Toxic heavy metals are ubiquitous environmental contaminants that can detrimentally influence human wellbeing,especially in the pediatric population.This study investigated soil,dust,and moss contamination collected f...Toxic heavy metals are ubiquitous environmental contaminants that can detrimentally influence human wellbeing,especially in the pediatric population.This study investigated soil,dust,and moss contamination collected from six urban children’s playground(parks 1 to 6)inÇankaya District with heavy metals(Cr,Cu,Cd,Ni,Pb,and Zn).The highest values of Cu(44.1 mg/kg),Ni(45.6 mg/kg),and Pb(44.2 mg/kg)were recorded from park dust.Moss samples showed higher values of Cr and Zn,respectively,as 68.7 mg/kg and 284.3 mg/kg.Of these,surface soil presented the lowest concentrations,with Zn showing the highest concentration at 259 mg/kg and Cd the lowest at 1.9 mg/kg.Moss showed the highest total metal loadΣ=482.1 mg/kg,followed by dustΣ=457.9 mg/kg and soilΣ=388.3 mg/kg.Significant differences of p<0.05 between the soil and other sample types,together with a strong correlation of R2=0.9443,may indicate that moss metal concentration is influenced by natural and anthropogenic sources by wet or dry deposition.Spatial analysis revealed metal hotspots near roadways,with Cr and Cu less concentrated in traffic areas.Significant variability was noted across parks,far from vehicular traffic and polluting land uses(parks 1 and 2),showing lower concentrations.Principal component analysis(PCA)and positive matrix factorization(PMF)identified four emission sources:diesel combustion,transportation,and fossil fuel combustion,which are transported up to several kilometers away from their sources and transferred to the soil by atmospheric deposition.Enrichment and bioaccumulation factors highlighted high Cd enrichment in dust,with significant bioaccumulation in mosses.Pollution index values varied,with parks under the pressure of vehicular traffic,commercial and industrial zones(park 6)showing the highest contamination.These local findings draw attention to the striking impact of land use decisions at a lower scale on the health risks of humans,especially children.展开更多
The cover photograph shows a herd of alpacas(Vicugna pacos) grazing on high-altitude Andean peatlands known as bofedales in Sajama National Park(SNP),Bolivia's first protected area,established in 1939.In the backg...The cover photograph shows a herd of alpacas(Vicugna pacos) grazing on high-altitude Andean peatlands known as bofedales in Sajama National Park(SNP),Bolivia's first protected area,established in 1939.In the background,the snow-capped Nevado Sajama(6,542 m a.s.l.),Bolivia's highest peak,dominates the landscape,with Polylepis tarapacana forests—considered the highest-elevation arboreal forests in the world—visible on its slopes.The image captures the intimate relationship between pastoral fivelihoods and mountain ecosystems that has sustained Aymara communities in the western Bolivian Andes for centuries.Located between 3,960 and 6,542 m a.s.l.,the park encompasses a diverse mosaic of ecological zones including peatlands,wet meadows,shrublands,grasslands,and high-Andean forests.Photograph was taken on April 16,2021 by Rosa Isela Meneses.展开更多
In an era of profound changes to global trade,food security,and industrial organization,the ChinaIndonesia“Two Countries,Twin Parks”initiative has emerged as a strategic experiment with farreaching implications.Anch...In an era of profound changes to global trade,food security,and industrial organization,the ChinaIndonesia“Two Countries,Twin Parks”initiative has emerged as a strategic experiment with farreaching implications.Anchored in marine protein processing and advanced food manufacturing,this collaboration reflects not only a convergence of economic interests but also a deliberate rethinking of how China engages with global resources,technology,and partners.展开更多
Electrical parking lots(EPLs)play a vital role in the current energy system to achieve the decarbonization goal.This paper proposes a novel structure for integrating EPLs into a multi-carrier energy system(MCES)using ...Electrical parking lots(EPLs)play a vital role in the current energy system to achieve the decarbonization goal.This paper proposes a novel structure for integrating EPLs into a multi-carrier energy system(MCES)using a Stackelberg game theory approach.The bi-level optimization is used to model the Stackelberg game.Within this bi-level optimization model,the MCES operator minimizes the MCES cost by participating in the upstream energy market at the upper level,and the EPL operators maximize their profits by participating in the local energy market between the MCES operator and themselves at the lower level.At the upper level,the MCES operator faces uncertainties in the wind and PV systems.The bi-level multi-objective information gap decision theory(MO-IGDT)is employed to address uncertainties at the upper level of the Stackelberg game problem,resulting in a nested bi-level optimization model.The nested bi-level optimization problem is converted into a mixed-integer linear programming(MILP)optimization problem using Karush–Kuhn–Tucker(KKT)conditions.The main research assumptions pertain to EPLs’privacy and the KKT-based approach.The results demonstrate that increasing the incentive/penalty price for self-sufficiency programs from 0.0$/%to 0.2$/%,with a 50%self-sufficiency target,can reduce MCES operation costs by 10.19%.展开更多
