Particle engineering has opened the floodgates to material science in both fundamental and application field. However, covalent interactions have not yet been adequately designed in the particle engineering for functi...Particle engineering has opened the floodgates to material science in both fundamental and application field. However, covalent interactions have not yet been adequately designed in the particle engineering for functional colloidal photonic crystals(CPCs). Herein, we achieved covalent coupling between carboxylrich poly(styrene-acrylic acid)(P(St-AA)) monodispersed colloidal particles and amine-rich carbon dots(CDs) based on an feasible and universal particle engineering strategy. The designed CDs-grafted P(St-AA)monodispersed colloidal particles initiate a hydrogen bond-driven assembly mode and ensure the construction of large-scale crack-free CPCs. Moreover, the CDs equipped with selective broad-band absorption capacity could improve the saturation of structural colors for high-visibility CPCs. Furthermore, an injectable photonic hydrogel(IPH) is developed to design CPC supraball hydrogel via integrating the CDsgrafted P(St-AA) CPC supraballs with supramolecular hydrogel. Combining superior flexibility, sufficient self-healing capacity of supramolecular hydrogel with visual optical information of our CPC supraballs, a cyclically reversible coding and decoding system was developed. Meanwhile, we firstly demonstrated the novel strategy of 3D supraballs-based passive cooling. The designed 3D CPC supraball hydrogel presents nearly full observation angle reflections behavior and excellent water evaporation capacity and achieves3.6 ℃ temperature drops, showing the application advantages in 3D thermal management. This work not only provides a new insight for manipulating optical properties of CPCs, but also demonstrates an easyto-perform platform, as well as indicates the direction for the promising application of CPCs.展开更多
Inhalation therapies are pivotal for treating pulmonary diseases, yet their efficacy critically depends on the physicochemical properties of drug particles. This study introduces a novel microdroplet cryo-crystallizat...Inhalation therapies are pivotal for treating pulmonary diseases, yet their efficacy critically depends on the physicochemical properties of drug particles. This study introduces a novel microdroplet cryo-crystallization (MCC) technique to fabricate inhalable budesonide (BUD) particles. The MCC process combines rapid cryogenic freezing of drug-loaded microdroplets in liquid nitrogen, followed by additive-guided suspension crystallization in an anti-solvent environment. Cryogenic freezing suppresses molecular mobility and prevents aggregation, preserving uniform solute distribution. Subsequent controlled crystallization in the anti-solvent system enables precise tailoring of nanoparticle morphologies while avoiding supersaturation-driven amorphization. Systematic optimization identified MCC conditions yielding BUD ultrafine crystals with a volume median diameter of 3.0 μm, >94 % sphericity, >98 % crystallinity, and minimal hygroscopicity (<0.5 %). Compared to conventional air-jet milled BUD (∼90 % crystallinity and ∼3 % hygroscopicity), the MCC-engineered particles exhibit significantly improved physicochemical stability and dissolution performance (94 % in 180 min). The MCC strategy decouples cryogenic freezing and phase transformation, avoiding top-down limitations (e.g., milling-induced amorphization) and bottom-up issues (uncontrolled nucleation/aggregation) to achieve scalable and highly precise production of inhalable drug particles.展开更多
Drug delivery via pulmonary inhalation can achieve targeted treatment by directly delivering the drugs to the area for treatment.The method is developing rapidly for the treatment of local and systemic diseases.Howeve...Drug delivery via pulmonary inhalation can achieve targeted treatment by directly delivering the drugs to the area for treatment.The method is developing rapidly for the treatment of local and systemic diseases.However,dry powders for inhalation need to exhibit excellent aerodynamic performance.Particle size,morphology and density need to be tightly regulated to guarantee effective lung deposition and assure long-term chemical stability of the drug.In this work,the compositions and requirements of dry powders for inhalation are discussed.Furthermore,the state-of-art methods in particle technology for dry powders for inhalation,such as milling,droplet evaporation,direct crystallization,supercritical fluid and particle surface coating technologies,are reviewed.In addition,the application of process analytical techniques in the preparation of dry powders for inhalation,which can improve process capability and drug safety,is also discussed.Finally,current challenges in the field of dry powders for inhalation are discussed and some directional guidance is proposed to promote delivery efficiency,drug efficacy and process development.展开更多
In the case of dry powder inhalation systems(DPIs),the development of carrierfree formulations has gained increased attention.Thereby,spray-drying is a promising technology and is widely used to produce carrier-free D...In the case of dry powder inhalation systems(DPIs),the development of carrierfree formulations has gained increased attention.Thereby,spray-drying is a promising technology and is widely used to produce carrier-free DPIs.Numerous works have been published about the co-spray-drying of active ingredients with various solid excipients and their effect on the physicochemical characteristics and aerodynamic properties of the formulations.However,only a few studies have been reported about the role of the solvents used in the stock solutions of spray-dried formulations.In the present work,DPI microcomposites containing ciprofloxacin hydrochloride were prepared by spray-drying in the presence of different ethanol concentrations.The work expresses the roughness,depth and width of the dimples for particle size as a novel calculation possibility,and as a correlation between the MMAD/D_(0.5)ratio and correlating it with cohesion work,these new terms and correlations have not been published–to the best of our knowledge–which has resulted in gap-filling findings.As a result,different proportions of solvent mixtures could be interpreted and placed in a new perspective,in which the influence of different concentrations of ethanol on the habit of the DPI formulations,and thus on in vitro aerodynamic results.Based on these,it became clear why we obtained the best in vitro aerodynamic results for DPI formulation containing 30%ethanol in the stock solution.展开更多
