Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding dril...Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.展开更多
With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychologic...With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychological factors in percussion performance impact stage expressiveness and to propose corresponding psychological training strategies.By analyzing relevant domestic and international literature,we found that psychological training not only enhances performers’confidence and alleviates performance anxiety but also contributes to an overall improvement in performance quality.This study shows that methods such as emotional management and cognitive restructuring exhibit promising application potential in practice.Therefore,exploring a systematic psychological training program is significant for improving the stage expressiveness of percussion performers.展开更多
We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal ...We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal cumulative effects,we obtained crack-free holes of aspect ratios exceeding 30 in sodalime and 70 in fused silica.The results are discussed in terms of inner wall morphology,aspect ratio and drilling speed.展开更多
This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDP...This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDPW factors, which will affect aluminum and copper dissimilar bonding, are described and these parameters have also been optimized. The fracture pull, interface compounds, microstructure and hardness are all studied. The results show that aluminum wire welding to copper sheet can form a sound weld and in some conditions the fracture pull is similar to that of the pure aluminum wires. The capacitance, discharge voltage, wire taper angle and machine oil as welding assistant medium affect fracture pull. The intermetaUic compounds A12 Cu appears on the copper side of joint. Narrower heat-affected zone is observed.展开更多
Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of...Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.展开更多
Background Traffic accidents,anti-terrorism,gas and chemical dangerous goods explosions,earthquake shock wave damage,and falling impacts in daily life and other events involving impact loads cause great harm to human ...Background Traffic accidents,anti-terrorism,gas and chemical dangerous goods explosions,earthquake shock wave damage,and falling impacts in daily life and other events involving impact loads cause great harm to human organs and tissues,and even life-threatening.Such injuries are called impact damage.Although during the previous wars,the treatment of impact injuries has been greatly improved,and its treatment has been widely used in clinical practice.However,under the current development of society,the impact damage incident has not only been limited to the battlefield.Extreme organizations,frequent industrial production accidents,aircraft trains and other accidents have extended the impact damage incidents into daily society,seriously jeopardizing the health of civilians.Therefore,in order to better treat the injured organs under the impact load,such as the reconstruction and recovery of organ tissues,it is necessary to establish a corresponding system of clinical treatment methods for impact damage.In vitro models of traumatic injury are helping elucidate the pathobiological mechanisms responsible for dysfunction and delayed cell functional variation after mechanical stimulation of the single waveform pressure.It is likely that injury outcome is related to the biomechanical parameters of the traumatic event such as amplitudes and durations.However,the influence of impulsive pressure on endothelial function has not yet been fully studied in vitro.In this study,we developed a pressure loading device that produced positive by modifying an in vitro fluid percussion model and examined the effects of the pressures on macrophages’basic functions.Methods To model variations in the biomechanical injury parameters and simplify the experiment,single-use syringe was chosen to be the cell container and a drop hammer driven fluid percussion injury system(FPI)was designed and built to generate a single waveform with adjustable peak pressure and durations.Mice macrophage cells(Raw 264.7)were subjected to three types of the single positive pressure(120 kPa,550 kPa and 1 100 kPa).Every 12 hours we detected its basic functions(including phagocytosis and proliferative capacity)during the following 48 hours,also the immediate cell death.Results This single waveform pressure loading device could produce positive pressure with amplitudes of 70~1 200 kPa.After the pressure loading,there is no significant differences between the control cells and experiment cells.However,it does have a notable effect on its basic functions.The results showed that its phagocytosis and proliferative capacity were getting increased with a peak value on36 h and suddenly decreasing on 48 h.Moreover,these 4 regular curves are in proportion to the pressure.And the experimental results also indicate that the cell impact platform can achieve a single impact loading on the cells.The impact mainly causes the functional changes of RAW264.7 cells instead of directly causing its death.The cell proliferation activity and phagocytosis function are enhanced to some extent.Conclusions Those results indicate that single waveform pressure have a main effect on cell’s biological functions,not on cell death.And these effects on functions did have a regular functional rela-tionship.To explore more regular curves and the mechanism,we need more experiments such as genomics technical.展开更多
