The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innova...The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innovative concept of the“AI-Driven Research Ecosystem”,a dynamic and collaborative research environment.Within this ecosystem,we focus on the unification of human-AI collaboration models and the emerging new research thinking paradigms.We analyze the multifaceted roles of AI within the research lifecycle,spanning from a passive tool to an active assistant and autonomous participants,and categorize these interactions into distinct human-AI collaboration models.Furthermore,we examine how the pervasive involvement of AI necessitates an evolution in human research thinking,emphasizing the significant roles of critical,creative,and computational thinking.Through a review of existing literature and illustrative case studies,this paper provides a comprehensive overview of the AI-driven research ecosystem,highlighting its potential for transforming scientific research.Our findings advance the current understanding of AI’s multiple roles in research and underscore its capacity to revolutionize both knowledge discovery and collaborative innovation,paving the way for a more integrated and impactful research paradigm.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why v...Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why various design approaches have been put forward. These approaches can be classified in three different paradigms according to the origin of the information requirements: supply-driven, demand-driven, and hybrids of these. This article compares the methodologies for the multidimensional design of DW through a systematic mapping as research methodology. The study is presented for each paradigm, the main characteristics of the methodologies, their notations and problem areas exhibited in each one of them. The results indicate that there is no follow-up to the complete process of implementing a DW in either an academic or industrial environment;however, there is also no evidence that the attempt is made to address the design and development of a DW by applying and comparing different methodologies existing in the field.展开更多
The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote th...The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote the modernization of the foreign language teaching through the informatization of the foreign language teaching. The new concept of the leapfrogging development in the foreign language teaching should be a hot topic and trend in the study of the foreign language teaching theories and practice in the new era. Under the "New liberal arts" paradigm, students are expected to take part in various activities to promote the transformation of the classroom theoretical knowledge into the specific practical skills and enhance their abilities to solve the practical problems in the real world.展开更多
This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structur...This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow causal-knowledge organization and decoupling better than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and lesser flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based on sequential evaluation searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based on small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. This paper presents a quantitative comparison between two equivalent implementations of a sale system, one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in C++ and other developed according to the principles of NOP based on a NOP framework in C++. The results showed that NOP implementation obtained quite equivalent results with respect to OOP implementation. This happened because the NOP framework uses considerable expensive data-structures over C++. Thus, it is necessary a new compiler to NOP in order to actually use its potentiality.展开更多
The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is...The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is introduced to construct and optimize an eco-productive paradigm system for the typical areas of the farming-pastoral zone. The system was constructed in the following steps: (1) design the framework of the paradigm system based on the data of physical site characteristics, biocommunities, production and economy, social culture and historical changes; (2) analyze the vegetation patterns, the interactions between vegetation and environmental factors (natural, social, economic, etc.) and the contributions of vegetation to the area, including the synthesis of the existing researches; and (3) provide the spatial arrangements of ecosystems and planning of each area, raise a comprehensive indicators of evaluation, evaluate the feasibility and soundness, and determine the optimum eco-productive paradigms for policy-makers which were land-use patterns within the threshold of ecological conservation. Three primitive paradigms of Maowusu (Mu Us) Ssandy Land, Loess Plateau and Huailai Basin in the farming-pastoral zone of northern China were proposed according to this paradigm system.展开更多
With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neu...With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education.展开更多
This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpre...This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpreting education faces dual challenges of technological substitution and pedagogical transformation.Based on Kuhn’s paradigm theory,the study analyzes the limitations of three traditional interpreting teaching paradigms,language-centric,knowledge-based,and skill-acquisition-oriented,and proposes a novel“teacher-AI-learner”triadic collaborative paradigm.Through reconstructing teaching subjects,environments,and curriculum systems,the integration of real-time translation tools and intelligent terminology databases facilitates the transition from static skill training to dynamic human-machine collaboration.The research simultaneously highlights challenges in technological ethics and curriculum design transformation pressures,emphasizing the necessity to balance technological empowerment with humanistic education.展开更多