A new production line has officially started operating at a green energy industrial park in the Shanxi Yungang Economic Development Zone.Tens of thousands of hair-thin black filaments flow uniformly like gleaming dark...A new production line has officially started operating at a green energy industrial park in the Shanxi Yungang Economic Development Zone.Tens of thousands of hair-thin black filaments flow uniformly like gleaming dark rivers from the winding machines.The Institute of Coal Chemistry of the Chinese Academy of Sciences(CAS)developed T1000-grade high-performance carbon fiber here,and it has fully independent intellectual property rights.“It took us 20 years to go from having‘no grain to cook’to achieving‘high-end iteration,’”said Zhang Shouchun,Deputy Director of the Institute of Coal Chemistry,CAS,and project leader.Behind this striking black thread lies an arduous,persistent campaign of material innovation.展开更多
DJ-1,also known as Parkinson’s disease protein 7(PARK7),is a multifunctional protein that plays an important role in oxidative stress regulation and neuroprotection.Previous studies have shown that DJ-1 affects early...DJ-1,also known as Parkinson’s disease protein 7(PARK7),is a multifunctional protein that plays an important role in oxidative stress regulation and neuroprotection.Previous studies have shown that DJ-1 affects early-onset Parkinson’s disease by regulating neuroinflammation,but its specific mechanism remains unclear.The study investigated the role of DJ-1 in mediating microglia-neuron communication to identify potential therapeutic targets for neuroinflammation in Parkinson’s disease.In this study,we observed a significant decrease in the levels of C-X3-C motif chemokine ligand 1(CX3CL1)in Park7 knockout mice and SH-SY5Y cells with Park7 knockdown.Protein microarray analysis and validation using GEO datasets confirmed that knockout of the Park7 gene led to downregulation of CX3CL1 and two other chemokines,namely monocyte chemoattractant protein-1 and interleukin-8.Further investigation revealed that Park7 deficiency reduced the processing of a disintegrin and metalloproteinase domain-containing protein 10(ADAM10)in the neuronal endoplasmic reticulum of both mice and SH-SY5Y cells,thereby decreasing CX3CL1 secretion.This subsequently led to abnormal microglial activation,with a shift toward the proinflammatory M1 phenotype,exacerbating neuroinflammatory responses.These effects were mitigated by exogenous CX3CL1 administration.Concurrently,exogenous CX3CL1 improved motor function in Parkinson’s disease model mice with the Park7 knockout,promoting survival of tyrosine hydroxylase-positive neurons in the substantia nigra and reducing Iba-1-positive microglial activation.These findings demonstrate that DJ-1 exerts neuroprotective effects on dopaminergic neurons by suppressing microglial activation through CX3CL1 regulation,suggesting that targeting the DJ-1/CX3CL1 axis may represent a novel therapeutic strategy for modulating neuroinflammation and protecting dopaminergic neurons.展开更多
Conversation A(in the coffee shop)Zach:What are you doing,Emily?I'm planning an event.I'm calling it“Neighborhood Snow Party!”Emily:Zach:Fun!When is it?It's this Saturday,January 31st.What's the time...Conversation A(in the coffee shop)Zach:What are you doing,Emily?I'm planning an event.I'm calling it“Neighborhood Snow Party!”Emily:Zach:Fun!When is it?It's this Saturday,January 31st.What's the time and place?It's from 10 a.m.to 4 p.m.at Emily:Zach:Emily:Green Hill Park.Zach:I can go!展开更多
Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing t...Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing the utilization of existing central processing unit(CPU)resources and reducing human and computational time costs via process automation.Accordingly,this paper proposes a scheme,called SSM,that combines“Srun job submission mode”,“Sbatch job submission mode”,and“Monitor function”.The SSM scheme includes three main modules:data management,command management,and resource management.Its core innovations are command splitting and parallel execution.The results show that this method effectively improves CPU utilization and reduces the time required for data processing.In terms of CPU utilization,the average value of this scheme is 89%.In contrast,the average CPU utilizations of“Srun job submission mode”and“Sbatch job submission mode”are significantly lower,at 43%and 52%,respectively.In terms of the data-processing time,SSM testing on the Five-hundred-meter Aperture Spherical radio Telescope(FAST)data requires only 5.5 h,compared with 8 h in the“Srun job submission mode”and 14 h in the“Sbatch job submission mode”.In addition,tests on the FAST and Parkes datasets demonstrate the universality of the SSM scheme,which can process data from different telescopes.The compatibility of the SSM scheme for pulsar searches is verified using 2 days of observational data from the globular cluster M2,with the scheme successfully discovering all published pulsars in M2.展开更多