Flax and jute fabrics are adopted to reinforce epoxy matrix composites in order to explore the feasibility of replacing wood in percussion instruments.The fabrics are treated with alkaline solutions to improve interfa...Flax and jute fabrics are adopted to reinforce epoxy matrix composites in order to explore the feasibility of replacing wood in percussion instruments.The fabrics are treated with alkaline solutions to improve interfacial adhesion between fibers and epoxy.The composites are fabricated using the hand-lay and vacuum assisted resin infusion process.Acoustic dynamic moduli,acoustic radiation damping coefficients,and acoustic impedances of the composites are tested and compared with those of the wood regularly used to make the percussion instruments.It is found that the acoustic properties of the composites are within the range of those of the wood,indicating that it could be feasible to replace the wood with natural cellulose fiber reinforced composites in percussion instrument production.展开更多
In this paper,the Kane’s equations for the Routh’s form of variable massnonholonomic systems are established.and the Kane’s equations for percussion motionof variable mass holonomic and nonholonomic systems are d...In this paper,the Kane’s equations for the Routh’s form of variable massnonholonomic systems are established.and the Kane’s equations for percussion motionof variable mass holonomic and nonholonomic systems are deduced from them. Secondly,the equivalence to Lagrange’s equations for percussion motion and Kane’sequations is obtained,and the application of the new equation is illustrated by anexample.展开更多
A three dimensional dynamic elastic-plastic finite element analysis of the interaction of percussion bits with rock masses is presented. The dynamic contact problem was investigated with the numerical method developed...A three dimensional dynamic elastic-plastic finite element analysis of the interaction of percussion bits with rock masses is presented. The dynamic contact problem was investigated with the numerical method developed for high velocity impact calculations[1]. The numerical analysis was carried out for three simultaneously loaded percussion bits arranged on a straight line on the rock surface, the loading time was kept constant throughout this work. The numerical calculation for various strengths of the dynamic load tm the percussion bits shows that a critical minimum dynamic load exists for the generation of plastic deformations in the rock. For this critical value of the load the maximum normal stress of the longitudinal wave in the percussion bit exceeds the yield stress of the rock mass.展开更多
This study was conducted to study the effects of Latin,rock,and African percussion music on milk production performance in cow. 72 Holstein cows with similar milk yield,age,parity and lactation were randomly divided i...This study was conducted to study the effects of Latin,rock,and African percussion music on milk production performance in cow. 72 Holstein cows with similar milk yield,age,parity and lactation were randomly divided into four groups,namely the Latin music group,rock music group,African percussion music group and control group,each 18 cows. The pretrial period lasted for 7 d,and the formal trial period was 60 d. The music began to be played in test group from pretrial period,while the control group received routine feeding. Milk yield was measured every 20 d,and milk sample was collected once. The results showed that African percussion music could increase the contents of GLB,ALT and LDH in the serum of cow,and reduce the milk yield of cow. Rock music would increase the serum LDH content in cow and reduce the milk yield of cow.展开更多
Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the mod...Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.展开更多
This paper examines the performance of three families of percussive drilling methods,Churn(CD),Down-the-Hole(DTH),and Top-Hammer(TH),through the prism of time scales.These time scales characterize different aspects of...This paper examines the performance of three families of percussive drilling methods,Churn(CD),Down-the-Hole(DTH),and Top-Hammer(TH),through the prism of time scales.These time scales characterize different aspects of the dynamics of the drilling process.One time scale represents the travel time of an elastic perturbation in the hammer,while another one corresponds to the travel time in the drillstring and/or the bit assembly.The duration of the response of the bit/rock interface to an impulse load,and the duration of the pulse generated by the impact of the hammer in DTH and TH tools are two other time scales.Within the simplified modeling framework considered in this study,the dynamics of the percussion tools is at most controlled by three numbers,which