Crude oil distillation is important in refining industry. Operating variables of distillation process have a critical effect on product output value and energy consumption. However, the objectives of minimum energy co...Crude oil distillation is important in refining industry. Operating variables of distillation process have a critical effect on product output value and energy consumption. However, the objectives of minimum energy consumption and maximum product output value do not coordinate with each other and do not lead to the maximum economic benefit of a refinery. In this paper, a systematic optimization approach is proposed for the maximum annual economic benefit of an existing crude oil distillation system, considering product output value and energy consumption simultaneously. A shortcut model in Aspen Plus is used to describe the crude oil distillation and the pinch analysis is adopted to identify the target of energy recovery. The optimization is a nonlinear programming problem and solved by stochastic algorithm of particle warm optimization.展开更多
The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases suc...The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy.Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path,therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high.Despite considerable attempts at the development of respiratory vaccines,the rational formulation design still warrants attention,i.e.,how the formulation composition,particle properties,formulation type(liquid or solid),and devices would influence the immune outcome.This article reviews the recent advances in the formulation design and development of respiratory vaccines.The focus is on the state of the art of delivering antigenic com-pounds through the respiratory tract,overcoming the pulmonary bio-barriers,enhancing delivery effi-ciencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use.The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed.展开更多
基金supported by the National Natural Science Foundation of China (No.22278225)Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)。
文摘Particle engineering has opened the floodgates to material science in both fundamental and application field. However, covalent interactions have not yet been adequately designed in the particle engineering for functional colloidal photonic crystals(CPCs). Herein, we achieved covalent coupling between carboxylrich poly(styrene-acrylic acid)(P(St-AA)) monodispersed colloidal particles and amine-rich carbon dots(CDs) based on an feasible and universal particle engineering strategy. The designed CDs-grafted P(St-AA)monodispersed colloidal particles initiate a hydrogen bond-driven assembly mode and ensure the construction of large-scale crack-free CPCs. Moreover, the CDs equipped with selective broad-band absorption capacity could improve the saturation of structural colors for high-visibility CPCs. Furthermore, an injectable photonic hydrogel(IPH) is developed to design CPC supraball hydrogel via integrating the CDsgrafted P(St-AA) CPC supraballs with supramolecular hydrogel. Combining superior flexibility, sufficient self-healing capacity of supramolecular hydrogel with visual optical information of our CPC supraballs, a cyclically reversible coding and decoding system was developed. Meanwhile, we firstly demonstrated the novel strategy of 3D supraballs-based passive cooling. The designed 3D CPC supraball hydrogel presents nearly full observation angle reflections behavior and excellent water evaporation capacity and achieves3.6 ℃ temperature drops, showing the application advantages in 3D thermal management. This work not only provides a new insight for manipulating optical properties of CPCs, but also demonstrates an easyto-perform platform, as well as indicates the direction for the promising application of CPCs.
基金supported by the National Natural Science Foundation of China(grant No.22378296)Shandong Provincial Key R&D Program(Major Key Technology Project)(grant No.2021CXGC010514).
文摘Inhalation therapies are pivotal for treating pulmonary diseases, yet their efficacy critically depends on the physicochemical properties of drug particles. This study introduces a novel microdroplet cryo-crystallization (MCC) technique to fabricate inhalable budesonide (BUD) particles. The MCC process combines rapid cryogenic freezing of drug-loaded microdroplets in liquid nitrogen, followed by additive-guided suspension crystallization in an anti-solvent environment. Cryogenic freezing suppresses molecular mobility and prevents aggregation, preserving uniform solute distribution. Subsequent controlled crystallization in the anti-solvent system enables precise tailoring of nanoparticle morphologies while avoiding supersaturation-driven amorphization. Systematic optimization identified MCC conditions yielding BUD ultrafine crystals with a volume median diameter of 3.0 μm, >94 % sphericity, >98 % crystallinity, and minimal hygroscopicity (<0.5 %). Compared to conventional air-jet milled BUD (∼90 % crystallinity and ∼3 % hygroscopicity), the MCC-engineered particles exhibit significantly improved physicochemical stability and dissolution performance (94 % in 180 min). The MCC strategy decouples cryogenic freezing and phase transformation, avoiding top-down limitations (e.g., milling-induced amorphization) and bottom-up issues (uncontrolled nucleation/aggregation) to achieve scalable and highly precise production of inhalable drug particles.