文摘Toxic heavy metals are ubiquitous environmental contaminants that can detrimentally influence human wellbeing,especially in the pediatric population.This study investigated soil,dust,and moss contamination collected from six urban children’s playground(parks 1 to 6)inÇankaya District with heavy metals(Cr,Cu,Cd,Ni,Pb,and Zn).The highest values of Cu(44.1 mg/kg),Ni(45.6 mg/kg),and Pb(44.2 mg/kg)were recorded from park dust.Moss samples showed higher values of Cr and Zn,respectively,as 68.7 mg/kg and 284.3 mg/kg.Of these,surface soil presented the lowest concentrations,with Zn showing the highest concentration at 259 mg/kg and Cd the lowest at 1.9 mg/kg.Moss showed the highest total metal loadΣ=482.1 mg/kg,followed by dustΣ=457.9 mg/kg and soilΣ=388.3 mg/kg.Significant differences of p<0.05 between the soil and other sample types,together with a strong correlation of R2=0.9443,may indicate that moss metal concentration is influenced by natural and anthropogenic sources by wet or dry deposition.Spatial analysis revealed metal hotspots near roadways,with Cr and Cu less concentrated in traffic areas.Significant variability was noted across parks,far from vehicular traffic and polluting land uses(parks 1 and 2),showing lower concentrations.Principal component analysis(PCA)and positive matrix factorization(PMF)identified four emission sources:diesel combustion,transportation,and fossil fuel combustion,which are transported up to several kilometers away from their sources and transferred to the soil by atmospheric deposition.Enrichment and bioaccumulation factors highlighted high Cd enrichment in dust,with significant bioaccumulation in mosses.Pollution index values varied,with parks under the pressure of vehicular traffic,commercial and industrial zones(park 6)showing the highest contamination.These local findings draw attention to the striking impact of land use decisions at a lower scale on the health risks of humans,especially children.
文摘The cover photograph shows a herd of alpacas(Vicugna pacos) grazing on high-altitude Andean peatlands known as bofedales in Sajama National Park(SNP),Bolivia's first protected area,established in 1939.In the background,the snow-capped Nevado Sajama(6,542 m a.s.l.),Bolivia's highest peak,dominates the landscape,with Polylepis tarapacana forests—considered the highest-elevation arboreal forests in the world—visible on its slopes.The image captures the intimate relationship between pastoral fivelihoods and mountain ecosystems that has sustained Aymara communities in the western Bolivian Andes for centuries.Located between 3,960 and 6,542 m a.s.l.,the park encompasses a diverse mosaic of ecological zones including peatlands,wet meadows,shrublands,grasslands,and high-Andean forests.Photograph was taken on April 16,2021 by Rosa Isela Meneses.
文摘In an era of profound changes to global trade,food security,and industrial organization,the ChinaIndonesia“Two Countries,Twin Parks”initiative has emerged as a strategic experiment with farreaching implications.Anchored in marine protein processing and advanced food manufacturing,this collaboration reflects not only a convergence of economic interests but also a deliberate rethinking of how China engages with global resources,technology,and partners.
基金supported by the first Cycle of ARG Grant No.ARG01-0504-230073,from the Qatar Research,Development and Innovation(QRDI)Council,Qatar.The findings herein reflect the work,and are solely the responsibility,of the authors.The authors also gratefully acknowledge support from Qatar University.
文摘Electrical parking lots(EPLs)play a vital role in the current energy system to achieve the decarbonization goal.This paper proposes a novel structure for integrating EPLs into a multi-carrier energy system(MCES)using a Stackelberg game theory approach.The bi-level optimization is used to model the Stackelberg game.Within this bi-level optimization model,the MCES operator minimizes the MCES cost by participating in the upstream energy market at the upper level,and the EPL operators maximize their profits by participating in the local energy market between the MCES operator and themselves at the lower level.At the upper level,the MCES operator faces uncertainties in the wind and PV systems.The bi-level multi-objective information gap decision theory(MO-IGDT)is employed to address uncertainties at the upper level of the Stackelberg game problem,resulting in a nested bi-level optimization model.The nested bi-level optimization problem is converted into a mixed-integer linear programming(MILP)optimization problem using Karush–Kuhn–Tucker(KKT)conditions.The main research assumptions pertain to EPLs’privacy and the KKT-based approach.The results demonstrate that increasing the incentive/penalty price for self-sufficiency programs from 0.0$/%to 0.2$/%,with a 50%self-sufficiency target,can reduce MCES operation costs by 10.19%.