are ratios of time scales.However,some of these numbers could be irrelevant depending on the design and class of the percussion drilling system,because they are either too small or too large and thus do not affect the dynamical response.For example,the energy transfer efficiency-the fraction of the impact energy effectively delivered to the rock-depends on one number when drilling with a TH tool,but on three numbers for a hydraulically powered DTH tool.This approach enables the identification of the point of maximum efficiency in the parametric space of the time scale ratios.The so-called sweet spot can thus be understood as representing an optimum match of the different timescales characterizing the drilling system.For instance,maximum performance is achieved with a TH tool if the two time scales controlling its dynamics are equal.展开更多
Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive ...Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive drilling simulation tools has the potential to be transformative.Such tools must accurately capture the rock’s response to enable an effective analysis of the fragmentation process.Traditional continuum numerical methods,such as the finite element method(FEM),do not simulate discrete cracks or the contact interaction between rock fragments.The finite-discrete element method(FDEM)is a three-dimensional hybrid method that combines FEM with the discrete element method(DEM)that addresses these limitations.New FDEM simulation results of impacts on Kuru Grey granite show good agreement with published experimental data.The interpretation focuses on two significant processes in percussive drilling:crack propagation and chipping generation.FDEM successfully simulates the evolution of cracks,including radial,side,and inclined cracks,as well as crushed and cracked zones.The simulation also reproduces the coalescence of adjacent craters to generate more chippings.Additionally,the stress state,velocity field and discrete fractures simulated by FDEM provide detailed insights into the different fracture patterns for Kuru Grey granite,enhancing understanding of the fundamental underlying mechanisms.展开更多
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve...Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016.展开更多
Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the...Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.展开更多
Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptos...Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.展开更多
A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this...A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.展开更多
The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal ...The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.展开更多
AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to sim...AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to simulate a spontaneously breathing patient(Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation(Group 2). An 8.5 mm endotracheal tube(ETT) connected to the test lung, simulated the patient airway. Artificial mucus was instilled into the mid-portion of the ETT. A filter was attached at both ends of the ETT to collect the mucus displaced proximally(mouth-piece filter) and distally(lung filter). The IPV machine was attached to the proximal end of the ETT and was applied for 10-min each to Group 1 and 2. After each experiment, the weight of the various circuit components were determined and compared to their dry weights to calculate the weight of the displaced mucus.RESULTS In Group 1(spontaneously breathing model), 26.8% ± 3.1% of the simulated mucus was displaced proximally, compared to 0% in Group 2(the mechanically ventilated model) with a P-value of < 0.01. In fact, 17% ± 1.5% of the mucus in Group 2 remained in the mid-portion of the ETT where it was initially instilled and 80% ± 4.2% was displaced distally back towards the lung(P < 0.01). There was an overall statistically significant amount of mucusmovement proximally towards the mouth-piece in the spontaneously breathing(SB) patient. There was also an overall statistically significant amount of mucus movement distally back towards the lung in the mechanically ventilated(MV) model. In the mechanically ventilated model, no mucus was observed to move towards the proximal/mouth piece section of the ETT. CONCLUSION This bench model suggests that IPV is associated with displacement of mucus towards the proximal mouthpiece in the SB patient, and distally in the MV model.展开更多
The paper presents the design and preliminary test results of a corer used for hard seafloor sediments sampling. Generally the sediment cores are provided by either gravity-type coting or deep-ocean drilling for a ran...The paper presents the design and preliminary test results of a corer used for hard seafloor sediments sampling. Generally the sediment cores are provided by either gravity-type coting or deep-ocean drilling for a range of studies. However, in consideration of the operability and available sample length in collecting hard sediments, these methods exhibit no advantages. In this paper, a new corer which can exploit both hydrostatic energy and gravity energy for hard sediments coting is presented. The hydrostatic energy is provided by pressure differential between ambient seawater pressure and air pressure in an empty cavity. During sampling process, the corer penetrates into the sediment like a gravity corer and then automatically shifts to the percussion mode. The experiments in the laboratory indicate that the corer can complete 40 cycles in the sea with a cycle time of 2.8 seconds in percussion mode and impact the sample tube with the velocity of 0.2 m/s during each cycle. Besides, its adjustable falling velocity can make the corer achieve the maximum efficiency in coring different sediments.展开更多
