the main crack.Hydraulic pressure can inhibit the formation of horizontal cracks,while lateral pressure can inhibit the formation of vertical cracks and reduce the proportion of tensile cracks.The research results can provide some reference and basis for improving the rock-breaking efficiency in deep hard formations.展开更多
The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal ...The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.展开更多
AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to sim...AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to simulate a spontaneously breathing patient(Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation(Group 2). An 8.5 mm endotracheal tube(ETT) connected to the test lung, simulated the patient airway. Artificial mucus was instilled into the mid-portion of the ETT. A filter was attached at both ends of the ETT to collect the mucus displaced proximally(mouth-piece filter) and distally(lung filter). The IPV machine was attached to the proximal end of the ETT and was applied for 10-min each to Group 1 and 2. After each experiment, the weight of the various circuit components were determined and compared to their dry weights to calculate the weight of the displaced mucus.RESULTS In Group 1(spontaneously breathing model), 26.8% ± 3.1% of the simulated mucus was displaced proximally, compared to 0% in Group 2(the mechanically ventilated model) with a P-value of < 0.01. In fact, 17% ± 1.5% of the mucus in Group 2 remained in the mid-portion of the ETT where it was initially instilled and 80% ± 4.2% was displaced distally back towards the lung(P < 0.01). There was an overall statistically significant amount of mucusmovement proximally towards the mouth-piece in the spontaneously breathing(SB) patient. There was also an overall statistically significant amount of mucus movement distally back towards the lung in the mechanically ventilated(MV) model. In the mechanically ventilated model, no mucus was observed to move towards the proximal/mouth piece section of the ETT. CONCLUSION This bench model suggests that IPV is associated with displacement of mucus towards the proximal mouthpiece in the SB patient, and distally in the MV model.展开更多
A possibility of the efficient use of rotary percussive drilling to provide drilling smaller diameter holes(40–70 mm) both in mining and prospecting is disclosed herein. A new construction designed for the nipple thr...A possibility of the efficient use of rotary percussive drilling to provide drilling smaller diameter holes(40–70 mm) both in mining and prospecting is disclosed herein. A new construction designed for the nipple thread connection is described. The relative amplitude variation, change of power pulse time and energy in their propagation throughout the drilling tool are determined. A possibility of the efficient power pulse transfer along the drill string to the rock destruction tools with new nipple connections which allow automating the make-up and breakout system of drill pipe was supported by experiments.展开更多
Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of...Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.展开更多
基金supported by the Major Program of National Natural Science Foundation of China(No.52192624)the Innovative Research Group Project of National Natural Science Foundation of China(No.52421002)+3 种基金Major Science and Technology Project of Yunnan Province(No.202302AF080001)NSFC Key International(Regional)Cooperative Research Projects(No.52020105001)General Program of National Natural Science Foundation of China(Nos.52204019 and 52274016)the Foundation of State Key Laboratory of Petroleum Resources and Prospecting(No.PRE/DX-2402)。
文摘Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.
文摘Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive drilling simulation tools has the potential to be transformative.Such tools must accurately capture the rock’s response to enable an effective analysis of the fragmentation process.Traditional continuum numerical methods,such as the finite element method(FEM),do not simulate discrete cracks or the contact interaction between rock fragments.The finite-discrete element method(FDEM)is a three-dimensional hybrid method that combines FEM with the discrete element method(DEM)that addresses these limitations.New FDEM simulation results of impacts on Kuru Grey granite show good agreement with published experimental data.The interpretation focuses on two significant processes in percussive drilling:crack propagation and chipping generation.FDEM successfully simulates the evolution of cracks,including radial,side,and inclined cracks,as well as crushed and cracked zones.The simulation also reproduces the coalescence of adjacent craters to generate more chippings.Additionally,the stress state,velocity field and discrete fractures simulated by FDEM provide detailed insights into the different fracture patterns for Kuru Grey granite,enhancing understanding of the fundamental underlying mechanisms.
文摘With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychological factors in percussion performance impact stage expressiveness and to propose corresponding psychological training strategies.By analyzing relevant domestic and international literature,we found that psychological training not only enhances performers’confidence and alleviates performance anxiety but also contributes to an overall improvement in performance quality.This study shows that methods such as emotional management and cognitive restructuring exhibit promising application potential in practice.Therefore,exploring a systematic psychological training program is significant for improving the stage expressiveness of percussion performers.
文摘In this study, we demonstrate the correctness of our 2010 hypothesis regarding the need to complete Coulomb’s FC law with the term lnr, resulting in the completed FCC force. For this purpose, we consider the electrical interactions between charged microparticles (MPs), which develop as fundamental vibrations (FVs) in ether, producing the vibrational strains εand γand the resulting stresses σand τ, as percussions of ether cells (ECs) upon the MP surface. The stresses σ?and?τproduce a resultant force FP, due to the percussions which constitute the real electric force FCC. The spatial effect of ether on FP is demonstrated by an analytical method, considering the electrical interaction between MPs through various equidistant spatial paths li of FVs, modelled on the basis of the Huygens principle for waves. For this issue, we utilized a numerical calculation, which could be generalized. But this spatial effect of the ether leads at a very slow decreasing of the FP forces ratio rF when doubling the distance l, in contrast to Coulomb’s FC forces whose ratio rF?decreases accentuate with doubling l. Accordingly, the necessity of including the term ln r in the FCC force, which is limited to 1.0 for doubling l, at long distances, was justified.
