目的系统评估卒中后失语(PSA)患者Papez环路的损伤和恢复特征。方法检索Pubmed、Embase、Cochrane library、Web of Scienc、中国知网、维普数据库、万方数据库、中国生物医学文献数据库,时限为建库至2024年9月30日。结果纳入39篇文献,...目的系统评估卒中后失语(PSA)患者Papez环路的损伤和恢复特征。方法检索Pubmed、Embase、Cochrane library、Web of Scienc、中国知网、维普数据库、万方数据库、中国生物医学文献数据库,时限为建库至2024年9月30日。结果纳入39篇文献,涉及1488例参与者。PSA患者左侧半球Papez环路主要表现为功能活动减弱、连接纤维破坏,以丘脑、扣带回和穹窿为主;在右侧半球Papez环路主要表现为功能活动增强,以丘脑、海马和扣带回为主。经治疗后PSA患者双侧半球Papez环路主要表现为功能活动增强、连接纤维修复,以海马和扣带回为主。结论PSA患者损伤机制以左侧Papez环路功能减退为主,右侧以功能增强主。恢复机制以双侧Papez环路功能增强为主。未来研究应增加围绕Papez环路的纵向神经影像学研究,扩宽研究内容,增加研究深度,以进一步探究PSA患者损伤和恢复过程中Papez环路结构和功能变化。展开更多
BACKGROUND It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain injury.Diffusion tensor imaging can visualize the integrity of neural tracts in the white matter(WM)thr...BACKGROUND It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain injury.Diffusion tensor imaging can visualize the integrity of neural tracts in the white matter(WM)three-dimensionally.It is unclear whether encephalitis following scrub typhus damages the WM.For the first time,we aimed to report diffusion tensor tractography(DTT)findings in a chronic patient with cognitive impairment following scrub typhus encephalitis,which revealed injury to the Papez circuit of the WM.CASE SUMMARY A 70-year-old male patient was affected by encephalitis caused by scrub typhus that occurred 23 years ago.He had poor cognition and his clinical examination findings were as follows:Mini-Mental Status Examination score,14;and handgrip strength(right/left,kg),32.3/31.3.DTT revealed serious injuries of the left thalamocingulate tract and right mammillothalamic tract in the Papez circuit,and a partial injury of the anterior part of the fornix.CONCLUSION Using DTT,we found a relationship between cognitive impairment and the integrity of the Papez circuit following scrub typhus.展开更多
目的通过磁共振波谱(MRS)观察母婴分离子代大鼠成年后Papez环路海马和前额叶皮质内代谢物水平,探讨参芪解郁方对其抑郁、焦虑样行为的作用及机制。方法将24只孕16 d SD大鼠按照随机数字表法分为正常组、模型组、参芪解郁方组、盐酸氟西...目的通过磁共振波谱(MRS)观察母婴分离子代大鼠成年后Papez环路海马和前额叶皮质内代谢物水平,探讨参芪解郁方对其抑郁、焦虑样行为的作用及机制。方法将24只孕16 d SD大鼠按照随机数字表法分为正常组、模型组、参芪解郁方组、盐酸氟西汀组,每组6只。仔鼠出生后第1~21天每天进行4 h母婴分离。从第15天开始,给母鼠灌胃相应药物,每天1次,连续7 d(参芪解郁方组:12.5 g/kg,盐酸氟西汀组:2.33 mg/kg),灌胃期间正常哺乳。第22天,仔鼠断乳,按母鼠的实验分组,将每只母鼠分娩的子代仔鼠按照随机数字表法,选取雌雄各1只,每组6只,组成正常雌鼠组、模型雌鼠组、参芪解郁方雌鼠组、盐酸氟西汀雌鼠组、正常雄鼠组、模型雄鼠组、参芪解郁方雄鼠组、盐酸氟西汀雄鼠组。饲养8周后,各组子代大鼠分别进行强迫游泳实验、蔗糖水消耗实验、旷场实验和高架十字迷宫实验,采用MRS检测海马和前额叶皮质N-乙酰天[门]冬氨酸(NAA)、胆碱化合物(Cho)、谷氨酸(Glu)、肌醇(mI)和肌酸(Cr)的相对值。结果与正常雌鼠和雄鼠组比较,模型雌鼠和雄鼠组体质量降低,蔗糖水消耗量、旷场实验水平得分和垂直得分减少,强迫游泳不动时间增加,双侧海马和前额叶皮质NAA/Cr、Glu/Cr值下降(均P<0.01);模型雌鼠组高架十字迷宫进入开放臂次数比例和开放臂停留时间比例减少,右侧海马的Cho/Cr值升高(P<0.05)。与模型雌鼠和雄鼠组比较,参芪解郁方、盐酸氟西汀雌鼠和雄鼠组体质量增加,强迫游泳不动时间减少,蔗糖水消耗量、旷场实验水平得分和垂直得分增加(P<0.01);参芪解郁方和盐酸氟西汀雌鼠组高架十字迷宫进入开放臂次数比例和开放臂停留时间比例较模型雌鼠组增加(P<0.01)。与模型雌鼠组比较,参芪解郁方和盐酸氟西汀雌鼠组双侧海马和前额叶皮质的NAA/Cr、Glu/Cr值升高(P<0.05);参芪解郁方和盐酸氟西汀雄鼠组右侧海马、双侧前额叶皮质的NAA/Cr值和双侧海马、右侧前额叶皮质的Glu/Cr值较模型雄鼠组升高(P<0.05);参芪解郁方、盐酸氟西汀雌鼠和雄鼠组右侧海马的Cho/Cr值降低(P<0.05)。结论生命早期,母婴分离可致子代成年后出现抑郁、焦虑样行为,参芪解郁方可能通过调节Papez环路相关脑区代谢物水平发挥抗抑郁、焦虑作用。展开更多
