Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,con...Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.展开更多
Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each ch...Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each child)who were admitted to the hospital between January 2024 and June 2024 were selected and randomly divided into two groups using a random number table.The combined group received childlike nursing combined with Chinese herbal patching,while the control group received routine nursing.Symptom recovery time,treatment compliance,inflammatory factor levels,quality of life of the children,and family satisfaction were compared between the two groups.Results:The symptom recovery time in the combined group was shorter than that in the control group,treatment compliance was higher,inflammatory factor levels after intervention were lower,quality of life scores of the children were lower,and family satisfaction was higher(P<0.05).Conclusion:The implementation of childlike nursing combined with Chinese herbal patching for children with bronchopneumonia can shorten their symptom recovery time,significantly improve treatment compliance and quality of life,reduce inflammatory reactions,and achieve high satisfaction among family members.展开更多
Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water pos...Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water poses a great challenge in the stability of anode.In this study,we present a straightforward strategy to protect the anode from corrosion by patching the catalyst layer through a treatment of the anode with a sodium sulfide(Na2S) solution followed by electrochemical activation.The rapid sulfurization of the Ni electrode in Na2S results in the formation of a Na2S layer,which can subsequently be converted to NiOOH upon electrochemical activation,thereby shielding the inner Ni electrode from corrosion.The as-prepared electrode (P-NiFe-LDH/Ni) based on the strategy demonstrated stability over 3,500 h at an industrial current density of 0.5 A cm^(-2)in a 0.5 M NaCl and 1 M KOH solution.This study presents an effective strategy to significantly enhance the stability of anodes for saline water electrolysis by effectively patching the cracks in the catalyst layer.展开更多
A wideband low-profile aperture-coupled antenna based on a novel dual-mode-composite scheme is presented.The mode-composite scheme where the TM10 cavity mode and the TE121 dielec-tric resonator(DR)mode are combined of...A wideband low-profile aperture-coupled antenna based on a novel dual-mode-composite scheme is presented.The mode-composite scheme where the TM10 cavity mode and the TE121 dielec-tric resonator(DR)mode are combined offers an ap-proach to obtain a wide bandwidth accompanied by stable unidirectional radiation and high efficiency.The use of a lengthened coupling aperture that supports the one-wavelength resonance in the band of interest is an effective feed method of simultaneously excit-ing the two composite modes without compromising the increased complexity of the antenna geometry.An impedance bandwidth of 49%for|S_(11)|of less than-10 dB,a maximum gain of 10.8 dBi,and stable radiation patterns with low cross-polarization are realized ex-perimentally by a fabricated prototype.Considering the simplicity of the geometry,the wide bandwidth that can cover n77,n78,and n79 bands for the fifth generation(5G)mobile communications and the sat-isfying radiation performance,the proposed antenna would be a promising candidate for advanced wireless applications.展开更多
The authors used suspension cells of Populus euphratica to isolate protoplast in the present study. Protoplasts were successfully obtained after 4 hours incubation in enzyme solution containing 1 0% cellulase “o...The authors used suspension cells of Populus euphratica to isolate protoplast in the present study. Protoplasts were successfully obtained after 4 hours incubation in enzyme solution containing 1 0% cellulase “onozuka” R\|10, 0\^01% pectolyase Y\|23,0\^15% macerozyme R\|10 and 0\^1% hemicellulase at 25℃. Outward and inward single channels in plasma membrane were observed using cell\|attached recording of patch\|clamp technique. In this study, single channel records showed that more than one species of channel were obtained. These attempts in protoplast isolation and ion channel recording offers the opportunity to characterize cellular mechanisms of salt tolerance in tree species.展开更多
To obtain accurate forms and surfaces in free surface grinding, it is important to provide grinding conditions suitable for a curved surface. A grinding support system for the free surface （GSX-F） is proposed to hel...To obtain accurate forms and surfaces in free surface grinding, it is important to provide grinding conditions suitable for a curved surface. A grinding support system for the free surface （GSX-F） is proposed to help the operator grind a free surface with the high accuracy and the high productivity. To succeed in free surface grinding, the property of a ball type wheel must be known. Therefore, a basic study of free surface grinding with a ball type wheel is carried out based on the grinding center （GC）. Some working points for achieving sufficient accuracy in free surface grinding are discussed. GSX-F is constructed using the patch division method and is used to test grinding. Reasonable results are obtained.展开更多