基金supported by the Major Program of National Natural Science Foundation of China(No.52192624)the Innovative Research Group Project of National Natural Science Foundation of China(No.52421002)+3 种基金Major Science and Technology Project of Yunnan Province(No.202302AF080001)NSFC Key International(Regional)Cooperative Research Projects(No.52020105001)General Program of National Natural Science Foundation of China(Nos.52204019 and 52274016)the Foundation of State Key Laboratory of Petroleum Resources and Prospecting(No.PRE/DX-2402)。
文摘Percussion drilling is a promising approach for hot dry rock(HDR)fragmentation.However,understanding of HDR fragmentation mechanism under multi-dimensional percussion remains limited and hinders the corresponding drilling performance.Herein,an innovative true triaxial multi-dimensional percussion device was developed for the study of HDR fragmentation mechanism under in-situ temperature and stress conditions.Multi-dimensional percussion,involving both axial and torsional components,was applied to drilling in granite and carbonatite rocks sampled from the typical HDR target areas.Multiscale visualization techniques and a whale optimization-variational mode decomposition algorithm were employed to investigate the rock failure patterns and drilling energy characteristics.Results indicated that multi-dimensional percussion enhances brittle-ductile mixed failure in granite,characterized by transgranular,intergranular,and combined fracture patterns that promote rock cracking.In contrast,carbonatite drillhole displays enhanced brittle fragmentation and tortuous failure surface dominated by transgranular fracture pattern.Frequency-domain characteristics of penetration force signals for multidimensional percussion,especially the significant dominant frequency,amplitude,and high-frequency dissipation,indicate an increase in net energy for drilling into HDR and intensified rock fragmentation.Further,the effect of impact frequency on rock fragmentation performance was emphasized to maximize drilling efficiency.The optimal regulation schemes between axial and torsional impact frequencies are identified as 15 Hz+15 Hz for granite and 30 Hz+15 Hz for carbonatite.The reliability of the optimization approach was validated through a field test that employed a novel impactor in the geothermal well Fushen-1.
文摘With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychological factors in percussion performance impact stage expressiveness and to propose corresponding psychological training strategies.By analyzing relevant domestic and international literature,we found that psychological training not only enhances performers’confidence and alleviates performance anxiety but also contributes to an overall improvement in performance quality.This study shows that methods such as emotional management and cognitive restructuring exhibit promising application potential in practice.Therefore,exploring a systematic psychological training program is significant for improving the stage expressiveness of percussion performers.
文摘We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal cumulative effects,we obtained crack-free holes of aspect ratios exceeding 30 in sodalime and 70 in fused silica.The results are discussed in terms of inner wall morphology,aspect ratio and drilling speed.
文摘This paper presents the results of a research into capacitor discharge percussion welding （CDPW） of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDPW factors, which will affect aluminum and copper dissimilar bonding, are described and these parameters have also been optimized. The fracture pull, interface compounds, microstructure and hardness are all studied. The results show that aluminum wire welding to copper sheet can form a sound weld and in some conditions the fracture pull is similar to that of the pure aluminum wires. The capacitance, discharge voltage, wire taper angle and machine oil as welding assistant medium affect fracture pull. The intermetaUic compounds A12 Cu appears on the copper side of joint. Narrower heat-affected zone is observed.
基金supported by a grant from the International S cience and Technology Cooperation Projects of China,No.2011DFG33430
文摘Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic element. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a fluid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm（101.32 ± 11.16 k Pa）, 2.6 ± 0.16 atm（263.44 ± 16.21 k Pa）, and 3.6 ± 0.16 atm（364.77 ± 16.21 k Pa）, respectively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established fluid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.
