Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant...Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health.展开更多
Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant...Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant are used to treat various ailments like,cough,cold and as an antiseptic.Interestingly.P.murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men.nocturnal emissions,gonorrhoea as well as leucorrhoea in women.The plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract disorders.Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids.Other phytochemicals reported in the plant includes quercetin.ursolic acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,nonacosane.tritriacontane.tetratriacontanyl and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. nephroprotective.hypolipidemic,aphrodisiac,antioxidant,antimicrobial and insecticidal activities.From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease.The overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for P.murex published so far.展开更多
Bada Gokhru(Pedalium murex L.) is perhaps the most useful traditional medicinal plant in India.Each part of the neem tree has some medicinal property and is thus commercially exploitable.During the last five decades,a...Bada Gokhru(Pedalium murex L.) is perhaps the most useful traditional medicinal plant in India.Each part of the neem tree has some medicinal property and is thus commercially exploitable.During the last five decades,apart from the chemistrv ol the Pedalium murex compounds.considerable progress has been achieved regarding the biological activity and medicinal applications of litis plant.It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products.This review gives a bird's eye view mainlv on the biological activities ol some of this compounds isolated.pharmacological actions of the extracts.clinical studies and plausible medicinal applications ol gokharu along with their safety evaluation.展开更多
The aim of this study is to assess the pharmacological and phytochemical aspects of the Pedalium murex(Linn)(P.murex)and its traditional medicinal uses of different parts of the plant.Flavonoids,phenolic compounds,gly...The aim of this study is to assess the pharmacological and phytochemical aspects of the Pedalium murex(Linn)(P.murex)and its traditional medicinal uses of different parts of the plant.Flavonoids,phenolic compounds,glycosides,carbohydrates,reducing sugars,phytosterols,tannins,triterpenoids,alkaloids,xanthoproteins,aromatic oil,stable oil,saponins and resins are the main phytochemical groups that have been found in different chemical extracts of P.murex.Pharmacological activities of P.murex have proven its importance for medicinal uses.This review will be helpful to create interest to use P.murex for developing new formulation in therapeutic medicines.展开更多
基金Supported by University Grant Commision,New Delhi,India(No:IT/DEV/08-09/3252/L)
文摘Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health.
文摘Pedalium murex Linn(family:Pedaliaceae)(P.murex) commonly known as Large Caltrops and Gokhru(India) is a shrub found in the Southern part.Deccan region of India and in some parts of Ceylon.Different parts of the plant are used to treat various ailments like,cough,cold and as an antiseptic.Interestingly.P.murex is reported traditionally to have an excellent cure in patients with reproductive disorders which are mainly impotency in men.nocturnal emissions,gonorrhoea as well as leucorrhoea in women.The plant has also benifiled in complications like urinary track disorder as well as gastro intestinal tract disorders.Phytochemically the plant is popular for the presence of a considerable amount of diosgenin and vanillin which are regarded as an important source and useful starting materials for synthesizing steroidal contraceptive drugs and isatin alkaloids.Other phytochemicals reported in the plant includes quercetin.ursolic acid,caffeic acid,amino acids(glycine,histidine,tyrosine,threonine,aspartie acid and glutamic acid) and various classes of fatty acids(triacontanoic acid,nonacosane.tritriacontane.tetratriacontanyl and heptatriacontan-4-one).Pharmacologically,the plant have been investigated for antiulcerogenic. nephroprotective.hypolipidemic,aphrodisiac,antioxidant,antimicrobial and insecticidal activities.From all these reports it can be concluded that the plant were found to have a better profile with potential natural source for the treatment of various range of either acute or chronic disease.The overall database of our review article was collected from the scientific sources in regards with all the information ol the research article for P.murex published so far.
文摘Bada Gokhru(Pedalium murex L.) is perhaps the most useful traditional medicinal plant in India.Each part of the neem tree has some medicinal property and is thus commercially exploitable.During the last five decades,apart from the chemistrv ol the Pedalium murex compounds.considerable progress has been achieved regarding the biological activity and medicinal applications of litis plant.It is now considered as a valuable source of unique natural products for development of medicines against various diseases and also for the development of industrial products.This review gives a bird's eye view mainlv on the biological activities ol some of this compounds isolated.pharmacological actions of the extracts.clinical studies and plausible medicinal applications ol gokharu along with their safety evaluation.
基金Supported by Director/CE Chemical UCG Project via Grant No.Chemistry-K10.
文摘The aim of this study is to assess the pharmacological and phytochemical aspects of the Pedalium murex(Linn)(P.murex)and its traditional medicinal uses of different parts of the plant.Flavonoids,phenolic compounds,glycosides,carbohydrates,reducing sugars,phytosterols,tannins,triterpenoids,alkaloids,xanthoproteins,aromatic oil,stable oil,saponins and resins are the main phytochemical groups that have been found in different chemical extracts of P.murex.Pharmacological activities of P.murex have proven its importance for medicinal uses.This review will be helpful to create interest to use P.murex for developing new formulation in therapeutic medicines.