文摘Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.
基金supported by the National Natural Science Foundation of China (No. 50475056)
文摘The process of DTH（down-the-hole） hammer drilling has been characterized as a very complex phenomenon due to its high nonlinearity,large deformation and damage behaviors.Taking brittle materials（concrete,granite and sandstone） as impact specimens,the explicit time integration nonlinear finite element code LS-DYNA was employed to analyze the impact process and the penetration boundary conditions of DTH hammer percussive drilling system.Compared with previous studies,the present model contains several new features.One is that the 3D effects of DTH hammer drilling system were considered.Another important feature is that it took the coupling effects of brittle materials into account to the bit-specimen boundary of the drilling system.This distinguishes it from the traditional approaches to the bit-rock intersection,in which nonlinear spring models are usually imposed.The impact forces,bit insert penetrations and force-penetration curves of concrete,granite and sandstone under DTH hammer impact have been recorded;the formation of craters and fractures has been also investigated.The impact loads of piston-bit interaction appear to be relatively sensitive to piston impact velocity.The impact between piston-bit interaction occurs at two times larger forces,whereas the duration of the first impact doesn＇t change with respect to the piston velocity.The material properties of impact specimen do not affect the first impact process between the piston and bit.However,the period between the two impacts and the magnitudes of the second impact forces greatly depend on the specimen material properties.It is found that the penetration depth of specimen is dependent on the impact force magnitude and the macro-mechanical properties of the brittle materials.
基金supported by the National Natural Science Foundation of China,No.81501690(to ZTG)the Scientific Research Staring Foundation for Talent Introduction for Southern Medical University(to MM)
文摘Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016.
文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.
文摘Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.
基金supported by the National Natural Science Foundation of China(10872136 and 10932006)the EPSRC Grant (GR/R85556)
文摘In this paper, we investigate a low dimensional model of percussive drilling with vibro-impact to mimic the nonlinear dynamics of the bounded progression. Non- holonomity which arises in the stick-slip caused by the impact during drilling fails to be correctly identified via the classical techniques. A reduced model without non-holono- mity is derived by the introduction of a new state variable, of which averaging technique is employed successfully to detect the periodic motions. Local bifurcations are presented directly by using C-L method. Numerical simulations and the penetrating rate analysis along different choices of parame- ters have been carried out to probe the nonlinear behaviour and the optimal penetrating rate of the drilling system.
文摘In order to develop a rotary percussive bit with diamond enhanced cutters assisted by high pressure water jets, it is necessary to study the damage mechanism and the penetration properties of PDC cutters subject to different impact load level and rock types. Therefore the impact experiments of the single PDC cutters with different attack angles in four rocks: black basalt, Missouri red granite, Halston limestone, and a very soft (Roubidoux) sandstone were carried out, and the effects of rake angles of PDC cutters on both the penetration and impact resistance of PDC cutters have been discussed in detail. Test results show that a PDC insert can withstand a very strong impact in compression but is easily damaged by impact shearing, the PDC cutters are more easily damaged by shearing if the attack angles are relatively small, the 45? PDC cutters have the least penetration resistance among the cutters tested. Thus it is suggested that the attack angles of PDC cutters should be larger than 30? for bits which must withstand impact from a hammer.
基金supported by the Russian Science Foundation (Grant No. 17-17-01282)RFBR (Grant No. 20-05-00051)。
文摘This paper sets forth a geomechanics framework for assessing the energy efficiency of rotary percussive drilling using the energy criterion, which has been proposed by Victor Oparin for volumetric destruction of high-stress rocks having nonuniform physico-mechanical properties. We review the long-term research and development in the specified area of science and technology, including research and development projects implemented at the Institute of Mining, Siberian Branch of the Russian Academy of Sciences. A new modified expression of Oparin’s dimensionless energy criterion of volumetric rock destruction k is introduced. The range of in situ values is determined for the energy criterion of volumetric rock destruction at the optimized energy efficiency of rotary percussive drilling. The temporospatial intervals of geotechnical monitoring are found to control pneumatic drilling energy efficiency at subsoil use objects in Russia. The integrated experimental, theoretical and geotechnical approach to the comprehensive investigation of real-time processes of rock fracture in rotary percussive drilling using the energy concept possesses the necessary geomechanical performance-and-technology potential to create the next level geotechnical monitoring of drilling systems for various purposes, including determination of physico-mechanical properties and the stress-strain analysis of rock mass in full-scale drilling.
文摘We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal cumulative effects,we obtained crack-free holes of aspect ratios exceeding 30 in sodalime and 70 in fused silica.The results are discussed in terms of inner wall morphology,aspect ratio and drilling speed.