文摘A new production line has officially started operating at a green energy industrial park in the Shanxi Yungang Economic Development Zone.Tens of thousands of hair-thin black filaments flow uniformly like gleaming dark rivers from the winding machines.The Institute of Coal Chemistry of the Chinese Academy of Sciences(CAS)developed T1000-grade high-performance carbon fiber here,and it has fully independent intellectual property rights.“It took us 20 years to go from having‘no grain to cook’to achieving‘high-end iteration,’”said Zhang Shouchun,Deputy Director of the Institute of Coal Chemistry,CAS,and project leader.Behind this striking black thread lies an arduous,persistent campaign of material innovation.
基金National Natural Science Foundation of China,Nos.82471264(to YL),82201392(to AZ),82071415(to JL)Shanghai Rising Stars of Medical Talents Youth Development Program,No.2023-62(to YL)+2 种基金the Shanghai Municipal Health Commission Clinical Research Special Fund for the Health Industry,No.20234Y0026(to YL)the Shanghai Sailing Program,No.22YF1425100(to AZ)Chinese Postdoctoral Science Foundation,No.2021M702169(to YJ).
文摘DJ-1,also known as Parkinson’s disease protein 7(PARK7),is a multifunctional protein that plays an important role in oxidative stress regulation and neuroprotection.Previous studies have shown that DJ-1 affects early-onset Parkinson’s disease by regulating neuroinflammation,but its specific mechanism remains unclear.The study investigated the role of DJ-1 in mediating microglia-neuron communication to identify potential therapeutic targets for neuroinflammation in Parkinson’s disease.In this study,we observed a significant decrease in the levels of C-X3-C motif chemokine ligand 1(CX3CL1)in Park7 knockout mice and SH-SY5Y cells with Park7 knockdown.Protein microarray analysis and validation using GEO datasets confirmed that knockout of the Park7 gene led to downregulation of CX3CL1 and two other chemokines,namely monocyte chemoattractant protein-1 and interleukin-8.Further investigation revealed that Park7 deficiency reduced the processing of a disintegrin and metalloproteinase domain-containing protein 10(ADAM10)in the neuronal endoplasmic reticulum of both mice and SH-SY5Y cells,thereby decreasing CX3CL1 secretion.This subsequently led to abnormal microglial activation,with a shift toward the proinflammatory M1 phenotype,exacerbating neuroinflammatory responses.These effects were mitigated by exogenous CX3CL1 administration.Concurrently,exogenous CX3CL1 improved motor function in Parkinson’s disease model mice with the Park7 knockout,promoting survival of tyrosine hydroxylase-positive neurons in the substantia nigra and reducing Iba-1-positive microglial activation.These findings demonstrate that DJ-1 exerts neuroprotective effects on dopaminergic neurons by suppressing microglial activation through CX3CL1 regulation,suggesting that targeting the DJ-1/CX3CL1 axis may represent a novel therapeutic strategy for modulating neuroinflammation and protecting dopaminergic neurons.
文摘Conversation A(in the coffee shop)Zach:What are you doing,Emily?I'm planning an event.I'm calling it“Neighborhood Snow Party!”Emily:Zach:Fun!When is it?It's this Saturday,January 31st.What's the time and place?It's from 10 a.m.to 4 p.m.at Emily:Zach:Emily:Green Hill Park.Zach:I can go!
基金supported by the National Nature Science Foundation of China(12363010)supported by the Guizhou Provincial Basic Research Program(Natural Science)(ZK[2023]039)the Key Technology R&D Program([2023]352).
文摘Previous studies aiming to accelerate data processing have focused on enhancement algorithms,using the graphics processing unit(GPU)to speed up programs,and thread-level parallelism.These methods overlook maximizing the utilization of existing central processing unit(CPU)resources and reducing human and computational time costs via process automation.Accordingly,this paper proposes a scheme,called SSM,that combines“Srun job submission mode”,“Sbatch job submission mode”,and“Monitor function”.The SSM scheme includes three main modules:data management,command management,and resource management.Its core innovations are command splitting and parallel execution.The results show that this method effectively improves CPU utilization and reduces the time required for data processing.In terms of CPU utilization,the average value of this scheme is 89%.In contrast,the average CPU utilizations of“Srun job submission mode”and“Sbatch job submission mode”are significantly lower,at 43%and 52%,respectively.In terms of the data-processing time,SSM testing on the Five-hundred-meter Aperture Spherical radio Telescope(FAST)data requires only 5.5 h,compared with 8 h in the“Srun job submission mode”and 14 h in the“Sbatch job submission mode”.In addition,tests on the FAST and Parkes datasets demonstrate the universality of the SSM scheme,which can process data from different telescopes.The compatibility of the SSM scheme for pulsar searches is verified using 2 days of observational data from the globular cluster M2,with the scheme successfully discovering all published pulsars in M2.