The Chinese Grouse (Tetrastes sewerzowi) is a rare, endemic bird in China, inhabiting conifer-dominated mountain forests. Both the natural fragmentation and heavy cutting of mature forests have resulted in patchy grou...The Chinese Grouse (Tetrastes sewerzowi) is a rare, endemic bird in China, inhabiting conifer-dominated mountain forests. Both the natural fragmentation and heavy cutting of mature forests have resulted in patchy grouse habitats. We used SPOT (XS-sensor) satellite imagery to discriminate between open land and conifer or broadleaf forests. The area analyzed is about 120000 ha in size and includes the Lianhuashan Nature Reserve and the Yeliguan Forestry Park. We identiifed 4111 ha of mature coniferous forests in 229 patches (maximum 332 ha, mean 18 ha) as the habitat used by Chinese Grouse throughout the year. We examined 31 forest islands of different sizes and degrees of isolation for the presence of Chinese Grouse. We used generalized linear models (GLM) with binomial error structure and logit link function to estimate the probability of Chinese Grouse occupancy in a forest fragment. Habitat patch size (hs) and distance to the next occupied fragment (doc) were used as predictor variables, important for occupancy. Small habitat islands were disproportionately less likely to be occupied than large, nearby habitats. There was a clear speciifc habitat size of about 40 ha, above which habitat fragments were occupied more often. Suitable habitat fragments isolated by more than 2 km appeared to be inaccessible to Chinese Grouse. The results have been used in reforestation projects to establish linking corridors in the study area.展开更多
In this article, we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models, which have not only an exchange of individuals between patches through migration but also cross patch in...In this article, we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models, which have not only an exchange of individuals between patches through migration but also cross patch infection between different groups. As a result, we partially generalize the recent result in the article [16].展开更多
Traditionally,patch-based analysis at the landscape scale fragmentation has been used in the study of landscape ecology while the study of boundary and node has not been considered as much detail until recently.This s...Traditionally,patch-based analysis at the landscape scale fragmentation has been used in the study of landscape ecology while the study of boundary and node has not been considered as much detail until recently.This study investigated the possibility of applying boundary-and node-based methods in landscape pattern analysis to the upper reaches of the Minjiang River in the southwestern China.Boundary-based and node-based landscape indices were selected to be used in analyzing changes in landscape patterns,and the results were compared with analysis using traditional pattern indices.We compared the responses of patch-area-based,boundary-length-based and node-number-based indices,and concluded that boundary-based and node-based indices are more sensitive to disturbance than patch-based indices with various patterns,and node-based indices are even more sensitive than boundary-based ones.Thus,the results suggest that boundary-based and node-based pattern analysis methods provide helpful supplementary information to traditional patch-based pattern analysis methods.The results about pattern dynamics of landscapes in the upper reaches of the Minjiang River based on boundaries and nodes showed that with human disturbance,the dominance of forest landscape was weakened by other landscape types;thus the landscape pattern of the study area became more homogeneous and the boundary network became more complex.These changes further augmented disturbance interfaces in the landscape and increased the possibilities of further landscape fragmentation.展开更多
Cervical inlet patch(CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of C...Cervical inlet patch(CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps(H^+, K^+ -ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors. This case indicated that CIP should be considered as a differential diagnosis for the cause of globus symptoms in rare cases.展开更多
The effects of types and amounts of silane coupling agent on mechanical properties of vuleanized rubber microwave absorbing patch （VRMAP） were studied. The mechanisms of silane coupling agent＇s effects on mechanica...The effects of types and amounts of silane coupling agent on mechanical properties of vuleanized rubber microwave absorbing patch （VRMAP） were studied. The mechanisms of silane coupling agent＇s effects on mechanical properties of rubber microwave absorbing patch （ RMAP ） and microvave absorbing patch＇s （MAP＇s） mierostrueture were also discussed by using SEM and FT-IR. The experimental results show that the tensile strength of RMAP could be increased through adding the filler of carbonyl iron powder （CIP） modified by silane coupling agent. RMAP fiUed with CIP, which was treated by silane coupling agent KH550, possessed a high tensile strength of 11.5 MPa, which was 448% more than that of MAP whose filler wus not modified by any coupling agent. It was found that the optimal amount of KH550 was 1.0 phr to 100.0 phr carbonyl iron powder. The effects of different modifying techniques on RMAP＇s mechanical properties were also inrestigated. It is indieated that MAP whose filler is modified by the wet process has the highest tensile strength, but it is not the optimal modiifying technique due to complieated wet process. On the contrary, the dry process was very simple, and VRMAP possessed fairly high mechanical properties, therefore, it was the perfect modifying process.展开更多
