This review examines inflammation as a physiological defense mechanism against infectious agents,physical trauma,reactive oxygen species(ROS),and metabolic stress,which,under dysregulated conditions,may progress into ...This review examines inflammation as a physiological defense mechanism against infectious agents,physical trauma,reactive oxygen species(ROS),and metabolic stress,which,under dysregulated conditions,may progress into chronic diseases.Nanomedicine,which integrates nanotechnology with medicine,suppresses inflammatory signaling pathways and overexpressed pro-inflammatory cytokines,such as ROS,to address inflammationrelated pathologies.Current advances in nanomaterial design and synthesis strategies are systematically analyzed,with parallel discussions on toxicity mechanisms,influencing factors,and evaluation methods that are critical for clinical translation.Applications of functional nanomaterials are highlighted in the context of refractory inflammatory conditions,including wound healing,gastrointestinal disorders,and immune,neurological,or circulatory diseases,along with targeted delivery strategies.Persistent challenges in nanomedicine development,such as biocompatibility optimization,precise biodistribution control,and standardized toxicity assessment,are critically assessed.By bridging material innovation with therapeutic efficacy,this review establishes a framework for advancing nanomedicine to improve treatment outcomes while addressing translational barriers.展开更多
基金supported by the National Key Research and Development Program of China(Grants No.2023YFC2306500)Scientific Research Project Program of the Shanghai Municipal Health and Wellness Commission(Grant No.202140061)+3 种基金Key Science and Technology Research and Development Projects of Jiangxi Province(Grant No.20223BBH80014)“Shuguang Program”supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(Grant No.21SG39)Excellent Talents Program of Naval Medical Center of PLA(21TPZYL01)Military Projects(CHJ24C025,24AZL01,CB2023A03,JPY2022B06).
文摘This review examines inflammation as a physiological defense mechanism against infectious agents,physical trauma,reactive oxygen species(ROS),and metabolic stress,which,under dysregulated conditions,may progress into chronic diseases.Nanomedicine,which integrates nanotechnology with medicine,suppresses inflammatory signaling pathways and overexpressed pro-inflammatory cytokines,such as ROS,to address inflammationrelated pathologies.Current advances in nanomaterial design and synthesis strategies are systematically analyzed,with parallel discussions on toxicity mechanisms,influencing factors,and evaluation methods that are critical for clinical translation.Applications of functional nanomaterials are highlighted in the context of refractory inflammatory conditions,including wound healing,gastrointestinal disorders,and immune,neurological,or circulatory diseases,along with targeted delivery strategies.Persistent challenges in nanomedicine development,such as biocompatibility optimization,precise biodistribution control,and standardized toxicity assessment,are critically assessed.By bridging material innovation with therapeutic efficacy,this review establishes a framework for advancing nanomedicine to improve treatment outcomes while addressing translational barriers.