目的:通过CiteSpace对Web of Science数据库中涉及遗忘型轻度认知障碍(aMCI)患者Papez环路的相关文献进行可视化分析,探讨此领域的地域分布、机构合作网络、核心作者集群、研究热点及发展趋势。方法:检索Web of Science核心集合数据库,...目的:通过CiteSpace对Web of Science数据库中涉及遗忘型轻度认知障碍(aMCI)患者Papez环路的相关文献进行可视化分析,探讨此领域的地域分布、机构合作网络、核心作者集群、研究热点及发展趋势。方法:检索Web of Science核心集合数据库,共筛选出486篇与aMCI患者Papez环路相关的文献。利用CiteSpace对研究方向、期刊共被引、国家、机构及作者等特征进行可视化分析,并通过关键词聚类、共被引文献、时间线和突现词揭示研究热点和前沿。结果:Papez环路在aMCI中的核心地位得到确认,MRI技术在监测环路变化中占据主导。研究热点从基础病理机制转向多模态生物标志物和临床应用。未来研究应关注多模态数据整合和个性化干预策略。结论:本研究为Papez环路与aMCI相关性研究提供了系统性梳理,揭示了研究趋势和前沿,为未来研究的方向提供了参考。展开更多
The fornix,which connects the medial temporal lobe and the medial diencephalon,is involved in episodic memory as an important part of the Papez circuit.The mechanisms of recovery of an injured fornix revealed by diffu...The fornix,which connects the medial temporal lobe and the medial diencephalon,is involved in episodic memory as an important part of the Papez circuit.The mechanisms of recovery of an injured fornix revealed by diffusion tensor tractography in the five studies are summarized as follows：1） recovery through the nerve tract from an injured fornical crus to the medial temporal lobe via the normal pathway of the fornical crus;2）recovery through the nerve tract originating from an ipsi-lesional fornical body connected to the ipsi-lesional medial temporal lobe via the splenium of the corpus callosum;3） recovery through the nerve tract from the ipsi-lesional fornical body extending to the contra-lesional medial temporal lobe via the splenium of the corpus callosum;4） recovery through the nerve tract originating from the ipsi-lesional fornical column connected to the ipsi-lesional medial temporal lobe;and 5） recovery through the nerve tract originating from the contra-lesional fornical column connected to the ipsi-lesional medial temporal lobe via the contra-lesional medial temporal lobe and the splenium of the corpus callosum.These diffusion tensor tractography studies on mechanisms of recovery of injured fornical crus appeared to provide useful information for clinicians caring for patients with brain injury,however,studies on this topic are still in the beginning stages.展开更多
文摘目的系统评估卒中后失语(PSA)患者Papez环路的损伤和恢复特征。方法检索Pubmed、Embase、Cochrane library、Web of Scienc、中国知网、维普数据库、万方数据库、中国生物医学文献数据库,时限为建库至2024年9月30日。结果纳入39篇文献,涉及1488例参与者。PSA患者左侧半球Papez环路主要表现为功能活动减弱、连接纤维破坏,以丘脑、扣带回和穹窿为主;在右侧半球Papez环路主要表现为功能活动增强,以丘脑、海马和扣带回为主。经治疗后PSA患者双侧半球Papez环路主要表现为功能活动增强、连接纤维修复,以海马和扣带回为主。结论PSA患者损伤机制以左侧Papez环路功能减退为主,右侧以功能增强主。恢复机制以双侧Papez环路功能增强为主。未来研究应增加围绕Papez环路的纵向神经影像学研究,扩宽研究内容,增加研究深度,以进一步探究PSA患者损伤和恢复过程中Papez环路结构和功能变化。
基金National Research Foundation of Korea funded by the Ministry of Education,No.2013R1A1A4A01013178.
