Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have b...Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.展开更多
目的:应用功能性磁共振成像(functional magnetic resonance imaging,fMRI)观察针刺治疗腰痛时脑疼痛矩阵的变化。方法:先在15名右利手、健康受试者的右侧腰部肌肉注射0.3 ml 2.4%的氯化钠溶液,产生实验性腰痛;然后将所有受试者按随机...目的:应用功能性磁共振成像(functional magnetic resonance imaging,fMRI)观察针刺治疗腰痛时脑疼痛矩阵的变化。方法:先在15名右利手、健康受试者的右侧腰部肌肉注射0.3 ml 2.4%的氯化钠溶液,产生实验性腰痛;然后将所有受试者按随机方法分配给针刺组(真针刺)和触觉组(假针刺);刺激各受试者右下肢委中穴,同时采集脑fMRI信号;最后应用SPM8软件处理fMRI信号。结果:相对于假针刺的fMRI结果,针刺组岛叶显示显著正激活,而前扣带回显示显著负激活;但两组在疼痛矩阵的感觉部分(S1和S2)无显著性差异。结论:真、假针刺治疗腰痛都可以引起脑疼痛矩阵中不同部位的改变;其中在疼痛矩阵的情绪部分(岛叶和扣带回)二者间有显著差异。展开更多
文摘Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.
文摘目的:应用功能性磁共振成像(functional magnetic resonance imaging,fMRI)观察针刺治疗腰痛时脑疼痛矩阵的变化。方法:先在15名右利手、健康受试者的右侧腰部肌肉注射0.3 ml 2.4%的氯化钠溶液,产生实验性腰痛;然后将所有受试者按随机方法分配给针刺组(真针刺)和触觉组(假针刺);刺激各受试者右下肢委中穴,同时采集脑fMRI信号;最后应用SPM8软件处理fMRI信号。结果:相对于假针刺的fMRI结果,针刺组岛叶显示显著正激活,而前扣带回显示显著负激活;但两组在疼痛矩阵的感觉部分(S1和S2)无显著性差异。结论:真、假针刺治疗腰痛都可以引起脑疼痛矩阵中不同部位的改变;其中在疼痛矩阵的情绪部分(岛叶和扣带回)二者间有显著差异。