基金supported by a grant from the Incubation Project of Natural Science Foundation of Tianjin Medical University General Hospital in China,No.303071901401the Natural Science Foundation of Tianjin of China,No.13JCZDJC30800the National Natural Science Foundation of China,No.81271361 and 81330029
文摘A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.
文摘This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDPW factors, which will affect aluminum and copper dissimilar bonding, are described and these parameters have also been optimized. The fracture pull, interface compounds, microstructure and hardness are all studied. The results show that aluminum wire welding to copper sheet can form a sound weld and in some conditions the fracture pull is similar to that of the pure aluminum wires. The capacitance, discharge voltage, wire taper angle and machine oil as welding assistant medium affect fracture pull. The intermetaUic compounds A12 Cu appears on the copper side of joint. Narrower heat-affected zone is observed.
基金supported by the National Natural Science Foundation of China(Grant No.52034006,No.52004229,No.52225401,No.52274231)Regional Innovation Cooperation Project of Sichuan Province(2022YFQ0059)+2 种基金Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(2020CX040301)Natural Science Foundation of Sichuan Province(23NSFSC 2099)Science and Technology Strategic Cooperation Project between Nanchong City and Southwest Petroleum University(SXHZ004).
文摘The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard formations.Percussive drilling is the most potential approach to increase rock-breaking efficiency and ROP.However,the rock-breaking mechanism of percussive drilling is still unclear enough,especially the micro-fracture mechanism of rock under confining pressure(under lateral pressure and hydraulic pressure).In this paper,the impact rock breaking experiments by four kinds of Polycrystalline Diamond Compact(PDC)cutters are carried out using a drop-weight impact testing machine and an acoustic emission(AE)recording system,the influence of parameters such as cutter shape,rake angle,and impact energy on rock-breaking are systematically analyzed.This study includes a numerical simulation to examine the process of crack initiation,propagation,and cuttings formation during the impact process with the consideration of confining pressure.The results show the conicalshaped cutter is the most aggressive with high breaking efficiency.The penetration depth of the cutter is mainly influenced by the impact energy and cutter shape than the rake angle of the cutter.There exists critical impact energy makes the rock breaking efficiency the highest.The critical impact energy is about 40 J when using the conical-shaped cutter with a rake angle of 15°.The rock mainly failed in tensile mode,and the inter-grain crack is the main crack.Hydraulic pressure can inhibit the formation of horizontal cracks,while lateral pressure can inhibit the formation of vertical cracks and reduce the proportion of tensile cracks.The research results can provide some reference and basis for improving the rock-breaking efficiency in deep hard formations.
基金supported by the National Natural Science Foundation of China,No.81201984the Scientific Research Project of Shaanxi Provincial Health Department in China,No.2010E03the Yulin Municipal Science and Technology Research and Development Project,No.Sf12-06
文摘The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.
文摘AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to simulate a spontaneously breathing patient(Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation(Group 2). An 8.5 mm endotracheal tube(ETT) connected to the test lung, simulated the patient airway. Artificial mucus was instilled into the mid-portion of the ETT. A filter was attached at both ends of the ETT to collect the mucus displaced proximally(mouth-piece filter) and distally(lung filter). The IPV machine was attached to the proximal end of the ETT and was applied for 10-min each to Group 1 and 2. After each experiment, the weight of the various circuit components were determined and compared to their dry weights to calculate the weight of the displaced mucus.RESULTS In Group 1(spontaneously breathing model), 26.8% ± 3.1% of the simulated mucus was displaced proximally, compared to 0% in Group 2(the mechanically ventilated model) with a P-value of < 0.01. In fact, 17% ± 1.5% of the mucus in Group 2 remained in the mid-portion of the ETT where it was initially instilled and 80% ± 4.2% was displaced distally back towards the lung(P < 0.01). There was an overall statistically significant amount of mucusmovement proximally towards the mouth-piece in the spontaneously breathing(SB) patient. There was also an overall statistically significant amount of mucus movement distally back towards the lung in the mechanically ventilated(MV) model. In the mechanically ventilated model, no mucus was observed to move towards the proximal/mouth piece section of the ETT. CONCLUSION This bench model suggests that IPV is associated with displacement of mucus towards the proximal mouthpiece in the SB patient, and distally in the MV model.
基金supported by the research Grant within the framework of the Federal Target Program ‘Scientific and Academic Staff of Innovative Russia’ during the years of 2009–2013competitive activity 1.3.1. ‘Research conducted by young researchers, Ph.D. holders’, the project theme ‘Research of power pulse interaction in a drilling tool and in rock mass in underground borehole drilling’
文摘A possibility of the efficient use of rotary percussive drilling to provide drilling smaller diameter holes(40–70 mm) both in mining and prospecting is disclosed herein. A new construction designed for the nipple thread connection is described. The relative amplitude variation, change of power pulse time and energy in their propagation throughout the drilling tool are determined. A possibility of the efficient power pulse transfer along the drill string to the rock destruction tools with new nipple connections which allow automating the make-up and breakout system of drill pipe was supported by experiments.
基金supported by a grant from the International S cience and Technology Cooperation Projects of China,No.2011DFG33430
文摘Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.