基金supported by the National Natural Science Foundation of China(grant number 22478288).
文摘Drug delivery via pulmonary inhalation can achieve targeted treatment by directly delivering the drugs to the area for treatment.The method is developing rapidly for the treatment of local and systemic diseases.However,dry powders for inhalation need to exhibit excellent aerodynamic performance.Particle size,morphology and density need to be tightly regulated to guarantee effective lung deposition and assure long-term chemical stability of the drug.In this work,the compositions and requirements of dry powders for inhalation are discussed.Furthermore,the state-of-art methods in particle technology for dry powders for inhalation,such as milling,droplet evaporation,direct crystallization,supercritical fluid and particle surface coating technologies,are reviewed.In addition,the application of process analytical techniques in the preparation of dry powders for inhalation,which can improve process capability and drug safety,is also discussed.Finally,current challenges in the field of dry powders for inhalation are discussed and some directional guidance is proposed to promote delivery efficiency,drug efficacy and process development.
基金supported by the UNKP-19–3-SZTE New National Excellence Program of the Ministry for Innovationthe EFOP-3.6.2-16-2017-00006‘LIVE LONGER—Development of Modern Medical Diagnostic Procedures and Therapies in a Translational Approach:from a Laboratory to a Patient Bed’project+1 种基金by the EFOP 3.6.3-VEKOP-16–2017–00009 projectwithin the CEEPUS CIII-RS-1113 short-term student mobility scholarship at the University of Graz,Austria。
文摘In the case of dry powder inhalation systems(DPIs),the development of carrierfree formulations has gained increased attention.Thereby,spray-drying is a promising technology and is widely used to produce carrier-free DPIs.Numerous works have been published about the co-spray-drying of active ingredients with various solid excipients and their effect on the physicochemical characteristics and aerodynamic properties of the formulations.However,only a few studies have been reported about the role of the solvents used in the stock solutions of spray-dried formulations.In the present work,DPI microcomposites containing ciprofloxacin hydrochloride were prepared by spray-drying in the presence of different ethanol concentrations.The work expresses the roughness,depth and width of the dimples for particle size as a novel calculation possibility,and as a correlation between the MMAD/D_(0.5)ratio and correlating it with cohesion work,these new terms and correlations have not been published–to the best of our knowledge–which has resulted in gap-filling findings.As a result,different proportions of solvent mixtures could be interpreted and placed in a new perspective,in which the influence of different concentrations of ethanol on the habit of the DPI formulations,and thus on in vitro aerodynamic results.Based on these,it became clear why we obtained the best in vitro aerodynamic results for DPI formulation containing 30%ethanol in the stock solution.
基金Supported by the National Natural Science Foundation of China(21176178)the State Key Laboratory of Chemical Engineering(SKL-Ch E-13B02)
文摘Crude oil distillation is important in refining industry. Operating variables of distillation process have a critical effect on product output value and energy consumption. However, the objectives of minimum energy consumption and maximum product output value do not coordinate with each other and do not lead to the maximum economic benefit of a refinery. In this paper, a systematic optimization approach is proposed for the maximum annual economic benefit of an existing crude oil distillation system, considering product output value and energy consumption simultaneously. A shortcut model in Aspen Plus is used to describe the crude oil distillation and the pinch analysis is adopted to identify the target of energy recovery. The optimization is a nonlinear programming problem and solved by stochastic algorithm of particle warm optimization.
基金supported by the Liaoning Pan Deng Xue Zhe Scholar(No.XLYC2002061,China)the National Natural Science Foundation of China(No.82173768)+4 种基金the Overseas Expertise Introduction Project for Discipline Innovation(“111 Project”)(No.D20029,China)D.C.acknowledges financial support from the Science and Technology Foundation of Liaoning Province(NO.2022-MS-241,China)the Ministry of Education Chunhui Program(2020)L.W.acknowledges the financial support from the National Natural Science Foundation of China(No.82204316)the China Postdoctoral Science Foundation(No.2021TQ0219 and 2022MD713776,China).
文摘The respiratory tract is susceptible to various infections and can be affected by many serious diseases.Vaccination is one of the most promising ways that prevent infectious diseases and treatment of some diseases such as malignancy.Direct delivery of vaccines to the respiratory tract could mimic the natural process of infection and shorten the delivery path,therefore unique mucosal immunity at the first line might be induced and the efficiency of delivery can be high.Despite considerable attempts at the development of respiratory vaccines,the rational formulation design still warrants attention,i.e.,how the formulation composition,particle properties,formulation type(liquid or solid),and devices would influence the immune outcome.This article reviews the recent advances in the formulation design and development of respiratory vaccines.The focus is on the state of the art of delivering antigenic com-pounds through the respiratory tract,overcoming the pulmonary bio-barriers,enhancing delivery effi-ciencies of respiratory vaccines as well as maintaining the stability of vaccines during storage and use.The choice of devices and the influence of deposition sites on vaccine efficiencies were also reviewed.
