The optimal therapy for Helicobacter pylori(H.pylori) infection should combine a high cure rate and a short treatment duration with a favorable side-effect profile and should maintain a low cost.Several strategies hav...The optimal therapy for Helicobacter pylori(H.pylori) infection should combine a high cure rate and a short treatment duration with a favorable side-effect profile and should maintain a low cost.Several strategies have been proposed to increase the H.pylori eradication rate,including the extension of the treatment duration to 14 d,the use of a four-drug regimen(quadruple,sequential,and concomitant treatments),and the use of novel antibiotics,such as levofloxacin.However,triple therapy remains the most widely accepted firstline treatment regimen in Brazil and the United Statesand throughout Europe.Because this therapy is limited by resistance to clarithromycin,other therapeutic regimens have been investigated worldwide.This review describes the current literature involving studies directly comparing these different therapies and their efficacies.展开更多
文摘The optimal therapy for Helicobacter pylori(H.pylori) infection should combine a high cure rate and a short treatment duration with a favorable side-effect profile and should maintain a low cost.Several strategies have been proposed to increase the H.pylori eradication rate,including the extension of the treatment duration to 14 d,the use of a four-drug regimen(quadruple,sequential,and concomitant treatments),and the use of novel antibiotics,such as levofloxacin.However,triple therapy remains the most widely accepted firstline treatment regimen in Brazil and the United Statesand throughout Europe.Because this therapy is limited by resistance to clarithromycin,other therapeutic regimens have been investigated worldwide.This review describes the current literature involving studies directly comparing these different therapies and their efficacies.