This article makes the first attempt in assessing the influence of active constrained layer damping(ACLD)treatment towards precise control of frequency responses of functionally graded skew-magneto-electroelastic(FGSM...This article makes the first attempt in assessing the influence of active constrained layer damping(ACLD)treatment towards precise control of frequency responses of functionally graded skew-magneto-electroelastic(FGSMEE)plates by employing finite element methods.The materials are functionally graded across the thickness of the plate in terms of modest power-law distributions.The principal equations of motion of FGSMEE are derived via Hamilton’s principle and solved using condensation technique.The effect of ACLD patches are modelled by following the complex modulus approach(CMA).Additionally,distinctive emphasis is laid to evaluate the influence of geometrical skewness on the attenuation capabilities of the plate.The accuracy of the current analysis is corroborated with comparison of previous researches of similar kind.Additionally,a complete parametric study is directed to understand the combined impacts of various factors like coupling fields,patch location,fiber orientation of piezoelectric patch in association with skew angle and power-law index.展开更多
Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this...Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug delivery.This patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster angiogen-esis.Consequently,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.展开更多
Sparse representation has attracted extensive attention and performed well on image super-resolution（SR） in the last decade. However, many current image SR methods face the contradiction of detail recovery and artif...Sparse representation has attracted extensive attention and performed well on image super-resolution（SR） in the last decade. However, many current image SR methods face the contradiction of detail recovery and artifact suppression. We propose a multi-resolution dictionary learning（MRDL） model to solve this contradiction, and give a fast single image SR method based on the MRDL model. To obtain the MRDL model, we first extract multi-scale patches by using our proposed adaptive patch partition method（APPM）. The APPM divides images into patches of different sizes according to their detail richness. Then, the multiresolution dictionary pairs, which contain structural primitives of various resolutions, can be trained from these multi-scale patches.Owing to the MRDL strategy, our SR algorithm not only recovers details well, with less jag and noise, but also significantly improves the computational efficiency. Experimental results validate that our algorithm performs better than other SR methods in evaluation metrics and visual perception.展开更多
AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnos...AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnosis of amblyopia,were evaluated retrospectively.Forty eyes of 26 patients who had received patching therapy and 24 eyes of 24 patients who had received penalization therapy included in this study.The latencies and amplitudes of visual evoked potential(VEP)records and best corrected visual acuities(BCVA)of these two groups were compared before and six months after the treatment.RESULTS:In both patching and the penalization groups,the visual acuities increased significantly following the treatments(P【0.05).The latency measurements of the P100 wave obtained at 1.0°,15 arc min.Patterns of both groups significantly decreased following the 6-months-treatment.However,the amplitude measurements increased(P【0.05).CONCLUSION:The patching and the penalization methods,which are the main methods used in the treatment of amblyopia,were also effective over the age of 7y,which has been accepted as the critical age for the treatment of amblyopia.展开更多
Alopecia areata is characterized bysudden loss of hair in patches from normalscalp.It may occur in patients of all ages,particularly in young adults.The etiology isunknown,possibly related to emotional orimmune factor...Alopecia areata is characterized bysudden loss of hair in patches from normalscalp.It may occur in patients of all ages,particularly in young adults.The etiology isunknown,possibly related to emotional orimmune factors.The onset is sudden,withno subjective symptoms.Several patches ofhair may fall during one night.The baldareas may be round,oval or irregular inshape,and the scalp smooth,with normalhair follicles visible.展开更多
To make use of the prior knowledge of the image more effectively and restore more details of the edges and structures, a novel sparse coding objective function is proposed by applying the principle of the non-local si...To make use of the prior knowledge of the image more effectively and restore more details of the edges and structures, a novel sparse coding objective function is proposed by applying the principle of the non-local similarity and manifold learning on the basis of super-resolution algorithm via sparse representation. Firstly, the non-local similarity regularization term is constructed by using the similar image patches to preserve the edge information. Then, the manifold learning regularization term is constructed by utilizing the locally linear embedding approach to enhance the structural information. The experimental results validate that the proposed algorithm has a significant improvement compared with several super-resolution algorithms in terms of the subjective visual effect and objective evaluation indices.展开更多
基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(No.RS-2023-00256265,RS-2024-00352352,RS-2024-00405818)the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare).(No.25A0102L1)support from the Market-led K-sensor technology program(RS-2022-00154781,Development of large-area wafer-level flexible/stretchable hybrid sensor platform technology for form factor-free highly integrated convergence sensor),funded By the Ministry of Trade,Industry&Energy(MOTIE,Korea).
