This paper is concerned with the Hopf bifurcation control of a modified Pan-like chaotic system. Based on the Routh-Hurwtiz theory and high-dimensional Hopf bifurcation theory, the existence and stability of the Hopf ...This paper is concerned with the Hopf bifurcation control of a modified Pan-like chaotic system. Based on the Routh-Hurwtiz theory and high-dimensional Hopf bifurcation theory, the existence and stability of the Hopf bifurcation depending on selected values of the system parameters are studied. The region of the stability for the Hopf bifurcation is investigated.By the hybrid control method, a nonlinear controller is designed for changing the Hopf bifurcation point and expanding the range of the stability. Discussions show that with the change of parameters of the controller, the Hopf bifurcation emerges at an expected location with predicted properties and the range of the Hopf bifurcation stability is expanded. Finally,numerical simulation is provided to confirm the analytic results.展开更多
采用固体13 C核磁共振(13 C Solid-NMR)、差示扫描量热分析(DSC)研究了不同温度场对聚丙烯腈纤维预氧过程中类萘啶结构生成的影响。研究结果表明:提高预氧化温度纤维中易于形成类萘啶的梯形含氮芳杂环结构,预氧化热处理温度高于230℃时...采用固体13 C核磁共振(13 C Solid-NMR)、差示扫描量热分析(DSC)研究了不同温度场对聚丙烯腈纤维预氧过程中类萘啶结构生成的影响。研究结果表明:提高预氧化温度纤维中易于形成类萘啶的梯形含氮芳杂环结构,预氧化热处理温度高于230℃时,类萘啶结构生成速度较快。梯度升温方式影响类萘啶结构的生成,三温区温度场条件下(210-230-245℃),在高温区(245℃)停留时间较长时有利于类萘啶结构的形成和发展;四温区温度场中(210-230-245-260℃),均匀分配各温区的热处理时间更有利于类萘啶结构的生成。展开更多
The fabrication of raspberry-like poly（ethylene terephthalate）/polyacrylonitrile（PET/PAN） microspheres by g-ray radiation-induced polymerization of acrylonitrile on micron-sized PET microspheres were first reporte...The fabrication of raspberry-like poly（ethylene terephthalate）/polyacrylonitrile（PET/PAN） microspheres by g-ray radiation-induced polymerization of acrylonitrile on micron-sized PET microspheres were first reported in this work. A PET emulsion was firstly prepared by dispersing a PET solution with 1,1,2,2-tetrachloroethane/phenol mixture as the solvent into an aqueous solution of sodium dodecyl sulfate.Then, PET microspheres were formed by precipitating the PET emulsion droplets from ethanol. The influence of the PET solvent and the weight ratio of ethanol to PET emulsion on the morphology of the PET microspheres had been investigated. After the surface of the prepared PET microspheres was grafted with poly（acrylic acid）, the grafting polymerization of AN also had been successfully initiated by g-ray radiation to form PAN microspheres with a size of about 100 nm on the PET microspheres. This work provides a new method to fabricate micron-sized PET microspheres, and further expands the functionalization of PET and its application fields.展开更多
目的分析m6A甲基转移酶样3(methyltransferase like 3,METTL3)基因在泛癌中的表达及对肿瘤微环境的影响。方法在癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库下载多种癌症患者的基因测序结果及临床资料,分析METTL3基因在各类型...目的分析m6A甲基转移酶样3(methyltransferase like 3,METTL3)基因在泛癌中的表达及对肿瘤微环境的影响。方法在癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库下载多种癌症患者的基因测序结果及临床资料,分析METTL3基因在各类型肿瘤中的表达以及其与肿瘤微环境相关细胞浸润及预后的关系。结果METTL3基因在大多数恶性肿瘤中表达上调,导致肝细胞癌和前列腺癌患者无进展生存期缩短(P<0.05)。肝细胞癌和前列腺癌中,METTL3表达与多种免疫细胞浸润水平及抑制性免疫检查点基因表达水平相关(P<0.05)。结论METTL3基因表达增加导致肝细胞癌和前列腺癌患者的不良预后,可能通过促进免疫浸润及增加抑制性免疫检查点基因表达发挥作用。展开更多
目的探索睾丸蛋白聚糖2(sparc/osteonectin,cwcv and kazal-like domains proteoglycan 2,SPOCK2)在泛癌中的预后及免疫治疗反应中的作用。方法基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)和临床蛋白质组学肿瘤分析联盟(Clinical...目的探索睾丸蛋白聚糖2(sparc/osteonectin,cwcv and kazal-like domains proteoglycan 2,SPOCK2)在泛癌中的预后及免疫治疗反应中的作用。方法基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)和临床蛋白质组学肿瘤分析联盟(Clinical Proteomic Tumor Analysis Consortium,CPTAC)数据库检测SPOCK2在肿瘤组织与正常组织中的表达差异,并通过人类蛋白质图谱(Human Protein Atlas,HPA)数据库SPOCK2进行初步验证。关于SPOCK2对患者生存预后的影响采用Kaplan-Meier方法进行分析。采用基因富集工具进一步分析SPOCK2在肿瘤中参与的通路。最后通过桑格数据库研究SPOCK2与免疫细胞及免疫相关基因的关系。结果SPOCK2在14种肿瘤中高表达,在12种肿瘤中低表达,且HPA数据库显示在肝细胞性肝癌、甲状腺癌、皮肤黑色素瘤及卵巢浆液性囊腺癌中SPOCK2高表达,与基因表达水平分析结果一致。生存分析结果表明SPOCK2高表达在多种肿瘤中预示预后良好。富集分析发现SPOCK2参与T细胞和辅助性T细胞的分化和激活过程。此外,与免疫浸润细胞的相关性分析显示SPOCK2水平与多数肿瘤中的B淋巴细胞、CD4^(+)T淋巴细胞、CD8^(+)T淋巴细胞和树突状细胞等免疫细胞浸润呈正相关。SPOCK2的表达水平与免疫调节因子和免疫检查点相关基因存在密切联系。结论SPOCK2在泛癌中是一种免疫相关的生物标志物,具有调节肿瘤免疫微环境的作用,在免疫治疗中具有潜在的价值。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.11372102)
文摘This paper is concerned with the Hopf bifurcation control of a modified Pan-like chaotic system. Based on the Routh-Hurwtiz theory and high-dimensional Hopf bifurcation theory, the existence and stability of the Hopf bifurcation depending on selected values of the system parameters are studied. The region of the stability for the Hopf bifurcation is investigated.By the hybrid control method, a nonlinear controller is designed for changing the Hopf bifurcation point and expanding the range of the stability. Discussions show that with the change of parameters of the controller, the Hopf bifurcation emerges at an expected location with predicted properties and the range of the Hopf bifurcation stability is expanded. Finally,numerical simulation is provided to confirm the analytic results.