This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interaction...This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interactions.Within the context of large models,AIx is characterized by its innovative interaction patterns and a plethora of application scenarios that hold great potential.The paper highlights the pivotal role of AIx in shaping the future landscape of the large model industry,emphasizing its adoption and necessity from a user's perspective.This study underscores the pivotal role of AIx in dictating the future trajectory of a large model industry by emphasizing the importance of its adoption and necessity from a user-centric perspective.The fundamental drivers of AIx include the introduction of novel capabilities,replication of capabilities(both anthropomorphic and superhuman),migration of capabilities,aggregation of intelligence,and multiplication of capabilities.These elements are essential for propelling innovation,expanding the frontiers of capability,and realizing the exponential superposition of capabilities,thereby mitigating labor redundancy and addressing a spectrum of human needs.Furthermore,this study provides an in-depth analysis of the structural components and operational mechanisms of agents supported by large models.Such advancements significantly enhance the capacity of agents to tackle complex problems and provide intelligent services,thereby facilitating a more intuitive,adaptive,and personalized engagement between humans and machines.The study further delineates four principal categories of interaction patterns that encompass eight distinct modalities of interaction,corresponding to twenty-one specific scenarios,including applications in smart home systems,health assistance,and elderly care.This emphasizes the significance of this new paradigm in advancing HCI,fostering technological advancements,and redefining user experiences.However,it also acknowledges the challenges and ethical considerations that accompany this paradigm shift,recognizing the need for a balanced approach to harness the full potential of AIx in modern society.展开更多
Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry....Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.展开更多
Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and...Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and p53.While p16 is a well-established surrogate for HPV in oropharyngeal cancer,our review highlights its unreliable role in HNCSCC,where positivity is instead associated with recurrence and metastasis.Similarly,p53 illustrates a dual role-wild-type as a genomic safeguard,mutated as an oncogenic driver-complicating prognostication.Methodological considerations,including the limitations of immunohistochemistry for HPV detection,underscore the need for multi-method and molecular validation in future studies.Ultraviolet radiation is posited as a key modifier of p16 function,decoupling expression from tumor suppression.To contextualize these findings,we draw parallels to glioblastoma(GBM),where subclonal evolution,p53 dysfunction,and intratumoral heterogeneity drive relapse despite aggressive multimodal therapies.GBM exemplifies how bulk-level biomarker generalizations often obscure dynamic cellular ecosystems,reinforcing the necessity of single-cell and spatial approaches.Multi-omics integration-encompassing genome,transcriptome,proteome,and tumor microenvironment mapping-coupled with single-cell RNA sequencing and spatial transcriptomics,offers a path forward for resolving subclonal dynamics in both HNCSCC and GBM.These technologies provide the resolution needed to track tumor-immunestromal co-evolution,identify therapy-resistant clones,and anticipate recurrence.We argue for a N-of-1,patient-and cell-centric paradigm that reframes biomarkers not as static surrogates but as dynamic readouts of cancer evolution across time and tissue contexts.Conceptually,we propose kinetic and microenvironmental frameworks(e.g.,“load-and-lock”barriers;dormancy and immunesynapse stabilization)as hypothesis-generating avenues to stall clonal handoffs and improve outcome prediction.Together,these perspectives argue for revised biomarker frameworks in HNCSCC and ethically inclusive,mechanism-anchored studies that bridge discovery with individualized care.By bridging insights from HNCSCC with the lessons of GBM,this review underscores the need for ethically inclusive,mechanistically informed frameworks that integrate subclonal evolution,biomarker re-interpretation,and precision-personalized hybrid models.Such an approach will be essential for advancing from one-size-fits-all strategies to individualized lifetime cancer care.展开更多
Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim...Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim to control the spread of neuroinflammation during the acute phase but later hinder axon regeneration in later stages.Recent studies have enhanced our understanding of immunomodulation,revealing that injury-associated inflammation involves various cell types and molecules with positive and negative effects.This review employs bibliometric analysis to examine the literature on inflammatory mediators in spinal cord injury,highlighting recent research and providing a comprehensive overview of the current state of research and the latest advances in studies on neuroinflammation related to spinal cord injury.We summarize the immune and inflammatory responses at different stages of spinal cord injury,offering crucial insights for future research.Additionally,we review repair strategies based on inflammatory mediators for the injured spinal cord.Finally,this review discusses the current status and future directions of translational research focused on immune-targeting strategies,including pharmaceuticals,biomedical engineering,and gene therapy.The development of a combined,precise,and multitemporal strategy for the repair of injured spinal cords represents a promising direction for future research.展开更多
With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge ...With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge has shifted to a mixed cultures instead of just British and American. But the standard varieties of British and American English have been accepted as the only generally accepted forms of standard English in China.The language learning fashion in China is about to undertake a big paradigm shift.This paper is an analysis of the English learning pattern shift in Chinese setting and therefore suggests a practical activities to apply this concept in English learning classes.展开更多
In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are als...In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are also led by their epistemology.It is proposed that a critical,bio-social paradigm be taken in the field of applied linguistics.展开更多
This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chines...This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chinese applied linguists.ANO?VA tests revealed marked cross-language and cross-paradigmatic differences in stance-based dialogic engagement.展开更多
This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication ...This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication as examples. To a good researcher, heneeds not only clarifying the paradigm his research is positioned, but also integrating the theories in his paradigm.展开更多
基金funded by the General Program of the National Natural Science Foundation of China grant number 62277022.