基金financially supported by the National Natural Science Foundation of China ( 11722220, 11672246,11472224)
文摘Background Traffic accidents,anti-terrorism,gas and chemical dangerous goods explosions,earthquake shock wave damage,and falling impacts in daily life and other events involving impact loads cause great harm to human organs and tissues,and even life-threatening.Such injuries are called impact damage.Although during the previous wars,the treatment of impact injuries has been greatly improved,and its treatment has been widely used in clinical practice.However,under the current development of society,the impact damage incident has not only been limited to the battlefield.Extreme organizations,frequent industrial production accidents,aircraft trains and other accidents have extended the impact damage incidents into daily society,seriously jeopardizing the health of civilians.Therefore,in order to better treat the injured organs under the impact load,such as the reconstruction and recovery of organ tissues,it is necessary to establish a corresponding system of clinical treatment methods for impact damage.In vitro models of traumatic injury are helping elucidate the pathobiological mechanisms responsible for dysfunction and delayed cell functional variation after mechanical stimulation of the single waveform pressure.It is likely that injury outcome is related to the biomechanical parameters of the traumatic event such as amplitudes and durations.However,the influence of impulsive pressure on endothelial function has not yet been fully studied in vitro.In this study,we developed a pressure loading device that produced positive by modifying an in vitro fluid percussion model and examined the effects of the pressures on macrophages’basic functions.Methods To model variations in the biomechanical injury parameters and simplify the experiment,single-use syringe was chosen to be the cell container and a drop hammer driven fluid percussion injury system(FPI)was designed and built to generate a single waveform with adjustable peak pressure and durations.Mice macrophage cells(Raw 264.7)were subjected to three types of the single positive pressure(120 kPa,550 kPa and 1 100 kPa).Every 12 hours we detected its basic functions(including phagocytosis and proliferative capacity)during the following 48 hours,also the immediate cell death.Results This single waveform pressure loading device could produce positive pressure with amplitudes of 70~1 200 kPa.After the pressure loading,there is no significant differences between the control cells and experiment cells.However,it does have a notable effect on its basic functions.The results showed that its phagocytosis and proliferative capacity were getting increased with a peak value on36 h and suddenly decreasing on 48 h.Moreover,these 4 regular curves are in proportion to the pressure.And the experimental results also indicate that the cell impact platform can achieve a single impact loading on the cells.The impact mainly causes the functional changes of RAW264.7 cells instead of directly causing its death.The cell proliferation activity and phagocytosis function are enhanced to some extent.Conclusions Those results indicate that single waveform pressure have a main effect on cell’s biological functions,not on cell death.And these effects on functions did have a regular functional rela-tionship.To explore more regular curves and the mechanism,we need more experiments such as genomics technical.
基金National Natural Science Foundation of China(No.51803108)Natural Science Foundation of Fujian Province,China(Nos.2019J01740,2019J05106)+2 种基金Quanzhou City Science&Technology Program,China(Nos.2016Z071,2018K002,2018G011)Startup Foundation for Doctors of Quanzhou Normal University,China(No.H18028)Science and Technology Program of Quanzhou Normal University,China(No.2013KJ04)。
文摘Flax and jute fabrics are adopted to reinforce epoxy matrix composites in order to explore the feasibility of replacing wood in percussion instruments.The fabrics are treated with alkaline solutions to improve interfacial adhesion between fibers and epoxy.The composites are fabricated using the hand-lay and vacuum assisted resin infusion process.Acoustic dynamic moduli,acoustic radiation damping coefficients,and acoustic impedances of the composites are tested and compared with those of the wood regularly used to make the percussion instruments.It is found that the acoustic properties of the composites are within the range of those of the wood,indicating that it could be feasible to replace the wood with natural cellulose fiber reinforced composites in percussion instrument production.