文摘采用固体13 C核磁共振(13 C Solid-NMR)、差示扫描量热分析(DSC)研究了不同温度场对聚丙烯腈纤维预氧过程中类萘啶结构生成的影响。研究结果表明:提高预氧化温度纤维中易于形成类萘啶的梯形含氮芳杂环结构,预氧化热处理温度高于230℃时,类萘啶结构生成速度较快。梯度升温方式影响类萘啶结构的生成,三温区温度场条件下(210-230-245℃),在高温区(245℃)停留时间较长时有利于类萘啶结构的形成和发展;四温区温度场中(210-230-245-260℃),均匀分配各温区的热处理时间更有利于类萘啶结构的生成。
基金the National Natural Science Foundation of China (Nos. 51573174, 51473172, 51173175, 51073146 and 51103143)Foshan Scientific and Technological Innovation Team Project (No. 2013IT100041)the Fundamental Research Funds for the Central Universities (Nos. WK2060200012 and WK3450000001)
文摘The fabrication of raspberry-like poly（ethylene terephthalate）/polyacrylonitrile（PET/PAN） microspheres by g-ray radiation-induced polymerization of acrylonitrile on micron-sized PET microspheres were first reported in this work. A PET emulsion was firstly prepared by dispersing a PET solution with 1,1,2,2-tetrachloroethane/phenol mixture as the solvent into an aqueous solution of sodium dodecyl sulfate.Then, PET microspheres were formed by precipitating the PET emulsion droplets from ethanol. The influence of the PET solvent and the weight ratio of ethanol to PET emulsion on the morphology of the PET microspheres had been investigated. After the surface of the prepared PET microspheres was grafted with poly（acrylic acid）, the grafting polymerization of AN also had been successfully initiated by g-ray radiation to form PAN microspheres with a size of about 100 nm on the PET microspheres. This work provides a new method to fabricate micron-sized PET microspheres, and further expands the functionalization of PET and its application fields.
文摘目的分析m6A甲基转移酶样3(methyltransferase like 3,METTL3)基因在泛癌中的表达及对肿瘤微环境的影响。方法在癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库下载多种癌症患者的基因测序结果及临床资料,分析METTL3基因在各类型肿瘤中的表达以及其与肿瘤微环境相关细胞浸润及预后的关系。结果METTL3基因在大多数恶性肿瘤中表达上调,导致肝细胞癌和前列腺癌患者无进展生存期缩短(P<0.05)。肝细胞癌和前列腺癌中,METTL3表达与多种免疫细胞浸润水平及抑制性免疫检查点基因表达水平相关(P<0.05)。结论METTL3基因表达增加导致肝细胞癌和前列腺癌患者的不良预后,可能通过促进免疫浸润及增加抑制性免疫检查点基因表达发挥作用。
文摘目的探索睾丸蛋白聚糖2(sparc/osteonectin,cwcv and kazal-like domains proteoglycan 2,SPOCK2)在泛癌中的预后及免疫治疗反应中的作用。方法基于癌症基因组图谱(The Cancer Genome Atlas,TCGA)和临床蛋白质组学肿瘤分析联盟(Clinical Proteomic Tumor Analysis Consortium,CPTAC)数据库检测SPOCK2在肿瘤组织与正常组织中的表达差异,并通过人类蛋白质图谱(Human Protein Atlas,HPA)数据库SPOCK2进行初步验证。关于SPOCK2对患者生存预后的影响采用Kaplan-Meier方法进行分析。采用基因富集工具进一步分析SPOCK2在肿瘤中参与的通路。最后通过桑格数据库研究SPOCK2与免疫细胞及免疫相关基因的关系。结果SPOCK2在14种肿瘤中高表达,在12种肿瘤中低表达,且HPA数据库显示在肝细胞性肝癌、甲状腺癌、皮肤黑色素瘤及卵巢浆液性囊腺癌中SPOCK2高表达,与基因表达水平分析结果一致。生存分析结果表明SPOCK2高表达在多种肿瘤中预示预后良好。富集分析发现SPOCK2参与T细胞和辅助性T细胞的分化和激活过程。此外,与免疫浸润细胞的相关性分析显示SPOCK2水平与多数肿瘤中的B淋巴细胞、CD4^(+)T淋巴细胞、CD8^(+)T淋巴细胞和树突状细胞等免疫细胞浸润呈正相关。SPOCK2的表达水平与免疫调节因子和免疫检查点相关基因存在密切联系。结论SPOCK2在泛癌中是一种免疫相关的生物标志物,具有调节肿瘤免疫微环境的作用,在免疫治疗中具有潜在的价值。