文摘The integration of artificial intelligence(AI)is fundamentally reshaping the scientific research,giving rise to a new era of discovery and innovation.This paper explores this transformative shift,introducing an innovative concept of the“AI-Driven Research Ecosystem”,a dynamic and collaborative research environment.Within this ecosystem,we focus on the unification of human-AI collaboration models and the emerging new research thinking paradigms.We analyze the multifaceted roles of AI within the research lifecycle,spanning from a passive tool to an active assistant and autonomous participants,and categorize these interactions into distinct human-AI collaboration models.Furthermore,we examine how the pervasive involvement of AI necessitates an evolution in human research thinking,emphasizing the significant roles of critical,creative,and computational thinking.Through a review of existing literature and illustrative case studies,this paper provides a comprehensive overview of the AI-driven research ecosystem,highlighting its potential for transforming scientific research.Our findings advance the current understanding of AI’s multiple roles in research and underscore its capacity to revolutionize both knowledge discovery and collaborative innovation,paving the way for a more integrated and impactful research paradigm.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘Data warehouses (DW) must integrate information from the different areas and sources of an organization in order to extract knowledge relevant to decision-making. The DW development is not an easy task, which is why various design approaches have been put forward. These approaches can be classified in three different paradigms according to the origin of the information requirements: supply-driven, demand-driven, and hybrids of these. This article compares the methodologies for the multidimensional design of DW through a systematic mapping as research methodology. The study is presented for each paradigm, the main characteristics of the methodologies, their notations and problem areas exhibited in each one of them. The results indicate that there is no follow-up to the complete process of implementing a DW in either an academic or industrial environment;however, there is also no evidence that the attempt is made to address the design and development of a DW by applying and comparing different methodologies existing in the field.
文摘The main features of the foreign language education in the information age are to realize the modernization, informatization, intellectualization and diversification of the foreign language teaching, and to promote the modernization of the foreign language teaching through the informatization of the foreign language teaching. The new concept of the leapfrogging development in the foreign language teaching should be a hot topic and trend in the study of the foreign language teaching theories and practice in the new era. Under the "New liberal arts" paradigm, students are expected to take part in various activities to promote the transformation of the classroom theoretical knowledge into the specific practical skills and enhance their abilities to solve the practical problems in the real world.
基金R. F. Banaszewski’s M.Sc. thesis [10] was supported by CAPES Foundation (Brazil) as well as R. F. Banas- zewski’s Ph.D. thesis and A. F. Ronszcka’s M.Sc. thesis are under CAPES support
文摘This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow causal-knowledge organization and decoupling better than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and lesser flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based on sequential evaluation searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based on small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. This paper presents a quantitative comparison between two equivalent implementations of a sale system, one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in C++ and other developed according to the principles of NOP based on a NOP framework in C++. The results showed that NOP implementation obtained quite equivalent results with respect to OOP implementation. This happened because the NOP framework uses considerable expensive data-structures over C++. Thus, it is necessary a new compiler to NOP in order to actually use its potentiality.