文摘BACKGROUND It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain injury.Diffusion tensor imaging can visualize the integrity of neural tracts in the white matter(WM)three-dimensionally.It is unclear whether encephalitis following scrub typhus damages the WM.For the first time,we aimed to report diffusion tensor tractography(DTT)findings in a chronic patient with cognitive impairment following scrub typhus encephalitis,which revealed injury to the Papez circuit of the WM.CASE SUMMARY A 70-year-old male patient was affected by encephalitis caused by scrub typhus that occurred 23 years ago.He had poor cognition and his clinical examination findings were as follows:Mini-Mental Status Examination score,14;and handgrip strength(right/left,kg),32.3/31.3.DTT revealed serious injuries of the left thalamocingulate tract and right mammillothalamic tract in the Papez circuit,and a partial injury of the anterior part of the fornix.CONCLUSION Using DTT,we found a relationship between cognitive impairment and the integrity of the Papez circuit following scrub typhus.
文摘目的:通过CiteSpace对Web of Science数据库中涉及遗忘型轻度认知障碍(aMCI)患者Papez环路的相关文献进行可视化分析,探讨此领域的地域分布、机构合作网络、核心作者集群、研究热点及发展趋势。方法:检索Web of Science核心集合数据库,共筛选出486篇与aMCI患者Papez环路相关的文献。利用CiteSpace对研究方向、期刊共被引、国家、机构及作者等特征进行可视化分析,并通过关键词聚类、共被引文献、时间线和突现词揭示研究热点和前沿。结果:Papez环路在aMCI中的核心地位得到确认,MRI技术在监测环路变化中占据主导。研究热点从基础病理机制转向多模态生物标志物和临床应用。未来研究应关注多模态数据整合和个性化干预策略。结论:本研究为Papez环路与aMCI相关性研究提供了系统性梳理,揭示了研究趋势和前沿,为未来研究的方向提供了参考。
基金supported by the National Research Foundation(NRF)of Korea Grant funded by the Korean Government(MSIP)(2015R1A2A2A01004073)
文摘The fornix,which connects the medial temporal lobe and the medial diencephalon,is involved in episodic memory as an important part of the Papez circuit.The mechanisms of recovery of an injured fornix revealed by diffusion tensor tractography in the five studies are summarized as follows：1） recovery through the nerve tract from an injured fornical crus to the medial temporal lobe via the normal pathway of the fornical crus;2）recovery through the nerve tract originating from an ipsi-lesional fornical body connected to the ipsi-lesional medial temporal lobe via the splenium of the corpus callosum;3） recovery through the nerve tract from the ipsi-lesional fornical body extending to the contra-lesional medial temporal lobe via the splenium of the corpus callosum;4） recovery through the nerve tract originating from the ipsi-lesional fornical column connected to the ipsi-lesional medial temporal lobe;and 5） recovery through the nerve tract originating from the contra-lesional fornical column connected to the ipsi-lesional medial temporal lobe via the contra-lesional medial temporal lobe and the splenium of the corpus callosum.These diffusion tensor tractography studies on mechanisms of recovery of injured fornical crus appeared to provide useful information for clinicians caring for patients with brain injury,however,studies on this topic are still in the beginning stages.