文摘Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.
文摘Objective:To evaluate the intervention effect of childlike nursing combined with Chinese herbal patching on pediatric bronchopneumonia.Methods:1036 children with bronchopneumonia(one family member included for each child)who were admitted to the hospital between January 2024 and June 2024 were selected and randomly divided into two groups using a random number table.The combined group received childlike nursing combined with Chinese herbal patching,while the control group received routine nursing.Symptom recovery time,treatment compliance,inflammatory factor levels,quality of life of the children,and family satisfaction were compared between the two groups.Results:The symptom recovery time in the combined group was shorter than that in the control group,treatment compliance was higher,inflammatory factor levels after intervention were lower,quality of life scores of the children were lower,and family satisfaction was higher(P<0.05).Conclusion:The implementation of childlike nursing combined with Chinese herbal patching for children with bronchopneumonia can shorten their symptom recovery time,significantly improve treatment compliance and quality of life,reduce inflammatory reactions,and achieve high satisfaction among family members.
基金financially supported by the National Key Research and Development Program(No.2023YFB4006100)the National Natural Science Foundation of China(No.52271232)+3 种基金Ningbo Youth Science and Technology Leading Talents Project(No.2023QL026)the Youth Innovation Promotion Association,CAS(No.2020300)the Natural Science Foundation of Zhejiang Province(Nos.LY21E020008 and LD21E020001)the“From 0 to 1”Innovative Program of CAS(No.ZDBS-LY-JSC021)
文摘Using abundant saline water for electrolysis,rather than limited freshwater,presents a promising technique for generating clean hydrogen energy.However,high concentration of corrosive chloride ions in saline water poses a great challenge in the stability of anode.In this study,we present a straightforward strategy to protect the anode from corrosion by patching the catalyst layer through a treatment of the anode with a sodium sulfide(Na2S) solution followed by electrochemical activation.The rapid sulfurization of the Ni electrode in Na2S results in the formation of a Na2S layer,which can subsequently be converted to NiOOH upon electrochemical activation,thereby shielding the inner Ni electrode from corrosion.The as-prepared electrode (P-NiFe-LDH/Ni) based on the strategy demonstrated stability over 3,500 h at an industrial current density of 0.5 A cm^(-2)in a 0.5 M NaCl and 1 M KOH solution.This study presents an effective strategy to significantly enhance the stability of anodes for saline water electrolysis by effectively patching the cracks in the catalyst layer.
基金supported in part by the Beijing Natural Science Foundation No.JQ22011the National Science Foundation of China for Distinguished Young Scholars under Grant No.62325102+1 种基金the National Natural Science Foundation of China under Grant No.62031004the Fundamental Research Funds for the Central Universities No.2023YJS160.
文摘A wideband low-profile aperture-coupled antenna based on a novel dual-mode-composite scheme is presented.The mode-composite scheme where the TM10 cavity mode and the TE121 dielec-tric resonator(DR)mode are combined offers an ap-proach to obtain a wide bandwidth accompanied by stable unidirectional radiation and high efficiency.The use of a lengthened coupling aperture that supports the one-wavelength resonance in the band of interest is an effective feed method of simultaneously excit-ing the two composite modes without compromising the increased complexity of the antenna geometry.An impedance bandwidth of 49%for|S_(11)|of less than-10 dB,a maximum gain of 10.8 dBi,and stable radiation patterns with low cross-polarization are realized ex-perimentally by a fabricated prototype.Considering the simplicity of the geometry,the wide bandwidth that can cover n77,n78,and n79 bands for the fifth generation(5G)mobile communications and the sat-isfying radiation performance,the proposed antenna would be a promising candidate for advanced wireless applications.
文摘The authors used suspension cells of Populus euphratica to isolate protoplast in the present study. Protoplasts were successfully obtained after 4 hours incubation in enzyme solution containing 1 0% cellulase “onozuka” R\|10, 0\^01% pectolyase Y\|23,0\^15% macerozyme R\|10 and 0\^1% hemicellulase at 25℃. Outward and inward single channels in plasma membrane were observed using cell\|attached recording of patch\|clamp technique. In this study, single channel records showed that more than one species of channel were obtained. These attempts in protoplast isolation and ion channel recording offers the opportunity to characterize cellular mechanisms of salt tolerance in tree species.
