We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-yearold patient who was admitted to the intensive care unit （ICU） with fever of two days, headache and vomiting...We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-yearold patient who was admitted to the intensive care unit （ICU） with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5℃, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.展开更多
Background:Salmonella Paratyphi C is an infrequent etiological agent of enteric fever,with sporadic cases pri-marily reported in Asia and Africa.Documented outbreaks remain exceedingly rare,and epidemiological data on...Background:Salmonella Paratyphi C is an infrequent etiological agent of enteric fever,with sporadic cases pri-marily reported in Asia and Africa.Documented outbreaks remain exceedingly rare,and epidemiological data on such events are notably scarce.Methods:This study investigated a paratyphoid fever outbreak caused by S.Paratyphi C at a secondary school in China in 2023.Comprehensive field epidemiological investigations were conducted,including environmental sampling and the collection of clinical specimens.All outbreak-associated isolates underwent antimicrobial sus-ceptibility testing,whole-genome sequencing,and in-depth bioinformatics analysis.Single-nucleotide polymor-phism profiling and core genome multilocus sequence typing were employed to elucidate the genetic relatedness of the isolates.Results:A total of 11 S.Paratyphi C strains,characterized by the antigenic formula 6,7:c:1,5,were recovered from a variety of sample sources.Genomic analyses revealed striking homogeneity across all isolates,with uniform multilocus sequence types,identical antimicrobial resistance patterns,and shared virulence-associated genes.Phylogenetic reconstruction demonstrated a tightly clustered lineage,corroborated by highly similar circular genome structures,suggesting a common source of infection.Conclusions:This investigation offered critical insights into a rare foodborne outbreak caused by S.Paraty-phi C,bridging significant knowledge gaps regarding its epidemiology and genetic characteristics.The find-ings underscored the global diversity and potential public health threat of S.Paratyphi C,reinforcing the ur-gent need to enhance food safety monitoring and improve outbreak preparedness strategies both in China and internationally.展开更多
文摘We report a case of fulminant hepatic failure associated with Salmonella paratyphi A infection, in a 29-yearold patient who was admitted to the intensive care unit （ICU） with fever of two days, headache and vomiting followed by behavioural changes and disorientation. On examination, the patient appeared acutely ill, agitated, confused, and deeply jaundiced. Temperature 38.5℃, pulse 92/min, blood pressure 130/89 mmHg. Both samples of blood grew S. paratyphi A, which was sensitive to ceftriaxone and ciprofloxacin. Ceftriaxon was administered with high-dose dexamethasone. Two weeks after treatment with ceftriaxon, the patient was discharged in satisfactory condition.
基金supported by the Medical and Health Development Plan of Shandong Province(Grants numbers 202312050986,202412051230,and 202012051035)the Shandong Key Research and Development Plan Project(Grant No.2017GSF218062)the Natural Science Foundation of Shandong Province(Grant No.ZR2024MH289).
文摘Background:Salmonella Paratyphi C is an infrequent etiological agent of enteric fever,with sporadic cases pri-marily reported in Asia and Africa.Documented outbreaks remain exceedingly rare,and epidemiological data on such events are notably scarce.Methods:This study investigated a paratyphoid fever outbreak caused by S.Paratyphi C at a secondary school in China in 2023.Comprehensive field epidemiological investigations were conducted,including environmental sampling and the collection of clinical specimens.All outbreak-associated isolates underwent antimicrobial sus-ceptibility testing,whole-genome sequencing,and in-depth bioinformatics analysis.Single-nucleotide polymor-phism profiling and core genome multilocus sequence typing were employed to elucidate the genetic relatedness of the isolates.Results:A total of 11 S.Paratyphi C strains,characterized by the antigenic formula 6,7:c:1,5,were recovered from a variety of sample sources.Genomic analyses revealed striking homogeneity across all isolates,with uniform multilocus sequence types,identical antimicrobial resistance patterns,and shared virulence-associated genes.Phylogenetic reconstruction demonstrated a tightly clustered lineage,corroborated by highly similar circular genome structures,suggesting a common source of infection.Conclusions:This investigation offered critical insights into a rare foodborne outbreak caused by S.Paraty-phi C,bridging significant knowledge gaps regarding its epidemiology and genetic characteristics.The find-ings underscored the global diversity and potential public health threat of S.Paratyphi C,reinforcing the ur-gent need to enhance food safety monitoring and improve outbreak preparedness strategies both in China and internationally.