文摘The farming-pastoral zone of northern China plays a dual role in ecological conditions and production and occupies an important position in the national economy. In this paper, the methodology of system engineering is introduced to construct and optimize an eco-productive paradigm system for the typical areas of the farming-pastoral zone. The system was constructed in the following steps: (1) design the framework of the paradigm system based on the data of physical site characteristics, biocommunities, production and economy, social culture and historical changes; (2) analyze the vegetation patterns, the interactions between vegetation and environmental factors (natural, social, economic, etc.) and the contributions of vegetation to the area, including the synthesis of the existing researches; and (3) provide the spatial arrangements of ecosystems and planning of each area, raise a comprehensive indicators of evaluation, evaluate the feasibility and soundness, and determine the optimum eco-productive paradigms for policy-makers which were land-use patterns within the threshold of ecological conservation. Three primitive paradigms of Maowusu (Mu Us) Ssandy Land, Loess Plateau and Huailai Basin in the farming-pastoral zone of northern China were proposed according to this paradigm system.
文摘With the continuous improvement of the medical industry’s requirements for the professional capabilities of nursing talents,traditional nursing teaching models can hardly meet the needs of complex nursing work in neurology.This paper focuses on nursing education for neurology nursing students and explores the construction of the“one-on-one”teaching model,aiming to achieve a paradigm shift in nursing education.By analyzing the current status of neurology nursing education,this paper identifies the problems in traditional teaching models.Combining the advantages of the“one-on-one”teaching model,it elaborates on the construction path of this model from aspects such as the selection and training of teaching instructors,the design of teaching content,the innovation of teaching methods,and the improvement of the teaching evaluation system.The research shows that the“one-on-one”teaching model can significantly enhance nursing students’mastery of professional knowledge,clinical operation skills,communication skills,and emergency response capabilities,as well as strengthen their professional identity and sense of responsibility.It provides an effective way to cultivate high-quality nursing talents who can meet the needs of neurology nursing work and promotes the innovative development of nursing education.
基金2025 General Project of Humanities and Social Sciences Research in Henan Higher Education Institutions,“Research on the Dynamic Mechanisms and Paths of Innovative Development of Undergraduate Translation Programs Empowered by New Productive Forces”(Project No.:2025-ZDJH-885)2024 College-Level Undergraduate Teaching Reform Project of the School of Foreign Languages,Henan University of Technology,“Research on Implementation Paths of New Models for Interpreter Training Based on AI Large Models”(Project No.:2024YJWYJG06)+1 种基金2025 First-Class Undergraduate Program Construction Special Project of the School of Foreign Languages,Henan University of Technology,titled“Research on Development Paths for Innovative Development of Undergraduate Translation Programs Empowered by New Productive Forces”(Project No.:2025WYZYJS30)2025 Educational Reform Project of the School of International Education,Henan University of Technology,“A Study on the Language Competence Development Model for International Talents Based on the Al Large Model-Taking IELTS Reading and Writing Teaching Practice as an Example”(Project No.:GJXY202533)。
文摘This paper explores the paradigm reconstruction of interpreting pedagogy driven by generative AI technology.With the breakthroughs of AI technologies such as ChatGPT in natural language processing,traditional interpreting education faces dual challenges of technological substitution and pedagogical transformation.Based on Kuhn’s paradigm theory,the study analyzes the limitations of three traditional interpreting teaching paradigms,language-centric,knowledge-based,and skill-acquisition-oriented,and proposes a novel“teacher-AI-learner”triadic collaborative paradigm.Through reconstructing teaching subjects,environments,and curriculum systems,the integration of real-time translation tools and intelligent terminology databases facilitates the transition from static skill training to dynamic human-machine collaboration.The research simultaneously highlights challenges in technological ethics and curriculum design transformation pressures,emphasizing the necessity to balance technological empowerment with humanistic education.