文摘In this paper,the Kane’s equations for the Routh’s form of variable massnonholonomic systems are established.and the Kane’s equations for percussion motionof variable mass holonomic and nonholonomic systems are deduced from them. Secondly,the equivalence to Lagrange’s equations for percussion motion and Kane’sequations is obtained,and the application of the new equation is illustrated by anexample.
文摘A three dimensional dynamic elastic-plastic finite element analysis of the interaction of percussion bits with rock masses is presented. The dynamic contact problem was investigated with the numerical method developed for high velocity impact calculations[1]. The numerical analysis was carried out for three simultaneously loaded percussion bits arranged on a straight line on the rock surface, the loading time was kept constant throughout this work. The numerical calculation for various strengths of the dynamic load tm the percussion bits shows that a critical minimum dynamic load exists for the generation of plastic deformations in the rock. For this critical value of the load the maximum normal stress of the longitudinal wave in the percussion bit exceeds the yield stress of the rock mass.
基金Supported by Special Fund for Modern Agricultural(Cow)Industry Technology System Construction(CARS-37)
文摘This study was conducted to study the effects of Latin,rock,and African percussion music on milk production performance in cow. 72 Holstein cows with similar milk yield,age,parity and lactation were randomly divided into four groups,namely the Latin music group,rock music group,African percussion music group and control group,each 18 cows. The pretrial period lasted for 7 d,and the formal trial period was 60 d. The music began to be played in test group from pretrial period,while the control group received routine feeding. Milk yield was measured every 20 d,and milk sample was collected once. The results showed that African percussion music could increase the contents of GLB,ALT and LDH in the serum of cow,and reduce the milk yield of cow. Rock music would increase the serum LDH content in cow and reduce the milk yield of cow.
文摘Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.
基金This study was a part of the research project INNO-Drill(Technology platform for research-based innovations in deep geothermal drilling)funded by The Research Council of Norway(grant 254984)industry partners.
文摘This paper examines the performance of three families of percussive drilling methods,Churn(CD),Down-the-Hole(DTH),and Top-Hammer(TH),through the prism of time scales.These time scales characterize different aspects of the dynamics of the drilling process.One time scale represents the travel time of an elastic perturbation in the hammer,while another one corresponds to the travel time in the drillstring and/or the bit assembly.The duration of the response of the bit/rock interface to an impulse load,and the duration of the pulse generated by the impact of the hammer in DTH and TH tools are two other time scales.Within the simplified modeling framework considered in this study,the dynamics of the percussion tools is at most controlled by three numbers,which are ratios of time scales.However,some of these numbers could be irrelevant depending on the design and class of the percussion drilling system,because they are either too small or too large and thus do not affect the dynamical response.For example,the energy transfer efficiency-the fraction of the impact energy effectively delivered to the rock-depends on one number when drilling with a TH tool,but on three numbers for a hydraulically powered DTH tool.This approach enables the identification of the point of maximum efficiency in the parametric space of the time scale ratios.The so-called sweet spot can thus be understood as representing an optimum match of the different timescales characterizing the drilling system.For instance,maximum performance is achieved with a TH tool if the two time scales controlling its dynamics are equal.
文摘Percussive drilling is gaining interest for both shallow and deep applications due to its potential for higher drilling rates in hard rocks.Therefore,for efficient rock breaking,the development of advanced percussive drilling simulation tools has the potential to be transformative.Such tools must accurately capture the rock’s response to enable an effective analysis of the fragmentation process.Traditional continuum numerical methods,such as the finite element method(FEM),do not simulate discrete cracks or the contact interaction between rock fragments.The finite-discrete element method(FDEM)is a three-dimensional hybrid method that combines FEM with the discrete element method(DEM)that addresses these limitations.New FDEM simulation results of impacts on Kuru Grey granite show good agreement with published experimental data.The interpretation focuses on two significant processes in percussive drilling:crack propagation and chipping generation.FDEM successfully simulates the evolution of cracks,including radial,side,and inclined cracks,as well as crushed and cracked zones.The simulation also reproduces the coalescence of adjacent craters to generate more chippings.Additionally,the stress state,velocity field and discrete fractures simulated by FDEM provide detailed insights into the different fracture patterns for Kuru Grey granite,enhancing understanding of the fundamental underlying mechanisms.