文摘To obtain accurate forms and surfaces in free surface grinding, it is important to provide grinding conditions suitable for a curved surface. A grinding support system for the free surface （GSX-F） is proposed to help the operator grind a free surface with the high accuracy and the high productivity. To succeed in free surface grinding, the property of a ball type wheel must be known. Therefore, a basic study of free surface grinding with a ball type wheel is carried out based on the grinding center （GC）. Some working points for achieving sufficient accuracy in free surface grinding are discussed. GSX-F is constructed using the patch division method and is used to test grinding. Reasonable results are obtained.
基金supported by the National Natural Science Foundation of China(Grant No.31270468,30620130110)
文摘The Chinese Grouse (Tetrastes sewerzowi) is a rare, endemic bird in China, inhabiting conifer-dominated mountain forests. Both the natural fragmentation and heavy cutting of mature forests have resulted in patchy grouse habitats. We used SPOT (XS-sensor) satellite imagery to discriminate between open land and conifer or broadleaf forests. The area analyzed is about 120000 ha in size and includes the Lianhuashan Nature Reserve and the Yeliguan Forestry Park. We identiifed 4111 ha of mature coniferous forests in 229 patches (maximum 332 ha, mean 18 ha) as the habitat used by Chinese Grouse throughout the year. We examined 31 forest islands of different sizes and degrees of isolation for the presence of Chinese Grouse. We used generalized linear models (GLM) with binomial error structure and logit link function to estimate the probability of Chinese Grouse occupancy in a forest fragment. Habitat patch size (hs) and distance to the next occupied fragment (doc) were used as predictor variables, important for occupancy. Small habitat islands were disproportionately less likely to be occupied than large, nearby habitats. There was a clear speciifc habitat size of about 40 ha, above which habitat fragments were occupied more often. Suitable habitat fragments isolated by more than 2 km appeared to be inaccessible to Chinese Grouse. The results have been used in reforestation projects to establish linking corridors in the study area.
基金supported by Japan Society for the Promotion of Science (Grant Scientific Research (c), No. 24540219 to the first author, JSPS Fellows, No.237213 to the second author, and No. 222176 to the third author)
文摘In this article, we establish the global stability of an endemic equilibrium of multi-group SIR epidemic models, which have not only an exchange of individuals between patches through migration but also cross patch infection between different groups. As a result, we partially generalize the recent result in the article [16].
基金Under the auspices of Major State Basic Research Development Program of China(No.2006CB403201)
文摘Traditionally,patch-based analysis at the landscape scale fragmentation has been used in the study of landscape ecology while the study of boundary and node has not been considered as much detail until recently.This study investigated the possibility of applying boundary-and node-based methods in landscape pattern analysis to the upper reaches of the Minjiang River in the southwestern China.Boundary-based and node-based landscape indices were selected to be used in analyzing changes in landscape patterns,and the results were compared with analysis using traditional pattern indices.We compared the responses of patch-area-based,boundary-length-based and node-number-based indices,and concluded that boundary-based and node-based indices are more sensitive to disturbance than patch-based indices with various patterns,and node-based indices are even more sensitive than boundary-based ones.Thus,the results suggest that boundary-based and node-based pattern analysis methods provide helpful supplementary information to traditional patch-based pattern analysis methods.The results about pattern dynamics of landscapes in the upper reaches of the Minjiang River based on boundaries and nodes showed that with human disturbance,the dominance of forest landscape was weakened by other landscape types;thus the landscape pattern of the study area became more homogeneous and the boundary network became more complex.These changes further augmented disturbance interfaces in the landscape and increased the possibilities of further landscape fragmentation.
文摘Cervical inlet patch(CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps(H^+, K^+ -ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors. This case indicated that CIP should be considered as a differential diagnosis for the cause of globus symptoms in rare cases.
文摘The effects of types and amounts of silane coupling agent on mechanical properties of vuleanized rubber microwave absorbing patch （VRMAP） were studied. The mechanisms of silane coupling agent＇s effects on mechanical properties of rubber microwave absorbing patch （ RMAP ） and microvave absorbing patch＇s （MAP＇s） mierostrueture were also discussed by using SEM and FT-IR. The experimental results show that the tensile strength of RMAP could be increased through adding the filler of carbonyl iron powder （CIP） modified by silane coupling agent. RMAP fiUed with CIP, which was treated by silane coupling agent KH550, possessed a high tensile strength of 11.5 MPa, which was 448% more than that of MAP whose filler wus not modified by any coupling agent. It was found that the optimal amount of KH550 was 1.0 phr to 100.0 phr carbonyl iron powder. The effects of different modifying techniques on RMAP＇s mechanical properties were also inrestigated. It is indieated that MAP whose filler is modified by the wet process has the highest tensile strength, but it is not the optimal modiifying technique due to complieated wet process. On the contrary, the dry process was very simple, and VRMAP possessed fairly high mechanical properties, therefore, it was the perfect modifying process.