文摘This study examines the advent of agent interaction(AIx)as a transformative paradigm in humancomputer interaction(HCI),signifying a notable evolution beyond traditional graphical interfaces and touchscreen interactions.Within the context of large models,AIx is characterized by its innovative interaction patterns and a plethora of application scenarios that hold great potential.The paper highlights the pivotal role of AIx in shaping the future landscape of the large model industry,emphasizing its adoption and necessity from a user's perspective.This study underscores the pivotal role of AIx in dictating the future trajectory of a large model industry by emphasizing the importance of its adoption and necessity from a user-centric perspective.The fundamental drivers of AIx include the introduction of novel capabilities,replication of capabilities(both anthropomorphic and superhuman),migration of capabilities,aggregation of intelligence,and multiplication of capabilities.These elements are essential for propelling innovation,expanding the frontiers of capability,and realizing the exponential superposition of capabilities,thereby mitigating labor redundancy and addressing a spectrum of human needs.Furthermore,this study provides an in-depth analysis of the structural components and operational mechanisms of agents supported by large models.Such advancements significantly enhance the capacity of agents to tackle complex problems and provide intelligent services,thereby facilitating a more intuitive,adaptive,and personalized engagement between humans and machines.The study further delineates four principal categories of interaction patterns that encompass eight distinct modalities of interaction,corresponding to twenty-one specific scenarios,including applications in smart home systems,health assistance,and elderly care.This emphasizes the significance of this new paradigm in advancing HCI,fostering technological advancements,and redefining user experiences.However,it also acknowledges the challenges and ethical considerations that accompany this paradigm shift,recognizing the need for a balanced approach to harness the full potential of AIx in modern society.
基金funded by Research on Policy Design and Implementation Path for High-Quality Development of Digital Cultural Industry(23&ZD087),a major project of the National Social Science Foundation of China.
文摘Digital-intelligent technologies represent the advanced direction of new quality productive forces and are becoming a driving force for the digital transformation and high-quality development of the cultural industry.Empowered by new quality productive forces,the digital cultural industry has demonstrated diverse characteristics,including the innovation of cultural production subjects,the intelligentization of production tools,the digitization of production objects,the systematization of production methods,and the diversification of production factors.Leveraging technologies such as AIGC,virtual-physical integration,and DAOs based on Web 3.0,the digital cultural industry has established an innovative paradigm,fostering a new method of AIGC production in the digital cultural industry,a new business format of virtual-physical integration,and a new collaborative ecosystem characterized by co-creation,co-building,and co-governance.Meanwhile,the innovative paradigm of the digital cultural industry also faces a series of new challenges,such as the adaptability issues with AIGC algorithm models,creative bottlenecks,and content quality control problems.Additionally,there are obstacles like the immaturity of international development channels for new business formats,the lack of cultural connotations in creative products,and the lag of the digital-intelligent governance of the industry ecosystem behind digital practices.In light of this,there is an urgent need to establish an optimization mechanism for the high-quality development of digital cultural industries driven by new quality productive forces.This includes optimizing the content production mechanism for AIGC-led high-quality innovation in the digital cultural industry;improving the leapfrog development mechanism for new digital cultural business formats through global-regional collaboration;and enhancing the accurate,high-quality governance mechanism for the digital cultural industry that is aligned with the goals of Chinese modernization.