基金supported by the National Natural Science Foundation of China,No.81501690(to ZTG)the Scientific Research Staring Foundation for Talent Introduction for Southern Medical University(to MM)
文摘Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016.
文摘Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions.
文摘Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective （Flavopiridol） and selective （Roscovitine and CR-8） cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials.
基金supported by a grant from the Incubation Project of Natural Science Foundation of Tianjin Medical University General Hospital in China,No.303071901401the Natural Science Foundation of Tianjin of China,No.13JCZDJC30800the National Natural Science Foundation of China,No.81271361 and 81330029
文摘A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.
基金supported by the National Natural Science Foundation of China,No.81201984the Scientific Research Project of Shaanxi Provincial Health Department in China,No.2010E03the Yulin Municipal Science and Technology Research and Development Project,No.Sf12-06
文摘The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal neurons after injury, but the mechanism by which it affects excitatory synaptic transmission remains poorly understood. Our results showed that diazepam treatment signiifcantly increased the slope of input-output curves in rat neurons after lfuid per-cussion injury. Diazepam signiifcantly decreased the numbers of spikes evoked by super stimuli in the presence of 15 μmol/L bicuculline, indicating the existence of inhibitory pathways in the injured rat hippocampus. Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release. These data suggest that diazepam could decrease the lfuid per-cussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.
文摘AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to simulate a spontaneously breathing patient(Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation(Group 2). An 8.5 mm endotracheal tube(ETT) connected to the test lung, simulated the patient airway. Artificial mucus was instilled into the mid-portion of the ETT. A filter was attached at both ends of the ETT to collect the mucus displaced proximally(mouth-piece filter) and distally(lung filter). The IPV machine was attached to the proximal end of the ETT and was applied for 10-min each to Group 1 and 2. After each experiment, the weight of the various circuit components were determined and compared to their dry weights to calculate the weight of the displaced mucus.RESULTS In Group 1(spontaneously breathing model), 26.8% ± 3.1% of the simulated mucus was displaced proximally, compared to 0% in Group 2(the mechanically ventilated model) with a P-value of < 0.01. In fact, 17% ± 1.5% of the mucus in Group 2 remained in the mid-portion of the ETT where it was initially instilled and 80% ± 4.2% was displaced distally back towards the lung(P < 0.01). There was an overall statistically significant amount of mucusmovement proximally towards the mouth-piece in the spontaneously breathing(SB) patient. There was also an overall statistically significant amount of mucus movement distally back towards the lung in the mechanically ventilated(MV) model. In the mechanically ventilated model, no mucus was observed to move towards the proximal/mouth piece section of the ETT. CONCLUSION This bench model suggests that IPV is associated with displacement of mucus towards the proximal mouthpiece in the SB patient, and distally in the MV model.
基金supported by the National Natural Science Foundation of China (Grant No. 40806043)
文摘The paper presents the design and preliminary test results of a corer used for hard seafloor sediments sampling. Generally the sediment cores are provided by either gravity-type coting or deep-ocean drilling for a range of studies. However, in consideration of the operability and available sample length in collecting hard sediments, these methods exhibit no advantages. In this paper, a new corer which can exploit both hydrostatic energy and gravity energy for hard sediments coting is presented. The hydrostatic energy is provided by pressure differential between ambient seawater pressure and air pressure in an empty cavity. During sampling process, the corer penetrates into the sediment like a gravity corer and then automatically shifts to the percussion mode. The experiments in the laboratory indicate that the corer can complete 40 cycles in the sea with a cycle time of 2.8 seconds in percussion mode and impact the sample tube with the velocity of 0.2 m/s during each cycle. Besides, its adjustable falling velocity can make the corer achieve the maximum efficiency in coring different sediments.