文摘This article makes the first attempt in assessing the influence of active constrained layer damping(ACLD)treatment towards precise control of frequency responses of functionally graded skew-magneto-electroelastic(FGSMEE)plates by employing finite element methods.The materials are functionally graded across the thickness of the plate in terms of modest power-law distributions.The principal equations of motion of FGSMEE are derived via Hamilton’s principle and solved using condensation technique.The effect of ACLD patches are modelled by following the complex modulus approach(CMA).Additionally,distinctive emphasis is laid to evaluate the influence of geometrical skewness on the attenuation capabilities of the plate.The accuracy of the current analysis is corroborated with comparison of previous researches of similar kind.Additionally,a complete parametric study is directed to understand the combined impacts of various factors like coupling fields,patch location,fiber orientation of piezoelectric patch in association with skew angle and power-law index.
基金supported by the National Natural Science Foundation of China(No.31971271)The Natural Science Foundation of Fujian Province of China(No.2022J01794)The Science and Technology Plan Project of Quanzhou(No.2021N033S).
文摘Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug delivery.This patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-l-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster angiogen-esis.Consequently,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.
文摘Sparse representation has attracted extensive attention and performed well on image super-resolution（SR） in the last decade. However, many current image SR methods face the contradiction of detail recovery and artifact suppression. We propose a multi-resolution dictionary learning（MRDL） model to solve this contradiction, and give a fast single image SR method based on the MRDL model. To obtain the MRDL model, we first extract multi-scale patches by using our proposed adaptive patch partition method（APPM）. The APPM divides images into patches of different sizes according to their detail richness. Then, the multiresolution dictionary pairs, which contain structural primitives of various resolutions, can be trained from these multi-scale patches.Owing to the MRDL strategy, our SR algorithm not only recovers details well, with less jag and noise, but also significantly improves the computational efficiency. Experimental results validate that our algorithm performs better than other SR methods in evaluation metrics and visual perception.
文摘AIM:To compare the efficacies of patching and penalization therapies for the treatment of amblyopia patients.METHODS:The records of 64 eyes of 50 patients 7 to16y of age who had presented to our clinics with a diagnosis of amblyopia,were evaluated retrospectively.Forty eyes of 26 patients who had received patching therapy and 24 eyes of 24 patients who had received penalization therapy included in this study.The latencies and amplitudes of visual evoked potential(VEP)records and best corrected visual acuities(BCVA)of these two groups were compared before and six months after the treatment.RESULTS:In both patching and the penalization groups,the visual acuities increased significantly following the treatments(P【0.05).The latency measurements of the P100 wave obtained at 1.0°,15 arc min.Patterns of both groups significantly decreased following the 6-months-treatment.However,the amplitude measurements increased(P【0.05).CONCLUSION:The patching and the penalization methods,which are the main methods used in the treatment of amblyopia,were also effective over the age of 7y,which has been accepted as the critical age for the treatment of amblyopia.
文摘Alopecia areata is characterized bysudden loss of hair in patches from normalscalp.It may occur in patients of all ages,particularly in young adults.The etiology isunknown,possibly related to emotional orimmune factors.The onset is sudden,withno subjective symptoms.Several patches ofhair may fall during one night.The baldareas may be round,oval or irregular inshape,and the scalp smooth,with normalhair follicles visible.
基金supported by the National Natural Science Foundation of China(Nos.61672335 and 61602191)the Foundation of Fujian Education Department(No.JAT170053)
文摘To make use of the prior knowledge of the image more effectively and restore more details of the edges and structures, a novel sparse coding objective function is proposed by applying the principle of the non-local similarity and manifold learning on the basis of super-resolution algorithm via sparse representation. Firstly, the non-local similarity regularization term is constructed by using the similar image patches to preserve the edge information. Then, the manifold learning regularization term is constructed by utilizing the locally linear embedding approach to enhance the structural information. The experimental results validate that the proposed algorithm has a significant improvement compared with several super-resolution algorithms in terms of the subjective visual effect and objective evaluation indices.