文摘Head and neck cutaneous squamous cell carcinoma(HNCSCC)remains underexplored compared to oropharyngeal squamous cell carcinoma,particularly in relation to human papillomavirus(HPV)and molecular markers such as p16 and p53.While p16 is a well-established surrogate for HPV in oropharyngeal cancer,our review highlights its unreliable role in HNCSCC,where positivity is instead associated with recurrence and metastasis.Similarly,p53 illustrates a dual role-wild-type as a genomic safeguard,mutated as an oncogenic driver-complicating prognostication.Methodological considerations,including the limitations of immunohistochemistry for HPV detection,underscore the need for multi-method and molecular validation in future studies.Ultraviolet radiation is posited as a key modifier of p16 function,decoupling expression from tumor suppression.To contextualize these findings,we draw parallels to glioblastoma(GBM),where subclonal evolution,p53 dysfunction,and intratumoral heterogeneity drive relapse despite aggressive multimodal therapies.GBM exemplifies how bulk-level biomarker generalizations often obscure dynamic cellular ecosystems,reinforcing the necessity of single-cell and spatial approaches.Multi-omics integration-encompassing genome,transcriptome,proteome,and tumor microenvironment mapping-coupled with single-cell RNA sequencing and spatial transcriptomics,offers a path forward for resolving subclonal dynamics in both HNCSCC and GBM.These technologies provide the resolution needed to track tumor-immunestromal co-evolution,identify therapy-resistant clones,and anticipate recurrence.We argue for a N-of-1,patient-and cell-centric paradigm that reframes biomarkers not as static surrogates but as dynamic readouts of cancer evolution across time and tissue contexts.Conceptually,we propose kinetic and microenvironmental frameworks(e.g.,“load-and-lock”barriers;dormancy and immunesynapse stabilization)as hypothesis-generating avenues to stall clonal handoffs and improve outcome prediction.Together,these perspectives argue for revised biomarker frameworks in HNCSCC and ethically inclusive,mechanism-anchored studies that bridge discovery with individualized care.By bridging insights from HNCSCC with the lessons of GBM,this review underscores the need for ethically inclusive,mechanistically informed frameworks that integrate subclonal evolution,biomarker re-interpretation,and precision-personalized hybrid models.Such an approach will be essential for advancing from one-size-fits-all strategies to individualized lifetime cancer care.
基金supported by the National Natural Science Foundation of China,Nos.82272470 (to GN),82072439 (to GN),81930070 (to SF)the Tianjin Health Key Discipline Special Project,No.TJWJ2022XK011 (to GN)+2 种基金the Outstanding Youth Foundation of Tianjin Medical University General Hospital,No.22ZYYJQ01 (to GN)Tianjin Key Medical Disciplines,No.TJYXZDXK-027A (to SF)National Key Research and Development Program-Stem Cells and Transformation Research,No.2019YFA0112100 (to SF)
文摘Traumatic spinal cord injury result in considerable and lasting functional impairments,triggering complex inflammatory and pathological events.Spinal cord scars,often metaphorically referred to as“fire barriers,”aim to control the spread of neuroinflammation during the acute phase but later hinder axon regeneration in later stages.Recent studies have enhanced our understanding of immunomodulation,revealing that injury-associated inflammation involves various cell types and molecules with positive and negative effects.This review employs bibliometric analysis to examine the literature on inflammatory mediators in spinal cord injury,highlighting recent research and providing a comprehensive overview of the current state of research and the latest advances in studies on neuroinflammation related to spinal cord injury.We summarize the immune and inflammatory responses at different stages of spinal cord injury,offering crucial insights for future research.Additionally,we review repair strategies based on inflammatory mediators for the injured spinal cord.Finally,this review discusses the current status and future directions of translational research focused on immune-targeting strategies,including pharmaceuticals,biomedical engineering,and gene therapy.The development of a combined,precise,and multitemporal strategy for the repair of injured spinal cords represents a promising direction for future research.
文摘With the development of English as an international language,English speakers are widely spread in the world.The English learning fashion has been greatly changed since the culture background of English as a langauge has shifted to a mixed cultures instead of just British and American. But the standard varieties of British and American English have been accepted as the only generally accepted forms of standard English in China.The language learning fashion in China is about to undertake a big paradigm shift.This paper is an analysis of the English learning pattern shift in Chinese setting and therefore suggests a practical activities to apply this concept in English learning classes.
文摘In this article,some new developments in the field of applied linguistics are summarized.In addition,it is illustrated that researchers’epistemology determines their methodology.And their research conclusions are also led by their epistemology.It is proposed that a critical,bio-social paradigm be taken in the field of applied linguistics.
文摘This study examines how writer stance is projected in citation from a comparative perspective.The dataset consisted of 120 qualitative and quantitative research articles(RAs)that were authored by Anglophone and Chinese applied linguists.ANO?VA tests revealed marked cross-language and cross-paradigmatic differences in stance-based dialogic engagement.
文摘This article discusses the importance of theory and paradigm to a researcher. It starts from introducing and analyzing thedefinition of the two terms, by using the theories in the field of intercultural communication as examples. To a good researcher, heneeds not only clarifying the paradigm his research is positioned, but also integrating the theories in his paradigm.
